David Kuster
@rnadavid.bsky.social
RNA & Metabolism. Ancient companions for Life. RNA as spatial organizer of the Cell. IDPs, biomolecular condensates and RNA fun @HymanLab. And birds.
ebird.org/profile/MjcyMDU0Nw
inaturalist.org/people/9261834
ebird.org/profile/MjcyMDU0Nw
inaturalist.org/people/9261834
Reposted by David Kuster
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs - new from @drummondlab.bsky.social www.cell.com/molecular-ce...
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs
Glauninger, Bard, Wong Hickernell, et al. reveal that stress causes transcriptome-wide
mRNP condensation, largely independent of length and often without stress granule
formation, but newly synthesize...
www.cell.com
November 25, 2025 at 3:32 PM
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs - new from @drummondlab.bsky.social www.cell.com/molecular-ce...
Reposted by David Kuster
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Kuster
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
November 23, 2025 at 11:18 PM
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
Reposted by David Kuster
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 21, 2025 at 5:37 PM
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
Reposted by David Kuster
Universität Heidelberg mit drei Förderanträgen für Sonderforschungsbereiche erfolgreich – Für die Verlängerung von zwei transregionalen ... www.uni-heidelberg.de/de/newsroom/...
#universität #heidelberg #uniheidelberg #sfb #forschung #förderung #dfg #lebenswissenschaften #medizin #mathematik
#universität #heidelberg #uniheidelberg #sfb #forschung #förderung #dfg #lebenswissenschaften #medizin #mathematik
November 21, 2025 at 10:56 AM
Universität Heidelberg mit drei Förderanträgen für Sonderforschungsbereiche erfolgreich – Für die Verlängerung von zwei transregionalen ... www.uni-heidelberg.de/de/newsroom/...
#universität #heidelberg #uniheidelberg #sfb #forschung #förderung #dfg #lebenswissenschaften #medizin #mathematik
#universität #heidelberg #uniheidelberg #sfb #forschung #förderung #dfg #lebenswissenschaften #medizin #mathematik
Reposted by David Kuster
Complex life of RNA is now open for registration (though deadline is Sept 1 so take your time...)
this is a very good meeting.
www.embl.org/about/info/c...
this is a very good meeting.
www.embl.org/about/info/c...
The complex life of RNA
www.embl.org
November 20, 2025 at 1:07 PM
Complex life of RNA is now open for registration (though deadline is Sept 1 so take your time...)
this is a very good meeting.
www.embl.org/about/info/c...
this is a very good meeting.
www.embl.org/about/info/c...
Reposted by David Kuster
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.
www.science.org
November 20, 2025 at 7:46 AM
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Reposted by David Kuster
Published in Science Advances! Looking forward to discussing the implications of our results and their applications with many researchers.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 20, 2025 at 2:24 AM
Published in Science Advances! Looking forward to discussing the implications of our results and their applications with many researchers.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by David Kuster
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
Reposted by David Kuster
Happy #WorldAnteaterDay! This Giant Anteater (Myrmecophaga tridactyla) #SciArt is by Édouard Traviès for Charles Dessalines d'Orbigny, Dictionnaire d'Histoire Naturelle (1849). Contributed to BHL by @ncsulibraries.bsky.social: www.biodiversitylibrary.org/page/19538021 🧪 📖 🌎 🐜 #ILoveBHL
November 19, 2025 at 4:27 PM
Happy #WorldAnteaterDay! This Giant Anteater (Myrmecophaga tridactyla) #SciArt is by Édouard Traviès for Charles Dessalines d'Orbigny, Dictionnaire d'Histoire Naturelle (1849). Contributed to BHL by @ncsulibraries.bsky.social: www.biodiversitylibrary.org/page/19538021 🧪 📖 🌎 🐜 #ILoveBHL
Reposted by David Kuster
🙌 Hello from #EESNucleus.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
November 19, 2025 at 1:46 PM
🙌 Hello from #EESNucleus.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
The organisers Simone Köhler, Patrick Lusk,
Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.
Reposted by David Kuster
Last Friday, we had an inspiring 10th Rhineland RNA Club meeting with top class speakers. It's great to see how the community is growing and the range of topics we're covering. Special thanks to Didier Stainier @stainierlab.bsky.social Simon Bekker-Jensen @bekkerjensenlab.bsky.social, Ranen Aviner!
November 19, 2025 at 10:17 AM
Last Friday, we had an inspiring 10th Rhineland RNA Club meeting with top class speakers. It's great to see how the community is growing and the range of topics we're covering. Special thanks to Didier Stainier @stainierlab.bsky.social Simon Bekker-Jensen @bekkerjensenlab.bsky.social, Ranen Aviner!
Reposted by David Kuster
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2025 at 10:43 PM
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by David Kuster
A few py2Dmol updates 🧬
py2dmol.solab.org
Integration with AlphaFoldDB (will auto fetch results). Drag and drop results from AF3-server or ColabFold for interactive experience! (1/4)
py2dmol.solab.org
Integration with AlphaFoldDB (will auto fetch results). Drag and drop results from AF3-server or ColabFold for interactive experience! (1/4)
November 19, 2025 at 8:15 AM
A few py2Dmol updates 🧬
py2dmol.solab.org
Integration with AlphaFoldDB (will auto fetch results). Drag and drop results from AF3-server or ColabFold for interactive experience! (1/4)
py2dmol.solab.org
Integration with AlphaFoldDB (will auto fetch results). Drag and drop results from AF3-server or ColabFold for interactive experience! (1/4)
Reposted by David Kuster
World-renowned cell biologist Ron Vale will join Whitehead Institute this December as a Member. Known for discovering the motor protein kinesin, he will explore how proteins function under different stressors—a direction that aligns with the Institute's focus on resilience.
🔗 shorturl.at/28Gpl
🔗 shorturl.at/28Gpl
November 18, 2025 at 3:25 PM
World-renowned cell biologist Ron Vale will join Whitehead Institute this December as a Member. Known for discovering the motor protein kinesin, he will explore how proteins function under different stressors—a direction that aligns with the Institute's focus on resilience.
🔗 shorturl.at/28Gpl
🔗 shorturl.at/28Gpl
Reposted by David Kuster
Very excited to present OpenCGChromatin🔥🔥🔥
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
November 18, 2025 at 3:07 PM
Very excited to present OpenCGChromatin🔥🔥🔥
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
Reposted by David Kuster
Our enhanced knowledge base for condensates is online @narjournal.bsky.social! Congratulations to the first authors @kkuznetsova.bsky.social and @mscheremetjew.bsky.social and all co-authors & curators! What a wonderful team effort to advance condensate research! 🤩 @mpi-cbg.de @hymanlab.bsky.social
CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
November 17, 2025 at 9:31 PM
Our enhanced knowledge base for condensates is online @narjournal.bsky.social! Congratulations to the first authors @kkuznetsova.bsky.social and @mscheremetjew.bsky.social and all co-authors & curators! What a wonderful team effort to advance condensate research! 🤩 @mpi-cbg.de @hymanlab.bsky.social
Congratulations DOCTOR @michaelcchung.bsky.social!! May the crabs be with you & see you soon!:) 🐸🔮🦀🐙
November 18, 2025 at 5:58 AM
Congratulations DOCTOR @michaelcchung.bsky.social!! May the crabs be with you & see you soon!:) 🐸🔮🦀🐙
Reposted by David Kuster
Bald ist es soweit - das #Hannah_Arendt_Forum findet wieder am 4. Dezember 2025 statt!🎉
Anlässlich des 50. Todestages unserer Namensgeberin richtet sich das diesjährige Forum ganz auf das Leben und Wirken Hannah Arendts aus: "„Es kommt darauf an, ganz gegenwärtig zu sein"
Anlässlich des 50. Todestages unserer Namensgeberin richtet sich das diesjährige Forum ganz auf das Leben und Wirken Hannah Arendts aus: "„Es kommt darauf an, ganz gegenwärtig zu sein"
November 17, 2025 at 1:01 PM
Bald ist es soweit - das #Hannah_Arendt_Forum findet wieder am 4. Dezember 2025 statt!🎉
Anlässlich des 50. Todestages unserer Namensgeberin richtet sich das diesjährige Forum ganz auf das Leben und Wirken Hannah Arendts aus: "„Es kommt darauf an, ganz gegenwärtig zu sein"
Anlässlich des 50. Todestages unserer Namensgeberin richtet sich das diesjährige Forum ganz auf das Leben und Wirken Hannah Arendts aus: "„Es kommt darauf an, ganz gegenwärtig zu sein"
Reposted by David Kuster
As my conference year draws to a close: still one last highlight coming up #EESNucleus on home turf @events.embl.org!
November 17, 2025 at 9:55 AM
As my conference year draws to a close: still one last highlight coming up #EESNucleus on home turf @events.embl.org!
Reposted by David Kuster
Active droplets are fundamental in cell biology and origin of life. With Jonathan Bauermann, @boekhovenlab.bsky.social, Frank Jülicher, and @m-pol.bsky.social, we show that a critical transition influences their size, morphology, ripening and division propensity
journals.aps.org/prx/abstract...
journals.aps.org/prx/abstract...
November 15, 2025 at 11:28 AM
Active droplets are fundamental in cell biology and origin of life. With Jonathan Bauermann, @boekhovenlab.bsky.social, Frank Jülicher, and @m-pol.bsky.social, we show that a critical transition influences their size, morphology, ripening and division propensity
journals.aps.org/prx/abstract...
journals.aps.org/prx/abstract...
Reposted by David Kuster
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
November 15, 2025 at 9:51 AM
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
Reposted by David Kuster
Now in print: @lortzrodz.bsky.social with @schraderlab.bsky.social found that the stress-induced transition of the material properties of bacterial ribonucleoprotein bodies repurposes them from sites of mRNA decay to reservoirs for mRNA storage.
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Stress changes the material state of a bacterial biomolecular condensate and shifts its function from mRNA decay to storage - Nature Communications
Bacterial ribonucleoprotein bodies are dynamic biomolecular condensates that play roles in RNA metabolism. Here, Ortiz-Rodríguez et al. show that, under stress, these condensates shift from a liquid s...
www.nature.com
November 14, 2025 at 4:32 PM
Now in print: @lortzrodz.bsky.social with @schraderlab.bsky.social found that the stress-induced transition of the material properties of bacterial ribonucleoprotein bodies repurposes them from sites of mRNA decay to reservoirs for mRNA storage.
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Reposted by David Kuster
CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
November 14, 2025 at 1:20 PM
CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...