Sudipta Mondal
@sudipta-cryoet.bsky.social
In situ structural biology enthusiast | chasing molecular machines in their native habitat #cryoET Postdoc @ParkLab Scripps
Do #lipids carry the signatures of #evolution?🤔
In #Biochemistry Perspective, We 'provocatively' (as my former PhD guide & scientific guru Sankar put it ) propose an expanded view of the classic “lipid divide” idea
feedback/critiques all welcome 🙌 #lipidtime
pubs.acs.org/doi/10.1021/...
In #Biochemistry Perspective, We 'provocatively' (as my former PhD guide & scientific guru Sankar put it ) propose an expanded view of the classic “lipid divide” idea
feedback/critiques all welcome 🙌 #lipidtime
pubs.acs.org/doi/10.1021/...
An Integrative View on Multiple “Lipid Divide” Events as Hallmarks of Distinct Evolutionary Transitions
Lipids are fundamental to life, serving not only as membrane components but also as key players in signaling, energy storage, and cellular identity. While the well-known “lipid divide” between Bacteri...
pubs.acs.org
October 29, 2025 at 12:59 AM
Do #lipids carry the signatures of #evolution?🤔
In #Biochemistry Perspective, We 'provocatively' (as my former PhD guide & scientific guru Sankar put it ) propose an expanded view of the classic “lipid divide” idea
feedback/critiques all welcome 🙌 #lipidtime
pubs.acs.org/doi/10.1021/...
In #Biochemistry Perspective, We 'provocatively' (as my former PhD guide & scientific guru Sankar put it ) propose an expanded view of the classic “lipid divide” idea
feedback/critiques all welcome 🙌 #lipidtime
pubs.acs.org/doi/10.1021/...
Reposted by Sudipta Mondal
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 12:05 AM
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
#NotTheCover @cellpress.bsky.social ...but, we’re still pretty proud of it! 😄 Had an awesome time putting this together with the amazing @kfreeman.bsky.social and @raphaelpark.bsky.social What a ride! 🚀
#SciArt #CryoET #CryoEM
Paper👉 www.cell.com/cell/fulltex...
#SciArt #CryoET #CryoEM
Paper👉 www.cell.com/cell/fulltex...
July 8, 2025 at 9:28 PM
#NotTheCover @cellpress.bsky.social ...but, we’re still pretty proud of it! 😄 Had an awesome time putting this together with the amazing @kfreeman.bsky.social and @raphaelpark.bsky.social What a ride! 🚀
#SciArt #CryoET #CryoEM
Paper👉 www.cell.com/cell/fulltex...
#SciArt #CryoET #CryoEM
Paper👉 www.cell.com/cell/fulltex...
Reposted by Sudipta Mondal
The very first structural images of a tuberculosis-fighting virus
New insights could advance phage therapies for the world’s deadliest bacteria—including drug-resistant strains.
www.scripps.edu/news...
New insights could advance phage therapies for the world’s deadliest bacteria—including drug-resistant strains.
www.scripps.edu/news...
May 18, 2025 at 6:21 PM
The very first structural images of a tuberculosis-fighting virus
New insights could advance phage therapies for the world’s deadliest bacteria—including drug-resistant strains.
www.scripps.edu/news...
New insights could advance phage therapies for the world’s deadliest bacteria—including drug-resistant strains.
www.scripps.edu/news...
Reposted by Sudipta Mondal
@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
May 15, 2025 at 11:12 PM
@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
Reposted by Sudipta Mondal
Scripps Research and @pittofficial.bsky.social capture the first cryo-EM & cryo-ET images of a virus infecting TB-causing Mycobacteria, revealing an unexpected infection mechanism that could inform phage therapies for drug-resistant TB, per @cellpress.bsky.social.
The very first structural images of a tuberculosis-fighting virus
www.scripps.edu
April 23, 2025 at 5:37 PM
Scripps Research and @pittofficial.bsky.social capture the first cryo-EM & cryo-ET images of a virus infecting TB-causing Mycobacteria, revealing an unexpected infection mechanism that could inform phage therapies for drug-resistant TB, per @cellpress.bsky.social.
Reposted by Sudipta Mondal
Some eye-catching #TeamTomo work here. Congrats to @kfreeman.bsky.social and all the authors! 🧪🧶🧬🔬
Krista Freeman et al 𝘊𝘌𝘓𝘓
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
April 18, 2025 at 7:55 PM
Some eye-catching #TeamTomo work here. Congrats to @kfreeman.bsky.social and all the authors! 🧪🧶🧬🔬
Host invasion by a mycobacteriophage—visualized in action! 🦠✨
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Structure and infection dynamics of mycobacteriophage Bxb1
Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…
www.sciencedirect.com
April 17, 2025 at 12:58 AM
Host invasion by a mycobacteriophage—visualized in action! 🦠✨
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
Had an amazing week at the Gordon Research Conference on Biology of Mycobacteria! Great chats, exciting posters and the chance to meet both legends in the field and awesome new peers…
#mycobacteria
#mycobacteria
April 11, 2025 at 4:28 PM
Had an amazing week at the Gordon Research Conference on Biology of Mycobacteria! Great chats, exciting posters and the chance to meet both legends in the field and awesome new peers…
#mycobacteria
#mycobacteria