Charlie Evavold
@synth-immune.bsky.social
Ragon Early Independence Fellow at Ragon Institute of Mass General, MIT, and Harvard.
PhD in Immunology from Harvard Medical School.
Kagan Lab alum.
Cell biologist. Immunologist. Canoer. Hiker.
PhD in Immunology from Harvard Medical School.
Kagan Lab alum.
Cell biologist. Immunologist. Canoer. Hiker.
Scooby Doo and the Cell Death Mystery from #Evavold lab @ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social
November 3, 2025 at 3:59 PM
Scooby Doo and the Cell Death Mystery from #Evavold lab @ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social
Reposted by Charlie Evavold
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
October 27, 2025 at 2:07 PM
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Reposted by Charlie Evavold
Reposted by Charlie Evavold
Meet Lindsey Adams: a scientist, adventurer, and puzzle enthusiast. As a graduate student working in the Lingwood Lab at the Ragon, Lindsey spends her days studying autoimmune diseases and antibody output, diving into the molecular world of protein interactions.
#WeAreRagon
#WeAreRagon
September 30, 2025 at 12:01 PM
Meet Lindsey Adams: a scientist, adventurer, and puzzle enthusiast. As a graduate student working in the Lingwood Lab at the Ragon, Lindsey spends her days studying autoimmune diseases and antibody output, diving into the molecular world of protein interactions.
#WeAreRagon
#WeAreRagon
Reposted by Charlie Evavold
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
www.nature.com
August 19, 2025 at 8:57 AM
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Reposted by Charlie Evavold
Ludwig @mit.edu Co-director Tyler Jacks spoke with us at the Center’s 2025 retreat about his career and how interdisciplinary collaboration fuels cancer research at Ludwig MIT. Check it out here: youtu.be/dHJgSbvCc5Y
#CanSky #OncoSky
#CanSky #OncoSky
Tyler Jacks, Ludwig MIT
YouTube video by Ludwig Cancer Research
youtu.be
June 27, 2025 at 2:21 PM
Ludwig @mit.edu Co-director Tyler Jacks spoke with us at the Center’s 2025 retreat about his career and how interdisciplinary collaboration fuels cancer research at Ludwig MIT. Check it out here: youtu.be/dHJgSbvCc5Y
#CanSky #OncoSky
#CanSky #OncoSky
Reposted by Charlie Evavold
Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications
NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...
www.nature.com
May 27, 2025 at 8:40 AM
Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Wild.
Cell-intrinsic #proteasome derived #defense peptides.
@nature.com
www.nature.com/articles/s41...
Cell-intrinsic #proteasome derived #defense peptides.
@nature.com
www.nature.com/articles/s41...
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 8, 2025 at 2:32 AM
Wild.
Cell-intrinsic #proteasome derived #defense peptides.
@nature.com
www.nature.com/articles/s41...
Cell-intrinsic #proteasome derived #defense peptides.
@nature.com
www.nature.com/articles/s41...
Reposted by Charlie Evavold
Wow! #Chronogenetic is here—an innovative system that harnesses circadian gene control to precisely time the release of drugs and compounds in sync with an individual’s natural biological rhythms.
A new era of personalized medicine begins!
🧪
www.nature.com/articles/s41...
A new era of personalized medicine begins!
🧪
www.nature.com/articles/s41...
A synthetic chronogenetic gene circuit for programmed circadian drug delivery - Nature Communications
Circadian medicine, or chronotherapy, seeks to improve drug efficacy based on individuals’ circadian rhythms. Here, the authors combine principles of tissue engineering and synthetic biology to create...
www.nature.com
March 5, 2025 at 1:26 PM
Wow! #Chronogenetic is here—an innovative system that harnesses circadian gene control to precisely time the release of drugs and compounds in sync with an individual’s natural biological rhythms.
A new era of personalized medicine begins!
🧪
www.nature.com/articles/s41...
A new era of personalized medicine begins!
🧪
www.nature.com/articles/s41...
Reposted by Charlie Evavold
Great to see paper from Alva Casey out today in Nature Metabolism - from her PhD.
Well done Alva!
doi.org/10.1038/s422...
Well done Alva!
doi.org/10.1038/s422...
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation - Nature Metabolism
Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.
doi.org
February 19, 2025 at 12:06 PM
Great to see paper from Alva Casey out today in Nature Metabolism - from her PhD.
Well done Alva!
doi.org/10.1038/s422...
Well done Alva!
doi.org/10.1038/s422...
Reposted by Charlie Evavold
More evidence accumulates that pyroptosis is regulated by ROS after GSDMD cleavage occurs. A beautiful mechanistic study on mitochondrial ROS acting downstream of NLRP3 activation.
Kudos to all authors.
www.nature.com/articles/s42...
Kudos to all authors.
www.nature.com/articles/s42...
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation - Nature Metabolism
Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.
www.nature.com
February 19, 2025 at 4:37 PM
More evidence accumulates that pyroptosis is regulated by ROS after GSDMD cleavage occurs. A beautiful mechanistic study on mitochondrial ROS acting downstream of NLRP3 activation.
Kudos to all authors.
www.nature.com/articles/s42...
Kudos to all authors.
www.nature.com/articles/s42...
Reposted by Charlie Evavold
Thinking back on all this I better understand the pain I feel to see science under devastating attack here. It’s not just about my livelihood or my university. It’s about my identity. And it’s about a pursuit that I see as standing along with art, literature, and music as among our highest callings.
February 8, 2025 at 9:41 PM
Thinking back on all this I better understand the pain I feel to see science under devastating attack here. It’s not just about my livelihood or my university. It’s about my identity. And it’s about a pursuit that I see as standing along with art, literature, and music as among our highest callings.
Now we know a major function of #Granzyme K is #extracellular to activate the #complement cascade.
Out now @nature.com from Carlos Donado and Michael Brenner.
@harvard.edu @harvardmed.bsky.social
www.nature.com/articles/s41...
Out now @nature.com from Carlos Donado and Michael Brenner.
@harvard.edu @harvardmed.bsky.social
www.nature.com/articles/s41...
February 6, 2025 at 7:29 PM
Now we know a major function of #Granzyme K is #extracellular to activate the #complement cascade.
Out now @nature.com from Carlos Donado and Michael Brenner.
@harvard.edu @harvardmed.bsky.social
www.nature.com/articles/s41...
Out now @nature.com from Carlos Donado and Michael Brenner.
@harvard.edu @harvardmed.bsky.social
www.nature.com/articles/s41...
January 30, 2025 at 10:41 PM
Reposted by Charlie Evavold
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
Institut Pasteur decides to leave X
The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...
www.pasteur.fr
January 16, 2025 at 9:18 AM
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
Evavold Lab and Garris Lab 2024 Holiday Dinner!
December 12, 2024 at 1:13 AM
Evavold Lab and Garris Lab 2024 Holiday Dinner!
Reposted by Charlie Evavold
Max deserves a Nobel. In the meantime, you can nominate someone for the Max Cooper Prize, deadline is April 1st.
"Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact."
#Immunology
"Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact."
#Immunology
Emory Max Cooper Prize in Immunology | Emory School of MedicineToggleToggleToggleToggleSearchCloseSearch
SearchToggle openToggle closeSub linkSub linkSub linkSub linkSub linkSub linkToggle openToggle ...
med.emory.edu
December 4, 2024 at 2:15 PM
Max deserves a Nobel. In the meantime, you can nominate someone for the Max Cooper Prize, deadline is April 1st.
"Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact."
#Immunology
"Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact."
#Immunology
Reposted by Charlie Evavold
With lab members Ravi Bharadwaj and Swati Jaiswal, put together this review highlighting the connectivity between transports of cyclic dinucleotides and muropeptide as well as attempted to parse the confusing literature on SLC function in the NOD1/NOD2 pathways: authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 22, 2024 at 3:59 PM
With lab members Ravi Bharadwaj and Swati Jaiswal, put together this review highlighting the connectivity between transports of cyclic dinucleotides and muropeptide as well as attempted to parse the confusing literature on SLC function in the NOD1/NOD2 pathways: authors.elsevier.com/sd/article/S...