VIGILANT_EU
@vigilant-eu.bsky.social
The VIGILANT project is funded by #HorizonEurope and develops broad spectrum antivirals for pandemic preparedness. Find more information at https://linktr.ee/VIGILANT_EU
MEET THE VIGILANT TEAM
We are interviewing Project VIGILANT staff to introduce them to you!
Ville Paavilainen
Research Director - Chemical Biology & Proteostasis Research Group, Institute of Biotechnology, University of Helsinki - www.helsinki.fi/en/researchgroups/proteostasis-and-chemical-biology
We are interviewing Project VIGILANT staff to introduce them to you!
Ville Paavilainen
Research Director - Chemical Biology & Proteostasis Research Group, Institute of Biotechnology, University of Helsinki - www.helsinki.fi/en/researchgroups/proteostasis-and-chemical-biology
November 26, 2025 at 12:12 PM
MEET THE VIGILANT TEAM
We are interviewing Project VIGILANT staff to introduce them to you!
Ville Paavilainen
Research Director - Chemical Biology & Proteostasis Research Group, Institute of Biotechnology, University of Helsinki - www.helsinki.fi/en/researchgroups/proteostasis-and-chemical-biology
We are interviewing Project VIGILANT staff to introduce them to you!
Ville Paavilainen
Research Director - Chemical Biology & Proteostasis Research Group, Institute of Biotechnology, University of Helsinki - www.helsinki.fi/en/researchgroups/proteostasis-and-chemical-biology
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Gerald McInerney
Professor of Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Gerald McInerney
Professor of Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute
October 7, 2025 at 11:04 AM
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Gerald McInerney
Professor of Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Gerald McInerney
Professor of Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Andrea Marzi
Chief of the Immunobiology & Molecular Virology Section, Laboratory of Virology, DIR, NIAID
National Institutes of Health
Rocky Mountain Laboratories
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Andrea Marzi
Chief of the Immunobiology & Molecular Virology Section, Laboratory of Virology, DIR, NIAID
National Institutes of Health
Rocky Mountain Laboratories
September 15, 2025 at 1:35 PM
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Andrea Marzi
Chief of the Immunobiology & Molecular Virology Section, Laboratory of Virology, DIR, NIAID
National Institutes of Health
Rocky Mountain Laboratories
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Andrea Marzi
Chief of the Immunobiology & Molecular Virology Section, Laboratory of Virology, DIR, NIAID
National Institutes of Health
Rocky Mountain Laboratories
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Wolfgang Knecht
Director of the Lund Protein Production Platform (LP3, www.lp3.lu.se), Deputy Director of Protein Production Sweden (PPS, www.pps.gu.se/en) and Group Leader of SciLifeLab.
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Wolfgang Knecht
Director of the Lund Protein Production Platform (LP3, www.lp3.lu.se), Deputy Director of Protein Production Sweden (PPS, www.pps.gu.se/en) and Group Leader of SciLifeLab.
September 1, 2025 at 11:18 AM
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Wolfgang Knecht
Director of the Lund Protein Production Platform (LP3, www.lp3.lu.se), Deputy Director of Protein Production Sweden (PPS, www.pps.gu.se/en) and Group Leader of SciLifeLab.
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Wolfgang Knecht
Director of the Lund Protein Production Platform (LP3, www.lp3.lu.se), Deputy Director of Protein Production Sweden (PPS, www.pps.gu.se/en) and Group Leader of SciLifeLab.
3/
And here’s the key: Sec61 can be blocked.
Certain small molecules stop the channel and halt protein import. 👇ACS Chemical Biology 2020 15 (8), 2125-2136
And here’s the key: Sec61 can be blocked.
Certain small molecules stop the channel and halt protein import. 👇ACS Chemical Biology 2020 15 (8), 2125-2136
August 25, 2025 at 11:48 AM
3/
And here’s the key: Sec61 can be blocked.
Certain small molecules stop the channel and halt protein import. 👇ACS Chemical Biology 2020 15 (8), 2125-2136
And here’s the key: Sec61 can be blocked.
Certain small molecules stop the channel and halt protein import. 👇ACS Chemical Biology 2020 15 (8), 2125-2136
4/
Three main host proteases are hijacked by viruses:
🔹TMPRSS2 → at/near cell surface
🔹 Furin → inside cells (mainly Trans-Golgi)
🔹 Cathepsin B/L → in endo/lysosomes
Activation of Viruses by Host Proteases. Springer, Cham. doi.org/10.1007/978-...
Three main host proteases are hijacked by viruses:
🔹TMPRSS2 → at/near cell surface
🔹 Furin → inside cells (mainly Trans-Golgi)
🔹 Cathepsin B/L → in endo/lysosomes
Activation of Viruses by Host Proteases. Springer, Cham. doi.org/10.1007/978-...
August 25, 2025 at 11:48 AM
4/
Three main host proteases are hijacked by viruses:
🔹TMPRSS2 → at/near cell surface
🔹 Furin → inside cells (mainly Trans-Golgi)
🔹 Cathepsin B/L → in endo/lysosomes
Activation of Viruses by Host Proteases. Springer, Cham. doi.org/10.1007/978-...
Three main host proteases are hijacked by viruses:
🔹TMPRSS2 → at/near cell surface
🔹 Furin → inside cells (mainly Trans-Golgi)
🔹 Cathepsin B/L → in endo/lysosomes
Activation of Viruses by Host Proteases. Springer, Cham. doi.org/10.1007/978-...
3/
If a virus has a strong cleavage motif, it can be efficiently activated by proteases across many tissues.
➡️Activation no longer limits spread.
➡️Severe disease becomes possible.
Nat Rev Microbiol 3, 591–600 (2005). doi.org/10.1038/nrmi... 👇
If a virus has a strong cleavage motif, it can be efficiently activated by proteases across many tissues.
➡️Activation no longer limits spread.
➡️Severe disease becomes possible.
Nat Rev Microbiol 3, 591–600 (2005). doi.org/10.1038/nrmi... 👇
August 25, 2025 at 11:48 AM
3/
If a virus has a strong cleavage motif, it can be efficiently activated by proteases across many tissues.
➡️Activation no longer limits spread.
➡️Severe disease becomes possible.
Nat Rev Microbiol 3, 591–600 (2005). doi.org/10.1038/nrmi... 👇
If a virus has a strong cleavage motif, it can be efficiently activated by proteases across many tissues.
➡️Activation no longer limits spread.
➡️Severe disease becomes possible.
Nat Rev Microbiol 3, 591–600 (2005). doi.org/10.1038/nrmi... 👇
3/
And here’s the key: Sec61 can be blocked.
Certain small molecules stop the channel and halt protein import. 👇ACS Chemical Biology 2020 15 (8), 2125-2136
And here’s the key: Sec61 can be blocked.
Certain small molecules stop the channel and halt protein import. 👇ACS Chemical Biology 2020 15 (8), 2125-2136
August 25, 2025 at 9:44 AM
3/
And here’s the key: Sec61 can be blocked.
Certain small molecules stop the channel and halt protein import. 👇ACS Chemical Biology 2020 15 (8), 2125-2136
And here’s the key: Sec61 can be blocked.
Certain small molecules stop the channel and halt protein import. 👇ACS Chemical Biology 2020 15 (8), 2125-2136
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Stefan Pöhlmann
Head of the Infection Biology Unit @ German Primate Centre.
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Stefan Pöhlmann
Head of the Infection Biology Unit @ German Primate Centre.
July 22, 2025 at 11:53 AM
MEET THE VIGILANT TEAM
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Stefan Pöhlmann
Head of the Infection Biology Unit @ German Primate Centre.
We are interviewing the staff at Project Vigilant to introduce them to you!
Meet Stefan Pöhlmann
Head of the Infection Biology Unit @ German Primate Centre.
VIGILANT public outreach at the Night of Science in Göttingen — sharing perspectives on broad-spectrum antivirals and pandemic preparedness. Thanks to all who stopped by and joined the conversation!
#VIGILANT #snpoehlm #NightOfScience #Göttingen
#VIGILANT #snpoehlm #NightOfScience #Göttingen
June 22, 2025 at 1:26 PM
VIGILANT public outreach at the Night of Science in Göttingen — sharing perspectives on broad-spectrum antivirals and pandemic preparedness. Thanks to all who stopped by and joined the conversation!
#VIGILANT #snpoehlm #NightOfScience #Göttingen
#VIGILANT #snpoehlm #NightOfScience #Göttingen