Snu Nini
@snunini.bsky.social
Reposted by Snu Nini
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
October 14, 2025 at 9:02 AM
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
"jewel of the collection"
A storied trove of documents, photos, and lab tools from the race to decipher DNA’s structure and function is finally being made public. https://scim.ag/47GNqze
After bizarre journey, prized history of molecular biology archive finds new home
Science History Institute makes public multimillion-dollar collection, including Rosalind Franklin’s famous DNA image, assembled by fake scientist
scim.ag
September 17, 2025 at 3:05 AM
"jewel of the collection"
Just when she was starting to doubt whether it is all in vein. There was this person who said, "it's all very nice". In those exact words.
The simple words has so much power when people try to be kind!
The simple words has so much power when people try to be kind!
September 12, 2025 at 3:33 AM
Just when she was starting to doubt whether it is all in vein. There was this person who said, "it's all very nice". In those exact words.
The simple words has so much power when people try to be kind!
The simple words has so much power when people try to be kind!
Reposted by Snu Nini
Deciphering microbial spatial organization: insights from synthetic and engineered communities url: academic.oup.com/ismecommun/a...
Deciphering microbial spatial organization: insights from synthetic and engineered communities
Abstract. Microbial communities are frequently organized into complex spatial structures, shaped by intrinsic cellular traits, interactions between communi
academic.oup.com
September 10, 2025 at 7:45 PM
Deciphering microbial spatial organization: insights from synthetic and engineered communities url: academic.oup.com/ismecommun/a...
Reposted by Snu Nini
A timeless model for writing a research summary.
1/2
1/2
September 6, 2025 at 10:51 AM
A timeless model for writing a research summary.
1/2
1/2
Reposted by Snu Nini
Does your lab perform killing assays?
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...
1/n
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...
1/n
Type VI secretion system activity at lethal antibiotic concentrations leads to overestimation of weapon potency
Competition assays are a mainstay of modern microbiology, offering a simple and cost-effective means to quantify microbe–microbe interactions in vitro. Here, we demonstrate a key weakness of this meth...
www.microbiologyresearch.org
August 31, 2025 at 9:30 PM
Does your lab perform killing assays?
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...
1/n
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...
1/n
Reposted by Snu Nini
www.nature.com/articles/s41... #microsky 🦠 model in which the entire cell envelope, including the periplasm, collectively enables Gram-negative bacteria to overcome osmotic challenges
Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature Microbiology
Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.
www.nature.com
August 23, 2025 at 8:58 AM
www.nature.com/articles/s41... #microsky 🦠 model in which the entire cell envelope, including the periplasm, collectively enables Gram-negative bacteria to overcome osmotic challenges
Reposted by Snu Nini
Like woodpeckers?
Like pretty colors?
Like genomics of pretty colors in woodpeckers?
Then this is for you!
"Biochemical and Genomic Underpinnings of Carotenoid Colour Variation Across a Hybrid Zone Between South Asian Flameback Woodpeckers"
Lead author: Rashika Ranasinghe
doi.org/10.1111/mec....
Like pretty colors?
Like genomics of pretty colors in woodpeckers?
Then this is for you!
"Biochemical and Genomic Underpinnings of Carotenoid Colour Variation Across a Hybrid Zone Between South Asian Flameback Woodpeckers"
Lead author: Rashika Ranasinghe
doi.org/10.1111/mec....
August 19, 2025 at 4:47 PM
Like woodpeckers?
Like pretty colors?
Like genomics of pretty colors in woodpeckers?
Then this is for you!
"Biochemical and Genomic Underpinnings of Carotenoid Colour Variation Across a Hybrid Zone Between South Asian Flameback Woodpeckers"
Lead author: Rashika Ranasinghe
doi.org/10.1111/mec....
Like pretty colors?
Like genomics of pretty colors in woodpeckers?
Then this is for you!
"Biochemical and Genomic Underpinnings of Carotenoid Colour Variation Across a Hybrid Zone Between South Asian Flameback Woodpeckers"
Lead author: Rashika Ranasinghe
doi.org/10.1111/mec....
Reposted by Snu Nini
My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
Mathematical modelling for biologists - Modelling concepts in biological research
Mathematical modelling for biologists - Modelling concepts in biological research
www.ebi.ac.uk
August 15, 2025 at 10:39 AM
My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
www.ebi.ac.uk/training/onl...
Including both molecular and epidemiological examples
Reposted by Snu Nini
If you’re interested in learning more about protein folding and misfolding, I’ve created a convenient reading list with a few essential papers:
scholar.google.com/citations?us...
scholar.google.com/citations?us...
scholar.google.com/citations?us...
scholar.google.com/citations?us...
August 6, 2025 at 7:01 PM
If you’re interested in learning more about protein folding and misfolding, I’ve created a convenient reading list with a few essential papers:
scholar.google.com/citations?us...
scholar.google.com/citations?us...
scholar.google.com/citations?us...
scholar.google.com/citations?us...
Reposted by Snu Nini
Being free and open-source, this is how you can support #tidyplots ❤️
tidyplots.org
#rstats #dataviz #phd
tidyplots.org
#rstats #dataviz #phd
July 16, 2025 at 2:15 PM
Being free and open-source, this is how you can support #tidyplots ❤️
tidyplots.org
#rstats #dataviz #phd
tidyplots.org
#rstats #dataviz #phd
Reposted by Snu Nini
Check out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications
This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...
www.nature.com
July 6, 2025 at 6:54 AM
Check out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Snu Nini
Register now for our next webinar on 26 June! Don't miss a deep dive into the exciting use of native mass spectrometry to uncover BiP molecular chaperone function and how Ribosome Quality Control can be a hidden ally of cancer cells against chemotherapy🧪: register.gotowebinar.com/register/838...
June 17, 2025 at 4:15 PM
Register now for our next webinar on 26 June! Don't miss a deep dive into the exciting use of native mass spectrometry to uncover BiP molecular chaperone function and how Ribosome Quality Control can be a hidden ally of cancer cells against chemotherapy🧪: register.gotowebinar.com/register/838...
Reposted by Snu Nini
The latest work from my lab, Phage Disco, a method
@ellie-rand.bsky.social
developed for targeted discovery of bacteriophages based on the bacterial receptor, defense system, or other component they interact with, is now live in mSystems
journals.asm.org/doi/10.1128/...
@ellie-rand.bsky.social
developed for targeted discovery of bacteriophages based on the bacterial receptor, defense system, or other component they interact with, is now live in mSystems
journals.asm.org/doi/10.1128/...
Phage DisCo: targeted discovery of bacteriophages by co-culture | mSystems
In this work, we describe a targeted phage discovery method that allows immediate
isolation of phages with specific traits. Currently, to find a phage with specific
properties, huge libraries of phage...
journals.asm.org
May 29, 2025 at 2:17 AM
The latest work from my lab, Phage Disco, a method
@ellie-rand.bsky.social
developed for targeted discovery of bacteriophages based on the bacterial receptor, defense system, or other component they interact with, is now live in mSystems
journals.asm.org/doi/10.1128/...
@ellie-rand.bsky.social
developed for targeted discovery of bacteriophages based on the bacterial receptor, defense system, or other component they interact with, is now live in mSystems
journals.asm.org/doi/10.1128/...
Reposted by Snu Nini
You can also design in Colab now: colab.research.google.com/github/patri...
May 27, 2025 at 12:40 PM
You can also design in Colab now: colab.research.google.com/github/patri...
Reposted by Snu Nini
AMRrules encode organism-specific rules for interpreting AMR genotype calls: if I find this gene/mutation in this organism, what does it mean for clinical resistance?
May 22, 2025 at 9:36 AM
AMRrules encode organism-specific rules for interpreting AMR genotype calls: if I find this gene/mutation in this organism, what does it mean for clinical resistance?
Reposted by Snu Nini
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
May 13, 2025 at 7:55 PM
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
Apps are great.... until they lead to a crash course in the soft skills of survival. (TMI: I once overheard someone say that purifying her protein would make her happy but making the relationship work would make her happier. They broke up. The protein? purified with a codon optimized plasmid)
💕 Is lasting love more likely if you date only other scientists?
💕 How much should you talk about your research on a first date?
Researchers lift the lid on their experiences of when science meets affairs of the heart
https://go.nature.com/43el0ZD
💕 How much should you talk about your research on a first date?
Researchers lift the lid on their experiences of when science meets affairs of the heart
https://go.nature.com/43el0ZD
‘I don’t have the bandwidth’: how to juggle dating alongside a PhD
Is lasting love more likely if you date only other scientists? How much should you talk about your research on a first date? Researchers lift the lid on their experiences of when science meets affairs of the heart.
go.nature.com
May 14, 2025 at 4:02 PM
Apps are great.... until they lead to a crash course in the soft skills of survival. (TMI: I once overheard someone say that purifying her protein would make her happy but making the relationship work would make her happier. They broke up. The protein? purified with a codon optimized plasmid)
Reposted by Snu Nini
🚨 Teaching bioinformatics? Or learning it solo?
Check out my free & open Fundamentals of Bioinformatics course materials: lectures, slides, and exercises — no coding background required.
🔬🧬👩💻
📚 github.com/lskatz/funda...
⭐️ Star it, share it, and level up!
#bioinformatics #opensource #STEMeducation
Check out my free & open Fundamentals of Bioinformatics course materials: lectures, slides, and exercises — no coding background required.
🔬🧬👩💻
📚 github.com/lskatz/funda...
⭐️ Star it, share it, and level up!
#bioinformatics #opensource #STEMeducation
GitHub - lskatz/fundamentals-of-bioinformatics
Contribute to lskatz/fundamentals-of-bioinformatics development by creating an account on GitHub.
github.com
May 12, 2025 at 6:00 PM
🚨 Teaching bioinformatics? Or learning it solo?
Check out my free & open Fundamentals of Bioinformatics course materials: lectures, slides, and exercises — no coding background required.
🔬🧬👩💻
📚 github.com/lskatz/funda...
⭐️ Star it, share it, and level up!
#bioinformatics #opensource #STEMeducation
Check out my free & open Fundamentals of Bioinformatics course materials: lectures, slides, and exercises — no coding background required.
🔬🧬👩💻
📚 github.com/lskatz/funda...
⭐️ Star it, share it, and level up!
#bioinformatics #opensource #STEMeducation
Predatory bacteria making it into Hollywood!
youtu.be/Gp6FKWkNV5Y?...
youtu.be/Gp6FKWkNV5Y?...
Doctor Must Save His Daughter's Partner From a Deadly Infection | Pure Genius | MD TV
YouTube video by MD TV
youtu.be
April 13, 2025 at 8:54 PM
Predatory bacteria making it into Hollywood!
youtu.be/Gp6FKWkNV5Y?...
youtu.be/Gp6FKWkNV5Y?...
Reposted by Snu Nini
For a good start into 2025 we offer a small treat 🎁 (preprint) to quantitative proteomics and predatory bacteria 🦠 researchers. Our predatory proteome of B.bacteriovorus offers high temporal resolution (based on n=5 biological repeats!) for a better understanding of the killing process. #MicroSky
January 7, 2025 at 5:27 PM
For a good start into 2025 we offer a small treat 🎁 (preprint) to quantitative proteomics and predatory bacteria 🦠 researchers. Our predatory proteome of B.bacteriovorus offers high temporal resolution (based on n=5 biological repeats!) for a better understanding of the killing process. #MicroSky
As an international student I put all eggs in one basket and applied to my dream PhD in the US and got rejected after the interviews. They did not mention fund cuts as the reason. Bt I suspect that. It took me a while bt I picked myself up (I think) to go forward!
March 18, 2025 at 4:48 PM
As an international student I put all eggs in one basket and applied to my dream PhD in the US and got rejected after the interviews. They did not mention fund cuts as the reason. Bt I suspect that. It took me a while bt I picked myself up (I think) to go forward!
Yup! This is not talked about enough and there is no answer for that. For me it's if "A" happens by "X" it will be "B". If it's "C", then "D" and "E". Anyways no regrets!
"The academic structure … makes planning for a family feel like an impossible luxury."
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/3F60VMt #InternationalWomensDay
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/3F60VMt #InternationalWomensDay
As women in academia, having children can feel impossible. Talking about it makes us feel less alone
The struggle is “balancing their careers not just with motherhood, but with what comes before: relationships and planning for a family,” these postdocs write
scim.ag
March 9, 2025 at 10:56 AM
Yup! This is not talked about enough and there is no answer for that. For me it's if "A" happens by "X" it will be "B". If it's "C", then "D" and "E". Anyways no regrets!
Reposted by Snu Nini
Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication 🧪
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...
Color blind friendly palettes for data visualizations with categories
A discussion of color blind friendly palettes for labeling unique catergories in data visualization.
thenode.biologists.com
December 8, 2024 at 9:48 PM
Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication 🧪
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...
Reposted by Snu Nini
Cool, nice chart! I have made a similar one showing also commercialization and resistance.
Interestingly, resistance was sometimes observed before market introduction.
bsky.app/profile/dani...
Interestingly, resistance was sometimes observed before market introduction.
bsky.app/profile/dani...
7️⃣ New drugs are getting rare:
90% of the major classes of antibiotics have been discovered before 1980, only 3 out of 29 after 1980.
Pharma companies have little financial incitation to invest, as new compounds often have to be kept as “last resource” drugs.
Still, new approaches exist.
/end
90% of the major classes of antibiotics have been discovered before 1980, only 3 out of 29 after 1980.
Pharma companies have little financial incitation to invest, as new compounds often have to be kept as “last resource” drugs.
Still, new approaches exist.
/end
December 24, 2024 at 3:42 PM
Cool, nice chart! I have made a similar one showing also commercialization and resistance.
Interestingly, resistance was sometimes observed before market introduction.
bsky.app/profile/dani...
Interestingly, resistance was sometimes observed before market introduction.
bsky.app/profile/dani...