Silvia Anderle
@silvia-anderle.bsky.social
Post doctoral researcher in the Attwell lab at UCL. Interested in anything related to vasculature and blood flow ♥️🧠🩸
Pinned
New paper led by @silvia-anderle.bsky.social
Lifestyle matters for genetic Alzheimer’s disease risk: APOE4 reduces neurovascular function most in an already-stressed system, when neurons are active and mice do less exercise.
I'll tell you all about it! 🧪 #neuroscience #alzheimers
rdcu.be/d74uh
Lifestyle matters for genetic Alzheimer’s disease risk: APOE4 reduces neurovascular function most in an already-stressed system, when neurons are active and mice do less exercise.
I'll tell you all about it! 🧪 #neuroscience #alzheimers
rdcu.be/d74uh
APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice
Communications Biology - Lifestyle matters for genetic Alzheimer’s disease risk: In vivo imaging of mouse blood vessels and neurons shows that APOE4 reduces neurovascular function most in an...
rdcu.be
My first first author paper is finally out! 🎉 Go check it out or read the fantastic blue-torial put together by @cathnaledi.bsky.social 😍 hope you enjoy the read and let us know what you think! 😊
Reposted by Silvia Anderle
Delighted to welcome a new Group Leader to our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏
Prof Catherine Hall @cathnaledi.bsky.social and her team will examine how changes in blood flow & oxygen supply drive the onset of vascular dementia & Alzheimer’s👉 buff.ly/gyouoEV
Prof Catherine Hall @cathnaledi.bsky.social and her team will examine how changes in blood flow & oxygen supply drive the onset of vascular dementia & Alzheimer’s👉 buff.ly/gyouoEV
August 4, 2025 at 8:16 AM
Delighted to welcome a new Group Leader to our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏
Prof Catherine Hall @cathnaledi.bsky.social and her team will examine how changes in blood flow & oxygen supply drive the onset of vascular dementia & Alzheimer’s👉 buff.ly/gyouoEV
Prof Catherine Hall @cathnaledi.bsky.social and her team will examine how changes in blood flow & oxygen supply drive the onset of vascular dementia & Alzheimer’s👉 buff.ly/gyouoEV
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience
Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...
www.nature.com
August 5, 2025 at 10:26 AM
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
Reposted by Silvia Anderle
We're excited to welcome a new Group Leader to our vascular dementia research centre with the BHF🎉👏
Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz
Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz
June 24, 2025 at 4:08 PM
We're excited to welcome a new Group Leader to our vascular dementia research centre with the BHF🎉👏
Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz
Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz
Reposted by Silvia Anderle
Come and join us in Manchester... We are looking for candidates interested in vascular health and neurodegeneration. This project is specifically exploring how menopause may increase Alzheimer's risk.
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...
July 16, 2025 at 7:39 AM
Come and join us in Manchester... We are looking for candidates interested in vascular health and neurodegeneration. This project is specifically exploring how menopause may increase Alzheimer's risk.
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Silvia Anderle
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Research Fellow
We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
July 10, 2025 at 11:08 AM
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Reposted by Silvia Anderle
🚨 Review Alert
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
Frontiers | Walking on the tightrope: the shared roles of the bridging pericytes in the brain
The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...
www.frontiersin.org
July 22, 2025 at 6:48 AM
🚨 Review Alert
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
Reposted by Silvia Anderle
Vittani, Lee, Wang, Hiraoka, et al.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025...
We hope this method is useful to a wide range of the biology community.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025...
We hope this method is useful to a wide range of the biology community.
March 19, 2025 at 7:40 AM
Vittani, Lee, Wang, Hiraoka, et al.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025...
We hope this method is useful to a wide range of the biology community.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025...
We hope this method is useful to a wide range of the biology community.
Reposted by Silvia Anderle
Reposted by Silvia Anderle
Reposted by Silvia Anderle
@physoc.bsky.social has a starter pack of physiologists. Hooray!! go.bsky.app/2KU1XD6
February 13, 2025 at 6:57 PM
@physoc.bsky.social has a starter pack of physiologists. Hooray!! go.bsky.app/2KU1XD6
My first first author paper is finally out! 🎉 Go check it out or read the fantastic blue-torial put together by @cathnaledi.bsky.social 😍 hope you enjoy the read and let us know what you think! 😊
New paper led by @silvia-anderle.bsky.social
Lifestyle matters for genetic Alzheimer’s disease risk: APOE4 reduces neurovascular function most in an already-stressed system, when neurons are active and mice do less exercise.
I'll tell you all about it! 🧪 #neuroscience #alzheimers
rdcu.be/d74uh
Lifestyle matters for genetic Alzheimer’s disease risk: APOE4 reduces neurovascular function most in an already-stressed system, when neurons are active and mice do less exercise.
I'll tell you all about it! 🧪 #neuroscience #alzheimers
rdcu.be/d74uh
APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice
Communications Biology - Lifestyle matters for genetic Alzheimer’s disease risk: In vivo imaging of mouse blood vessels and neurons shows that APOE4 reduces neurovascular function most in an...
rdcu.be
January 30, 2025 at 4:47 PM
My first first author paper is finally out! 🎉 Go check it out or read the fantastic blue-torial put together by @cathnaledi.bsky.social 😍 hope you enjoy the read and let us know what you think! 😊
Reposted by Silvia Anderle
Outstanding and inspiring study!
Norepinephrine (NE)-mediated slow vasomotion drives glymphatic clearance during sleep
www.cell.com/cell/fulltex...
- NE release drives slow vasomotion in NREM sleep
- NE oscillations trigger opposing changes in blood/CSF volumes & predicts glymphatic clearance
Norepinephrine (NE)-mediated slow vasomotion drives glymphatic clearance during sleep
www.cell.com/cell/fulltex...
- NE release drives slow vasomotion in NREM sleep
- NE oscillations trigger opposing changes in blood/CSF volumes & predicts glymphatic clearance
January 11, 2025 at 12:12 PM
Outstanding and inspiring study!
Norepinephrine (NE)-mediated slow vasomotion drives glymphatic clearance during sleep
www.cell.com/cell/fulltex...
- NE release drives slow vasomotion in NREM sleep
- NE oscillations trigger opposing changes in blood/CSF volumes & predicts glymphatic clearance
Norepinephrine (NE)-mediated slow vasomotion drives glymphatic clearance during sleep
www.cell.com/cell/fulltex...
- NE release drives slow vasomotion in NREM sleep
- NE oscillations trigger opposing changes in blood/CSF volumes & predicts glymphatic clearance
Reposted by Silvia Anderle
Infection with #SARSCoV2 has highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of #COVID19 and potentially to the longer-term consequences associated with #LongCovid.
Learn more in a new #SciencePerspective:
Learn more in a new #SciencePerspective:
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
scim.ag
December 17, 2024 at 7:45 PM
Infection with #SARSCoV2 has highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of #COVID19 and potentially to the longer-term consequences associated with #LongCovid.
Learn more in a new #SciencePerspective:
Learn more in a new #SciencePerspective:
Reposted by Silvia Anderle
Some of our work: "Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats"
#neurovascular #cognition
#nitricoxide #diabetes
www.sciencedirect.com/science/arti...
#neurovascular #cognition
#nitricoxide #diabetes
www.sciencedirect.com/science/arti...
Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats
Numerous epidemiological and preclinical studies have established a strong correlation between type 2 diabetes (T2DM) and cognitive impairment and T2D…
www.sciencedirect.com
December 12, 2024 at 7:24 PM
Some of our work: "Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats"
#neurovascular #cognition
#nitricoxide #diabetes
www.sciencedirect.com/science/arti...
#neurovascular #cognition
#nitricoxide #diabetes
www.sciencedirect.com/science/arti...
Reposted by Silvia Anderle
🎉A bit late to the party, but happy to be joining this community!
💫The Down syndrome and Alzheimer’s disease PIA has put together a webinar on cerebrovascular pathology in DS and AD. Please join us on Zoom on Friday 13th, 10:30 am PST, 12:30 CT USA.
✏️Register here: alz-org.zoom.us/webinar/regi...
💫The Down syndrome and Alzheimer’s disease PIA has put together a webinar on cerebrovascular pathology in DS and AD. Please join us on Zoom on Friday 13th, 10:30 am PST, 12:30 CT USA.
✏️Register here: alz-org.zoom.us/webinar/regi...
December 11, 2024 at 7:50 PM
🎉A bit late to the party, but happy to be joining this community!
💫The Down syndrome and Alzheimer’s disease PIA has put together a webinar on cerebrovascular pathology in DS and AD. Please join us on Zoom on Friday 13th, 10:30 am PST, 12:30 CT USA.
✏️Register here: alz-org.zoom.us/webinar/regi...
💫The Down syndrome and Alzheimer’s disease PIA has put together a webinar on cerebrovascular pathology in DS and AD. Please join us on Zoom on Friday 13th, 10:30 am PST, 12:30 CT USA.
✏️Register here: alz-org.zoom.us/webinar/regi...
I guess it was about time to ditch X.
Hello Bluesky! 👋🏼
Hello Bluesky! 👋🏼
December 11, 2024 at 10:01 PM
I guess it was about time to ditch X.
Hello Bluesky! 👋🏼
Hello Bluesky! 👋🏼
Reposted by Silvia Anderle
For more on this subject, follow the researchers in the following starter packs:
Pericytes: go.bsky.app/GhVdxzC
Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy
Cardiovascular research: go.bsky.app/SgaGkv5
Pericytes: go.bsky.app/GhVdxzC
Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy
Cardiovascular research: go.bsky.app/SgaGkv5
November 30, 2024 at 1:45 PM
For more on this subject, follow the researchers in the following starter packs:
Pericytes: go.bsky.app/GhVdxzC
Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy
Cardiovascular research: go.bsky.app/SgaGkv5
Pericytes: go.bsky.app/GhVdxzC
Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy
Cardiovascular research: go.bsky.app/SgaGkv5
Reposted by Silvia Anderle
For more on this subject, follow the researchers in the following starter packs:
Pericytes: go.bsky.app/GhVdxzC
Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy
Cardiovascular research: go.bsky.app/SgaGkv5
Neuroimmunology: go.bsky.app/Eaua5Jk
Pericytes: go.bsky.app/GhVdxzC
Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy
Cardiovascular research: go.bsky.app/SgaGkv5
Neuroimmunology: go.bsky.app/Eaua5Jk
November 30, 2024 at 1:47 PM
For more on this subject, follow the researchers in the following starter packs:
Pericytes: go.bsky.app/GhVdxzC
Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy
Cardiovascular research: go.bsky.app/SgaGkv5
Neuroimmunology: go.bsky.app/Eaua5Jk
Pericytes: go.bsky.app/GhVdxzC
Blood-brain barrier & neurovasculature: go.bsky.app/RB6RXKy
Cardiovascular research: go.bsky.app/SgaGkv5
Neuroimmunology: go.bsky.app/Eaua5Jk