FlexNP
@rnflex.bsky.social
Jack of all trades nurse practitioner, trail runner photographer, coonhound rescuer, lover of glucagon agonism in the liver, kidney and pancreas, fascinated by obesity medicine, retatrutide fan boy
At first blush, great results, however, no mention of side effects and earlier Ph2 data showed this drug is rough on the GI tract. 60% nausea 30% vomiting. That's not 'tolerable' by any stretch. I'll be curious what the actual side effects are when published.
New top line P2 data for Amycretin, a unimolecular agonist of the glucagon-like peptide 1 (GLP-1) and amylin receptors, intended for once-weekly subcutaneous administration and once-daily oral administration, in PPL with #T2D #weightloss
www.novonordisk.com/content/nnco...
www.novonordisk.com/content/nnco...
November 25, 2025 at 12:24 PM
At first blush, great results, however, no mention of side effects and earlier Ph2 data showed this drug is rough on the GI tract. 60% nausea 30% vomiting. That's not 'tolerable' by any stretch. I'll be curious what the actual side effects are when published.
Andor season 2 was just 4 actually good Star Wars movies chopped up into shorter episodes.
Andor was better than a movie and S2 came out just this year.
November 24, 2025 at 10:22 PM
Andor season 2 was just 4 actually good Star Wars movies chopped up into shorter episodes.
We'll see what the raw data shows but this was a moonshot trial regardless. If there's signs of progress I'd honestly hope someone tries again but with an injectable to get more steady blood levels of whatever drug.
Regardless dementia is a tough disease to crack. Appreciate they tried.
Regardless dementia is a tough disease to crack. Appreciate they tried.
Novo Nordisk A/S: Evoke phase 3 trials did not demonstrate a statistically significant reduction in Alzheimer's disease progression
Bagsværd, Denmark, 24 November 2025 – Novo Nordisk today announced the top-line results from the 2-year primary analysis of evoke and evoke+ phase 3 trials...
www.globenewswire.com
November 24, 2025 at 12:46 PM
We'll see what the raw data shows but this was a moonshot trial regardless. If there's signs of progress I'd honestly hope someone tries again but with an injectable to get more steady blood levels of whatever drug.
Regardless dementia is a tough disease to crack. Appreciate they tried.
Regardless dementia is a tough disease to crack. Appreciate they tried.
2 years ago on a whim I planted the crown of a pineapple we bought from the store. In the last week it's finally showing signs it's about to bloom and create another pineapple!
November 22, 2025 at 6:27 PM
2 years ago on a whim I planted the crown of a pineapple we bought from the store. In the last week it's finally showing signs it's about to bloom and create another pineapple!
Had leftover sloppy joes and decided I'd turn them into nachos. 8/10. Especially good with raw onion and pickled jalapenos.
November 21, 2025 at 12:01 AM
Had leftover sloppy joes and decided I'd turn them into nachos. 8/10. Especially good with raw onion and pickled jalapenos.
If you work as a primary care provider or really any medical speciality provider having your Epic in basket look like this is 🤌🤌
Savoring the fact that it'll look like this for maybe 30 minutes
Savoring the fact that it'll look like this for maybe 30 minutes
November 20, 2025 at 1:30 PM
If you work as a primary care provider or really any medical speciality provider having your Epic in basket look like this is 🤌🤌
Savoring the fact that it'll look like this for maybe 30 minutes
Savoring the fact that it'll look like this for maybe 30 minutes
8 years ago I was here. Fakarava in French Polynesia.
One of the most magical places I've ever been in my life.
One of the most magical places I've ever been in my life.
November 19, 2025 at 12:11 AM
8 years ago I was here. Fakarava in French Polynesia.
One of the most magical places I've ever been in my life.
One of the most magical places I've ever been in my life.
NOOOOO Dragon dictation software is down because of the Cloudflare outage. This is going to be hell trying to document today 🫣🫣😭😭
November 18, 2025 at 1:54 PM
NOOOOO Dragon dictation software is down because of the Cloudflare outage. This is going to be hell trying to document today 🫣🫣😭😭
Pulmonary medicine and Neurology/addiction medicine come on down. It's your turn for GLP1 medications! Eli Lilly(again!) has a new GLP1/GIP dual agonist on phase 2 & 3 trials for alcohol use disroder, smoking cessation and moderate asthma! @ryanmarino.bsky.social @proptermalone.bsky.social
November 17, 2025 at 4:17 PM
Pulmonary medicine and Neurology/addiction medicine come on down. It's your turn for GLP1 medications! Eli Lilly(again!) has a new GLP1/GIP dual agonist on phase 2 & 3 trials for alcohol use disroder, smoking cessation and moderate asthma! @ryanmarino.bsky.social @proptermalone.bsky.social
Want some dirt on the newest obesity medicines in development? I did a whole article on 5 new GLP-1 or Amylin agonist drugs and the benefits, and pitfalls on the data so far
I had a blast at Obesity Week 2025 & multiple new drugs were discussed there. I picked out 5 of the most promising & prominent meds to deep dive on! These include Orforglipron, Eloralintide, Mazdutide, MET-097 & HRS-9531
The GLP1 space is jam packed with exciting new developments!
The GLP1 space is jam packed with exciting new developments!
Obesity Week 2025 Medications
Orforglipron, HRS 9531, MET-097, Eloralintide and Mazdutide, OH MY!
the-incretins.beehiiv.com
November 16, 2025 at 1:26 PM
Want some dirt on the newest obesity medicines in development? I did a whole article on 5 new GLP-1 or Amylin agonist drugs and the benefits, and pitfalls on the data so far
Reposted by FlexNP
I had a blast at Obesity Week 2025 & multiple new drugs were discussed there. I picked out 5 of the most promising & prominent meds to deep dive on! These include Orforglipron, Eloralintide, Mazdutide, MET-097 & HRS-9531
The GLP1 space is jam packed with exciting new developments!
The GLP1 space is jam packed with exciting new developments!
Obesity Week 2025 Medications
Orforglipron, HRS 9531, MET-097, Eloralintide and Mazdutide, OH MY!
the-incretins.beehiiv.com
November 14, 2025 at 8:02 PM
I had a blast at Obesity Week 2025 & multiple new drugs were discussed there. I picked out 5 of the most promising & prominent meds to deep dive on! These include Orforglipron, Eloralintide, Mazdutide, MET-097 & HRS-9531
The GLP1 space is jam packed with exciting new developments!
The GLP1 space is jam packed with exciting new developments!
MY PATIENT IS GETTING A NEW LIVER TODAY. I'M WEEPING Y'ALL 🎉😭🎉😭🎉
One of my patients got accepted onto the Transplant List for their particular organ. I'm so excited for them! We've been working towards this goal for 6 months now and finally got accepted today! 🎉🎉
(It's still a long shot but it's a huge milestone and gives hope!)
(It's still a long shot but it's a huge milestone and gives hope!)
November 15, 2025 at 1:18 PM
MY PATIENT IS GETTING A NEW LIVER TODAY. I'M WEEPING Y'ALL 🎉😭🎉😭🎉
I had a blast at Obesity Week 2025 & multiple new drugs were discussed there. I picked out 5 of the most promising & prominent meds to deep dive on! These include Orforglipron, Eloralintide, Mazdutide, MET-097 & HRS-9531
The GLP1 space is jam packed with exciting new developments!
The GLP1 space is jam packed with exciting new developments!
Obesity Week 2025 Medications
Orforglipron, HRS 9531, MET-097, Eloralintide and Mazdutide, OH MY!
the-incretins.beehiiv.com
November 14, 2025 at 8:02 PM
I had a blast at Obesity Week 2025 & multiple new drugs were discussed there. I picked out 5 of the most promising & prominent meds to deep dive on! These include Orforglipron, Eloralintide, Mazdutide, MET-097 & HRS-9531
The GLP1 space is jam packed with exciting new developments!
The GLP1 space is jam packed with exciting new developments!
Reposted by FlexNP
Always read the supplementary appendix because you find buried treasure. Phase 2 Eloralintide data from Eli Lilly
⏬ Aldosterone
⏬ UACR
⬆️Renin
And increased GFR over 48 weeks. What the heck is going on #NephSky?!
First it was Glucagon agonism and now Amylin may have some renal effect too?!
⏬ Aldosterone
⏬ UACR
⬆️Renin
And increased GFR over 48 weeks. What the heck is going on #NephSky?!
First it was Glucagon agonism and now Amylin may have some renal effect too?!
November 14, 2025 at 12:42 AM
Always read the supplementary appendix because you find buried treasure. Phase 2 Eloralintide data from Eli Lilly
⏬ Aldosterone
⏬ UACR
⬆️Renin
And increased GFR over 48 weeks. What the heck is going on #NephSky?!
First it was Glucagon agonism and now Amylin may have some renal effect too?!
⏬ Aldosterone
⏬ UACR
⬆️Renin
And increased GFR over 48 weeks. What the heck is going on #NephSky?!
First it was Glucagon agonism and now Amylin may have some renal effect too?!
Always read the supplementary appendix because you find buried treasure. Phase 2 Eloralintide data from Eli Lilly
⏬ Aldosterone
⏬ UACR
⬆️Renin
And increased GFR over 48 weeks. What the heck is going on #NephSky?!
First it was Glucagon agonism and now Amylin may have some renal effect too?!
⏬ Aldosterone
⏬ UACR
⬆️Renin
And increased GFR over 48 weeks. What the heck is going on #NephSky?!
First it was Glucagon agonism and now Amylin may have some renal effect too?!
November 14, 2025 at 12:42 AM
Always read the supplementary appendix because you find buried treasure. Phase 2 Eloralintide data from Eli Lilly
⏬ Aldosterone
⏬ UACR
⬆️Renin
And increased GFR over 48 weeks. What the heck is going on #NephSky?!
First it was Glucagon agonism and now Amylin may have some renal effect too?!
⏬ Aldosterone
⏬ UACR
⬆️Renin
And increased GFR over 48 weeks. What the heck is going on #NephSky?!
First it was Glucagon agonism and now Amylin may have some renal effect too?!
Why is Eli Lilly a juggernaut??
It's at least in part because of this man, David Ricks. Fascinating 2 hour listen about GLP1 meds, the fact that Lilly expects to spend more money on R&D than the NIH in 2 years time(!!!), patient access, cost and more.
It's at least in part because of this man, David Ricks. Fascinating 2 hour listen about GLP1 meds, the fact that Lilly expects to spend more money on R&D than the NIH in 2 years time(!!!), patient access, cost and more.
Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
YouTube video by Stripe
youtu.be
November 13, 2025 at 3:49 PM
Why is Eli Lilly a juggernaut??
It's at least in part because of this man, David Ricks. Fascinating 2 hour listen about GLP1 meds, the fact that Lilly expects to spend more money on R&D than the NIH in 2 years time(!!!), patient access, cost and more.
It's at least in part because of this man, David Ricks. Fascinating 2 hour listen about GLP1 meds, the fact that Lilly expects to spend more money on R&D than the NIH in 2 years time(!!!), patient access, cost and more.
One of my patients got accepted onto the Transplant List for their particular organ. I'm so excited for them! We've been working towards this goal for 6 months now and finally got accepted today! 🎉🎉
(It's still a long shot but it's a huge milestone and gives hope!)
(It's still a long shot but it's a huge milestone and gives hope!)
November 13, 2025 at 1:19 AM
One of my patients got accepted onto the Transplant List for their particular organ. I'm so excited for them! We've been working towards this goal for 6 months now and finally got accepted today! 🎉🎉
(It's still a long shot but it's a huge milestone and gives hope!)
(It's still a long shot but it's a huge milestone and gives hope!)
So gonna tag in some of #NephSky. There's an apparent class effect for GLP1 RA to potently lower BP in patients with existing hypertension. Seen here is orforglipron which Lilly is now trialing for high blood pressure(!!) @littlebiggloms.bsky.social @brianrifkin.bsky.social @hswapnil.medsky.social
November 12, 2025 at 1:40 AM
So gonna tag in some of #NephSky. There's an apparent class effect for GLP1 RA to potently lower BP in patients with existing hypertension. Seen here is orforglipron which Lilly is now trialing for high blood pressure(!!) @littlebiggloms.bsky.social @brianrifkin.bsky.social @hswapnil.medsky.social
CC: @mikejohansenmd.medsky.social
In what might be one of the hilariously beneficial Kaplan Meier curves I've ever seen. TTE study of GLP1 meds and alcohol use disorder with the top left graph being incident of alcohol use tirzepatide vs DPP-4i
dom-pubs.onlinelibrary.wiley.com/doi/full/10....
In what might be one of the hilariously beneficial Kaplan Meier curves I've ever seen. TTE study of GLP1 meds and alcohol use disorder with the top left graph being incident of alcohol use tirzepatide vs DPP-4i
dom-pubs.onlinelibrary.wiley.com/doi/full/10....
November 11, 2025 at 5:04 PM
CC: @mikejohansenmd.medsky.social
In what might be one of the hilariously beneficial Kaplan Meier curves I've ever seen. TTE study of GLP1 meds and alcohol use disorder with the top left graph being incident of alcohol use tirzepatide vs DPP-4i
dom-pubs.onlinelibrary.wiley.com/doi/full/10....
In what might be one of the hilariously beneficial Kaplan Meier curves I've ever seen. TTE study of GLP1 meds and alcohol use disorder with the top left graph being incident of alcohol use tirzepatide vs DPP-4i
dom-pubs.onlinelibrary.wiley.com/doi/full/10....
Primary care is really really hard most days. But when you get notes like this. It makes everything worth it.
November 11, 2025 at 2:31 PM
Primary care is really really hard most days. But when you get notes like this. It makes everything worth it.
Another day another telmisartan and tirzepatide combo prescribed. It's like the Konami cheat code combo for dyslipidemia, high blood pressure and obesity +/- diabetes.
a man in a purple shirt and tie is sitting at a table .
ALT: a man in a purple shirt and tie is sitting at a table .
media.tenor.com
November 10, 2025 at 11:00 PM
Another day another telmisartan and tirzepatide combo prescribed. It's like the Konami cheat code combo for dyslipidemia, high blood pressure and obesity +/- diabetes.
We invented the most powerful weight loss drug ever and it might be an effective oncology drug too 😳🤯
"Low-dose RETA significantly reduced tumor volume by 3-fold compared to vehicle, demonstrating efficacy comparable to anti-PD-1 therapy, which achieved a 5-fold reduction in tumor volume"
"Low-dose RETA significantly reduced tumor volume by 3-fold compared to vehicle, demonstrating efficacy comparable to anti-PD-1 therapy, which achieved a 5-fold reduction in tumor volume"
November 9, 2025 at 10:03 PM
We invented the most powerful weight loss drug ever and it might be an effective oncology drug too 😳🤯
"Low-dose RETA significantly reduced tumor volume by 3-fold compared to vehicle, demonstrating efficacy comparable to anti-PD-1 therapy, which achieved a 5-fold reduction in tumor volume"
"Low-dose RETA significantly reduced tumor volume by 3-fold compared to vehicle, demonstrating efficacy comparable to anti-PD-1 therapy, which achieved a 5-fold reduction in tumor volume"
This is an "oof" result. Triglycerides and acute pancreatitis decreased. *Waves tiny flag*
But increased fatty liver disease and 60%(!!!!) increase in LDL cholesterol. Yikes.
@mikejohansenmd.medsky.social tell me I'm reading this wrong? I don't think I am 😳
But increased fatty liver disease and 60%(!!!!) increase in LDL cholesterol. Yikes.
@mikejohansenmd.medsky.social tell me I'm reading this wrong? I don't think I am 😳
In the CORE-TIMI 72a and CORE2-TIMI 72b phase 3 trials involving patients with severe hypertriglyceridemia, olezarsen led to a significantly greater reduction in the triglyceride level and in acute pancreatitis events than placebo. Full results: nej.md/491XG5V
#AHA25
#AHA25
November 8, 2025 at 3:00 PM
This is an "oof" result. Triglycerides and acute pancreatitis decreased. *Waves tiny flag*
But increased fatty liver disease and 60%(!!!!) increase in LDL cholesterol. Yikes.
@mikejohansenmd.medsky.social tell me I'm reading this wrong? I don't think I am 😳
But increased fatty liver disease and 60%(!!!!) increase in LDL cholesterol. Yikes.
@mikejohansenmd.medsky.social tell me I'm reading this wrong? I don't think I am 😳
I want to believe.
No benefit from GLP1 meds for movement disorders, but in this retrospective cohort there *is* a clear signal for a possible dementia benefit?!
Maybe? Maybe? First RCT on this question should have topline data in the next month or two
No benefit from GLP1 meds for movement disorders, but in this retrospective cohort there *is* a clear signal for a possible dementia benefit?!
Maybe? Maybe? First RCT on this question should have topline data in the next month or two
November 8, 2025 at 12:31 PM
I want to believe.
No benefit from GLP1 meds for movement disorders, but in this retrospective cohort there *is* a clear signal for a possible dementia benefit?!
Maybe? Maybe? First RCT on this question should have topline data in the next month or two
No benefit from GLP1 meds for movement disorders, but in this retrospective cohort there *is* a clear signal for a possible dementia benefit?!
Maybe? Maybe? First RCT on this question should have topline data in the next month or two
Chattanooga Whiskey again with the amazing stuff.
Bourbon x Limecello.
It's like a sour key lime pie in a bottle in the best way. Great way for me and the wifey to relax after a long week for us both
Bourbon x Limecello.
It's like a sour key lime pie in a bottle in the best way. Great way for me and the wifey to relax after a long week for us both
November 8, 2025 at 12:15 AM
Chattanooga Whiskey again with the amazing stuff.
Bourbon x Limecello.
It's like a sour key lime pie in a bottle in the best way. Great way for me and the wifey to relax after a long week for us both
Bourbon x Limecello.
It's like a sour key lime pie in a bottle in the best way. Great way for me and the wifey to relax after a long week for us both