Scott Keeney
@spo11rulz.bsky.social
Scientist. Meiosis nerd. 🏳️🌈 Queer as a $3 bill. He/him. Spo11 Rules!
New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...
Insight into Meiotic DNA End Resection: Mechanisms and Regulation
Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic ch…
www.sciencedirect.com
August 16, 2025 at 7:32 PM
New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...
Please repost: I'm looking for suggestions for activities (scientific, social, team-building, whatever) for a lab retreat. What worked well in retreats you've been to?
(I put this on Twitter a while ago and got some great responses, but lost the info when I deleted that account.)
(I put this on Twitter a while ago and got some great responses, but lost the info when I deleted that account.)
May 6, 2025 at 11:55 AM
Please repost: I'm looking for suggestions for activities (scientific, social, team-building, whatever) for a lab retreat. What worked well in retreats you've been to?
(I put this on Twitter a while ago and got some great responses, but lost the info when I deleted that account.)
(I put this on Twitter a while ago and got some great responses, but lost the info when I deleted that account.)
Reposted by Scott Keeney
Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
April 29, 2025 at 8:52 PM
Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
Proud of PhD student Zack Zheng for his successful thesis defense today. Here's the cake to prove it...
April 21, 2025 at 10:03 PM
Proud of PhD student Zack Zheng for his successful thesis defense today. Here's the cake to prove it...
Reposted by Scott Keeney
>1900 members of the National Academies of Science, Engineering & Medicine issued a statement supporting science for the benefit of all citizens, and ... 1/2
docs.google.com/document/d/1...
docs.google.com/document/d/1...
Public Statement on Supporting Science for the Benefit of All Citizens
TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...
docs.google.com
March 31, 2025 at 4:28 PM
>1900 members of the National Academies of Science, Engineering & Medicine issued a statement supporting science for the benefit of all citizens, and ... 1/2
docs.google.com/document/d/1...
docs.google.com/document/d/1...
Pro tip: if you have a really important zoom interview, double check that you are not in the same room as a cat that is likely to start crying to be let out #HypotheticallySpeaking
March 5, 2025 at 8:17 PM
Pro tip: if you have a really important zoom interview, double check that you are not in the same room as a cat that is likely to start crying to be let out #HypotheticallySpeaking
Reposted by Scott Keeney
MSK has been recognized as one of the national's top workplaces for inclusion and diversity by @newsweek.com magazine. 🎉
MSK earned five stars, the highest ranking, among mid to large employers in America. Learn more: www.newsweek.com/rankings/ame...
MSK earned five stars, the highest ranking, among mid to large employers in America. Learn more: www.newsweek.com/rankings/ame...
America's Greatest Workplaces for Inclusion & Diversity 2025
Newsweek is partnering with Plant-A Insights Group to honor America's Greatest Workplaces for Inclusion & Diversity 2025. These companies are committed to fostering an inclusive and diverse work envir...
www.newsweek.com
March 4, 2025 at 6:36 PM
MSK has been recognized as one of the national's top workplaces for inclusion and diversity by @newsweek.com magazine. 🎉
MSK earned five stars, the highest ranking, among mid to large employers in America. Learn more: www.newsweek.com/rankings/ame...
MSK earned five stars, the highest ranking, among mid to large employers in America. Learn more: www.newsweek.com/rankings/ame...
Reposted by Scott Keeney
Cell-free system enables detailed study of the role of SPO11 in meiosis
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@ccb-lab.bsky.social @spo11rulz.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@ccb-lab.bsky.social @spo11rulz.bsky.social
Key process in sex-cell formation can finally be studied in vitro
Activity of the purified SPO11 enzyme reconstituted in cell-free system.
www.nature.com
February 19, 2025 at 6:52 PM
Cell-free system enables detailed study of the role of SPO11 in meiosis
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@ccb-lab.bsky.social @spo11rulz.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@ccb-lab.bsky.social @spo11rulz.bsky.social
Reposted by Scott Keeney
Our latest preprint describes methods and tools that enable >99% efficient short homology-dependent genome editing in the human fungal pathogen Cryptococcus neoformans. Congratulations to Matt, Sanjita, and Manning!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Near 100% efficient homology-dependent genome engineering in the human fungal pathogen Cryptococcus neoformans
We recently described CRISPR/Cas9-based short homology-dependent genome engineering in the human fungal pathogen Cryptococcus neoformans , a haploid budding yeast that is the most common cause of fung...
www.biorxiv.org
February 18, 2025 at 10:23 PM
Our latest preprint describes methods and tools that enable >99% efficient short homology-dependent genome editing in the human fungal pathogen Cryptococcus neoformans. Congratulations to Matt, Sanjita, and Manning!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Scott Keeney
the version of record (VoR) of our most recent paper has been published @elife.bsky.social! 🎉🥳 🧪
elifesciences.org/articles/102...
elifesciences.org/articles/102...
February 19, 2025 at 12:35 AM
the version of record (VoR) of our most recent paper has been published @elife.bsky.social! 🎉🥳 🧪
elifesciences.org/articles/102...
elifesciences.org/articles/102...
Reposted by Scott Keeney
Sadly, our colleague and friend Scott Hawley passed away this morning. He was an irreplaceable presence and force for good in the meiosis an Drosophila communities and will be sorely missed.
January 31, 2025 at 3:45 PM
Sadly, our colleague and friend Scott Hawley passed away this morning. He was an irreplaceable presence and force for good in the meiosis an Drosophila communities and will be sorely missed.
Reposted by Scott Keeney
Feeling very lost today with the news of the passing of my undergrad advisor Scott Hawley. He had a huge impact on the field and on me personally. He was the first person to see me as a scientist and gave me the confidence to apply to grad school. I am so grateful to be a part of his legacy.
January 31, 2025 at 4:37 PM
Feeling very lost today with the news of the passing of my undergrad advisor Scott Hawley. He had a huge impact on the field and on me personally. He was the first person to see me as a scientist and gave me the confidence to apply to grad school. I am so grateful to be a part of his legacy.
Reposted by Scott Keeney
New year, new beginnings! 🎉
The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!
We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.
#NewPI #AcademicSky #WomenInSTEM
(1/2)
The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!
We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.
#NewPI #AcademicSky #WomenInSTEM
(1/2)
January 2, 2025 at 4:01 PM
New year, new beginnings! 🎉
The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!
We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.
#NewPI #AcademicSky #WomenInSTEM
(1/2)
The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social!
We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity.
#NewPI #AcademicSky #WomenInSTEM
(1/2)
Reposted by Scott Keeney
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
December 17, 2024 at 1:15 AM
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
Reposted by Scott Keeney
Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...
Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress - Nature Communications
Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...
www.nature.com
December 5, 2024 at 2:30 PM
Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...
Reposted by Scott Keeney
Shoutout to the unknown artist and their work in the mskcc elevator this morning 😂
November 27, 2024 at 4:34 PM
Shoutout to the unknown artist and their work in the mskcc elevator this morning 😂
Reposted by Scott Keeney
Our latest paper showing that DNA nicks drive expansions of both normal and disease-size alleles. All credit goes to a fantastic graduate student Liangzi Li as well as to a terrific team of current and former undergraduate and graduate students in the lab.
www.pnas.org/doi/10.1073/pnas.2413298121
www.pnas.org/doi/10.1073/pnas.2413298121
Recurrent DNA nicks drive massive expansions of (GAA)n repeats | PNAS
Over 50 hereditary degenerative disorders are caused by expansions of short tandem
DNA repeats (STRs). (GAA)n repeat expansions are responsible for...
www.pnas.org
November 25, 2024 at 9:08 PM
Our latest paper showing that DNA nicks drive expansions of both normal and disease-size alleles. All credit goes to a fantastic graduate student Liangzi Li as well as to a terrific team of current and former undergraduate and graduate students in the lab.
www.pnas.org/doi/10.1073/pnas.2413298121
www.pnas.org/doi/10.1073/pnas.2413298121
Reposted by Scott Keeney
Pretty excited to see our review & DNA Typewriter covered by NY Times! Perhaps too much excitement for one Monday 🥲 www.nytimes.com/2024/11/25/s...
‘DNA Typewriters’ Can Record a Cell’s History
Labs around the world are trying to turn cells into autobiographers, tracking their own development from embryos to adults.
www.nytimes.com
November 25, 2024 at 10:47 PM
Pretty excited to see our review & DNA Typewriter covered by NY Times! Perhaps too much excitement for one Monday 🥲 www.nytimes.com/2024/11/25/s...
To journal editorial folks: If your journal doesn't already, please consider changing your work flow to return to authors at the proof stage a copy-edited version of their paper with editors' changes tracked. Just caught a major editor's mistake in some proofs.
November 24, 2024 at 2:38 PM
To journal editorial folks: If your journal doesn't already, please consider changing your work flow to return to authors at the proof stage a copy-edited version of their paper with editors' changes tracked. Just caught a major editor's mistake in some proofs.
Reposted by Scott Keeney
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.
November 23, 2024 at 4:00 PM
Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.
Reposted by Scott Keeney
Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11.
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation
SPO11 initiates meiotic recombination through the induction of programmed DNA double-strand breaks (DSBs), but this catalytic activity had never been reconstituted in vitro. Here, using Mus musculus S...
www.biorxiv.org
November 21, 2024 at 10:18 AM
Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11.
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...