University of Iowa Health Care Department of Pathology
@uipathology.bsky.social
Official account for the Department of Pathology at University of Iowa Health Care
Using spatial transcriptomics and high-throughput Xenium in situ analyses, Dr. Wen discovered that loss of MANF altered the transcriptomic landscape of PCs in a sex-specific manner, elevating the expression of genes involved in protein folding, transport, and ER stress response.
December 9, 2025 at 7:20 PM
Using spatial transcriptomics and high-throughput Xenium in situ analyses, Dr. Wen discovered that loss of MANF altered the transcriptomic landscape of PCs in a sex-specific manner, elevating the expression of genes involved in protein folding, transport, and ER stress response.
MANF is highly expressed in PCs and upregulated by alcohol exposure. To investigate its role, the team generated a PC-specific MANF knockout mouse model.
December 9, 2025 at 7:20 PM
MANF is highly expressed in PCs and upregulated by alcohol exposure. To investigate its role, the team generated a PC-specific MANF knockout mouse model.
Alcohol exposure induces endoplasmic reticulum stress and activates the unfolded protein response in the cerebellum and PCs.
Research scientist Wen Wen, PhD identified mesencephalic astrocyte-derived neurotrophic factor (MANF) as a critical mediator in this process. #PathSky
Research scientist Wen Wen, PhD identified mesencephalic astrocyte-derived neurotrophic factor (MANF) as a critical mediator in this process. #PathSky
December 9, 2025 at 7:20 PM
Alcohol exposure induces endoplasmic reticulum stress and activates the unfolded protein response in the cerebellum and PCs.
Research scientist Wen Wen, PhD identified mesencephalic astrocyte-derived neurotrophic factor (MANF) as a critical mediator in this process. #PathSky
Research scientist Wen Wen, PhD identified mesencephalic astrocyte-derived neurotrophic factor (MANF) as a critical mediator in this process. #PathSky
Cerebellar atrophy and Purkinje cell degeneration are common features for those with Alcohol Use Disorder.
A recent study from Jia Luo, PhD's research lab has identified a key protein that links alcohol-induced cerebellar degeneration and age-related neurobehavioral decline.
A recent study from Jia Luo, PhD's research lab has identified a key protein that links alcohol-induced cerebellar degeneration and age-related neurobehavioral decline.
December 9, 2025 at 7:20 PM
Cerebellar atrophy and Purkinje cell degeneration are common features for those with Alcohol Use Disorder.
A recent study from Jia Luo, PhD's research lab has identified a key protein that links alcohol-induced cerebellar degeneration and age-related neurobehavioral decline.
A recent study from Jia Luo, PhD's research lab has identified a key protein that links alcohol-induced cerebellar degeneration and age-related neurobehavioral decline.
Our Microbiology Lab is leading the way to make HPV clinic self-collection a reality for our patients with plans to partner with the Holden Cancer Center and the Iowa Department of Health and Human Services to help support their cervical cancer screen initiatives and reach patients across the state.
December 3, 2025 at 4:48 PM
Our Microbiology Lab is leading the way to make HPV clinic self-collection a reality for our patients with plans to partner with the Holden Cancer Center and the Iowa Department of Health and Human Services to help support their cervical cancer screen initiatives and reach patients across the state.
Jianyu Yu, a PhD candidate in the Molecular Medicine Graduate Program received a travel award for the 4th Metabolic Dysregulation and Cancer Risk Consortium Meeting in Memphis, delivering a presentation on his abstract, "FABP4-expressing CD14intCD16+ Monocytes Mark Aggressive Human Breast Cancer."
November 28, 2025 at 7:46 PM
Jianyu Yu, a PhD candidate in the Molecular Medicine Graduate Program received a travel award for the 4th Metabolic Dysregulation and Cancer Risk Consortium Meeting in Memphis, delivering a presentation on his abstract, "FABP4-expressing CD14intCD16+ Monocytes Mark Aggressive Human Breast Cancer."
The Blood Bank, located in DeGowin Blood Center, processes and stores blood products for University of Iowa Health Care and associated locations. These products are used for various medical needs, such as transfusions, self-donations for future procedures, apheresis, and much more. #PathSky
November 22, 2025 at 7:51 PM
The Blood Bank, located in DeGowin Blood Center, processes and stores blood products for University of Iowa Health Care and associated locations. These products are used for various medical needs, such as transfusions, self-donations for future procedures, apheresis, and much more. #PathSky
#GrandRounds are an opportunity for our residents and fellows to practice their presentation skills while advancing their knowledge on a chosen topic in their specialty. We've had a great group this semester- we can't wait to see what's in store for the spring!
#PathTwitter
#PathTwitter
November 13, 2025 at 9:26 PM
#GrandRounds are an opportunity for our residents and fellows to practice their presentation skills while advancing their knowledge on a chosen topic in their specialty. We've had a great group this semester- we can't wait to see what's in store for the spring!
#PathTwitter
#PathTwitter
Are you ready to start your #PathologyFellowship experience? We have several fellowship positions available for 2026-2027! #PathSky
Learn more about our open fellowships and find application details on our website: https://pathology.medicine.uiowa.edu/education/fellowships
Learn more about our open fellowships and find application details on our website: https://pathology.medicine.uiowa.edu/education/fellowships
November 12, 2025 at 6:51 PM
Are you ready to start your #PathologyFellowship experience? We have several fellowship positions available for 2026-2027! #PathSky
Learn more about our open fellowships and find application details on our website: https://pathology.medicine.uiowa.edu/education/fellowships
Learn more about our open fellowships and find application details on our website: https://pathology.medicine.uiowa.edu/education/fellowships
Congratulations to Connor Wilhelm, MS on receiving a National Multiple Sclerosis Society Travel Grant Award for the 2025 Autumn Immunology Conference!
Connor will present a poster and short discussion for his abstract. Read more about his research on our website: https://bit.ly/49A0jvP
Connor will present a poster and short discussion for his abstract. Read more about his research on our website: https://bit.ly/49A0jvP
November 5, 2025 at 4:47 PM
Congratulations to Connor Wilhelm, MS on receiving a National Multiple Sclerosis Society Travel Grant Award for the 2025 Autumn Immunology Conference!
Connor will present a poster and short discussion for his abstract. Read more about his research on our website: https://bit.ly/49A0jvP
Connor will present a poster and short discussion for his abstract. Read more about his research on our website: https://bit.ly/49A0jvP
Our brain bank in the Iowa Neuropathology Resource Library contributed rare brain samples to a CTE study from @bu-cte.bsky.social investigating the effects of repetitive head trauma-related injuries in the formation of CTE.
Read more about the study on our website: https://bit.ly/48Kf5Qo
Read more about the study on our website: https://bit.ly/48Kf5Qo
October 27, 2025 at 5:07 PM
Our brain bank in the Iowa Neuropathology Resource Library contributed rare brain samples to a CTE study from @bu-cte.bsky.social investigating the effects of repetitive head trauma-related injuries in the formation of CTE.
Read more about the study on our website: https://bit.ly/48Kf5Qo
Read more about the study on our website: https://bit.ly/48Kf5Qo
Congratulations to Payton Kahl on successfully defending her thesis, "Identification and Characterization of CD8 T Cell Epitopes Within an Influenza B Virus Model of Infection," and has completed the Masters of Science in Pathology program!
Read more about Payton's thesis: https://bit.ly/3KVkbQ1
Read more about Payton's thesis: https://bit.ly/3KVkbQ1
October 23, 2025 at 9:02 PM
Congratulations to Payton Kahl on successfully defending her thesis, "Identification and Characterization of CD8 T Cell Epitopes Within an Influenza B Virus Model of Infection," and has completed the Masters of Science in Pathology program!
Read more about Payton's thesis: https://bit.ly/3KVkbQ1
Read more about Payton's thesis: https://bit.ly/3KVkbQ1
Peritoneal fluid sample was presented to our core lab for a cell count and differential from a 54-year-old woman. 80% of the cells returned atypical. What's your diagnosis? #WhatThePath #PathX
October 22, 2025 at 5:05 PM
Peritoneal fluid sample was presented to our core lab for a cell count and differential from a 54-year-old woman. 80% of the cells returned atypical. What's your diagnosis? #WhatThePath #PathX
Today for #GrandRounds we had an excellent presentation from one of our PGY-3s on effects of patient self-collections and changing cervical cancer screening guidelines.
October 16, 2025 at 9:01 PM
Today for #GrandRounds we had an excellent presentation from one of our PGY-3s on effects of patient self-collections and changing cervical cancer screening guidelines.
Thank you J. Julie Kim, PhD, Susy Y. Hung Research Professor from Northwestern University's Department of Obstetrics and Gynecology, for presenting on the impact of obesity and race on endometrial cancer through transcriptomic signatures at #GrandRounds!
October 2, 2025 at 9:02 PM
Thank you J. Julie Kim, PhD, Susy Y. Hung Research Professor from Northwestern University's Department of Obstetrics and Gynecology, for presenting on the impact of obesity and race on endometrial cancer through transcriptomic signatures at #GrandRounds!
Congratulations to Shravan Kumar Kannan, MS, for receiving the Ballard & Seashore Dissertation Fellowship for the Spring 2026 semester!
This award provides students in their final semester supported time to focus on completing their research activities.
This award provides students in their final semester supported time to focus on completing their research activities.
October 1, 2025 at 8:14 PM
Congratulations to Shravan Kumar Kannan, MS, for receiving the Ballard & Seashore Dissertation Fellowship for the Spring 2026 semester!
This award provides students in their final semester supported time to focus on completing their research activities.
This award provides students in their final semester supported time to focus on completing their research activities.
Congratulations to Kshitija Kale, MD, a student in our Experimental Pathology PhD program, who has been awarded the Ballard & Seashore Dissertation Fellowship!
This award provides students in their final semester supported time to focus on completing their research activities.
This award provides students in their final semester supported time to focus on completing their research activities.
September 30, 2025 at 5:06 PM
Congratulations to Kshitija Kale, MD, a student in our Experimental Pathology PhD program, who has been awarded the Ballard & Seashore Dissertation Fellowship!
This award provides students in their final semester supported time to focus on completing their research activities.
This award provides students in their final semester supported time to focus on completing their research activities.
Thank you, Nathanael Christensen, DO for presenting on the validation process and its methods for building effective test menus!
Dr. Christensen is a Cytopathology Fellow in and was previously a resident in our program an served as co-chief resident.
Dr. Christensen is a Cytopathology Fellow in and was previously a resident in our program an served as co-chief resident.
September 26, 2025 at 9:08 PM
Thank you, Nathanael Christensen, DO for presenting on the validation process and its methods for building effective test menus!
Dr. Christensen is a Cytopathology Fellow in and was previously a resident in our program an served as co-chief resident.
Dr. Christensen is a Cytopathology Fellow in and was previously a resident in our program an served as co-chief resident.
Almost 100 years ago. Still committed to providing the same quality education for the next generation of pathologists. 💛 🖤
September 23, 2025 at 5:09 PM
Almost 100 years ago. Still committed to providing the same quality education for the next generation of pathologists. 💛 🖤
Congratulations on your retirement, Dr. Marcus Nashelsky!
After 22 years, Dr. Nashelsky hung up his white coat for the last time. An integral part of developing the Decedent Care Center at @uihealthcare, his lessons and guidance will live through these halls for years to come.
After 22 years, Dr. Nashelsky hung up his white coat for the last time. An integral part of developing the Decedent Care Center at @uihealthcare, his lessons and guidance will live through these halls for years to come.
September 19, 2025 at 8:46 PM
Congratulations on your retirement, Dr. Marcus Nashelsky!
After 22 years, Dr. Nashelsky hung up his white coat for the last time. An integral part of developing the Decedent Care Center at @uihealthcare, his lessons and guidance will live through these halls for years to come.
After 22 years, Dr. Nashelsky hung up his white coat for the last time. An integral part of developing the Decedent Care Center at @uihealthcare, his lessons and guidance will live through these halls for years to come.
CD8 directly interacted with cDC1 and indirectly influenced cDC2 through paracrine signaling.
Single-cell RNA sequencing revealed upregulation of key immunoregulatory genes in both cDC subsets with enrichment of pathways involved in immune regulation and T cell differentiation.
Single-cell RNA sequencing revealed upregulation of key immunoregulatory genes in both cDC subsets with enrichment of pathways involved in immune regulation and T cell differentiation.
September 15, 2025 at 2:33 PM
CD8 directly interacted with cDC1 and indirectly influenced cDC2 through paracrine signaling.
Single-cell RNA sequencing revealed upregulation of key immunoregulatory genes in both cDC subsets with enrichment of pathways involved in immune regulation and T cell differentiation.
Single-cell RNA sequencing revealed upregulation of key immunoregulatory genes in both cDC subsets with enrichment of pathways involved in immune regulation and T cell differentiation.
It was found that CD8 T cells induced regulatory changes in both cDC1 and cDC2, where both types:
1. Adopted a mature and regulatory phenotype with an anti-inflammatory cytokine profile
2. Reduced capacity to support CD4+ T cell proliferation
1. Adopted a mature and regulatory phenotype with an anti-inflammatory cytokine profile
2. Reduced capacity to support CD4+ T cell proliferation
September 15, 2025 at 2:33 PM
It was found that CD8 T cells induced regulatory changes in both cDC1 and cDC2, where both types:
1. Adopted a mature and regulatory phenotype with an anti-inflammatory cytokine profile
2. Reduced capacity to support CD4+ T cell proliferation
1. Adopted a mature and regulatory phenotype with an anti-inflammatory cytokine profile
2. Reduced capacity to support CD4+ T cell proliferation
Using a mouse model of multiple sclerosis called experimental autoimmune encephalomyelitis (EAE), they show that myelin-specific CD8 T cells influence dendritic cells (DC), an important antigen-presenting cell in immune systems.
September 15, 2025 at 2:33 PM
Using a mouse model of multiple sclerosis called experimental autoimmune encephalomyelitis (EAE), they show that myelin-specific CD8 T cells influence dendritic cells (DC), an important antigen-presenting cell in immune systems.
Dr. Karandikar's (@PathImmune) group was the first to show that CD8+ T cells targeted to CNS antigens can suppress disease activity and be used as a potential therapeutic approach.
This recent study digs into the mechanism in which these CD8+ T cells help in mitigating disease.
This recent study digs into the mechanism in which these CD8+ T cells help in mitigating disease.
September 15, 2025 at 2:33 PM
Dr. Karandikar's (@PathImmune) group was the first to show that CD8+ T cells targeted to CNS antigens can suppress disease activity and be used as a potential therapeutic approach.
This recent study digs into the mechanism in which these CD8+ T cells help in mitigating disease.
This recent study digs into the mechanism in which these CD8+ T cells help in mitigating disease.
Pathological examination of PCD airways found luminal broncholiths of varying sizes, often associated with inflammation, with several broncholiths adhered to the airway wall and composed of concentric lamellar mineralization with tethers attached to the airway wall.
September 8, 2025 at 7:06 PM
Pathological examination of PCD airways found luminal broncholiths of varying sizes, often associated with inflammation, with several broncholiths adhered to the airway wall and composed of concentric lamellar mineralization with tethers attached to the airway wall.