SCALE - SubCellular Architecture of LifE
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scale-cluster-ffm.bsky.social
SCALE - SubCellular Architecture of LifE
@scale-cluster-ffm.bsky.social
190 followers 140 following 57 posts
We are a Cluster of Excellence (EXC) based in Frankfurt, Germany, that explore the SubCellular Architecture of LifE. Our goal is to understand how the organizational principles within cells give rise to functional biological outcomes.
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Reposted by SCALE - SubCellular Architecture of LifE
heilemannlab.bsky.social
🚨🔬A great opportunity to work with high-end microscopy in an exciting scientific environment. Please re-post 🙏 @goetheuni.bsky.social @scale-cluster-ffm.bsky.social
👇🏻
yvonnestahl.bsky.social Yvonne Stahl @yvonnestahl.bsky.social · 5d
A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply!
Please share!
November 20, 2025 at 4:33 PM
Reposted by SCALE - SubCellular Architecture of LifE
yvonnestahl.bsky.social
A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply!
Please share!
November 19, 2025 at 5:20 PM
Reposted by SCALE - SubCellular Architecture of LifE
kurianlab.bsky.social
www.biorxiv.org/content/10.1...
Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains.
RNA-binding proteins (RBPs) with prion-like domains, including FUS, hnRNPA1, and hnRNPA2, assemble into functional, metastable condensates that organize ribostasis, but can also transition into self-t...
www.biorxiv.org
November 16, 2025 at 5:15 PM
Reposted by SCALE - SubCellular Architecture of LifE
rheinmainunis.bsky.social
💥"RMU-EXCITE": Die Allianz der Rhein-Main-Universitäten (RMU) @goetheuni.bsky.social, @unimainz.bsky.social und @tuda.bsky.social hat ihren gemeinsamen Antrag als #Exzellenzverbund (Förderlinie Exzellenzuniversitäten) eingereicht! Pressemitteilung: www.rhein-main-universitaeten.de/news/rhein-m...
November 12, 2025 at 11:03 AM
scale-cluster-ffm.bsky.social
📢 We’re hiring an Office and Financial Coordinator to support our team’s administrative operations. Learn more and apply here 👉
November 14, 2025 at 8:32 AM
Reposted by SCALE - SubCellular Architecture of LifE
goetheuni.bsky.social
🚀 #Karriere im Blick? #Mentoring Hessen unterstützt #Frauen auf ihrem Weg in Wissenschaft & Wirtschaft – mit vier Mentoring-Programmen für Studentinnen bis hin zu angehenden Professorinnen. Jetzt bis 1. Dezember (15. Dez. für ProProfessur) bewerben 👉 www.mentoringhessen.de/jetzt-bewerb...
©Mentoring Hessen
November 12, 2025 at 2:50 PM
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bjmurphylab.bsky.social
Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social
November 5, 2025 at 12:12 PM
Reposted by SCALE - SubCellular Architecture of LifE
jcb.org
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
November 4, 2025 at 5:30 PM
Reposted by SCALE - SubCellular Architecture of LifE
deglushk.bsky.social
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
November 6, 2025 at 7:38 AM
scale-cluster-ffm.bsky.social
Congratulations Melanie!
melaniemcdowell.bsky.social Melanie McDowell @melaniemcdowell.bsky.social · 25d
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
mpibp.bsky.social Max Planck Institute of Biophysics @mpibp.bsky.social · 25d
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 10:30 PM
Reposted by SCALE - SubCellular Architecture of LifE
mpibp.bsky.social
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
Structure of the ribosome-bound SND3 translocon complex from the heat-tolerant fungus Chaetomium thermophilum. The SND3 translocon inserts proteins into the endoplasmic reticulum membrane as they are produced by the ribosome.
October 30, 2025 at 8:55 AM
Reposted by SCALE - SubCellular Architecture of LifE
goetheuni.bsky.social
🧬 Der Paul Ehrlich- und Ludwig Darmstaedter-Preis 2026 geht an Davor Solter & Azim Surani – sie entdeckten, dass wir für ein gesundes Leben die Gene beider Eltern brauchen. Ihre Arbeit zur genomischen Prägung öffnete das Tor zur modernen Epigenetik. | tinygu.de/PELD-Preis-2...
October 27, 2025 at 11:06 AM
Reposted by SCALE - SubCellular Architecture of LifE
rheinmainunis.bsky.social
Im Exzellenzcluster @cpi-exstra.bsky.social untersuchen #Forschende interdisziplinär das Zusammenspiel von Herz und Lunge, Ziel ist u.a. die Entwicklung neuartiger Therapeutika. Zum Interview mit Prof. Dr. Dr. h.c. Stefanie Dimmeler von der @goetheuni.bsky.social geht es hier: youtu.be/aik52E5AlXg
RMU Insights: Exzellenzcluster Cardiopulmonary Institute (CPI)
YouTube video by Rhein-Main-Universitäten (RMU)
youtu.be
October 27, 2025 at 4:32 PM
scale-cluster-ffm.bsky.social
🚀 Exciting Job Opportunity: Project Coordinator at the Cluster of Excellence SCALE

We’re thrilled to announce an exceptional opportunity to join the newly founded Cluster of Excellence SCALE – Subcellular Architecture of Life from the @goetheuni.bsky.social.

👉 Learn more and apply here:
October 22, 2025 at 9:41 AM
Reposted by SCALE - SubCellular Architecture of LifE
sjorsscheres.bsky.social
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
beta.ideas.lego.com
October 16, 2025 at 8:07 AM
Reposted by SCALE - SubCellular Architecture of LifE
heilemannlab.bsky.social
It was a tremendous pleasure to have @zhixingchen2.bsky.social visiting us today in Frankfurt and listen to his great science on developing photostable and gentle fluorophores for microscopy.
Thank you, Zhixing, for this inspiring seminar! 🙏
@goetheuni.bsky.social @scale-cluster-ffm.bsky.social
October 7, 2025 at 3:29 PM
Reposted by SCALE - SubCellular Architecture of LifE
aklausnitzer.bsky.social
Proud that our work is online now in @jacs.acspublications.org 🎉 A big thanks to everyone involved in this project! If you are interested have a read:

doi.org/10.1021/jacs...
Conformational Plasticity of LptC Regulates Lipopolysaccharide Transport by the LptB2FGC Complex
The outer membrane of Gram-negative bacteria is coated with lipopolysaccharide (LPS). The Lpt system generates membrane asymmetry by transporting LPS from the inner to the outer membrane. Transport be...
doi.org
September 23, 2025 at 5:30 PM
Reposted by SCALE - SubCellular Architecture of LifE
gbmev.bsky.social
GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!
September 18, 2025 at 11:09 AM
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imprs-cbp.bsky.social
This morning we travelled into the fascinating world of neurons and synapses with @erin-schuman.bsky.social. We learnt how protein synthesis takes place in neuronal dendrites. 🧠

@mpibrain.bsky.social

#imprs_cbp #gradschool #brain
September 18, 2025 at 2:21 PM
Reposted by SCALE - SubCellular Architecture of LifE
imprs-cbp.bsky.social
We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.
September 18, 2025 at 3:28 PM
Reposted by SCALE - SubCellular Architecture of LifE
imprs-cbp.bsky.social
We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students!
#imprs_cbp #biophysics #gradschool
September 15, 2025 at 12:17 PM
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imprs-cbp.bsky.social
We had a great start of the #IMPRS Symposium on Cellular Biophysics to welcome our new students. Thank you for your fascinating talks Michaela Müller-McNicoll, Bernhard Hampölz and Christian Münch 👏

#imprs_cbp #phd #biophysics
September 15, 2025 at 3:04 PM
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mixmue.bsky.social
I am sooo excited. Starting tomorrow the next edition of the fabulous #emboiclip2 course begins. @koenig-lab.bsky.social, @zarnack-group.bsky.social, moi & Elias Bechara will present 3 improvements to the method, a semi-automated workflow for data analysis and an exciting line up of speakers. Ready?
September 6, 2025 at 8:42 PM
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goetheuni.bsky.social
Congratulations! 🎉
September 8, 2025 at 5:45 AM
scale-cluster-ffm.bsky.social
🎉 We congratulate Prof. Dr. Eric Helfrich on nomination for the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2026! 🔬👏
September 3, 2025 at 1:36 PM