PyrexCorex
@pyrexcorex.bsky.social
Following advances in cellular, molecular & structural biology in a mercifully bot-free space.
Reposted by PyrexCorex
The FDA is claiming without sharing their evidence or analysis that 10 deaths of children are linked to COVID-19 vaccinations.
1/2
1/2
Big change: FDA to impose strict new vaccine requirements under RFK Jr ally
Vinay Prasad signaled changes to annual flu shots, concurrent vaccines + more
Prasad said his team found link between covid-19 shots and kids' deaths, necessitating a new approach overall
with @rachelroubein.bsky.social
Vinay Prasad signaled changes to annual flu shots, concurrent vaccines + more
Prasad said his team found link between covid-19 shots and kids' deaths, necessitating a new approach overall
with @rachelroubein.bsky.social
FDA to impose strict new vaccine requirements, claiming child covid shot deaths
Vinay Prasad, the nation’s top vaccine regulator, said his team concluded that coronavirus shots were linked to children’s deaths, necessitating a new approach.
www.washingtonpost.com
November 29, 2025 at 7:33 PM
The FDA is claiming without sharing their evidence or analysis that 10 deaths of children are linked to COVID-19 vaccinations.
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1/2
Reposted by PyrexCorex
Wow
A 60-year old man in Germany became the seventh person with HIV to be announced free of the virus after receiving a stem-cell transplant
go.nature.com/48C68Ib
go.nature.com/48C68Ib
Seventh patient ‘cured’ of HIV: why scientists are excited
A man in Germany is HIV-free after receiving stem cells that are not resistant to the virus.
go.nature.com
November 26, 2025 at 6:47 PM
Wow
Reposted by PyrexCorex
Beautiful, layered argument for the use of model organisms, especially small ones, in research. A must read!
October 10, 2025 at 10:15 PM
Beautiful, layered argument for the use of model organisms, especially small ones, in research. A must read!
Reposted by PyrexCorex
Wrapping up a great weekend of “Stem Cell Stories” at the Deutsches Museum.
Science doesn’t exist in isolation. We are committed to engaging with society, exchanging ideas, and building trust through transparency. Let’s keep the conversation going.
#ScienceOutreach #Epigenetics #AIinBiomedicine
Science doesn’t exist in isolation. We are committed to engaging with society, exchanging ideas, and building trust through transparency. Let’s keep the conversation going.
#ScienceOutreach #Epigenetics #AIinBiomedicine
November 17, 2025 at 12:50 PM
Wrapping up a great weekend of “Stem Cell Stories” at the Deutsches Museum.
Science doesn’t exist in isolation. We are committed to engaging with society, exchanging ideas, and building trust through transparency. Let’s keep the conversation going.
#ScienceOutreach #Epigenetics #AIinBiomedicine
Science doesn’t exist in isolation. We are committed to engaging with society, exchanging ideas, and building trust through transparency. Let’s keep the conversation going.
#ScienceOutreach #Epigenetics #AIinBiomedicine
Reposted by PyrexCorex
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis - Nature Ecology & Evolution
In Caenorhabditis tropicalis, three toxin–antidote elements arose via gene duplication from the essential tRNA-synthetase subunit FARS-3. The ancestral antidote probably acquired affinity for FARS-3, ...
www.nature.com
November 24, 2025 at 9:10 PM
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Reposted by PyrexCorex
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
November 24, 2025 at 1:03 PM
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
Reposted by PyrexCorex
My quote of the day
As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them.
John F. Kennedy
As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them.
John F. Kennedy
November 25, 2025 at 11:14 AM
My quote of the day
As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them.
John F. Kennedy
As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them.
John F. Kennedy
Reposted by PyrexCorex
The hardest part about writing a review article, is composing emails to your colleagues that don't immediately get flagged as spam
November 24, 2025 at 10:32 PM
The hardest part about writing a review article, is composing emails to your colleagues that don't immediately get flagged as spam
Reposted by PyrexCorex
popEVE is out in Nature Genetics! 🎉
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Proteome-wide model for human disease genetics
Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.
rdcu.be
November 25, 2025 at 11:20 AM
Reposted by PyrexCorex
Do you have an exciting new chromatin/transcription story that you'd like to share with the #FN community?
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Application to speak in the Fragile Nucleosome series
Thank you for your interest in our seminar series!
We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...
forms.gle
November 24, 2025 at 1:50 PM
Do you have an exciting new chromatin/transcription story that you'd like to share with the #FN community?
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Reposted by PyrexCorex
Here is a video that explains the chemistry behind our recent paper in Nature Nanotechnology
video
www.youtube.com/watch?v=WnZN...
publication
www.nature.com/articles/s41...
news & views (Ouldridge & Mukherjee - thanks !)
www.nature.com/articles/s41...
video
www.youtube.com/watch?v=WnZN...
publication
www.nature.com/articles/s41...
news & views (Ouldridge & Mukherjee - thanks !)
www.nature.com/articles/s41...
An information ratchet improves selectivity in molecular recognition… | Nature Nanotechnology
YouTube video by SanGiacomoSpazioArte
www.youtube.com
November 7, 2025 at 2:19 PM
Here is a video that explains the chemistry behind our recent paper in Nature Nanotechnology
video
www.youtube.com/watch?v=WnZN...
publication
www.nature.com/articles/s41...
news & views (Ouldridge & Mukherjee - thanks !)
www.nature.com/articles/s41...
video
www.youtube.com/watch?v=WnZN...
publication
www.nature.com/articles/s41...
news & views (Ouldridge & Mukherjee - thanks !)
www.nature.com/articles/s41...
Reposted by PyrexCorex
Great work from the lab of @jojdavies.bsky.social
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 17, 2025 at 6:55 AM
Great work from the lab of @jojdavies.bsky.social
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Reposted by PyrexCorex
A new approach to pandemic preparedness:
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
NIH Directors: The World Needs a New Pandemic Playbook
The old one failed to cope with Covid and may even have caused it.
www.city-journal.org
November 14, 2025 at 3:21 PM
A new approach to pandemic preparedness:
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
Reposted by PyrexCorex
I hope someone is making plans to rebuild all our national science institutions when this nightmare is finally over
November 16, 2025 at 2:40 PM
I hope someone is making plans to rebuild all our national science institutions when this nightmare is finally over
Reposted by PyrexCorex
Holy shit.
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 15, 2025 at 1:41 PM
Holy shit.
DNA ‘top strand’ degrading.
James Watson, co-discoverer of the double-helix shape of DNA, has died at age 97
Scientist James Watson, who shared a Nobel prize for helping discover the double-helix shape of the DNA molecule, has died. He was 97.
apnews.com
November 7, 2025 at 9:12 PM
DNA ‘top strand’ degrading.
Reposted by PyrexCorex
Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the USA is losing
go.nature.com/3WB8bFS
go.nature.com/3WB8bFS
Dismantling of US federal agencies will ‘destroy science’
From NASA to the National Institutes of Health, federal agencies conduct research that universities cannot. Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the country is losing.
go.nature.com
November 3, 2025 at 12:24 PM
Agency scientists speak out about the irreplaceable facilities, institutional knowledge and training opportunities that the USA is losing
go.nature.com/3WB8bFS
go.nature.com/3WB8bFS
Reposted by PyrexCorex
When people learn with ChatGPT instead of following their own searches, they end up knowing less, caring less, and producing worse advice, even when the facts are the same.
Friction is an essential ingredient for learning! Convenience makes us shallow.
academic.oup.com/pnasnexus/ar...
Friction is an essential ingredient for learning! Convenience makes us shallow.
academic.oup.com/pnasnexus/ar...
Experimental evidence of the effects of large language models versus web search on depth of learning
Abstract. The effects of using large language models (LLMs) versus traditional web search on depth of learning are explored. A theory is proposed that when
academic.oup.com
October 28, 2025 at 3:14 PM
When people learn with ChatGPT instead of following their own searches, they end up knowing less, caring less, and producing worse advice, even when the facts are the same.
Friction is an essential ingredient for learning! Convenience makes us shallow.
academic.oup.com/pnasnexus/ar...
Friction is an essential ingredient for learning! Convenience makes us shallow.
academic.oup.com/pnasnexus/ar...
Reposted by PyrexCorex
A reminder that @science.org is a learned society journal, owned & published by the non-profit @aaas.org. It's green open access, with no article processing fees for authors - compatible with all major funder mandates. All subscription revenue is reinvested in science, not paid to shareholders.
🔭⚛️🧪
🔭⚛️🧪
October 17, 2025 at 11:27 AM
A reminder that @science.org is a learned society journal, owned & published by the non-profit @aaas.org. It's green open access, with no article processing fees for authors - compatible with all major funder mandates. All subscription revenue is reinvested in science, not paid to shareholders.
🔭⚛️🧪
🔭⚛️🧪
Reposted by PyrexCorex
The #MBioSys25 keynote lectures by Prof Caroline Dean (@johninnescentre.bsky.social) and Prof @elowitzlab.bsky.social (Caltech) are now online!
Watch (or revisit!) these two inspiring talks on gene regulation & functional genomics, available for free on our channel
www.youtube.com/@MolecularBi...
Watch (or revisit!) these two inspiring talks on gene regulation & functional genomics, available for free on our channel
www.youtube.com/@MolecularBi...
Molecular Biosystems Conference
Youtube Home Page for the Molecular Biosystems Conference (molbiosystems.com), the premier Latin American meeting on gene regulation.
www.youtube.com
October 27, 2025 at 6:35 PM
The #MBioSys25 keynote lectures by Prof Caroline Dean (@johninnescentre.bsky.social) and Prof @elowitzlab.bsky.social (Caltech) are now online!
Watch (or revisit!) these two inspiring talks on gene regulation & functional genomics, available for free on our channel
www.youtube.com/@MolecularBi...
Watch (or revisit!) these two inspiring talks on gene regulation & functional genomics, available for free on our channel
www.youtube.com/@MolecularBi...
Reposted by PyrexCorex
Holy shit, the NOAA hurricane hunters flying over Jamaica in Kermit are working without pay
God, I love scientists
#noaa #hurricane #melissa
God, I love scientists
#noaa #hurricane #melissa
October 27, 2025 at 12:09 PM
Holy shit, the NOAA hurricane hunters flying over Jamaica in Kermit are working without pay
God, I love scientists
#noaa #hurricane #melissa
God, I love scientists
#noaa #hurricane #melissa
Reposted by PyrexCorex
The body of evidence for persistent activation of the immune system in #LongCovid and related post-infective syndromes
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Immunological associations in post-infective fatigue syndromes including Long COVID—a systematic review and meta-analysis
These findings provide cautious support for persistent immune activation in PIFS,
but warrant further replication. Future studies should include better documentation
of acute infection and PIFS case c...
www.thelancet.com
October 28, 2025 at 7:46 AM
The body of evidence for persistent activation of the immune system in #LongCovid and related post-infective syndromes
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Reposted by PyrexCorex
Ascidians (Ciona intestinalis)🪸Our distant chordate cousins! 🌊 Simple sea squirts that reveal how vertebrate body plans evolved 🧬 A key model for notochord formation, neural induction, and cell lineage mapping 📸 Video by MBL Embryology 2019 #ModelMonday #DevBio #EvoDevo
October 28, 2025 at 12:46 AM
Ascidians (Ciona intestinalis)🪸Our distant chordate cousins! 🌊 Simple sea squirts that reveal how vertebrate body plans evolved 🧬 A key model for notochord formation, neural induction, and cell lineage mapping 📸 Video by MBL Embryology 2019 #ModelMonday #DevBio #EvoDevo