Tom Ellis
@proftomellis.bsky.social
Synthetic Biology & Synthetic Genomics @ Imperial College London and the Sanger Institute. Bilingual in English and DNA. Views are either my own or my microbes'
Pinned
Tom Ellis
@proftomellis.bsky.social
· Oct 23
A new review paper from our lab courtesy of @jazzsynbio.bsky.social is published in Trends in Biotechnology
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
Today marks my first day at VISTEC in Rayong 🇹🇭 - warm hosts for my sabbatical in Thailand 🙏🏻 My family and I will be spending time here and Bangkok over the next 8 months making connections and collaborations in synthetic biology and living materials work.
November 18, 2025 at 8:43 AM
Today marks my first day at VISTEC in Rayong 🇹🇭 - warm hosts for my sabbatical in Thailand 🙏🏻 My family and I will be spending time here and Bangkok over the next 8 months making connections and collaborations in synthetic biology and living materials work.
Reposted by Tom Ellis
🎄 Join us 6pm Thurs. Dec. 4 at Imperial!
🧬 How to build a protein
Noah Sprent (Change Bio)
🦠 Engineering altruism: How metabolic exchanges shape synthetic microbial communities in bio-manufacturing
Diego Ruiz (Ledesma-Amaro Lab / Imperial)
t.co/4tHIVGUJzc
🧬 How to build a protein
Noah Sprent (Change Bio)
🦠 Engineering altruism: How metabolic exchanges shape synthetic microbial communities in bio-manufacturing
Diego Ruiz (Ledesma-Amaro Lab / Imperial)
t.co/4tHIVGUJzc
https://events.humanitix.com/london-synbio-network-12
t.co
November 17, 2025 at 12:10 PM
🎄 Join us 6pm Thurs. Dec. 4 at Imperial!
🧬 How to build a protein
Noah Sprent (Change Bio)
🦠 Engineering altruism: How metabolic exchanges shape synthetic microbial communities in bio-manufacturing
Diego Ruiz (Ledesma-Amaro Lab / Imperial)
t.co/4tHIVGUJzc
🧬 How to build a protein
Noah Sprent (Change Bio)
🦠 Engineering altruism: How metabolic exchanges shape synthetic microbial communities in bio-manufacturing
Diego Ruiz (Ledesma-Amaro Lab / Imperial)
t.co/4tHIVGUJzc
Join us and these amazing speakers next March'26 at Synthetic Biology for Health and Sustainability - an international conference held at the Wellcome Genome campus near Cambridge UK.
Abstracts deadline: December 1st, 2025
Register here - x.com/gallowaylabm...
Abstracts deadline: December 1st, 2025
Register here - x.com/gallowaylabm...
November 17, 2025 at 12:14 PM
Join us and these amazing speakers next March'26 at Synthetic Biology for Health and Sustainability - an international conference held at the Wellcome Genome campus near Cambridge UK.
Abstracts deadline: December 1st, 2025
Register here - x.com/gallowaylabm...
Abstracts deadline: December 1st, 2025
Register here - x.com/gallowaylabm...
Reposted by Tom Ellis
An artificial flower design toolkit
November 17, 2025 at 11:32 AM
An artificial flower design toolkit
Reposted by Tom Ellis
#Lichens form their complex thalli through a partnership involving at least a fungus and an alga. But can these living structures be rebuilt in vitro? For more than a century, people have tried. With @spribille.bsky.social we revisited 150 years of #lichen #resynthesis to ask: has anyone succeeded?
November 7, 2025 at 2:07 AM
#Lichens form their complex thalli through a partnership involving at least a fungus and an alga. But can these living structures be rebuilt in vitro? For more than a century, people have tried. With @spribille.bsky.social we revisited 150 years of #lichen #resynthesis to ask: has anyone succeeded?
Reposted by Tom Ellis
@sacrozhangt.bsky.social and I wrote a commentary on Jordi van Gestel and Carol Gross's latest paper, check it out!
www.pnas.org/doi/10.1073/...
Sadly, the Editors at PNAS rejected our initial introduction, which was a David Attenborough style voice over of the microbial Serengeti (included below)
www.pnas.org/doi/10.1073/...
Sadly, the Editors at PNAS rejected our initial introduction, which was a David Attenborough style voice over of the microbial Serengeti (included below)
November 13, 2025 at 2:54 PM
@sacrozhangt.bsky.social and I wrote a commentary on Jordi van Gestel and Carol Gross's latest paper, check it out!
www.pnas.org/doi/10.1073/...
Sadly, the Editors at PNAS rejected our initial introduction, which was a David Attenborough style voice over of the microbial Serengeti (included below)
www.pnas.org/doi/10.1073/...
Sadly, the Editors at PNAS rejected our initial introduction, which was a David Attenborough style voice over of the microbial Serengeti (included below)
Was interesting to hear today about the annual “SynBio Challenges” competition that has got going in China as a cheaper/free alternative to iGEM - m.synbiochallenges.com/application/...
November 11, 2025 at 3:43 PM
Was interesting to hear today about the annual “SynBio Challenges” competition that has got going in China as a cheaper/free alternative to iGEM - m.synbiochallenges.com/application/...
Reposted by Tom Ellis
Share your synthetic based-biology insights at #SynBio26!
We welcome contributions from experts in biotech, genomics, computational, plant, or medical sciences to showcase the impact of advances in engineering biology on agriculture, personalised medicine, and diagnostics.
📎 bit.ly/3ZaYdwH
We welcome contributions from experts in biotech, genomics, computational, plant, or medical sciences to showcase the impact of advances in engineering biology on agriculture, personalised medicine, and diagnostics.
📎 bit.ly/3ZaYdwH
September 18, 2025 at 7:38 AM
Share your synthetic based-biology insights at #SynBio26!
We welcome contributions from experts in biotech, genomics, computational, plant, or medical sciences to showcase the impact of advances in engineering biology on agriculture, personalised medicine, and diagnostics.
📎 bit.ly/3ZaYdwH
We welcome contributions from experts in biotech, genomics, computational, plant, or medical sciences to showcase the impact of advances in engineering biology on agriculture, personalised medicine, and diagnostics.
📎 bit.ly/3ZaYdwH
Reposted by Tom Ellis
Meet our speakers for #SynBio26 🌟
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
October 15, 2025 at 10:00 AM
Meet our speakers for #SynBio26 🌟
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
Field experts will provide fascinating insights on how synthetic based-biology innovations are transforming human health and planetary sustainability.
Submit an abstract by 1 December 2025 - bursaries available
📎 bit.ly/43nlbBW
#ALife ⚙️🧫
Why is George Pig carrying a bacteria?
November 4, 2025 at 10:38 AM
Why is George Pig carrying a bacteria?
Reposted by Tom Ellis
A comprehensive genetic toolkit for Zymomonas mobilis; allowing rapid, high-resolution, combinatorial engineering of metabolic pathways. https://www.biorxiv.org/content/10.1101/2025.10.29.685439v1
October 31, 2025 at 2:04 AM
A comprehensive genetic toolkit for Zymomonas mobilis; allowing rapid, high-resolution, combinatorial engineering of metabolic pathways. https://www.biorxiv.org/content/10.1101/2025.10.29.685439v1
DISCARD - The aim is to combine gene segments to create a new genome, but recombination events will cause localised or system-wide death.
October 28, 2025 at 10:28 AM
DISCARD - The aim is to combine gene segments to create a new genome, but recombination events will cause localised or system-wide death.
Reposted by Tom Ellis
TRANCERs: Engineering enhancers into autonomous tissue-specific expression cassettes https://www.biorxiv.org/content/10.1101/2025.10.27.684763v1
October 27, 2025 at 9:05 PM
TRANCERs: Engineering enhancers into autonomous tissue-specific expression cassettes https://www.biorxiv.org/content/10.1101/2025.10.27.684763v1
Reposted by Tom Ellis
New Tuesday (Oct 28) in Heidelberg and online: kick off event of the Center for Synthetic Genomics: program and link to zoom: www.syn-gen.de/kick-off
Center Kick-Off Event | Center SynGen
www.syn-gen.de
October 24, 2025 at 11:19 AM
New Tuesday (Oct 28) in Heidelberg and online: kick off event of the Center for Synthetic Genomics: program and link to zoom: www.syn-gen.de/kick-off
A new review paper from our lab courtesy of @jazzsynbio.bsky.social is published in Trends in Biotechnology
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
October 23, 2025 at 10:09 AM
A new review paper from our lab courtesy of @jazzsynbio.bsky.social is published in Trends in Biotechnology
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
In this review, we look at the many opportunities for synthetic biology to be used in the research and applications of Holobionts.
Reposted by Tom Ellis
Please RP! A 4-day synbio and tissue engineering conference #MASSIV to transform biology and medicine together.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
October 18, 2025 at 5:50 PM
Please RP! A 4-day synbio and tissue engineering conference #MASSIV to transform biology and medicine together.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/
Poster due is Nov 7, but will be extended.
With @stemcellnetwork.ca and JST.
Reposted by Tom Ellis
Predicting sequence-specific amplification efficiency in multi-template PCR with deep learning
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Predicting sequence-specific amplification efficiency in multi-template PCR with deep learning - Nature Communications
Multi-template PCR enables parallel DNA amplification but suffers from sequence-specific biases. Here, the authors develop a 1D-CNN model predicting amplification efficiency directly from the DNA sequ...
doi.org
October 16, 2025 at 7:34 PM
Predicting sequence-specific amplification efficiency in multi-template PCR with deep learning
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Tom Ellis
Assembly and cell-free expression of a partial genome for the synthetic cell https://www.biorxiv.org/content/10.1101/2025.10.16.682769v1
October 16, 2025 at 9:04 PM
Assembly and cell-free expression of a partial genome for the synthetic cell https://www.biorxiv.org/content/10.1101/2025.10.16.682769v1
Reposted by Tom Ellis
Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation https://www.biorxiv.org/content/10.1101/2025.10.12.681955v1
October 14, 2025 at 3:04 AM
Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation https://www.biorxiv.org/content/10.1101/2025.10.12.681955v1
Reposted by Tom Ellis
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: boolean logic-gated protein presentation (h/t @coledeforest.bsky.social), bacterial grown living materials (h/t @proftomellis.bsky.social) & more 🧪
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: boolean logic-gated protein presentation (h/t @coledeforest.bsky.social), bacterial grown living materials (h/t @proftomellis.bsky.social) & more 🧪
Boolean logic-gated protein presentation through autonomously compiled molecular topology - Nature Chemical Biology
Programming stimulus responsiveness into living systems enables advanced biocomputation. Here, the authors autonomously compile proteins with defined topology that can be site-specifically tethered to and conditionally released from biomaterials and cells following user-specified Boolean logic.
www.nature.com
October 12, 2025 at 9:39 AM
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: boolean logic-gated protein presentation (h/t @coledeforest.bsky.social), bacterial grown living materials (h/t @proftomellis.bsky.social) & more 🧪
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social
includes research on: boolean logic-gated protein presentation (h/t @coledeforest.bsky.social), bacterial grown living materials (h/t @proftomellis.bsky.social) & more 🧪
Reposted by Tom Ellis
Reposted by Tom Ellis
Intracellularly Coupled Oscillators for Synthetic Biology https://www.biorxiv.org/content/10.1101/2025.09.23.678067v1
September 24, 2025 at 4:08 AM
Intracellularly Coupled Oscillators for Synthetic Biology https://www.biorxiv.org/content/10.1101/2025.09.23.678067v1
Yesterday was the first day of autumn and guess what appeared in the window of the Peninsula hotel in London.
September 23, 2025 at 9:09 PM
Yesterday was the first day of autumn and guess what appeared in the window of the Peninsula hotel in London.
Reposted by Tom Ellis
Reposted by Tom Ellis
