Adrian Woolfson
@adrianwoolfson.bsky.social
Opinions @WSJ.com & @Science.org. Author Life Without Genes @harpercollins.bsky.social & On The Future of Species bloomsburybooksuk.bsky.social (12 Feb 2026) & @MITpress.bsky.social (17 Mar, 2026). www.adrianwoolfson.com. Founder Genyro.com
Towards a biophysical understanding of the sequence features that establish accessible chromatin elements
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Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
In vitro-derived insights into features that drive transcription factor binding to
DNA, including motif-adjacent sequence, enable prediction of chromatin states and
transcription factor occupancy in c...
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November 29, 2025 at 4:29 PM
Towards a biophysical understanding of the sequence features that establish accessible chromatin elements
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A remarkable result. Potent anti-metastatic activity of the beta-blocker propanolol across multiple tumor models implemented by CD4+ T-cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
β-adrenergic signaling blockade attenuates metastasis through activation of cytotoxic CD4 T cells - Nature Communications
The interplay between neuronal activity and tumor progression is well-established. Here, the authors demonstrate that blockade of β-adrenergic signaling via administration of propranolol suppresses lu...
www.nature.com
November 29, 2025 at 2:21 PM
A remarkable result. Potent anti-metastatic activity of the beta-blocker propanolol across multiple tumor models implemented by CD4+ T-cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Adrian Woolfson
Terrific new paper by @jessicalwarelab.bsky.social and others on dragonfly wings, in particular the hydrocarbons which act in multiple ways - structurally, pheromonally and in terms of water resistance. Wish I were still teaching, I'd use this as a great example. of multiple adaptations.
The secrets of the extreme durability of odonata wings
Abstract. Essential properties considered in the design, fabrication, and application of contemporary bio/nanomaterials have been modeled on adaptations of
academic.oup.com
November 24, 2025 at 5:45 PM
Terrific new paper by @jessicalwarelab.bsky.social and others on dragonfly wings, in particular the hydrocarbons which act in multiple ways - structurally, pheromonally and in terms of water resistance. Wish I were still teaching, I'd use this as a great example. of multiple adaptations.
Yikes. Not a good time in history to be a radiologist. Looks like AI has outperformed humans in the radiological (CT) diagnosis of pancreatic cancer.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Artificial intelligence and radiologists in pancreatic cancer detection using standard of care CT scans (PANORAMA): an international, paired, non-inferiority, confirmatory, observational study
Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among major cancer types, primarily due to late diagnosis on contrast-enhanced CT. Art…
www.sciencedirect.com
November 24, 2025 at 12:20 PM
Yikes. Not a good time in history to be a radiologist. Looks like AI has outperformed humans in the radiological (CT) diagnosis of pancreatic cancer.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
You really absolutely have to read this paper, if you haven’t already. It’s one of the most important ones I have read for a while. Paradigm changing. Big congrats to the Brian Hie team! Super exciting. Important things ahead.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Semantic design of functional de novo genes from a genomic language model - Nature
By learning a semantics of gene function based on genomic context, the genomic language model Evo autocompletes DNA prompts to generate novel genes encoding protein and RNA molecules with defined acti...
www.nature.com
November 23, 2025 at 9:41 PM
You really absolutely have to read this paper, if you haven’t already. It’s one of the most important ones I have read for a while. Paradigm changing. Big congrats to the Brian Hie team! Super exciting. Important things ahead.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Therapeutic genome editing using PERT (prime editing-mediated readthrough of premature termination codons). Edits tRNA to rescue nonsense mutations in a disease-agnostic manner by allowing read-through of premature termination codons and with a very low off-target.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing - Nature
A new strategy that uses prime editing to convert an endogenous tRNA into a suppressor tRNA shows therapeutic potential for multiple genetic diseases that are caused by premature stop codons.
www.nature.com
November 22, 2025 at 10:00 AM
Therapeutic genome editing using PERT (prime editing-mediated readthrough of premature termination codons). Edits tRNA to rescue nonsense mutations in a disease-agnostic manner by allowing read-through of premature termination codons and with a very low off-target.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How do living things shape the materials around them? The Tom Ellis lab is set to find out.
www.imperial.ac.uk/news/article...
www.imperial.ac.uk/news/article...
€10m research grant to underpin sculptable tissues
Professor Tom Ellis has been awarded a €3.3 million share of a prestigious European Research Council (ERC) Synergy Grant.
www.imperial.ac.uk
November 21, 2025 at 4:08 PM
How do living things shape the materials around them? The Tom Ellis lab is set to find out.
www.imperial.ac.uk/news/article...
www.imperial.ac.uk/news/article...
