Warmflash lab
@warmflashlab.bsky.social
Quantitative development with pluripotent stem cells
Pinned
Warmflash lab
@warmflashlab.bsky.social
· Jul 14
Juxtaposition of human pluripotent stem cells with amnion-like cells is sufficient to trigger primitive streak formation
Studies in the mouse have established that communication between the trophectoderm and the epiblast is crucial for initiating gastrulation. In the primate embryo, the amnion rather than the trophectod...
www.biorxiv.org
Happy to share our latest preprint. We show that juxtaposing amnion cells with human pluripotent cells is enough to trigger gastrulation-like events. Great work by former student Xiangyu Kong now a postdoc in the Theunissen lab @washumedicine.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Warmflash lab
As stressful as it is to run a laboratory in the US right now, my thoughts are often with the NIH staff living in the awful chaos trying to preserve the whole enterprise. I’m grateful for every moment they choose not to give up. These people are the only thing keeping it from entirely collapsing.
July 31, 2025 at 12:15 AM
As stressful as it is to run a laboratory in the US right now, my thoughts are often with the NIH staff living in the awful chaos trying to preserve the whole enterprise. I’m grateful for every moment they choose not to give up. These people are the only thing keeping it from entirely collapsing.
Happy to share our latest preprint. We show that juxtaposing amnion cells with human pluripotent cells is enough to trigger gastrulation-like events. Great work by former student Xiangyu Kong now a postdoc in the Theunissen lab @washumedicine.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Juxtaposition of human pluripotent stem cells with amnion-like cells is sufficient to trigger primitive streak formation
Studies in the mouse have established that communication between the trophectoderm and the epiblast is crucial for initiating gastrulation. In the primate embryo, the amnion rather than the trophectod...
www.biorxiv.org
July 14, 2025 at 9:27 PM
Happy to share our latest preprint. We show that juxtaposing amnion cells with human pluripotent cells is enough to trigger gastrulation-like events. Great work by former student Xiangyu Kong now a postdoc in the Theunissen lab @washumedicine.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Warmflash lab
The "Big Beautiful Bill" isn’t the federal budget—it’s a reconciliation bill focused on tax cuts. The real FY26 funding decisions for NIH, NSF, and more are happening now in Congress.
www.ascb.org/science-poli...
www.ascb.org/science-poli...
The "Big Beautiful Bill" is Not the Budget - ASCB
If you’ve read recent news about Congress trying to pass “the budget,” you may have noticed that even Washington, D.C. reporters don’t always have a firm grasp on the details of what they’re covering....
www.ascb.org
July 1, 2025 at 2:14 PM
The "Big Beautiful Bill" isn’t the federal budget—it’s a reconciliation bill focused on tax cuts. The real FY26 funding decisions for NIH, NSF, and more are happening now in Congress.
www.ascb.org/science-poli...
www.ascb.org/science-poli...
Reposted by Warmflash lab
If one of these people is your senator, it is incredibly important that you call them today.
Urge them to vote NO on the Senate budget bill that would make most Americans poorer to give billionaires a tax cut they don't even need.
Urge them to vote NO on the Senate budget bill that would make most Americans poorer to give billionaires a tax cut they don't even need.
June 30, 2025 at 3:54 PM
If one of these people is your senator, it is incredibly important that you call them today.
Urge them to vote NO on the Senate budget bill that would make most Americans poorer to give billionaires a tax cut they don't even need.
Urge them to vote NO on the Senate budget bill that would make most Americans poorer to give billionaires a tax cut they don't even need.
Reposted by Warmflash lab
We're tired of the false information and wrote this letter to the NIH director Jay Bhattacharya. FACT: clinical trials have been halted. With real ethical impacts. Is this what Americans want to be known for? Let's see what the director says.
June 24, 2025 at 8:29 PM
We're tired of the false information and wrote this letter to the NIH director Jay Bhattacharya. FACT: clinical trials have been halted. With real ethical impacts. Is this what Americans want to be known for? Let's see what the director says.
Reposted by Warmflash lab
Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3
apnews.com/article/nih-...
apnews.com/article/nih-...
June 10, 2025 at 4:10 AM
Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3
apnews.com/article/nih-...
apnews.com/article/nih-...
Reposted by Warmflash lab
NEW: The Trump administration cut research funding that sought cures for future pandemics, examined the causes of dementia and tried to prevent HIV transmission.
ProPublica heard from more than 150 researchers to understand the work that’s been lost.
ProPublica heard from more than 150 researchers to understand the work that’s been lost.
Shattered Science: The Research Lost as Trump Targets NIH Funding
The Trump administration cut research funding that sought cures for future pandemics, examined the causes of dementia and tried to prevent HIV transmission. More than 150 researchers shared with…
projects.propublica.org
June 12, 2025 at 12:00 PM
NEW: The Trump administration cut research funding that sought cures for future pandemics, examined the causes of dementia and tried to prevent HIV transmission.
ProPublica heard from more than 150 researchers to understand the work that’s been lost.
ProPublica heard from more than 150 researchers to understand the work that’s been lost.
Happy to share our latest on a system to study anterior-posterior patterning of the nervous system. We show Wnt signaling pattern is not a simple low to high gradient and timing of activation is crucial to setting the pattern. From outstanding grad student Siqi Du.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A novel self-organizing embryonic stem cell system reveals the role of Wnt signaling parameters in anterior-posterior patterning of the nervous system
A Wnt activity gradient is essential for the formation of the anterior-posterior (AP) axis in all vertebrates. The relationship between the dynamics of Wnt signaling and specification of AP coordinate...
www.biorxiv.org
June 11, 2025 at 5:14 PM
Happy to share our latest on a system to study anterior-posterior patterning of the nervous system. We show Wnt signaling pattern is not a simple low to high gradient and timing of activation is crucial to setting the pattern. From outstanding grad student Siqi Du.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Warmflash lab
A Path Forward to Save American Bio-Medical Research talkingpointsmemo.com/edblog/a-pat...
A Path Forward to Save American Bio-Medical Research
Over the past four months I’ve spoken to dozens of biomedical researchers...
talkingpointsmemo.com
May 16, 2025 at 5:32 PM
A Path Forward to Save American Bio-Medical Research talkingpointsmemo.com/edblog/a-pat...
Reposted by Warmflash lab
Our work on mesoderm development in 2D gastruloids is now published in nature methods
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Extended culture of 2D gastruloids to model human mesoderm development - Nature Methods
This study reports an extended 2D gastruloid system for spatially modeling human mesoderm development.
www.nature.com
May 8, 2025 at 3:23 PM
Our work on mesoderm development in 2D gastruloids is now published in nature methods
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Many people are asking - what on earth is the point of killing biomedical research? Read this from @joshtpm.bsky.social who has covered this very well. Admin is using funding to exert control over universities, they don't care about resulting damage to science. talkingpointsmemo.com/edblog/why-d...
Why Do They Have It In For Biomedical Research?
Here is a brief follow-up on the question TPM Reader MA addresses...
talkingpointsmemo.com
May 7, 2025 at 9:30 PM
Many people are asking - what on earth is the point of killing biomedical research? Read this from @joshtpm.bsky.social who has covered this very well. Admin is using funding to exert control over universities, they don't care about resulting damage to science. talkingpointsmemo.com/edblog/why-d...
Reposted by Warmflash lab
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
the word alert is in a purple circle
ALT: the word alert is in a purple circle
media.tenor.com
April 23, 2025 at 6:03 PM
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Reposted by Warmflash lab
I received this letter, sent to 11 Republican members of Congress this weekend from anonymous NIHers.
1/n
.
1/n
.
April 22, 2025 at 4:06 PM
I received this letter, sent to 11 Republican members of Congress this weekend from anonymous NIHers.
1/n
.
1/n
.
Reposted by Warmflash lab
As someone directly affected by this, let me be clear:
I'd rather lose my job because Harvard chose to fight than keep my job and see a generation of white supremacists parade its corpse around like a war trophy.
I'd rather lose my job because Harvard chose to fight than keep my job and see a generation of white supremacists parade its corpse around like a war trophy.
Researchers at Harvard and its affiliates appreciate that the university resisted the Trump Administration's demands, but worry about what happens next.
At Harvard, scientists worry over the consequences of resisting the Trump administration: $2.2B in grants frozen
Researchers at Harvard and its affiliates appreciate that the university resisted the Trump Administration's demands, but worry about what happens next.
buff.ly
April 15, 2025 at 4:29 PM
As someone directly affected by this, let me be clear:
I'd rather lose my job because Harvard chose to fight than keep my job and see a generation of white supremacists parade its corpse around like a war trophy.
I'd rather lose my job because Harvard chose to fight than keep my job and see a generation of white supremacists parade its corpse around like a war trophy.
Reposted by Warmflash lab
This is a big deal. Spread the word. But it’s tiny compared to the totality of what’s happening at NIH. Cure Research for all cancers, Alzheimer’s, everything is being gutted. Intentionally. It’s all getting burned to the ground but the news isn’t getting out. The new cures won’t be there for you.
I would be making a big deal out of this if I were an elected Democrat
NIH scientists have a cancer breakthrough. Layoffs are delaying it.
A big step forward in cancer therapy has been slowed by layoffs and new restrictions at the National Institutes of Health, where it was developed.
www.washingtonpost.com
April 7, 2025 at 2:59 AM
This is a big deal. Spread the word. But it’s tiny compared to the totality of what’s happening at NIH. Cure Research for all cancers, Alzheimer’s, everything is being gutted. Intentionally. It’s all getting burned to the ground but the news isn’t getting out. The new cures won’t be there for you.
Reposted by Warmflash lab
From a source at NIH:
“Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed.
The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad.
Everything is stopped”
“Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed.
The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad.
Everything is stopped”
April 4, 2025 at 12:10 PM
From a source at NIH:
“Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed.
The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad.
Everything is stopped”
“Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed.
The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad.
Everything is stopped”
Reposted by Warmflash lab
It’s stunning to me that the New York Times did not put the story on the bloodbath at the NIH, CDC, and FDA on its front page this morning.
April 2, 2025 at 1:49 PM
It’s stunning to me that the New York Times did not put the story on the bloodbath at the NIH, CDC, and FDA on its front page this morning.
Reposted by Warmflash lab
Trump has cut the NIH budget by more than half in defiance of Congressionally mandated appropriations for the agency. No comparison historically, not even the Great Recession. This is clearly not legal and Congress needs to address it.
March 30, 2025 at 5:12 PM
Trump has cut the NIH budget by more than half in defiance of Congressionally mandated appropriations for the agency. No comparison historically, not even the Great Recession. This is clearly not legal and Congress needs to address it.
Reposted by Warmflash lab
"The consolidation/RIF plan pulls power away from scientists and puts it in the hands of political employees. It sets up Trump and Musk to kill NIH as an evidence-based science funder. We must stop this plan."
New contributed post on our blog: Please read.
It describes Orban and authoritarianism. 🧪
New contributed post on our blog: Please read.
It describes Orban and authoritarianism. 🧪
The NIH firing plan is really a radical institute merger and an authoritarian takeover
this is an Orbanization of US science: a move to exert political control over discovery, which will kill the US medical research industry and end cancer cures. The plan must be stopped. We can act.
open.substack.com
March 28, 2025 at 4:13 PM
"The consolidation/RIF plan pulls power away from scientists and puts it in the hands of political employees. It sets up Trump and Musk to kill NIH as an evidence-based science funder. We must stop this plan."
New contributed post on our blog: Please read.
It describes Orban and authoritarianism. 🧪
New contributed post on our blog: Please read.
It describes Orban and authoritarianism. 🧪
Reposted by Warmflash lab
Just before bedtime last night I got a message from inside NIH which read:
“It’s so, so bad and no one cares (who has any influence)”
I asked “What, in particular?”
My friend responded “Everything”
“It’s so, so bad and no one cares (who has any influence)”
I asked “What, in particular?”
My friend responded “Everything”
March 28, 2025 at 8:47 AM
Just before bedtime last night I got a message from inside NIH which read:
“It’s so, so bad and no one cares (who has any influence)”
I asked “What, in particular?”
My friend responded “Everything”
“It’s so, so bad and no one cares (who has any influence)”
I asked “What, in particular?”
My friend responded “Everything”
Reposted by Warmflash lab
The @standupforscience.bsky.social DC rally is on.
What we are hearing from around the country:
"this is big!"
"biggest rally I have seen around here in years and years"
The public cares about medical research--and students, GenZ, and other people too are ready to stand up.
What we are hearing from around the country:
"this is big!"
"biggest rally I have seen around here in years and years"
The public cares about medical research--and students, GenZ, and other people too are ready to stand up.
March 7, 2025 at 6:40 PM
The @standupforscience.bsky.social DC rally is on.
What we are hearing from around the country:
"this is big!"
"biggest rally I have seen around here in years and years"
The public cares about medical research--and students, GenZ, and other people too are ready to stand up.
What we are hearing from around the country:
"this is big!"
"biggest rally I have seen around here in years and years"
The public cares about medical research--and students, GenZ, and other people too are ready to stand up.
Good crowd to #StandUpForScience on Rice campus. Some powerful speeches from trainees about having opportunities suddenly taken from them and the personal impacts of the administration's targeting of minorities. Very real damage has already been done.
March 7, 2025 at 10:41 PM
Good crowd to #StandUpForScience on Rice campus. Some powerful speeches from trainees about having opportunities suddenly taken from them and the personal impacts of the administration's targeting of minorities. Very real damage has already been done.
Reposted by Warmflash lab
Richest guy in the world telling us we can’t afford to have our government fund cancer research.
March 2, 2025 at 8:28 PM
Richest guy in the world telling us we can’t afford to have our government fund cancer research.
Reposted by Warmflash lab
Reposted by Warmflash lab
We talk about Bezos, or Citi, or Big Tech, but cancer's brand is seriously in the toilet. Everyone hates it. And yet, day one hit from Trump/Musk was to shut down all federal funding for cancer cure research. And it's still mostly shut down. Have you ever known anyone with cancer?
Looking at some survey data here. Trump/Elon cutting off all cancer cure research is the issue that freaks voters out more than any other, also the one they've heard the least about. Important for voters to hear more about this.
February 28, 2025 at 2:02 PM
We talk about Bezos, or Citi, or Big Tech, but cancer's brand is seriously in the toilet. Everyone hates it. And yet, day one hit from Trump/Musk was to shut down all federal funding for cancer cure research. And it's still mostly shut down. Have you ever known anyone with cancer?