Discovery of a new konkovirus species in Lachenalia plants reveals possible co-evolution between 5′ and 3′ RNA sequence motifs. Published Open Access and fee-free in JGV using a Publish and Read agreement: doi.org/10.1099/jgv.... #JGV #PublishAndRead
November 11, 2025 at 12:01 PM
Discovery of a new konkovirus species in Lachenalia plants reveals possible co-evolution between 5′ and 3′ RNA sequence motifs. Published Open Access and fee-free in JGV using a Publish and Read agreement: doi.org/10.1099/jgv.... #JGV #PublishAndRead
A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness
For the production of RVFV PV, we compared two systems which have historically been successfully used, the non-replicative ΔG-VSV and a lentiviral vector based on HIV-128,30. The RVFV polyprotein GnGc precursor is encoded by the Medium (M) segment of the...
www.nature.com
November 7, 2025 at 3:29 AM
For all bunyavirus enthusiasts out there:
@alainkohlvirology.bsky.social
@clive-mckimmie.bsky.social
@cvrinfo.bsky.social
@alainkohlvirology.bsky.social
@clive-mckimmie.bsky.social
@cvrinfo.bsky.social
A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness - npj Vaccines
npj Vaccines - A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness
www.nature.com
November 6, 2025 at 5:55 PM
For all bunyavirus enthusiasts out there:
@alainkohlvirology.bsky.social
@clive-mckimmie.bsky.social
@cvrinfo.bsky.social
@alainkohlvirology.bsky.social
@clive-mckimmie.bsky.social
@cvrinfo.bsky.social
A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness - npj Vaccines
npj Vaccines - A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness
www.nature.com
November 6, 2025 at 3:13 PM
A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Culiseta annulata #mosquitoes were recently found for the first time in a glacial valley in Iceland. Iceland was previously one of only two mosquito-free regions globally (the other, Antarctica). Warmer temperatures are expanding the habitat range of this #bunyavirus vector species
bbc.in/47fsy1y
bbc.in/47fsy1y
Mosquitoes found in Iceland for first time after record heat
Previously the country was one of the world's only mosquito-free zones.
bbc.in
October 28, 2025 at 5:04 AM
Culiseta annulata #mosquitoes were recently found for the first time in a glacial valley in Iceland. Iceland was previously one of only two mosquito-free regions globally (the other, Antarctica). Warmer temperatures are expanding the habitat range of this #bunyavirus vector species
bbc.in/47fsy1y
bbc.in/47fsy1y
DoD still quietly (til now?) funding mRNA research against lethal bunyavirus CCHF, could protect troops in a ME theater. Seemingly beyond RFK Jr's reach.
I hope this continues. I even know of people doing officially verboten research thru agencies other than #NIH.
www.nature.com/articles/d41...
I hope this continues. I even know of people doing officially verboten research thru agencies other than #NIH.
www.nature.com/articles/d41...
Exclusive: RFK Jr cancelled mRNA research — but the US military is still funding it
The Department of Defense is continuing to bankroll projects to develop vaccines against deadly pathogens.
www.nature.com
September 28, 2025 at 5:03 PM
DoD still quietly (til now?) funding mRNA research against lethal bunyavirus CCHF, could protect troops in a ME theater. Seemingly beyond RFK Jr's reach.
I hope this continues. I even know of people doing officially verboten research thru agencies other than #NIH.
www.nature.com/articles/d41...
I hope this continues. I even know of people doing officially verboten research thru agencies other than #NIH.
www.nature.com/articles/d41...
Really depends what you want to to do! Engineering viruses or just use viruses to infect mosquito cells. There’s some papers that show bunyavirus canonical piRNAs and role of piwi proteins.
September 18, 2025 at 6:43 AM
Really depends what you want to to do! Engineering viruses or just use viruses to infect mosquito cells. There’s some papers that show bunyavirus canonical piRNAs and role of piwi proteins.
NSs: The Versatile Bunyavirus Virulence Factor
The battle between viruses and the host immune system is a complex and relentless arms race, with each side evolving new strategies to outmaneuver the other. Among the many viral families, bunyaviruses represent a formidable group of pathogens…
The battle between viruses and the host immune system is a complex and relentless arms race, with each side evolving new strategies to outmaneuver the other. Among the many viral families, bunyaviruses represent a formidable group of pathogens…
NSs: The Versatile Bunyavirus Virulence Factor
The battle between viruses and the host immune system is a complex and relentless arms race, with each side evolving new strategies to outmaneuver the other. Among the many viral families, bunyaviruses represent a formidable group of pathogens responsible for significant human and animal diseases worldwide. Central to their ability to cause disease and evade the host defenses is a viral protein known as NSs.
scienmag.com
September 3, 2025 at 5:31 PM
NSs: The Versatile Bunyavirus Virulence Factor
The battle between viruses and the host immune system is a complex and relentless arms race, with each side evolving new strategies to outmaneuver the other. Among the many viral families, bunyaviruses represent a formidable group of pathogens…
The battle between viruses and the host immune system is a complex and relentless arms race, with each side evolving new strategies to outmaneuver the other. Among the many viral families, bunyaviruses represent a formidable group of pathogens…
📢 Thrilled to share our NEW PREPRINT!
SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠
🧫 NSs essential for tick but not mammalian infection
🧬 Binds 22-nt viral siRNAs to block RNAi
🕷️ Reveals host-specific viral immune evasion
📖 doi.org/p2vf
#lovevirology #bunyavirus #tickborne
SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠
🧫 NSs essential for tick but not mammalian infection
🧬 Binds 22-nt viral siRNAs to block RNAi
🕷️ Reveals host-specific viral immune evasion
📖 doi.org/p2vf
#lovevirology #bunyavirus #tickborne
SFTSV NSs protein is a novel tick antiviral RNAi response suppressor
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the non-structural protein NSs is dispensable for replication in...
doi.org
August 15, 2025 at 8:11 AM
📢 Thrilled to share our NEW PREPRINT!
SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠
🧫 NSs essential for tick but not mammalian infection
🧬 Binds 22-nt viral siRNAs to block RNAi
🕷️ Reveals host-specific viral immune evasion
📖 doi.org/p2vf
#lovevirology #bunyavirus #tickborne
SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠
🧫 NSs essential for tick but not mammalian infection
🧬 Binds 22-nt viral siRNAs to block RNAi
🕷️ Reveals host-specific viral immune evasion
📖 doi.org/p2vf
#lovevirology #bunyavirus #tickborne
Post 3/5 🧵
DISCOVERY: Virus systematically hijacks tick RNA machinery:
🔹 RNAi pathway: UP (tick defense)
🔹 Translation: UP (viral protein synthesis)
🔹 rRNA processing: DOWN (disrupts cell proteins)
18 proteins both changed activity AND bound viral nucleocapsid!
#bunyavirus
DISCOVERY: Virus systematically hijacks tick RNA machinery:
🔹 RNAi pathway: UP (tick defense)
🔹 Translation: UP (viral protein synthesis)
🔹 rRNA processing: DOWN (disrupts cell proteins)
18 proteins both changed activity AND bound viral nucleocapsid!
#bunyavirus
August 13, 2025 at 12:32 PM
Post 3/5 🧵
DISCOVERY: Virus systematically hijacks tick RNA machinery:
🔹 RNAi pathway: UP (tick defense)
🔹 Translation: UP (viral protein synthesis)
🔹 rRNA processing: DOWN (disrupts cell proteins)
18 proteins both changed activity AND bound viral nucleocapsid!
#bunyavirus
DISCOVERY: Virus systematically hijacks tick RNA machinery:
🔹 RNAi pathway: UP (tick defense)
🔹 Translation: UP (viral protein synthesis)
🔹 rRNA processing: DOWN (disrupts cell proteins)
18 proteins both changed activity AND bound viral nucleocapsid!
#bunyavirus
Post 2/5 🧵
METHOD: Using RNA interactome capture (RIC), we UV-crosslinks RNA-bound proteins to map the "RBPome" in infected vs healthy tick cells.
Challenge: Bunyavirus RNA lacks poly(A) tails, yet found enough "poly(A)-like" sequences to capture viral RNAs too!
#RNABiology #collaboration #Scitech
METHOD: Using RNA interactome capture (RIC), we UV-crosslinks RNA-bound proteins to map the "RBPome" in infected vs healthy tick cells.
Challenge: Bunyavirus RNA lacks poly(A) tails, yet found enough "poly(A)-like" sequences to capture viral RNAs too!
#RNABiology #collaboration #Scitech
August 13, 2025 at 12:32 PM
Post 2/5 🧵
METHOD: Using RNA interactome capture (RIC), we UV-crosslinks RNA-bound proteins to map the "RBPome" in infected vs healthy tick cells.
Challenge: Bunyavirus RNA lacks poly(A) tails, yet found enough "poly(A)-like" sequences to capture viral RNAs too!
#RNABiology #collaboration #Scitech
METHOD: Using RNA interactome capture (RIC), we UV-crosslinks RNA-bound proteins to map the "RBPome" in infected vs healthy tick cells.
Challenge: Bunyavirus RNA lacks poly(A) tails, yet found enough "poly(A)-like" sequences to capture viral RNAs too!
#RNABiology #collaboration #Scitech
What's the tldr for us bunyavirus people?
August 12, 2025 at 10:29 AM
What's the tldr for us bunyavirus people?
This study systematically identified changes in the RNA-binding activity of 283 proteins in tick cells infected with the bunyavirus Uukuniemi virus (UUKV).
August 11, 2025 at 11:06 PM
This study systematically identified changes in the RNA-binding activity of 283 proteins in tick cells infected with the bunyavirus Uukuniemi virus (UUKV).
Remodelling of the tick cell RNA- binding proteome after bunyavirus infection! Great work led by Alex Wilson and @brennanlab.bsky.social - thanks for including me!
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells
Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions. ...
journals.plos.org
August 6, 2025 at 8:41 PM
Remodelling of the tick cell RNA- binding proteome after bunyavirus infection! Great work led by Alex Wilson and @brennanlab.bsky.social - thanks for including me!
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
oh it 1000% is. there’s a reason this has been a desk meme wall staple since I made it in undergrad
July 23, 2025 at 8:43 PM
oh it 1000% is. there’s a reason this has been a desk meme wall staple since I made it in undergrad
July 12, 2025 at 8:04 AM
Oh neat!! Thanks for thinking of me – I always love a new frontier of bunyavirus mischief, and this is EMINENTLY qualified 😅 & will second the welcome to bluesky, Dr. Kohl!!
June 29, 2025 at 4:06 PM
Oh neat!! Thanks for thinking of me – I always love a new frontier of bunyavirus mischief, and this is EMINENTLY qualified 😅 & will second the welcome to bluesky, Dr. Kohl!!
Finally we finalized our omics characterization by looking at the interactors of SFTSV N protein during an active infection. N interactors were mostly related to stress, or RNA regulation pathways. We identified interactors conserved in human, and other associated with immune response to bunyavirus.
May 23, 2025 at 2:02 PM
Finally we finalized our omics characterization by looking at the interactors of SFTSV N protein during an active infection. N interactors were mostly related to stress, or RNA regulation pathways. We identified interactors conserved in human, and other associated with immune response to bunyavirus.
NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts PubMed_
NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts
Bunyavirales is a very large order including viruses infecting a variety of taxonomic groups such as arthropods, vertebrates, plants, and protozoa. Some bunyaviruses are transmitted between vertebrate hosts by blood-sucking arthropods and cause major diseases in humans and animals. It is not understood why only some bunyaviruses have evolved the capacity to be transmitted by arthropod vectors. Here we show that only vector-borne bunyaviruses express a non-structural protein, NSm, whose function...
dlvr.it
May 12, 2025 at 3:37 AM
NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts PubMed_
NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts PubMed_
NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts
Bunyavirales is a very large order including viruses infecting a variety of taxonomic groups such as arthropods, vertebrates, plants, and protozoa. Some bunyaviruses are transmitted between vertebrate hosts by blood-sucking arthropods and cause major diseases in humans and animals. It is not understood why only some bunyaviruses have evolved the capacity to be transmitted by arthropod vectors. Here we show that only vector-borne bunyaviruses express a non-structural protein, NSm, whose function...
dlvr.it
May 10, 2025 at 8:36 PM
NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts PubMed_
🎓 Prix de thèse ANRS MIE & SFV 2025 - Virus émergent
🏅Nell Saunders : Entrée/réplication des coronavirus
🏅Adrian Gervais : Rôle des auto-anticorps anti-IFN I dans les formes sévères
🏅Quentin Durieux Trouilleton : Mécanismes de réplication des Bunyavirus
👏 Bravo pour ces travaux innovants !
🏅Nell Saunders : Entrée/réplication des coronavirus
🏅Adrian Gervais : Rôle des auto-anticorps anti-IFN I dans les formes sévères
🏅Quentin Durieux Trouilleton : Mécanismes de réplication des Bunyavirus
👏 Bravo pour ces travaux innovants !
May 6, 2025 at 8:02 AM
🎓 Prix de thèse ANRS MIE & SFV 2025 - Virus émergent
🏅Nell Saunders : Entrée/réplication des coronavirus
🏅Adrian Gervais : Rôle des auto-anticorps anti-IFN I dans les formes sévères
🏅Quentin Durieux Trouilleton : Mécanismes de réplication des Bunyavirus
👏 Bravo pour ces travaux innovants !
🏅Nell Saunders : Entrée/réplication des coronavirus
🏅Adrian Gervais : Rôle des auto-anticorps anti-IFN I dans les formes sévères
🏅Quentin Durieux Trouilleton : Mécanismes de réplication des Bunyavirus
👏 Bravo pour ces travaux innovants !
New OA Article: "Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin" rdcu.be/ecurQ
Full-length 3D structures of a virus replication machinery, providing insights into its activation and inhibition. #PlantScience
Full-length 3D structures of a virus replication machinery, providing insights into its activation and inhibition. #PlantScience
March 6, 2025 at 7:40 PM
New OA Article: "Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin" rdcu.be/ecurQ
Full-length 3D structures of a virus replication machinery, providing insights into its activation and inhibition. #PlantScience
Full-length 3D structures of a virus replication machinery, providing insights into its activation and inhibition. #PlantScience
New World tropical plague, the bunyavirus Oropouche, is perhaps showing teratogenic or lethal fetal effects in Brazil. Tho seemingly channeling Zika, these bugs aren't related.
February 14, 2025 at 4:57 PM
New World tropical plague, the bunyavirus Oropouche, is perhaps showing teratogenic or lethal fetal effects in Brazil. Tho seemingly channeling Zika, these bugs aren't related.