VIGILANT_EU
@vigilant-eu.bsky.social
The VIGILANT project is funded by #HorizonEurope and develops broad spectrum antivirals for pandemic preparedness. Find more information at https://linktr.ee/VIGILANT_EU
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VIGILANT_EU
@vigilant-eu.bsky.social
· Aug 25
🚨VIGILANT is developing antivirals that block cellular factors viruses depend on - proteases and Sec61.
This thread 🧵 explains why cellular proteases are attractive targets to stop viruses before they spread. 🦠🔒
This thread 🧵 explains why cellular proteases are attractive targets to stop viruses before they spread. 🦠🔒
MEET THE VIGILANT TEAM
We are interviewing Project VIGILANT staff to introduce them to you!
Ville Paavilainen
Research Director - Chemical Biology & Proteostasis Research Group, Institute of Biotechnology, University of Helsinki - www.helsinki.fi/en/researchgroups/proteostasis-and-chemical-biology
We are interviewing Project VIGILANT staff to introduce them to you!
Ville Paavilainen
Research Director - Chemical Biology & Proteostasis Research Group, Institute of Biotechnology, University of Helsinki - www.helsinki.fi/en/researchgroups/proteostasis-and-chemical-biology
November 26, 2025 at 12:12 PM
MEET THE VIGILANT TEAM
We are interviewing Project VIGILANT staff to introduce them to you!
Ville Paavilainen
Research Director - Chemical Biology & Proteostasis Research Group, Institute of Biotechnology, University of Helsinki - www.helsinki.fi/en/researchgroups/proteostasis-and-chemical-biology
We are interviewing Project VIGILANT staff to introduce them to you!
Ville Paavilainen
Research Director - Chemical Biology & Proteostasis Research Group, Institute of Biotechnology, University of Helsinki - www.helsinki.fi/en/researchgroups/proteostasis-and-chemical-biology
Reposted by VIGILANT_EU
I've got a bad feeling about the upcoming flu season, given the fact that there are a bunch of subtypes at this party with the potential to wreak varying amounts of havoc. So I broke it all down here.
open.substack.com/pub/rasmusse...
open.substack.com/pub/rasmusse...
The Real Subtypes of the 2025 Flu Season
Have you ever been to a party where you sensed the messiness before it happened?
open.substack.com
November 17, 2025 at 2:54 PM
I've got a bad feeling about the upcoming flu season, given the fact that there are a bunch of subtypes at this party with the potential to wreak varying amounts of havoc. So I broke it all down here.
open.substack.com/pub/rasmusse...
open.substack.com/pub/rasmusse...
Reposted by VIGILANT_EU
This is an interesting case of a patient from Chad infected with a novel arenavirus species/variant/strain, presenting with meningoencephalitis.
IMO, could be classified as a highly divergent Lassa virus strain in a new country (similar to what Togo has observed).
www.nejm.org/doi/10.1056/...
IMO, could be classified as a highly divergent Lassa virus strain in a new country (similar to what Togo has observed).
www.nejm.org/doi/10.1056/...
A Mammarenavirus Close to Lassa Virus in a Patient with Meningoencephalitis | NEJM
A 37-year-old man in Chad presented with a fever and a headache. An extensive evaluation
identified a mammarenavirus, close to Lassa virus, in samples of cerebrospinal fluid.
www.nejm.org
November 17, 2025 at 4:47 PM
This is an interesting case of a patient from Chad infected with a novel arenavirus species/variant/strain, presenting with meningoencephalitis.
IMO, could be classified as a highly divergent Lassa virus strain in a new country (similar to what Togo has observed).
www.nejm.org/doi/10.1056/...
IMO, could be classified as a highly divergent Lassa virus strain in a new country (similar to what Togo has observed).
www.nejm.org/doi/10.1056/...
Ethiopia confirms its first-ever Marburg virus outbreak in the South Ethiopia region. Rapid response activated - hoping for swift containment.
Marburg has no approved vaccine or specific treatment. Broad-spectrum antivirals are a critical unmet need to save lives and stop outbreaks faster.
Marburg has no approved vaccine or specific treatment. Broad-spectrum antivirals are a critical unmet need to save lives and stop outbreaks faster.
The outbreak in Ethiopia is #Marburg virus, the first such outbreak for this country. 9 cases so far, including some health workers. x.com/drtedros/sta...
Tedros Adhanom Ghebreyesus on X: "#Ethiopia has confirmed the outbreak that has infected at least 9 people in the south of the country is of #Marburg virus disease. I commend Ethiopia’s @FMoHealth for its rapid and transparent response to the outbreak, and the work of the Ethiopia Public Health Institute and" / X
#Ethiopia has confirmed the outbreak that has infected at least 9 people in the south of the country is of #Marburg virus disease. I commend Ethiopia’s @FMoHealth for its rapid and transparent response to the outbreak, and the work of the Ethiopia Public Health Institute and
x.com
November 16, 2025 at 11:57 AM
Ethiopia confirms its first-ever Marburg virus outbreak in the South Ethiopia region. Rapid response activated - hoping for swift containment.
Marburg has no approved vaccine or specific treatment. Broad-spectrum antivirals are a critical unmet need to save lives and stop outbreaks faster.
Marburg has no approved vaccine or specific treatment. Broad-spectrum antivirals are a critical unmet need to save lives and stop outbreaks faster.
Reposted by VIGILANT_EU
Proud that Markus Hoffmann and I made the 2025 Clarivate Highly Cited Researchers list.
Huge thanks to everyone in the Infection Biology Unit at the German Primate Center - honoured and grateful. @primatenzentrum.bsky.social
clarivate.com/highly-cited...
Huge thanks to everyone in the Infection Biology Unit at the German Primate Center - honoured and grateful. @primatenzentrum.bsky.social
clarivate.com/highly-cited...
Clarivate Highly Cited Researchers 2025
The Highly Cited Researchers 2025 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...
clarivate.com
November 15, 2025 at 9:07 AM
Proud that Markus Hoffmann and I made the 2025 Clarivate Highly Cited Researchers list.
Huge thanks to everyone in the Infection Biology Unit at the German Primate Center - honoured and grateful. @primatenzentrum.bsky.social
clarivate.com/highly-cited...
Huge thanks to everyone in the Infection Biology Unit at the German Primate Center - honoured and grateful. @primatenzentrum.bsky.social
clarivate.com/highly-cited...
Thank you for hosting this excellent symposium!
Special shout-out to our Horizon Europe partner consortia: @combatdengue.bsky.social, @shield-project.bsky.social , @vigilant-eu.bsky.social, and @combinemarvproject.bsky.social for your amazing contributions.
Here’s to more collaboration & discovery ahead! 🙌
#FundedByEU
Here’s to more collaboration & discovery ahead! 🙌
#FundedByEU
November 11, 2025 at 7:40 AM
Thank you for hosting this excellent symposium!
Reposted by VIGILANT_EU
New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir
Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.
www.science.org
November 10, 2025 at 12:14 AM
New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
Reposted by VIGILANT_EU
🔬🌍 On #WorldScienceDay, we focus on trust, transformation, and the science we need for 2050.
Transparency builds trust, open and collaborative research drives change, and safeguarding academic freedom shapes tomorrow.
Let’s reflect on the science we choose to build.
#ScienceFor2050
Transparency builds trust, open and collaborative research drives change, and safeguarding academic freedom shapes tomorrow.
Let’s reflect on the science we choose to build.
#ScienceFor2050
November 10, 2025 at 8:09 AM
🔬🌍 On #WorldScienceDay, we focus on trust, transformation, and the science we need for 2050.
Transparency builds trust, open and collaborative research drives change, and safeguarding academic freedom shapes tomorrow.
Let’s reflect on the science we choose to build.
#ScienceFor2050
Transparency builds trust, open and collaborative research drives change, and safeguarding academic freedom shapes tomorrow.
Let’s reflect on the science we choose to build.
#ScienceFor2050
Exciting advancements in research for pandemic preparedness from EU-funded consortia, with substantial opportunities for interdisciplinary collaboration.
#HorizonEurope
#HorizonEurope
It was a great pleasure presenting @vigilant-eu.bsky.social at the @defender-project.bsky.social International Symposium! 🌟 Inspiring talks, fantastic collab opportunities - grateful for the experience! #EUResearch
🌍 Join us at the @defender-project.bsky.social International Symposium for a keynote by our #combineMARV coordinator @christian-7.bsky.social!
🎟️ Register free of charge for a day of insights, collaboration & global exchange 🔗 lnkd.in/eY9JwzXY
#PandemicPreparedness #Collaboration #EUfunded
🎟️ Register free of charge for a day of insights, collaboration & global exchange 🔗 lnkd.in/eY9JwzXY
#PandemicPreparedness #Collaboration #EUfunded
November 9, 2025 at 11:53 AM
Exciting advancements in research for pandemic preparedness from EU-funded consortia, with substantial opportunities for interdisciplinary collaboration.
#HorizonEurope
#HorizonEurope
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Gerald McInerney
Professor of Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Gerald McInerney
Professor of Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute
October 7, 2025 at 11:04 AM
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Gerald McInerney
Professor of Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Gerald McInerney
Professor of Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute
VIGILANT theme highlighted by Stefan Pöhlmann at the 11th European Meeting on Viral Zoonoses (Saint-Raphaël, Sept 20–23, 2025). Focus: how Sec61 targeting disrupts filovirus glycoprotein function and infectivity.
#ViralZoonoses #EMVZ #SaintRaphael
#ViralZoonoses #EMVZ #SaintRaphael
September 22, 2025 at 10:12 AM
VIGILANT theme highlighted by Stefan Pöhlmann at the 11th European Meeting on Viral Zoonoses (Saint-Raphaël, Sept 20–23, 2025). Focus: how Sec61 targeting disrupts filovirus glycoprotein function and infectivity.
#ViralZoonoses #EMVZ #SaintRaphael
#ViralZoonoses #EMVZ #SaintRaphael
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Andrea Marzi
Chief of the Immunobiology & Molecular Virology Section, Laboratory of Virology, DIR, NIAID
National Institutes of Health
Rocky Mountain Laboratories
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Andrea Marzi
Chief of the Immunobiology & Molecular Virology Section, Laboratory of Virology, DIR, NIAID
National Institutes of Health
Rocky Mountain Laboratories
September 15, 2025 at 1:35 PM
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Andrea Marzi
Chief of the Immunobiology & Molecular Virology Section, Laboratory of Virology, DIR, NIAID
National Institutes of Health
Rocky Mountain Laboratories
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Andrea Marzi
Chief of the Immunobiology & Molecular Virology Section, Laboratory of Virology, DIR, NIAID
National Institutes of Health
Rocky Mountain Laboratories
Reposted by VIGILANT_EU
climate change - it's a thing. and it affects more than just the climate and weather
www.science.org/content/arti...
www.science.org/content/arti...
Mosquito-borne viruses surge in a warming Europe
Chikungunya cases break records in France; West Nile virus appears near Rome
www.science.org
September 15, 2025 at 9:39 AM
climate change - it's a thing. and it affects more than just the climate and weather
www.science.org/content/arti...
www.science.org/content/arti...
Ebola poses a serious global threat. We hope for swift containment and are committed to research for future prevention.
A new Ebola outbreak in the Democratic Republic of Congo is suspected of causing 15 deaths among 28 people with symptoms, the health ministry in the central African country said Thursday.
New Ebola outbreak in DR Congo suspected of causing 15 deaths | CNN
A new Ebola outbreak in the Democratic Republic of Congo is suspected of causing 15 deaths among 28 people with symptoms, the health ministry in the central African country said Thursday.
www.cnn.com
September 6, 2025 at 5:22 PM
Ebola poses a serious global threat. We hope for swift containment and are committed to research for future prevention.
1/
The protease furin activates dangerous viruses like H5N1. But since it has many close relatives, specifically targeting furin is a huge challenge.
#Virology #DrugDiscovery
The protease furin activates dangerous viruses like H5N1. But since it has many close relatives, specifically targeting furin is a huge challenge.
#Virology #DrugDiscovery
September 4, 2025 at 10:08 PM
1/
The protease furin activates dangerous viruses like H5N1. But since it has many close relatives, specifically targeting furin is a huge challenge.
#Virology #DrugDiscovery
The protease furin activates dangerous viruses like H5N1. But since it has many close relatives, specifically targeting furin is a huge challenge.
#Virology #DrugDiscovery
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Wolfgang Knecht
Director of the Lund Protein Production Platform (LP3, www.lp3.lu.se), Deputy Director of Protein Production Sweden (PPS, www.pps.gu.se/en) and Group Leader of SciLifeLab.
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Wolfgang Knecht
Director of the Lund Protein Production Platform (LP3, www.lp3.lu.se), Deputy Director of Protein Production Sweden (PPS, www.pps.gu.se/en) and Group Leader of SciLifeLab.
September 1, 2025 at 11:18 AM
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Wolfgang Knecht
Director of the Lund Protein Production Platform (LP3, www.lp3.lu.se), Deputy Director of Protein Production Sweden (PPS, www.pps.gu.se/en) and Group Leader of SciLifeLab.
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Wolfgang Knecht
Director of the Lund Protein Production Platform (LP3, www.lp3.lu.se), Deputy Director of Protein Production Sweden (PPS, www.pps.gu.se/en) and Group Leader of SciLifeLab.
🚨VIGILANT is developing antivirals that block cellular factors viruses depend on - proteases and Sec61.
This thread 🧵 explains why cellular proteases are attractive targets to stop viruses before they spread. 🦠🔒
This thread 🧵 explains why cellular proteases are attractive targets to stop viruses before they spread. 🦠🔒
August 25, 2025 at 11:48 AM
🚨VIGILANT is developing antivirals that block cellular factors viruses depend on - proteases and Sec61.
This thread 🧵 explains why cellular proteases are attractive targets to stop viruses before they spread. 🦠🔒
This thread 🧵 explains why cellular proteases are attractive targets to stop viruses before they spread. 🦠🔒
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Stefan Pöhlmann
Head of the Infection Biology Unit @ German Primate Centre.
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Stefan Pöhlmann
Head of the Infection Biology Unit @ German Primate Centre.
July 22, 2025 at 11:53 AM
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Stefan Pöhlmann
Head of the Infection Biology Unit @ German Primate Centre.
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Stefan Pöhlmann
Head of the Infection Biology Unit @ German Primate Centre.
Reposted by VIGILANT_EU
📢 Registration is OPEN for the 2025 edition of the European Research and Innovation Days #RiDaysEU!
📅 Join the ERC on 17 Sept for the session "Securing Europe’s place at the forefront of scientific discovery"
🔗 Register now 👉 t.co/nPQmG6ix1G for access & more info.
www.youtube.com/watch?v=o50Y...
📅 Join the ERC on 17 Sept for the session "Securing Europe’s place at the forefront of scientific discovery"
🔗 Register now 👉 t.co/nPQmG6ix1G for access & more info.
www.youtube.com/watch?v=o50Y...
European Research & Innovation Days 2025
YouTube video by EU Science & Innovation
www.youtube.com
July 15, 2025 at 11:15 AM
📢 Registration is OPEN for the 2025 edition of the European Research and Innovation Days #RiDaysEU!
📅 Join the ERC on 17 Sept for the session "Securing Europe’s place at the forefront of scientific discovery"
🔗 Register now 👉 t.co/nPQmG6ix1G for access & more info.
www.youtube.com/watch?v=o50Y...
📅 Join the ERC on 17 Sept for the session "Securing Europe’s place at the forefront of scientific discovery"
🔗 Register now 👉 t.co/nPQmG6ix1G for access & more info.
www.youtube.com/watch?v=o50Y...
Reposted by VIGILANT_EU
Next generation of infection biologists at the Nacht des Wissens #ndwgoe @uni-goettingen.de
June 21, 2025 at 6:34 PM
Next generation of infection biologists at the Nacht des Wissens #ndwgoe @uni-goettingen.de
VIGILANT public outreach at the Night of Science in Göttingen — sharing perspectives on broad-spectrum antivirals and pandemic preparedness. Thanks to all who stopped by and joined the conversation!
#VIGILANT #snpoehlm #NightOfScience #Göttingen
#VIGILANT #snpoehlm #NightOfScience #Göttingen
June 22, 2025 at 1:26 PM
VIGILANT public outreach at the Night of Science in Göttingen — sharing perspectives on broad-spectrum antivirals and pandemic preparedness. Thanks to all who stopped by and joined the conversation!
#VIGILANT #snpoehlm #NightOfScience #Göttingen
#VIGILANT #snpoehlm #NightOfScience #Göttingen
VIGILANT partners Eva Böttcher-Friebertshäuser and Torsten Steinmetzer will be hosting an online virology conference this week: “Nucleophilic Proteases: Structure, Function, Regulation, and Disease” - www.asbmb.org/meetings-events/nucleophilic-proteases
Registrations close 18th June. See you there!
Registrations close 18th June. See you there!
Nucleophilic proteases: Structure, function, regulation and disease
June 20–21, 2025 | Virtual
www.asbmb.org
June 16, 2025 at 11:32 AM
VIGILANT partners Eva Böttcher-Friebertshäuser and Torsten Steinmetzer will be hosting an online virology conference this week: “Nucleophilic Proteases: Structure, Function, Regulation, and Disease” - www.asbmb.org/meetings-events/nucleophilic-proteases
Registrations close 18th June. See you there!
Registrations close 18th June. See you there!