University of Iowa Health Care Department of Pathology
@uipathology.bsky.social
Official account for the Department of Pathology at University of Iowa Health Care
Read the full study here: jneuroinflammation.biomedcentral.com/articles/10....
Myelin-reactive CD8+ T cells influence conventional dendritic cell subsets towards a mature and regulatory phenotype in experimental autoimmune encephalomyelitis - Journal of Neuroinflammation
Multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system, is modeled in mice as experimental autoimmune encephalomyelitis (EAE). While CD4+ T cells, primarily Th1 and...
jneuroinflammation.biomedcentral.com
September 15, 2025 at 2:33 PM
Read the full study here: jneuroinflammation.biomedcentral.com/articles/10....
This study highlights a novel mechanism in which myelin-reactive CD8+ T cells directly interact with cDC1 and modulate cDC2 through paracrine mechanisms to induce mature, regulatory dendritic cells, which leads to inhibited CD4+ T cell responses and reduced EAE pathogenesis.
September 15, 2025 at 2:33 PM
This study highlights a novel mechanism in which myelin-reactive CD8+ T cells directly interact with cDC1 and modulate cDC2 through paracrine mechanisms to induce mature, regulatory dendritic cells, which leads to inhibited CD4+ T cell responses and reduced EAE pathogenesis.
CD8 directly interacted with cDC1 and indirectly influenced cDC2 through paracrine signaling.
Single-cell RNA sequencing revealed upregulation of key immunoregulatory genes in both cDC subsets with enrichment of pathways involved in immune regulation and T cell differentiation.
Single-cell RNA sequencing revealed upregulation of key immunoregulatory genes in both cDC subsets with enrichment of pathways involved in immune regulation and T cell differentiation.
September 15, 2025 at 2:33 PM
CD8 directly interacted with cDC1 and indirectly influenced cDC2 through paracrine signaling.
Single-cell RNA sequencing revealed upregulation of key immunoregulatory genes in both cDC subsets with enrichment of pathways involved in immune regulation and T cell differentiation.
Single-cell RNA sequencing revealed upregulation of key immunoregulatory genes in both cDC subsets with enrichment of pathways involved in immune regulation and T cell differentiation.
It was found that CD8 T cells induced regulatory changes in both cDC1 and cDC2, where both types:
1. Adopted a mature and regulatory phenotype with an anti-inflammatory cytokine profile
2. Reduced capacity to support CD4+ T cell proliferation
1. Adopted a mature and regulatory phenotype with an anti-inflammatory cytokine profile
2. Reduced capacity to support CD4+ T cell proliferation
September 15, 2025 at 2:33 PM
It was found that CD8 T cells induced regulatory changes in both cDC1 and cDC2, where both types:
1. Adopted a mature and regulatory phenotype with an anti-inflammatory cytokine profile
2. Reduced capacity to support CD4+ T cell proliferation
1. Adopted a mature and regulatory phenotype with an anti-inflammatory cytokine profile
2. Reduced capacity to support CD4+ T cell proliferation
Using a mouse model of multiple sclerosis called experimental autoimmune encephalomyelitis (EAE), they show that myelin-specific CD8 T cells influence dendritic cells (DC), an important antigen-presenting cell in immune systems.
September 15, 2025 at 2:33 PM
Using a mouse model of multiple sclerosis called experimental autoimmune encephalomyelitis (EAE), they show that myelin-specific CD8 T cells influence dendritic cells (DC), an important antigen-presenting cell in immune systems.
Read the full study here: www.atsjournals.org/doi/10.1164/...
Primary Ciliary Dyskinesia with Broncholithiasis | American Journal of Respiratory and Critical Care Medicine
www.atsjournals.org
September 8, 2025 at 7:06 PM
Read the full study here: www.atsjournals.org/doi/10.1164/...
2. Why do people with PCD >40 years of age have elevated susceptibility to broncholithiasis compared to younger ages?
3. Does the presence of mineralized concretions near and within submucosal glands suggest a role for altered secretions in broncholithiasis pathogenesis?
3. Does the presence of mineralized concretions near and within submucosal glands suggest a role for altered secretions in broncholithiasis pathogenesis?
September 8, 2025 at 7:06 PM
2. Why do people with PCD >40 years of age have elevated susceptibility to broncholithiasis compared to younger ages?
3. Does the presence of mineralized concretions near and within submucosal glands suggest a role for altered secretions in broncholithiasis pathogenesis?
3. Does the presence of mineralized concretions near and within submucosal glands suggest a role for altered secretions in broncholithiasis pathogenesis?