Ronald Beavis ❌
@ronbeavis.bsky.social
560 followers 65 following 1.9K posts
Doing science for money since 1981. Putting it online since 1995. Does not engage in cancer research. QA >> QC I enjoy doing things I am not very good at doing.
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ronbeavis.bsky.social
Canadian PSE is noted for being overly bureaucratic & these proposals (as reasonable as most of them are) are well-suited to paperwork solutions. Same thing that happened with the Naylor & Bouchard reports on federally funded research.
ronbeavis.bsky.social
I agree that most of these proposals are reasonable, but they seem biased in the direction of making the effected institutions as anodyne as possible.
ronbeavis.bsky.social
The forkhead domain is the more cward of the 2 structured interaction domains: the smaller, nward domain appears to be nameless at the moment.
ronbeavis.bsky.social
FOXM1:p (forkhead box family M, member 1) is a transcription factor mainly engaged during G2, controlling the production of proteins necessary for DNA repair. At least some of its pS acceptors are occupied during M phase, presumably to switch off its activity. αβ:IDR = 18:82.
Reposted by Ronald Beavis ❌
nolore.bsky.social
I think we should put everyone who responds "yes" to this question on a list.
ronbeavis.bsky.social
Turns out there were at least 2 of these pointless attacks going on simultaneously.
Reposted by Ronald Beavis ❌
theonion.com
Nation’s Indigenous People Confirm They Don’t Need Special Holiday, Just Large Swaths Of Land Returned Immediately https://theonion.com/nation-s-indigenous-people-confirm-they-don-t-need-spec-1839033177/
Nation’s Indigenous People Confirm They Don’t Need Special Holiday, Just Large Swaths Of Land Returned Immediately
ronbeavis.bsky.social
I guess I should have predicted a dopey, post-Columbus Day LLM-feeding attack.
ronbeavis.bsky.social
FOXK2:p (forkhead box family K, member 2) is commonly discussed with respect to its similarity of to yesterday's FOXK1:p and assumed to be part of switching on the synthesis of proteins needed for aerobic glycolysis. Its pS acceptor occupation pattern is not identical, though. #proteomics
Reposted by Ronald Beavis ❌
proftwolf.bsky.social
Join Together and Reject Trump's Loyalty Oath for Higher Ed-Penn, USC, Vanderbilt, University of Virginia, University of Arizona, UT-Austin, MIT, Brown & Dartmouth.
@aaup.org @aaup-penn.bsky.social @utaustinaaup.bsky.social @aaupbrownchapter.bsky.social
ronbeavis.bsky.social
I saw "House Full of Dynamite" yesterday & what struck me was how all of the civil servants were portrayed in a manner that was nothing like the behaviour of any US government employee I have ever met.
ronbeavis.bsky.social
FOXK1:p (forkhead box family K, member 1) has an nward, structured pS/T peptide binding domain (16%) & a cward forkhead domain (14%). The IDRs (70%) have plenty of conserved pS acceptors, although their role in governing the protein's role in transcriptional activity of is unknown. #proteomics
ronbeavis.bsky.social
The CoCoRaHS daily precipitation map for this morning shows the impact of the current nor'easter on the US Atlantic coast.
ronbeavis.bsky.social
FOXF1 (forkhead box family F, member 1) has a single structured domain (winged helix DNA-binding/forkhead box) with 2 or 3 well-conserved pS-IDRs. The ratio of residues associated with (α+β):(IDR) is 28:72. #proteomics
ronbeavis.bsky.social
Is it true that low complexity sequences are under-represented in MHC class I and/or II peptides? If it is true, what is the mechanism for leaving out these sequences? #proteomics
ronbeavis.bsky.social
The current wind prediction for Monday's nor'easter on the US Atlantic coast, driven by 2 lows & a ridge.
ronbeavis.bsky.social
As is usually the case, the kinase(s) & phosphatase(s) involved are unknown.
ronbeavis.bsky.social
FOXA1:p (forkhead box A1) has a single forkhead DNA binding domain just nward of the middle, with a two acceptor phosphoIDR just cward of the middle. Both of the pS acceptors are occupied most of the time. #proteomics
Reposted by Ronald Beavis ❌
pwilmarth.bsky.social
You have to pay extra to enable the pet scan mode on Thermo Oribis...
ronbeavis.bsky.social
IMHO paleoproteomics is for entertainment purposes, only.
Reposted by Ronald Beavis ❌
jrobson.bsky.social
Announcement from PM Carney moments ago and this is good news. I've been working on this issue with @saulschwartz.bsky.social and @agenestgregoire.bsky.social for years. We've documented how many Canadians don't file and miss out on or loose benefits, .. 1/3
ronbeavis.bsky.social
If there is a second DNA-binding domain nward of the homeodomain in the sequence, the active pS acceptors flank this nward domain. Ta-da!