Silvia Paracchini
@silparacchini.bsky.social
Prof of Neurogenetics & Genomics @St Andrews and Bonn; interested in cognition, neurodevelopment, dyslexia and handedness. Co-Chair of the @sldnetwork.bsky.social. Made in Italy.
https://neurogenetics.st-andrews.ac.uk/
https://neurogenetics.st-andrews.ac.uk/
Reposted by Silvia Paracchini
Sign up for this workshop by @damiepak.bsky.social about mathematical simulations!
❗️Our next workshop will be on Dec 11 6 pm CET titled A Gentle Introduction to Mathematical Simulation in R by
@damiepak.bsky.social
Register or sponsor a student by donating to support Ukraine!
Details: bit.ly/3wBeY4S
Please share!
#AcademicSky #EconSky #RStats
@damiepak.bsky.social
Register or sponsor a student by donating to support Ukraine!
Details: bit.ly/3wBeY4S
Please share!
#AcademicSky #EconSky #RStats
November 24, 2025 at 1:29 PM
Sign up for this workshop by @damiepak.bsky.social about mathematical simulations!
Reposted by Silvia Paracchini
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
What enables human language? A biocultural framework
Explaining the origins of language is a key challenge in understanding ourselves as a species. We present an empirical framework that draws on synergies across fields to facilitate robust studies of l...
www.science.org
November 23, 2025 at 11:54 AM
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
Reposted by Silvia Paracchini
popEVE is out in Nature Genetics! 🎉
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Proteome-wide model for human disease genetics
Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.
rdcu.be
November 24, 2025 at 1:35 PM
popEVE is out in Nature Genetics! 🎉
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Reposted by Silvia Paracchini
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
Reposted by Silvia Paracchini
🔍 Want to get the most out of the Atlas of Longitudinal Datasets?
We offer free online webinars with a tailored introduction and live demo to help you navigate the platform and make the most of its features.
📩 Interested? Email us to schedule a session: [email protected]
We offer free online webinars with a tailored introduction and live demo to help you navigate the platform and make the most of its features.
📩 Interested? Email us to schedule a session: [email protected]
November 20, 2025 at 11:11 AM
🔍 Want to get the most out of the Atlas of Longitudinal Datasets?
We offer free online webinars with a tailored introduction and live demo to help you navigate the platform and make the most of its features.
📩 Interested? Email us to schedule a session: [email protected]
We offer free online webinars with a tailored introduction and live demo to help you navigate the platform and make the most of its features.
📩 Interested? Email us to schedule a session: [email protected]
Reposted by Silvia Paracchini
PLEASE SHARE
🚨🚨 6-month RA position available at the Univ. of St Andrews to work with Sue Healy (@cogwild.bsky.social), Simone Meddle (@simonemeddle.bsky.social) and I on the behavioural neuroendocrinology of early reproduction in zebra finches.
tinyurl.com/577cx9tj
Deadline: 03/12/2025
⬇️
🚨🚨 6-month RA position available at the Univ. of St Andrews to work with Sue Healy (@cogwild.bsky.social), Simone Meddle (@simonemeddle.bsky.social) and I on the behavioural neuroendocrinology of early reproduction in zebra finches.
tinyurl.com/577cx9tj
Deadline: 03/12/2025
⬇️
November 19, 2025 at 6:23 PM
PLEASE SHARE
🚨🚨 6-month RA position available at the Univ. of St Andrews to work with Sue Healy (@cogwild.bsky.social), Simone Meddle (@simonemeddle.bsky.social) and I on the behavioural neuroendocrinology of early reproduction in zebra finches.
tinyurl.com/577cx9tj
Deadline: 03/12/2025
⬇️
🚨🚨 6-month RA position available at the Univ. of St Andrews to work with Sue Healy (@cogwild.bsky.social), Simone Meddle (@simonemeddle.bsky.social) and I on the behavioural neuroendocrinology of early reproduction in zebra finches.
tinyurl.com/577cx9tj
Deadline: 03/12/2025
⬇️
Reposted by Silvia Paracchini
Advances in genomics are giving exciting new perspectives on biology of speech, language & reading. My latest peer-reviewed paper is a tutorial, guiding readers from different backgrounds through the history of the field, current state-of-the-art, & where we’re heading. A taster in this thread.🧪
1/n
1/n
Genomic Investigations of Spoken and Written Language Abilities: A Guide to Advances in Approaches, Technologies, and Discovery
Purpose: The aim of this tutorial is to show how the rise of molecular technologies
and analytical methods in human genetics yields exciting new ...
pubs.asha.org
November 17, 2025 at 5:54 PM
Advances in genomics are giving exciting new perspectives on biology of speech, language & reading. My latest peer-reviewed paper is a tutorial, guiding readers from different backgrounds through the history of the field, current state-of-the-art, & where we’re heading. A taster in this thread.🧪
1/n
1/n
Reposted by Silvia Paracchini
Grateful to the Decoding the Gurus guys for having me on to discuss Autism, Microbiomes, & Mice Burying Marbles... @guruspod.bsky.social cc @statsepi.bsky.social @deevybee.bsky.social 😊 open.spotify.com/episode/01w8...
Autism, Microbiomes, & Mice Burying Marbles with Kevin Mitchell
open.spotify.com
November 19, 2025 at 9:32 AM
Grateful to the Decoding the Gurus guys for having me on to discuss Autism, Microbiomes, & Mice Burying Marbles... @guruspod.bsky.social cc @statsepi.bsky.social @deevybee.bsky.social 😊 open.spotify.com/episode/01w8...
The Tartan Army is already the highlight of the World Cup 😀
November 18, 2025 at 10:07 PM
The Tartan Army is already the highlight of the World Cup 😀
Reposted by Silvia Paracchini
COME ON SCOTLAND! 🏴⚽️
Scotland is in the World Cup for the first time since 1998 after a historic 4-2 win against Denmark 🏆
Scotland is in the World Cup for the first time since 1998 after a historic 4-2 win against Denmark 🏆
November 18, 2025 at 9:55 PM
COME ON SCOTLAND! 🏴⚽️
Scotland is in the World Cup for the first time since 1998 after a historic 4-2 win against Denmark 🏆
Scotland is in the World Cup for the first time since 1998 after a historic 4-2 win against Denmark 🏆
Reposted by Silvia Paracchini
Now is the time for professionals nationwide to connect. There is so much more we can do to support the SEND crisis.
If you work for a local authority as an SpLD specialist please consider joining us. Please share widely
Interested? Drop me a line [email protected]
If you work for a local authority as an SpLD specialist please consider joining us. Please share widely
Interested? Drop me a line [email protected]
November 18, 2025 at 9:36 AM
Now is the time for professionals nationwide to connect. There is so much more we can do to support the SEND crisis.
If you work for a local authority as an SpLD specialist please consider joining us. Please share widely
Interested? Drop me a line [email protected]
If you work for a local authority as an SpLD specialist please consider joining us. Please share widely
Interested? Drop me a line [email protected]
Reposted by Silvia Paracchini
#PhD opportunity: Join us in St Andrews to study brain health and healthy aging with data driven approaches in collaboration with brainsciences.scot as part of the EASTBIO DTP
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 16, 2025 at 10:27 AM
#PhD opportunity: Join us in St Andrews to study brain health and healthy aging with data driven approaches in collaboration with brainsciences.scot as part of the EASTBIO DTP
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Silvia Paracchini
New📢
Between molecular and human traits is a yawning gap: What do molecules do to single cells?
We tested *all* human or mouse miRNA mimics for their cell morphological effects on 5 cell lines.
To do so, we applied Cell Painting at the *single cell* level (100,000+ images).
doi.org/10.1101/2025...
Between molecular and human traits is a yawning gap: What do molecules do to single cells?
We tested *all* human or mouse miRNA mimics for their cell morphological effects on 5 cell lines.
To do so, we applied Cell Painting at the *single cell* level (100,000+ images).
doi.org/10.1101/2025...
Systematic morphological profiling of human and mouse miRNAs in 24M single cells
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression whose contributions to cell biology remain underexplored. Here, we used Cell Painting to quantify the morphological effect of ...
doi.org
November 16, 2025 at 10:33 AM
New📢
Between molecular and human traits is a yawning gap: What do molecules do to single cells?
We tested *all* human or mouse miRNA mimics for their cell morphological effects on 5 cell lines.
To do so, we applied Cell Painting at the *single cell* level (100,000+ images).
doi.org/10.1101/2025...
Between molecular and human traits is a yawning gap: What do molecules do to single cells?
We tested *all* human or mouse miRNA mimics for their cell morphological effects on 5 cell lines.
To do so, we applied Cell Painting at the *single cell* level (100,000+ images).
doi.org/10.1101/2025...
#PhD opportunity: Join us in St Andrews to study brain health and healthy aging with data driven approaches in collaboration with brainsciences.scot as part of the EASTBIO DTP
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 16, 2025 at 10:27 AM
#PhD opportunity: Join us in St Andrews to study brain health and healthy aging with data driven approaches in collaboration with brainsciences.scot as part of the EASTBIO DTP
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Silvia Paracchini
Congratulations @hilarycmartin.bsky.social from @sangerinstitute.bsky.social on being awarded the 2026 Balfour Lecture!
November 14, 2025 at 12:35 PM
Congratulations @hilarycmartin.bsky.social from @sangerinstitute.bsky.social on being awarded the 2026 Balfour Lecture!
Reposted by Silvia Paracchini
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 13, 2025 at 4:00 PM
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Reposted by Silvia Paracchini
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism
Claims that the gut microbiome causally contributes to autism regularly appear in
the scientific literature and popular press. Mitchell et al. critically examine influential
studies underpinning these...
www.cell.com
November 13, 2025 at 4:10 PM
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Reposted by Silvia Paracchini
Come to #Bonn next March and join the #BonnBrain Conference 2026! There’s still time left to register and submit your abstract:
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
November 12, 2025 at 4:20 AM
Come to #Bonn next March and join the #BonnBrain Conference 2026! There’s still time left to register and submit your abstract:
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
Reposted by Silvia Paracchini
New preprint on the drain that for-profit publishers place on the scientific ecosystem. We also point out that, though it's often presented as a global problem, it's actually a Global North problem: there are parts of the world with strong diamond #OA non-profit alternatives arxiv.org/abs/2511.04820
November 11, 2025 at 4:32 PM
New preprint on the drain that for-profit publishers place on the scientific ecosystem. We also point out that, though it's often presented as a global problem, it's actually a Global North problem: there are parts of the world with strong diamond #OA non-profit alternatives arxiv.org/abs/2511.04820
Reposted by Silvia Paracchini
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Faculty Position in Computational Biology
Applications are invited for an Assistant/ Associate Professorship in Computational Biology to commence on 1 April 2026 or shortly thereafter. This is a joint post between the Department of Applied
www.cam.ac.uk
November 11, 2025 at 9:05 PM
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Reposted by Silvia Paracchini
The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele?
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 11, 2025 at 3:20 PM
The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele?
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
On my reading list share.google/YppCLNJhP7KM...
David Szalay wins 2025 Booker prize for ‘dark’ Flesh
The judges ‘had never read anything quite like it’, says panel chair Roddy Doyle, announcing the Hungarian-British author’s novel as the winner of the £50,000 award
share.google
November 11, 2025 at 8:04 AM
On my reading list share.google/YppCLNJhP7KM...
Reposted by Silvia Paracchini
You attended the sessions; now it’s your turn to lead one at #ASHG26. Submit your Featured Symposium or Interactive Workshop proposal by January 20, 2026! We're looking for key breakthroughs in #AI, #GeneticCounseling, #PrecisionMedicine & more. 🔗 https://www.ashg.org/annual-meeting-2026/ #ASHG
November 10, 2025 at 7:47 PM
You attended the sessions; now it’s your turn to lead one at #ASHG26. Submit your Featured Symposium or Interactive Workshop proposal by January 20, 2026! We're looking for key breakthroughs in #AI, #GeneticCounseling, #PrecisionMedicine & more. 🔗 https://www.ashg.org/annual-meeting-2026/ #ASHG
Reposted by Silvia Paracchini
No clear evidence to support any link between maternal acetaminophen (Tylenol) intake and autism or ADHD in offspring, a new umbrella, systematic review
@bmj.com
@bmj.com
November 10, 2025 at 12:19 AM
No clear evidence to support any link between maternal acetaminophen (Tylenol) intake and autism or ADHD in offspring, a new umbrella, systematic review
@bmj.com
@bmj.com