David Kuster
@rnadavid.bsky.social
RNA & Metabolism. Ancient companions for Life. RNA as spatial organizer of the Cell. IDPs, biomolecular condensates and RNA fun @HymanLab. And birds.
ebird.org/profile/MjcyMDU0Nw
inaturalist.org/people/9261834
ebird.org/profile/MjcyMDU0Nw
inaturalist.org/people/9261834
Saw my first one two weeks ago & didn't suspect it of anything then, was just mesmerized!
www.inaturalist.org/observations...
www.inaturalist.org/observations...
August 17, 2025 at 8:25 AM
Saw my first one two weeks ago & didn't suspect it of anything then, was just mesmerized!
www.inaturalist.org/observations...
www.inaturalist.org/observations...
Least - but very pretty - sandpiper roaming the Sippewissett Marsh (MA) today!
July 14, 2025 at 2:58 AM
Least - but very pretty - sandpiper roaming the Sippewissett Marsh (MA) today!
Least Terns - exchanging a fish!
Early July, Surf Drive Beach, MA
Early July, Surf Drive Beach, MA
July 8, 2025 at 9:00 PM
Least Terns - exchanging a fish!
Early July, Surf Drive Beach, MA
Early July, Surf Drive Beach, MA
Rapid, nanoscale dynamics of individual IDPs determine bulk properties of the entire condensate, such as viscosity.
Amazing work by Nicola Galvanetto & the Schuler lab!
www.pnas.org/doi/10.1073/...
Amazing work by Nicola Galvanetto & the Schuler lab!
www.pnas.org/doi/10.1073/...
June 4, 2025 at 9:21 PM
Rapid, nanoscale dynamics of individual IDPs determine bulk properties of the entire condensate, such as viscosity.
Amazing work by Nicola Galvanetto & the Schuler lab!
www.pnas.org/doi/10.1073/...
Amazing work by Nicola Galvanetto & the Schuler lab!
www.pnas.org/doi/10.1073/...
European Peacock resting & sunbathing at the shores of the Elbe river. #butterflies
May 13, 2025 at 12:23 PM
European Peacock resting & sunbathing at the shores of the Elbe river. #butterflies
Vielleicht stünde ihm eine Bartfrisur.
May 11, 2025 at 2:22 PM
Vielleicht stünde ihm eine Bartfrisur.
Every Living Thing - Jason Roberts
On the beauty of making inventories, lists and classifying the natural world.
And the interesting, somewhat petty competition between Linnaeus (Systema Naturae) and Buffon (Histoire Naturelle) in doing so!
On the beauty of making inventories, lists and classifying the natural world.
And the interesting, somewhat petty competition between Linnaeus (Systema Naturae) and Buffon (Histoire Naturelle) in doing so!
May 10, 2025 at 3:44 PM
Every Living Thing - Jason Roberts
On the beauty of making inventories, lists and classifying the natural world.
And the interesting, somewhat petty competition between Linnaeus (Systema Naturae) and Buffon (Histoire Naturelle) in doing so!
On the beauty of making inventories, lists and classifying the natural world.
And the interesting, somewhat petty competition between Linnaeus (Systema Naturae) and Buffon (Histoire Naturelle) in doing so!
Scarce Swallowtail resting & sunbathing at the shores of the Elbe river.:)
May 8, 2025 at 8:18 AM
Scarce Swallowtail resting & sunbathing at the shores of the Elbe river.:)
And a plethora of pipers - with Wood sanpiper, Common sandpiper & the very small Temminck's stint!
May 4, 2025 at 7:27 PM
And a plethora of pipers - with Wood sanpiper, Common sandpiper & the very small Temminck's stint!
(dramatic change in pose)
May 4, 2025 at 1:13 PM
(dramatic change in pose)
April 16, 2025 at 10:09 AM
Internal phase separation in synthetic DNA condensates
Degree of mixing between A and B DNA Nanostars can be tuned by the fraction of AB Linker oligos (Fab).
Amazing work by @dianatanase.bsky.social & @dimichelelab1.bsky.social.
www.biorxiv.org/content/10.1...
Degree of mixing between A and B DNA Nanostars can be tuned by the fraction of AB Linker oligos (Fab).
Amazing work by @dianatanase.bsky.social & @dimichelelab1.bsky.social.
www.biorxiv.org/content/10.1...
April 14, 2025 at 6:13 PM
Internal phase separation in synthetic DNA condensates
Degree of mixing between A and B DNA Nanostars can be tuned by the fraction of AB Linker oligos (Fab).
Amazing work by @dianatanase.bsky.social & @dimichelelab1.bsky.social.
www.biorxiv.org/content/10.1...
Degree of mixing between A and B DNA Nanostars can be tuned by the fraction of AB Linker oligos (Fab).
Amazing work by @dianatanase.bsky.social & @dimichelelab1.bsky.social.
www.biorxiv.org/content/10.1...
Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD
TDP-43 APEX proximity labeling to identify interactors for cytoplasmic (ΔNLS) and RNA-binding deficient (5FL) TDP variants!
By Longxin Xie and @donnellylab.bsky.social.
www.biorxiv.org/content/10.1...
TDP-43 APEX proximity labeling to identify interactors for cytoplasmic (ΔNLS) and RNA-binding deficient (5FL) TDP variants!
By Longxin Xie and @donnellylab.bsky.social.
www.biorxiv.org/content/10.1...
April 12, 2025 at 1:25 PM
Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD
TDP-43 APEX proximity labeling to identify interactors for cytoplasmic (ΔNLS) and RNA-binding deficient (5FL) TDP variants!
By Longxin Xie and @donnellylab.bsky.social.
www.biorxiv.org/content/10.1...
TDP-43 APEX proximity labeling to identify interactors for cytoplasmic (ΔNLS) and RNA-binding deficient (5FL) TDP variants!
By Longxin Xie and @donnellylab.bsky.social.
www.biorxiv.org/content/10.1...
Grey heron sunbathing in a willow in the Great Garden of Dresden this week:)
March 21, 2025 at 1:40 PM
Grey heron sunbathing in a willow in the Great Garden of Dresden this week:)
Granular component sub-phases direct ribosome biogenesis in the nucleolus
Amazing super-resolution microscopy & in vitro reconstitutions by Priyanka Dogra, Kriwacki lab et al.!
www.biorxiv.org/content/10.1...
Amazing super-resolution microscopy & in vitro reconstitutions by Priyanka Dogra, Kriwacki lab et al.!
www.biorxiv.org/content/10.1...
March 5, 2025 at 10:21 AM
Granular component sub-phases direct ribosome biogenesis in the nucleolus
Amazing super-resolution microscopy & in vitro reconstitutions by Priyanka Dogra, Kriwacki lab et al.!
www.biorxiv.org/content/10.1...
Amazing super-resolution microscopy & in vitro reconstitutions by Priyanka Dogra, Kriwacki lab et al.!
www.biorxiv.org/content/10.1...
Condensates exhibit stronger interfacial electric fields than amyloid fibrils.
Condensates generate more reactive oxygen species (ROS), like hydroxyl radicals, than fibrils.
Amazing work by Michael Chen, ..., Richard Zare & Yifan Dai.
pubs.acs.org/doi/full/10....
Condensates generate more reactive oxygen species (ROS), like hydroxyl radicals, than fibrils.
Amazing work by Michael Chen, ..., Richard Zare & Yifan Dai.
pubs.acs.org/doi/full/10....
March 3, 2025 at 8:52 AM
Condensates exhibit stronger interfacial electric fields than amyloid fibrils.
Condensates generate more reactive oxygen species (ROS), like hydroxyl radicals, than fibrils.
Amazing work by Michael Chen, ..., Richard Zare & Yifan Dai.
pubs.acs.org/doi/full/10....
Condensates generate more reactive oxygen species (ROS), like hydroxyl radicals, than fibrils.
Amazing work by Michael Chen, ..., Richard Zare & Yifan Dai.
pubs.acs.org/doi/full/10....
Also supplementary Fig. 4A looks somewhat unexpected - as is part of the experimental validation of the model whereby 0/10 generated sequences localized to their designated target (nuclear speckles).
February 9, 2025 at 8:34 AM
Also supplementary Fig. 4A looks somewhat unexpected - as is part of the experimental validation of the model whereby 0/10 generated sequences localized to their designated target (nuclear speckles).
Just depends how deep, or shallow, the energy landscape for a given IDP and its conformational ensemble is - but should be possible in principle to retain some information (i.e. a specific folding state of an IDP) in an IDP.
December 3, 2024 at 11:39 AM
Just depends how deep, or shallow, the energy landscape for a given IDP and its conformational ensemble is - but should be possible in principle to retain some information (i.e. a specific folding state of an IDP) in an IDP.
While this amazing preprint beautifully demonstrates softening & fluidification of the cell's cytoplasm during mitosis - it attributes the effect to cytoskeletal elements, while not discussing global phosphorylation as contributor:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 2, 2024 at 8:09 PM
While this amazing preprint beautifully demonstrates softening & fluidification of the cell's cytoplasm during mitosis - it attributes the effect to cytoskeletal elements, while not discussing global phosphorylation as contributor:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
There is this beautiful example of a fairly well defined number of clusters with equidistant spacing - found within the condensed phase of the nucleolus:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 2, 2024 at 9:09 AM
There is this beautiful example of a fairly well defined number of clusters with equidistant spacing - found within the condensed phase of the nucleolus:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Especially when combined your set of questions seems quite illuminating - the relationship between spatial arrangement of biomolecules & information processing and retention probably still holds many surprises for generations of cell biologists & biochemists!:)
December 2, 2024 at 7:41 AM
Especially when combined your set of questions seems quite illuminating - the relationship between spatial arrangement of biomolecules & information processing and retention probably still holds many surprises for generations of cell biologists & biochemists!:)