Ragothaman Yennamalli
@structbioinfo.bsky.social
Sr. Asst Prof SASTRA Univ | Computational Biologist | YIM2024 organizer | Editor: CSBJ, BMC Bioinfo | Spl issue Ed: Biophys J | He/Him.
Wonderful read with my morning coffee. It was an absolute delight to read a fine piece of writing. It reaffirms the practice that scientific writing is not in linear time scale. It is in the presentation, where details are lost, and this leads to utter confusion in reproducibility. History Matters!!
Every biologist knows the story of Fleming's chance discovery of penicillin. But is it true?
Here, with @asimovpress.bsky.social, I write about inconsistencies in the canonical story, and explore a few alternative theories about what really happened in that St. Mary's lab in the summer of 1928.
Here, with @asimovpress.bsky.social, I write about inconsistencies in the canonical story, and explore a few alternative theories about what really happened in that St. Mary's lab in the summer of 1928.
The Penicillin Myth
Competing theories seek to explain inconsistencies surrounding Alexander Fleming’s famed discovery.
press.asimov.com
November 25, 2025 at 12:30 AM
Wonderful read with my morning coffee. It was an absolute delight to read a fine piece of writing. It reaffirms the practice that scientific writing is not in linear time scale. It is in the presentation, where details are lost, and this leads to utter confusion in reproducibility. History Matters!!
Reposted by Ragothaman Yennamalli
Editors have a really hard job, and the good ones can make something unreadable readable, and the great ones can make something unreadable into something good. But they're basically invisible, until someone tries to write without one.
November 17, 2025 at 3:35 PM
Editors have a really hard job, and the good ones can make something unreadable readable, and the great ones can make something unreadable into something good. But they're basically invisible, until someone tries to write without one.
Reposted by Ragothaman Yennamalli
Tout va bien, c'est humoristique
31 illegible black metal band logos
It’s one of the strange quirks of the extreme metal scene: band names have to be written in an ornate, impossible-to-decipher font. Here are few of our favourites. Check the caption on each one to fin...
www.nme.com
November 10, 2025 at 5:22 PM
Tout va bien, c'est humoristique
Reposted by Ragothaman Yennamalli
Nicolas-Sébastien Adam - Prometheus Bound 1762 - Marble (Louvre)
November 7, 2025 at 2:45 PM
Nicolas-Sébastien Adam - Prometheus Bound 1762 - Marble (Louvre)
Send us your proposals!
📣 The call for tutorials & workshops at #ECCB2026 is now open! Share your tools, methods or expertise with the community.
🗓️ Deadline: 5 January 2026
👉 Submit: tinyurl.com/tw-eccb26
💡 ECCB will take place on 31 Aug–4 Sept in Geneva, gathering 1,000+ scientists from academia, industry, & healthcare.
🗓️ Deadline: 5 January 2026
👉 Submit: tinyurl.com/tw-eccb26
💡 ECCB will take place on 31 Aug–4 Sept in Geneva, gathering 1,000+ scientists from academia, industry, & healthcare.
November 5, 2025 at 8:19 AM
Send us your proposals!
Reposted by Ragothaman Yennamalli
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 12:26 PM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Happy to share that our collaborative paper got featured as the cover page of the latest issue of JBC!
November 3, 2025 at 11:53 AM
Happy to share that our collaborative paper got featured as the cover page of the latest issue of JBC!
Reposted by Ragothaman Yennamalli
Who did this?!
November 1, 2025 at 8:38 PM
Who did this?!
Reposted by Ragothaman Yennamalli
maslow's hierarchy of cells
1. physiological needs: oxygen, nutrients
2. safety: a tissue culture dish to adhere to
3. love and belonging: contact with surrounding cells
1. physiological needs: oxygen, nutrients
2. safety: a tissue culture dish to adhere to
3. love and belonging: contact with surrounding cells
November 2, 2025 at 12:20 AM
maslow's hierarchy of cells
1. physiological needs: oxygen, nutrients
2. safety: a tissue culture dish to adhere to
3. love and belonging: contact with surrounding cells
1. physiological needs: oxygen, nutrients
2. safety: a tissue culture dish to adhere to
3. love and belonging: contact with surrounding cells
Reposted by Ragothaman Yennamalli
Success. Nearly 259 Foldscope deployed in hands of unsuspecting candy crazy kids. Halloween is always more colorful with the microscopes - specially in a few weeks they could look at the micro-fauna of the teeth with so much sugar consumption.
November 1, 2025 at 10:10 AM
Success. Nearly 259 Foldscope deployed in hands of unsuspecting candy crazy kids. Halloween is always more colorful with the microscopes - specially in a few weeks they could look at the micro-fauna of the teeth with so much sugar consumption.
Reposted by Ragothaman Yennamalli
I have started making a homemade electrolyte drink with sodium salt, potassium salt, powdered ginger, lemon juice, mint leaves, and carbonated water and I love it (and I feel noticeably better with 1/day).
Just ordered freeze dried lemon and mint leaves to make a dry mix 💪🏻
Just ordered freeze dried lemon and mint leaves to make a dry mix 💪🏻
October 30, 2025 at 3:59 AM
I have started making a homemade electrolyte drink with sodium salt, potassium salt, powdered ginger, lemon juice, mint leaves, and carbonated water and I love it (and I feel noticeably better with 1/day).
Just ordered freeze dried lemon and mint leaves to make a dry mix 💪🏻
Just ordered freeze dried lemon and mint leaves to make a dry mix 💪🏻
Reposted by Ragothaman Yennamalli
Just because this came up a few times recently
If you need to compare two or more ensembles (like RMSD for structures) we developed algorithms and code (ENCORE) to do just that
Similarity Measures for Protein Ensembles
journals.plos.org/plosone/arti...
ENCORE
journals.plos.org/ploscompbiol...
If you need to compare two or more ensembles (like RMSD for structures) we developed algorithms and code (ENCORE) to do just that
Similarity Measures for Protein Ensembles
journals.plos.org/plosone/arti...
ENCORE
journals.plos.org/ploscompbiol...
October 27, 2025 at 8:00 AM
Just because this came up a few times recently
If you need to compare two or more ensembles (like RMSD for structures) we developed algorithms and code (ENCORE) to do just that
Similarity Measures for Protein Ensembles
journals.plos.org/plosone/arti...
ENCORE
journals.plos.org/ploscompbiol...
If you need to compare two or more ensembles (like RMSD for structures) we developed algorithms and code (ENCORE) to do just that
Similarity Measures for Protein Ensembles
journals.plos.org/plosone/arti...
ENCORE
journals.plos.org/ploscompbiol...
A Sunday morning Data Wrangling Exercise...
Gaurav Sharma and I discussed what this new Sh-Index means. Post-preprint and now featured in Nature Index, there has been vocal criticism and rightly so. We discussed again and I have been using it not actually intended. Also.. 🧵 1/8
Gaurav Sharma and I discussed what this new Sh-Index means. Post-preprint and now featured in Nature Index, there has been vocal criticism and rightly so. We discussed again and I have been using it not actually intended. Also.. 🧵 1/8
I know the modified H index (or the Sh index) is getting a lot of grief in social media discussions but it allows a simple calculation: what’s the difference between your h index and your Sh index? If that difference is small or zero, what does that tell us about what kind of collaborator you are?
October 27, 2025 at 7:25 AM
A Sunday morning Data Wrangling Exercise...
Gaurav Sharma and I discussed what this new Sh-Index means. Post-preprint and now featured in Nature Index, there has been vocal criticism and rightly so. We discussed again and I have been using it not actually intended. Also.. 🧵 1/8
Gaurav Sharma and I discussed what this new Sh-Index means. Post-preprint and now featured in Nature Index, there has been vocal criticism and rightly so. We discussed again and I have been using it not actually intended. Also.. 🧵 1/8
Would be interested to see if the difference is significant for many? Cos it is for me.
I know the modified H index (or the Sh index) is getting a lot of grief in social media discussions but it allows a simple calculation: what’s the difference between your h index and your Sh index? If that difference is small or zero, what does that tell us about what kind of collaborator you are?
October 27, 2025 at 4:23 AM
Would be interested to see if the difference is significant for many? Cos it is for me.
Some say for every manuscript published one should peer-review three manuscripts. It is only October and I have peer-reviewed >30 (excluding editorial work). I have in fact declined couple of invitations suggesting other experts. The reason I am posting this is ...1/3
October 24, 2025 at 11:17 AM
Some say for every manuscript published one should peer-review three manuscripts. It is only October and I have peer-reviewed >30 (excluding editorial work). I have in fact declined couple of invitations suggesting other experts. The reason I am posting this is ...1/3
This is why first name of researchers and the history behind the discovery needs to be taught early on... #WomenInScience
Maud Menten was born in Canada in 1879 and completed her UG and MD education at University of Toronto. As a research assistant with Leonor Michaelis in 1912, they wrote the classic paper describing the “Michaelis-Menten” model of enzyme kinetics.. #WomenInScience
October 16, 2025 at 12:42 PM
This is why first name of researchers and the history behind the discovery needs to be taught early on... #WomenInScience
Art has the therapeutic effect of a much needed detox from mundanity. Languishing among Chola and Maratha periods on a Sunday. Feet are sore but in a good way.
October 13, 2025 at 11:31 PM
Art has the therapeutic effect of a much needed detox from mundanity. Languishing among Chola and Maratha periods on a Sunday. Feet are sore but in a good way.
Reposted by Ragothaman Yennamalli
I don’t think this is a controversial opinion but …
Indian style mutter-paneer definitely deserves the Nobel peas prize this year
www.indianhealthyrecipes.com/matar-paneer...
Indian style mutter-paneer definitely deserves the Nobel peas prize this year
www.indianhealthyrecipes.com/matar-paneer...
October 10, 2025 at 4:55 AM
I don’t think this is a controversial opinion but …
Indian style mutter-paneer definitely deserves the Nobel peas prize this year
www.indianhealthyrecipes.com/matar-paneer...
Indian style mutter-paneer definitely deserves the Nobel peas prize this year
www.indianhealthyrecipes.com/matar-paneer...
Post-review, your manuscript is not publishable!
The proposal was not uploaded properly.
Proposal is not recommended for funding!
we regret to inform...<anything after this is horror>!
The proposal was not uploaded properly.
Proposal is not recommended for funding!
we regret to inform...<anything after this is horror>!
October 8, 2025 at 1:21 PM
Post-review, your manuscript is not publishable!
The proposal was not uploaded properly.
Proposal is not recommended for funding!
we regret to inform...<anything after this is horror>!
The proposal was not uploaded properly.
Proposal is not recommended for funding!
we regret to inform...<anything after this is horror>!
Reposted by Ragothaman Yennamalli
The @itiscolossal.bsky.social Dire Wolf™ #DeExtinction #DisInformation campaign continues to deceive; GMO grey wolves are not dire ones 🧪 🧟 🐺
a black and white photo of a man in a fur coat standing next to a wolf .
ALT: a black and white photo of a man in a fur coat standing next to a wolf .
media.tenor.com
October 8, 2025 at 12:45 PM
The @itiscolossal.bsky.social Dire Wolf™ #DeExtinction #DisInformation campaign continues to deceive; GMO grey wolves are not dire ones 🧪 🧟 🐺
This is not funny! 😢 I see this scenario happening soon!🤷♂️
October 8, 2025 at 1:16 PM
This is not funny! 😢 I see this scenario happening soon!🤷♂️
Reposted by Ragothaman Yennamalli
New report on navigating challenges of doing science in Global South countries. We often hear about obstacles like bureaucracy and funding constraints. Some practical here on how to navigate
October 7, 2025 at 5:35 AM
New report on navigating challenges of doing science in Global South countries. We often hear about obstacles like bureaucracy and funding constraints. Some practical here on how to navigate
Reposted by Ragothaman Yennamalli
luckily, there are alternatives to PubMed, see libguides.exeter.ac.uk/c.php?g=7252...
LibGuides: Alternatives to United States NLM Resources: Databases which use PubMed
LibGuides: Alternatives to United States NLM Resources: Databases which use PubMed
libguides.exeter.ac.uk
October 3, 2025 at 9:43 AM
luckily, there are alternatives to PubMed, see libguides.exeter.ac.uk/c.php?g=7252...
Reposted by Ragothaman Yennamalli
Oct 3, 1946: #RosalindFranklin defended her PhD on coal chemistry. That path led to #Photo51—the image that revealed DNA’s double helix. A hidden spark that unlocked life’s blueprint.
🧪
🧪
October 3, 2025 at 8:02 AM
Oct 3, 1946: #RosalindFranklin defended her PhD on coal chemistry. That path led to #Photo51—the image that revealed DNA’s double helix. A hidden spark that unlocked life’s blueprint.
🧪
🧪
Reposted by Ragothaman Yennamalli
Check out our latest, where we investigate the molecular origin of differences between Lys and Arg and their roles in biomolecular #condensates
@dipcehu.bsky.social
www.biorxiv.org/content/10.1...
@dipcehu.bsky.social
www.biorxiv.org/content/10.1...
October 3, 2025 at 5:21 AM
Check out our latest, where we investigate the molecular origin of differences between Lys and Arg and their roles in biomolecular #condensates
@dipcehu.bsky.social
www.biorxiv.org/content/10.1...
@dipcehu.bsky.social
www.biorxiv.org/content/10.1...