Ronald Beavis ❌
@ronbeavis.bsky.social
Doing science for money since 1981.
Putting it online since 1995.
Does not engage in cancer research.
QA >> QC
I enjoy doing things I am not very good at doing.
Putting it online since 1995.
Does not engage in cancer research.
QA >> QC
I enjoy doing things I am not very good at doing.
Does anybody know if an N-degron mechanism has been discovered for proteins with unblocked N-terminal alanines? I can't seem to find one, but finding anything in "the literature" has become a hit or miss proposition.
December 1, 2025 at 5:11 PM
Does anybody know if an N-degron mechanism has been discovered for proteins with unblocked N-terminal alanines? I can't seem to find one, but finding anything in "the literature" has become a hit or miss proposition.
Nuclear receptor subfamily 3 group C member 1 (NR3C1:p) has 2 rigid features: a C-terminal ligand binding (in this case glucocorticoid) domain & a smaller zinc finger domain. The rest is a large dynamic/active region divvied up by a grid of PUZZLE domains (6 pS & 1 pT). #proteomics
December 1, 2025 at 1:01 PM
Nuclear receptor subfamily 3 group C member 1 (NR3C1:p) has 2 rigid features: a C-terminal ligand binding (in this case glucocorticoid) domain & a smaller zinc finger domain. The rest is a large dynamic/active region divvied up by a grid of PUZZLE domains (6 pS & 1 pT). #proteomics
Do the dozens of references to this that have just shown up on my feeds fit the definition?
www.dw.com/en/oxford-na...
www.dw.com/en/oxford-na...
Oxford names 'rage bait' as Word of the Year 2025 – DW – 12/01/2025
The term "rage bait" has been chosen as Oxford's Word of the Year for 2025, reflecting the rise of outrage-driven online content. It beat contenders "aura farming" and "biohack" in a public vote.
www.dw.com
December 1, 2025 at 12:45 PM
Do the dozens of references to this that have just shown up on my feeds fit the definition?
www.dw.com/en/oxford-na...
www.dw.com/en/oxford-na...
A new feature I'm sure everyone will appreciate.
www.forbes.com/sites/zakdof...
www.forbes.com/sites/zakdof...
Google Starts Sharing All Your Text Messages With Your Employer
Warning — what happens on your Android phone, doesn’t stay on your Android phone. Not if it's a work phone.
www.forbes.com
November 30, 2025 at 7:53 PM
A new feature I'm sure everyone will appreciate.
www.forbes.com/sites/zakdof...
www.forbes.com/sites/zakdof...
"N-terminal methionine excision from newly synthesized proteins, catalyzed cotranslationally by methionine aminopeptidases (METAPs), is an essential and universally conserved process that plays a key role in cell homeostasis and protein biogenesis." (Science, 22 Jun 2023, 380:6651, 1238-1243).
November 30, 2025 at 6:06 PM
"N-terminal methionine excision from newly synthesized proteins, catalyzed cotranslationally by methionine aminopeptidases (METAPs), is an essential and universally conserved process that plays a key role in cell homeostasis and protein biogenesis." (Science, 22 Jun 2023, 380:6651, 1238-1243).
Reposted by Ronald Beavis ❌
I do not accept the delineation of “predatory” journals when these for profits are not considered predatory simply because of prestige. And yeah, system has been broke for quite a while and now is just accelerating. One day scientists will realize what “publishing” means and doesn’t mean. I hope.
November 30, 2025 at 2:14 PM
I do not accept the delineation of “predatory” journals when these for profits are not considered predatory simply because of prestige. And yeah, system has been broke for quite a while and now is just accelerating. One day scientists will realize what “publishing” means and doesn’t mean. I hope.
Reposted by Ronald Beavis ❌
Particularly when the 'most prestigious' journals have their share of problematic publications & retractions but try to hide or delay a call on those in every manner imaginable.
Then again, the publishing system is also reflecting how broken our university & funding systems are.
Then again, the publishing system is also reflecting how broken our university & funding systems are.
November 30, 2025 at 3:25 PM
Particularly when the 'most prestigious' journals have their share of problematic publications & retractions but try to hide or delay a call on those in every manner imaginable.
Then again, the publishing system is also reflecting how broken our university & funding systems are.
Then again, the publishing system is also reflecting how broken our university & funding systems are.
Reposted by Ronald Beavis ❌
The guy mentioned had 45 retraction, all on the same journal (Science of the Total Environment) before someone said, "Well, there is something wrong here." Academy and founding agencies reward this hyperprolific behavior. Mass spec field is not an exception.
November 30, 2025 at 2:25 PM
The guy mentioned had 45 retraction, all on the same journal (Science of the Total Environment) before someone said, "Well, there is something wrong here." Academy and founding agencies reward this hyperprolific behavior. Mass spec field is not an exception.
The combination of a low pressure system centred in Michigan & a high off-shore of Maine are pumping up some wet air from the Atlantic & the Gulf of the Mad King is generating a storm in the upper Midwestern states & Southern Ontario.
November 30, 2025 at 3:13 PM
The combination of a low pressure system centred in Michigan & a high off-shore of Maine are pumping up some wet air from the Atlantic & the Gulf of the Mad King is generating a storm in the upper Midwestern states & Southern Ontario.
Reposted by Ronald Beavis ❌
I feel like one of the most underrated explanations for what's happening right now in global politics is that almost everyone has lost their minds.
November 30, 2025 at 2:59 AM
I feel like one of the most underrated explanations for what's happening right now in global politics is that almost everyone has lost their minds.
Nuclear receptor interacting protein 1 (NRIP1:p) is believed to interact with the ligand binding domains of nuclear receptors, modulating their transcription factor activity. It does so without any 2°/3° structure, but uses a grid of pS PUZZLE domain controls. #proteomics
November 30, 2025 at 1:18 PM
Nuclear receptor interacting protein 1 (NRIP1:p) is believed to interact with the ligand binding domains of nuclear receptors, modulating their transcription factor activity. It does so without any 2°/3° structure, but uses a grid of pS PUZZLE domain controls. #proteomics
Reposted by Ronald Beavis ❌
I think people really do not have enough disdain for politicians.
November 27, 2025 at 5:25 PM
I think people really do not have enough disdain for politicians.
What happens when a cat sits on a laptop keyboard.
November 29, 2025 at 4:38 PM
What happens when a cat sits on a laptop keyboard.
Have any #proteomics information analysis systems been developed that try to explain experimental results in terms of transcription factors & E3 ligases rather than metabolic/functional pathways?
November 29, 2025 at 3:56 PM
Have any #proteomics information analysis systems been developed that try to explain experimental results in terms of transcription factors & E3 ligases rather than metabolic/functional pathways?
Reposted by Ronald Beavis ❌
I’m turning down journal reviews if the journal doesn’t update activities to ORCID. I get a lot of requests and I need to prioritize somehow. I ain’t collecting “reviewer certifications” from Genome biology and scientific reports, etc., when Nature Family and ACS give me credit for my time.
November 29, 2025 at 1:50 PM
I’m turning down journal reviews if the journal doesn’t update activities to ORCID. I get a lot of requests and I need to prioritize somehow. I ain’t collecting “reviewer certifications” from Genome biology and scientific reports, etc., when Nature Family and ACS give me credit for my time.
Reposted by Ronald Beavis ❌
I’m visiting family in a rural red area where soybeans are a big deal, at least as rotational crops. From the road it looks like 3/4 of farms here are for sale. The car we brought doesn’t have a dash cam. I’d post it if I could, it’s unreal.
November 29, 2025 at 1:32 PM
I’m visiting family in a rural red area where soybeans are a big deal, at least as rotational crops. From the road it looks like 3/4 of farms here are for sale. The car we brought doesn’t have a dash cam. I’d post it if I could, it’s unreal.
Human ligand dependent nuclear receptor corepressor (LCOR:p) has 2 easily observed splice variants, 433 aa & 1557 aa, in which the 3rd exon gets swapped out for a very different sequence. The shorter one has a homeodomain that isn't in the long one replaced by multiple PUZZLE domains. #proteomics
November 29, 2025 at 12:48 PM
Human ligand dependent nuclear receptor corepressor (LCOR:p) has 2 easily observed splice variants, 433 aa & 1557 aa, in which the 3rd exon gets swapped out for a very different sequence. The shorter one has a homeodomain that isn't in the long one replaced by multiple PUZZLE domains. #proteomics
Reposted by Ronald Beavis ❌
…cool…. Guess I’m a Linux person now! www.windowslatest.com/2025/11/19/w...
Windows 11 will allow AI apps to access your personal files or folders using File Explorer integration
Windows 11 is testing a new feature that allows apps like Claude and Manus AI to access files stored on your PC using File Explorer.
www.windowslatest.com
November 28, 2025 at 10:46 PM
…cool…. Guess I’m a Linux person now! www.windowslatest.com/2025/11/19/w...
Ring finger protein 187 (RNF187:p) initiates translation at a "CGT" triplet (Leu), rather than the much more commonly used "AGT" (Met). Interestingly (for me) is the fact that the N-terminal L is co-translationally removed & N-acetyl is added to alanine exposed by that operation. #proteomics
November 28, 2025 at 8:07 PM
Ring finger protein 187 (RNF187:p) initiates translation at a "CGT" triplet (Leu), rather than the much more commonly used "AGT" (Met). Interestingly (for me) is the fact that the N-terminal L is co-translationally removed & N-acetyl is added to alanine exposed by that operation. #proteomics
I have heard several podcasts this week in which a Canadian commentator hosts an American commentator regarding the "51st state" meme. Unfortunately in the ones I have heard so far, the Canadian has never lived in the US & the American has never lived in Canada, so nothing of value can be discussed.
November 28, 2025 at 3:37 PM
I have heard several podcasts this week in which a Canadian commentator hosts an American commentator regarding the "51st state" meme. Unfortunately in the ones I have heard so far, the Canadian has never lived in the US & the American has never lived in Canada, so nothing of value can be discussed.
Reposted by Ronald Beavis ❌
30% overlap in predicted protein regulation vs measured. Maybe everyone should stop predicting and do more measuring? www.nature.com/articles/s41...
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform - Nature Genetics
Genome-wide association analyses of blood plasma samples using a mass spectrometry-based platform illustrate the complementarity of different proteomics approaches for identifying protein quantitative...
www.nature.com
November 28, 2025 at 2:29 PM
30% overlap in predicted protein regulation vs measured. Maybe everyone should stop predicting and do more measuring? www.nature.com/articles/s41...
When Gemini is asked: "What is the best brand of mass spectrometer to use in proteomics experiments?", after a lot of slop it answers:
November 28, 2025 at 1:48 PM
When Gemini is asked: "What is the best brand of mass spectrometer to use in proteomics experiments?", after a lot of slop it answers:
The polar vortex is continuing to open up over the North Atlantic, with the counter-rotating system now centred on the northern shore of the Yukon. (winds @ 10 hPa)
November 28, 2025 at 12:53 PM
The polar vortex is continuing to open up over the North Atlantic, with the counter-rotating system now centred on the northern shore of the Yukon. (winds @ 10 hPa)
Like NCOR1:p, nuclear receptor corepressor 2 (NCOR2:p) has ~5% of its sequence tied up in rigid structure (2× homeobox domains of unknown DNA specificity). The remaining 95% of the protein is chopped up into >10 evolutionarily conserved dynamic PUZZLE domains that do the work here. #proteomics
November 28, 2025 at 12:46 PM
Like NCOR1:p, nuclear receptor corepressor 2 (NCOR2:p) has ~5% of its sequence tied up in rigid structure (2× homeobox domains of unknown DNA specificity). The remaining 95% of the protein is chopped up into >10 evolutionarily conserved dynamic PUZZLE domains that do the work here. #proteomics