Alexander Honkala
@xhonk.bsky.social
immunologist turning towards computational biology
Reposted by Alexander Honkala
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
January 3, 2025 at 7:25 PM
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
Reposted by Alexander Honkala
Interesting work, it's becoming clear that @santiagozelenay.bsky.social's 2015 work on the COX-PGE axis' role in tumor immune evasion is robust (and also that we really need to focus on type I IFN in anti-tumor immunity).
#Immunology #Immunotherapy #Immunosky
#Immunology #Immunotherapy #Immunosky
December 15, 2024 at 10:20 AM
Interesting work, it's becoming clear that @santiagozelenay.bsky.social's 2015 work on the COX-PGE axis' role in tumor immune evasion is robust (and also that we really need to focus on type I IFN in anti-tumor immunity).
#Immunology #Immunotherapy #Immunosky
#Immunology #Immunotherapy #Immunosky
Reposted by Alexander Honkala
In which mast cells are found to not only emit lots of mediators, but occasionally ingest other white blood cells like neutrophils and either consume them, or emit their contents too...😮
www.sciencenews.org/article/some...
#MCAS #Masto #MastCells #Immunology #EDS #HSD #NEISvoid #MedSky
www.sciencenews.org/article/some...
#MCAS #Masto #MastCells #Immunology #EDS #HSD #NEISvoid #MedSky
During an allergic response, some immune cells digest others
Mast cells lure and trap other immune cells during allergic reactions, using their compounds to increase inflammation in a process dubbed nexocytosis
www.sciencenews.org
December 13, 2024 at 12:34 AM
In which mast cells are found to not only emit lots of mediators, but occasionally ingest other white blood cells like neutrophils and either consume them, or emit their contents too...😮
www.sciencenews.org/article/some...
#MCAS #Masto #MastCells #Immunology #EDS #HSD #NEISvoid #MedSky
www.sciencenews.org/article/some...
#MCAS #Masto #MastCells #Immunology #EDS #HSD #NEISvoid #MedSky
Reposted by Alexander Honkala
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Alexander Honkala
#MedSky🧪 #IDsky #cardiosky #Immunosky #Covidheart #publichealth Growing evidence suggests that #SARSCoV2 has the ability to induce #ferroptosis in host cells via various mechanisms www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social , medscimonit.com/abstract/ful...
SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells | Circulation Research
Background: Increasing evidence suggests that cardiac arrhythmias are frequent clinical features
of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to bradycardia.
However, it is chall...
www.ahajournals.org
December 4, 2024 at 2:12 PM
#MedSky🧪 #IDsky #cardiosky #Immunosky #Covidheart #publichealth Growing evidence suggests that #SARSCoV2 has the ability to induce #ferroptosis in host cells via various mechanisms www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social , medscimonit.com/abstract/ful...
Reposted by Alexander Honkala
Establishing a conceptual framework for holistic cell states and state transitions
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Establishing a conceptual framework for holistic cell states and state transitions
Technological advances have brought “big data” to the cellular level. Rafelski and
Theriot share their vision of defining a cell's state in a holistic way that reflects
all molecular, organizational, ...
www.cell.com
November 25, 2024 at 11:04 PM
Establishing a conceptual framework for holistic cell states and state transitions
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
starting a list for statistical hallucinations in single cell biology and just putting Louvain in big crayon colors at the top
November 25, 2024 at 8:27 PM
starting a list for statistical hallucinations in single cell biology and just putting Louvain in big crayon colors at the top
I’m generally convinced that cellular memory is way way wayyyyyy underexplored
How do cells remember transient signals? New work reveals that a transient pulse of histone deacetylase inhibition leaves a lasting mark on 3D genome architecture in mESCs, linking chromatin dynamics to cellular memory and gene expression robustness.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 25, 2024 at 7:47 AM
I’m generally convinced that cellular memory is way way wayyyyyy underexplored
Reposted by Alexander Honkala
Grant agency: "In the end, despite some initial enthusiasm, the panel was not convinced [...], and expected that the impact in the field is likely to be low."
Despite evidence to the contrary, funding bodies remain confident they can predict the success of a project.
elifesciences.org/articles/13323
Despite evidence to the contrary, funding bodies remain confident they can predict the success of a project.
elifesciences.org/articles/13323
November 24, 2024 at 11:43 PM
Grant agency: "In the end, despite some initial enthusiasm, the panel was not convinced [...], and expected that the impact in the field is likely to be low."
Despite evidence to the contrary, funding bodies remain confident they can predict the success of a project.
elifesciences.org/articles/13323
Despite evidence to the contrary, funding bodies remain confident they can predict the success of a project.
elifesciences.org/articles/13323
introductory post:
bench immunologist climbing the learning curve towards computational systems biology with a focus on identifying regulatory constraints in continua on manifold embeddings
interested in quite a lot: immune organization, molecular pathology, ML design
the pic is my ridiculous dog
bench immunologist climbing the learning curve towards computational systems biology with a focus on identifying regulatory constraints in continua on manifold embeddings
interested in quite a lot: immune organization, molecular pathology, ML design
the pic is my ridiculous dog
November 25, 2024 at 7:37 AM
introductory post:
bench immunologist climbing the learning curve towards computational systems biology with a focus on identifying regulatory constraints in continua on manifold embeddings
interested in quite a lot: immune organization, molecular pathology, ML design
the pic is my ridiculous dog
bench immunologist climbing the learning curve towards computational systems biology with a focus on identifying regulatory constraints in continua on manifold embeddings
interested in quite a lot: immune organization, molecular pathology, ML design
the pic is my ridiculous dog