ETH Laboratory of Toxicology
@sturlalab.bsky.social
Understanding biochemical mechanisms governing bioactive properties of chemicals. Developing novel chemical bioanalysis methods. Advancing precision approaches in disease prevention and therapy.
Visit us @ toxicology.ethz.ch
Visit us @ toxicology.ethz.ch
PhD position alert 📢📢📢
🦠 Emerging mycotoxins - human gut microbiota - molecular mecanisms
🏢 University of Vienna, Institute of Food Chemistry and Toxicology
💌 [email protected]
#microbiome #PhDPosition #toxicity #science #career #AcademicJobs
🦠 Emerging mycotoxins - human gut microbiota - molecular mecanisms
🏢 University of Vienna, Institute of Food Chemistry and Toxicology
💌 [email protected]
#microbiome #PhDPosition #toxicity #science #career #AcademicJobs
November 21, 2025 at 2:18 PM
PhD position alert 📢📢📢
🦠 Emerging mycotoxins - human gut microbiota - molecular mecanisms
🏢 University of Vienna, Institute of Food Chemistry and Toxicology
💌 [email protected]
#microbiome #PhDPosition #toxicity #science #career #AcademicJobs
🦠 Emerging mycotoxins - human gut microbiota - molecular mecanisms
🏢 University of Vienna, Institute of Food Chemistry and Toxicology
💌 [email protected]
#microbiome #PhDPosition #toxicity #science #career #AcademicJobs
Congratulations to Emile Aghajani for her poster "Developing mechanistic and responsive biomarkers of aging based on genome-wide maps of DNA breaks and oxidation" receiving award at #SST2025 ! ✨ @vakil-takhaveev.bsky.social @profshana.bsky.social
November 21, 2025 at 2:07 PM
Congratulations to Emile Aghajani for her poster "Developing mechanistic and responsive biomarkers of aging based on genome-wide maps of DNA breaks and oxidation" receiving award at #SST2025 ! ✨ @vakil-takhaveev.bsky.social @profshana.bsky.social
#SST2025 presenters from the laboratory of toxicology (1/3):
Emilie Aghajani - ⌛👵🧬
Hélène Bigonne - ♀️💻♂️
Blandine Descamps - 🍄🧫💻
Raúl Fernández Cereijo - 💻🦠📈
Emilie Aghajani - ⌛👵🧬
Hélène Bigonne - ♀️💻♂️
Blandine Descamps - 🍄🧫💻
Raúl Fernández Cereijo - 💻🦠📈
November 21, 2025 at 2:00 PM
#SST2025 presenters from the laboratory of toxicology (1/3):
Emilie Aghajani - ⌛👵🧬
Hélène Bigonne - ♀️💻♂️
Blandine Descamps - 🍄🧫💻
Raúl Fernández Cereijo - 💻🦠📈
Emilie Aghajani - ⌛👵🧬
Hélène Bigonne - ♀️💻♂️
Blandine Descamps - 🍄🧫💻
Raúl Fernández Cereijo - 💻🦠📈
#SST2025 presenters from the laboratory of toxicology (2/3):
Dr. Jacob Folz - 🦠💩🧪
Jasmin Huber - 🧬✂️👩🔬
Lucie Lefevre - 🧬💻📈
Livia Pietrow - 🧠🧬👵
Dr. Jacob Folz - 🦠💩🧪
Jasmin Huber - 🧬✂️👩🔬
Lucie Lefevre - 🧬💻📈
Livia Pietrow - 🧠🧬👵
November 21, 2025 at 1:57 PM
#SST2025 presenters from the laboratory of toxicology (2/3):
Dr. Jacob Folz - 🦠💩🧪
Jasmin Huber - 🧬✂️👩🔬
Lucie Lefevre - 🧬💻📈
Livia Pietrow - 🧠🧬👵
Dr. Jacob Folz - 🦠💩🧪
Jasmin Huber - 🧬✂️👩🔬
Lucie Lefevre - 🧬💻📈
Livia Pietrow - 🧠🧬👵
Huge turnout from our Toxicology Lab at yesterday’s SST meeting. Proud of the team and happy to share our work 💖
Special thanks to the organizers @profshana.bsky.social , Gina Montoya Parra and Laura Suter-Dick ! #SST2025
Special thanks to the organizers @profshana.bsky.social , Gina Montoya Parra and Laura Suter-Dick ! #SST2025
November 21, 2025 at 1:38 PM
Huge turnout from our Toxicology Lab at yesterday’s SST meeting. Proud of the team and happy to share our work 💖
Special thanks to the organizers @profshana.bsky.social , Gina Montoya Parra and Laura Suter-Dick ! #SST2025
Special thanks to the organizers @profshana.bsky.social , Gina Montoya Parra and Laura Suter-Dick ! #SST2025
PhD position alert 📢📢📢
🦠 Impact of microbiome biotransformation on chemical toxicity
🏢 ETH Zürich, Laboratory of toxicology
🧑🔬 @georgaichinger.bsky.social & @profshana.bsky.social
jobs.ethz.ch/job/view/JOP...
#NAMs #microbiome #bioinformatics #PhDPosition #toxicity #science #career #AcademicJobs
🦠 Impact of microbiome biotransformation on chemical toxicity
🏢 ETH Zürich, Laboratory of toxicology
🧑🔬 @georgaichinger.bsky.social & @profshana.bsky.social
jobs.ethz.ch/job/view/JOP...
#NAMs #microbiome #bioinformatics #PhDPosition #toxicity #science #career #AcademicJobs
PhD Position in Toxicology
jobs.ethz.ch
November 4, 2025 at 10:27 AM
PhD position alert 📢📢📢
🦠 Impact of microbiome biotransformation on chemical toxicity
🏢 ETH Zürich, Laboratory of toxicology
🧑🔬 @georgaichinger.bsky.social & @profshana.bsky.social
jobs.ethz.ch/job/view/JOP...
#NAMs #microbiome #bioinformatics #PhDPosition #toxicity #science #career #AcademicJobs
🦠 Impact of microbiome biotransformation on chemical toxicity
🏢 ETH Zürich, Laboratory of toxicology
🧑🔬 @georgaichinger.bsky.social & @profshana.bsky.social
jobs.ethz.ch/job/view/JOP...
#NAMs #microbiome #bioinformatics #PhDPosition #toxicity #science #career #AcademicJobs
Reposted by ETH Laboratory of Toxicology
New publication alert! Click-code-seq, our DNA-damage sequencing method, is now out! This tool can advance our understanding of aging, cancer and neurodegeneration. Huge thanks to the amazing collaborative team behind this! @sturlalab.bsky.social @ethz.ch
Mapping oxidatively damaged bases and abasic sites at single-nucleotide resolutions reveals transcription-related strand biases, patterns mirroring cancer mutational signatures, and the action of anticancer drug irofulven
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Click-code-seq reveals strand biases of DNA oxidation and depurination in human genome - Nature Chemical Biology
By mapping oxidatively damaged bases and abasic sites at single-nucleotide resolution in human cells, Takhaveev et al. observed transcription-related strand biases, patterns mirroring cancer mutationa...
www.nature.com
November 2, 2025 at 12:40 PM
New publication alert! Click-code-seq, our DNA-damage sequencing method, is now out! This tool can advance our understanding of aging, cancer and neurodegeneration. Huge thanks to the amazing collaborative team behind this! @sturlalab.bsky.social @ethz.ch
@georgaichinger.bsky.social & @profshana.bsky.social presented at #ICT2025 in Beijing! 🌏
KL “Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism”
“Quantifying the Gut Microbiome’s Impact on Toxicokinetics by PBK Modeling.”
#IUTOX2025 @nynkekramer.bsky.social
KL “Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism”
“Quantifying the Gut Microbiome’s Impact on Toxicokinetics by PBK Modeling.”
#IUTOX2025 @nynkekramer.bsky.social
October 29, 2025 at 1:36 PM
@georgaichinger.bsky.social & @profshana.bsky.social presented at #ICT2025 in Beijing! 🌏
KL “Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism”
“Quantifying the Gut Microbiome’s Impact on Toxicokinetics by PBK Modeling.”
#IUTOX2025 @nynkekramer.bsky.social
KL “Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism”
“Quantifying the Gut Microbiome’s Impact on Toxicokinetics by PBK Modeling.”
#IUTOX2025 @nynkekramer.bsky.social
Exciting contribution from our lab at the 8th EU–US Conference on Endogenous DNA Damage and Repair! 🔬🌍
Dr. Vakil Takhaveev (@vakil-takhaveev.bsky.social) presented a great showcase of how innovative sequencing approaches advance our understanding of genome integrity. 💡🧬
Dr. Vakil Takhaveev (@vakil-takhaveev.bsky.social) presented a great showcase of how innovative sequencing approaches advance our understanding of genome integrity. 💡🧬
October 17, 2025 at 9:29 AM
Exciting contribution from our lab at the 8th EU–US Conference on Endogenous DNA Damage and Repair! 🔬🌍
Dr. Vakil Takhaveev (@vakil-takhaveev.bsky.social) presented a great showcase of how innovative sequencing approaches advance our understanding of genome integrity. 💡🧬
Dr. Vakil Takhaveev (@vakil-takhaveev.bsky.social) presented a great showcase of how innovative sequencing approaches advance our understanding of genome integrity. 💡🧬
Great reception to our work in India! 🙌🏽
Shana Sturla presented our research “Mapping chemical modifications throughout the human genome” at the Global Scientific Conference 2025, VMCC IIT Bombay, bringing global experts together to turn discovery into impact. 🌍🔬
Shana Sturla presented our research “Mapping chemical modifications throughout the human genome” at the Global Scientific Conference 2025, VMCC IIT Bombay, bringing global experts together to turn discovery into impact. 🌍🔬
October 8, 2025 at 11:17 AM
Great reception to our work in India! 🙌🏽
Shana Sturla presented our research “Mapping chemical modifications throughout the human genome” at the Global Scientific Conference 2025, VMCC IIT Bombay, bringing global experts together to turn discovery into impact. 🌍🔬
Shana Sturla presented our research “Mapping chemical modifications throughout the human genome” at the Global Scientific Conference 2025, VMCC IIT Bombay, bringing global experts together to turn discovery into impact. 🌍🔬
If you need information on carcinogenic alkylating agents, check out this amazing new book chapter! 📘✨
Authors: Jasmin Huber, Monika Kojic, Claudia Aloisi, and Shana Sturla 👉 doi.org/10.1016/B978...
Congrats to all authors for this outstanding contribution to the field of molecular toxicology! 👏🧬
Authors: Jasmin Huber, Monika Kojic, Claudia Aloisi, and Shana Sturla 👉 doi.org/10.1016/B978...
Congrats to all authors for this outstanding contribution to the field of molecular toxicology! 👏🧬
Redirecting
doi.org
October 7, 2025 at 10:43 AM
If you need information on carcinogenic alkylating agents, check out this amazing new book chapter! 📘✨
Authors: Jasmin Huber, Monika Kojic, Claudia Aloisi, and Shana Sturla 👉 doi.org/10.1016/B978...
Congrats to all authors for this outstanding contribution to the field of molecular toxicology! 👏🧬
Authors: Jasmin Huber, Monika Kojic, Claudia Aloisi, and Shana Sturla 👉 doi.org/10.1016/B978...
Congrats to all authors for this outstanding contribution to the field of molecular toxicology! 👏🧬
🎓 Big congrats to our MSc student Emanuel Schönbächler for successfully defending his thesis: “Expanding Click-Code-Sequencing for Mapping Oxidative and Alkylation DNA Modifications.” 💥🧬
October 7, 2025 at 9:14 AM
🎓 Big congrats to our MSc student Emanuel Schönbächler for successfully defending his thesis: “Expanding Click-Code-Sequencing for Mapping Oxidative and Alkylation DNA Modifications.” 💥🧬
Reposted by ETH Laboratory of Toxicology
It's finally published in ES&T:
We developed a PBK model for BPA analogues with a multimodal parameterization approach.
👉 yes we can! (predict biokinetics without in vivo data)
👉 analogues reach much higher internal concentrations than BPA
#toxicology #plastics #EDCs
pubs.acs.org/doi/10.1021/...
We developed a PBK model for BPA analogues with a multimodal parameterization approach.
👉 yes we can! (predict biokinetics without in vivo data)
👉 analogues reach much higher internal concentrations than BPA
#toxicology #plastics #EDCs
pubs.acs.org/doi/10.1021/...
Human Internal Exposures of Bisphenol A and Six Data-Poor Analogs Predicted by Physiologically Based Kinetic Models with Multimodal Parametrization
Bisphenols (BP) AF, B, E, F, M, and S are increasingly used as bisphenol A (BPA) substitutes. Despite widespread exposure and potential adverse health outcomes, they are poorly understood in terms of ...
pubs.acs.org
September 26, 2025 at 7:41 AM
It's finally published in ES&T:
We developed a PBK model for BPA analogues with a multimodal parameterization approach.
👉 yes we can! (predict biokinetics without in vivo data)
👉 analogues reach much higher internal concentrations than BPA
#toxicology #plastics #EDCs
pubs.acs.org/doi/10.1021/...
We developed a PBK model for BPA analogues with a multimodal parameterization approach.
👉 yes we can! (predict biokinetics without in vivo data)
👉 analogues reach much higher internal concentrations than BPA
#toxicology #plastics #EDCs
pubs.acs.org/doi/10.1021/...
PhD student Emilie Aghajani and Dr. @vakil-takhaveev.bsky.social represented us at #ARDD2025 in Copenhagen, sharing their work on developing mechanistic biomarkers of aging through genome-wide DNA damage mapping. A fantastic opportunity to connect with the aging research community!
September 18, 2025 at 1:49 PM
PhD student Emilie Aghajani and Dr. @vakil-takhaveev.bsky.social represented us at #ARDD2025 in Copenhagen, sharing their work on developing mechanistic biomarkers of aging through genome-wide DNA damage mapping. A fantastic opportunity to connect with the aging research community!
Our fantastic postdoc Vakil Takhaveev (@vakil-takhaveev.bsky.social) rocked the EFMC Young Medicinal Chemists’ Symposium in Porto 🇵🇹 @euromedchem.bsky.social, presenting how DNA-damage sequencing can reveal anti-cancer drug mechanisms and push precision oncology forward! ✨🧬
September 18, 2025 at 1:14 PM
Our fantastic postdoc Vakil Takhaveev (@vakil-takhaveev.bsky.social) rocked the EFMC Young Medicinal Chemists’ Symposium in Porto 🇵🇹 @euromedchem.bsky.social, presenting how DNA-damage sequencing can reveal anti-cancer drug mechanisms and push precision oncology forward! ✨🧬
🌍 Our team had the privilege to showcase our latest advances in developing #NAMs under the equator at #WC13! ✨
🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling
🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics
⚖️ Hélène Bigonne – sex-informed PBK models
🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling
🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics
⚖️ Hélène Bigonne – sex-informed PBK models
September 18, 2025 at 12:34 PM
🌍 Our team had the privilege to showcase our latest advances in developing #NAMs under the equator at #WC13! ✨
🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling
🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics
⚖️ Hélène Bigonne – sex-informed PBK models
🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling
🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics
⚖️ Hélène Bigonne – sex-informed PBK models
✨ Our lab members Nina Frei, Jasmin Huber, and Lucie Lefevre had an inspiring day at the SCS Fall Meeting 2025 @swisschemistry.bsky.social in Zürich! It was a fantastic opportunity to exchange ideas, discover cutting-edge research, and connect with the vibrant Swiss chemistry community. 🌍🔬💡
September 11, 2025 at 5:20 PM
✨ Our lab members Nina Frei, Jasmin Huber, and Lucie Lefevre had an inspiring day at the SCS Fall Meeting 2025 @swisschemistry.bsky.social in Zürich! It was a fantastic opportunity to exchange ideas, discover cutting-edge research, and connect with the vibrant Swiss chemistry community. 🌍🔬💡
Great discussions at the #Metabolomics2025 in Prague ! ✨
Our brilliant postdoc Jacob Folz presented his research on "Quantifying rate and global profile of gut microbiota metabolism ex vivo by LC-MS/MS". 🦠
Stay tuned - his new publication is on the way ! 😉
Our brilliant postdoc Jacob Folz presented his research on "Quantifying rate and global profile of gut microbiota metabolism ex vivo by LC-MS/MS". 🦠
Stay tuned - his new publication is on the way ! 😉
September 11, 2025 at 12:53 PM
Great discussions at the #Metabolomics2025 in Prague ! ✨
Our brilliant postdoc Jacob Folz presented his research on "Quantifying rate and global profile of gut microbiota metabolism ex vivo by LC-MS/MS". 🦠
Stay tuned - his new publication is on the way ! 😉
Our brilliant postdoc Jacob Folz presented his research on "Quantifying rate and global profile of gut microbiota metabolism ex vivo by LC-MS/MS". 🦠
Stay tuned - his new publication is on the way ! 😉
Quite a day at the Annual Meeting of the Swiss Society of Toxicology with talks by @georgaichinger.bsky.social (microbiome-competent PK modeling) & @vakil-takhaveev.bsky.social (DNA damage sequencing).
Special Congrats to PhDs Alona Slastennikova and Blandine Descamps who received poster awards!💪🥳
Special Congrats to PhDs Alona Slastennikova and Blandine Descamps who received poster awards!💪🥳
November 21, 2024 at 10:08 AM
Quite a day at the Annual Meeting of the Swiss Society of Toxicology with talks by @georgaichinger.bsky.social (microbiome-competent PK modeling) & @vakil-takhaveev.bsky.social (DNA damage sequencing).
Special Congrats to PhDs Alona Slastennikova and Blandine Descamps who received poster awards!💪🥳
Special Congrats to PhDs Alona Slastennikova and Blandine Descamps who received poster awards!💪🥳