Prof. Shane Crotty
@profshanecrotty.bsky.social
Vaccines and immune system scientist. Professor and Chief Scientific Officer (CSO), La Jolla Institute for Immunology (LJI), a non-profit research institute.
Pinned
Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans
Seasonal influenza vaccines are most frequently delivered as intramuscular inactivated vaccines which elicit systemic responses against the immunodominant hemagglutinin (HA) head domain. An intranasal...
www.biorxiv.org
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
In our latest study in @cp-immunity.bsky.social, we followed dynamics of vaccine-specific Tfh cells for 60+ weeks after immunization.
authors.elsevier.com/a/1m3mV3qNrU...
We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
authors.elsevier.com/a/1m3mV3qNrU...
We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
November 12, 2025 at 7:45 PM
In our latest study in @cp-immunity.bsky.social, we followed dynamics of vaccine-specific Tfh cells for 60+ weeks after immunization.
authors.elsevier.com/a/1m3mV3qNrU...
We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
authors.elsevier.com/a/1m3mV3qNrU...
We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.
thanks!
Vaccine-specific Tfh undergo robust early expansion, sustained proliferation, months-long persistence w/o exhaustion, and functional specialization associated w/ enhanced germinal centers & humoral [email protected] @profshanecrotty.bsky.social
www.cell.com/immunity/ful... @lji.org
www.cell.com/immunity/ful... @lji.org
November 12, 2025 at 7:38 PM
thanks!
LJI is recruiting!
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
October 20, 2025 at 3:14 PM
LJI is recruiting!
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
Reposted by Prof. Shane Crotty
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies @sciimmunology.bsky.social @profshanecrotty.bsky.social SchiefLab @lji.org @scripps.edu
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 17, 2025 at 6:41 PM
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies @sciimmunology.bsky.social @profshanecrotty.bsky.social SchiefLab @lji.org @scripps.edu
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.
www.science.org
October 20, 2025 at 2:42 PM
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
1/ David Baltimore passed away this weekend. He was one of the greatest biologists of the past 100 years. He made extraordinary contributions to immunology, cancer, molecular biology, virology, HIV, biochemistry, genetics, and genetic engineering. He won the Nobel prize in Medicine at age 37.
September 8, 2025 at 2:26 PM
1/ David Baltimore passed away this weekend. He was one of the greatest biologists of the past 100 years. He made extraordinary contributions to immunology, cancer, molecular biology, virology, HIV, biochemistry, genetics, and genetic engineering. He won the Nobel prize in Medicine at age 37.
Reposted by Prof. Shane Crotty
Rest in peace, David Baltimore. explorers.com/david-baltim... @nationalacademies.org
@nobelprize.bsky.social
@nobelprize.bsky.social
New Heroes: David Baltimore
Dr. David Baltimore is a Nobel Prize-winning biologist whose work has profoundly shaped modern molecular biology and immunology. His discoveries have altered our understanding of viruses and immune…
explorers.com
September 7, 2025 at 11:03 PM
Rest in peace, David Baltimore. explorers.com/david-baltim... @nationalacademies.org
@nobelprize.bsky.social
@nobelprize.bsky.social
Reposted by Prof. Shane Crotty
A germline-targeting trimer consistently induced rare bnAb-like precursors specific for the HIV Env Apex in rhesus macaques @sciimmunology.bsky.social @profshanecrotty.bsky.social War ad & Schief
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 22, 2025 at 6:27 PM
A germline-targeting trimer consistently induced rare bnAb-like precursors specific for the HIV Env Apex in rhesus macaques @sciimmunology.bsky.social @profshanecrotty.bsky.social War ad & Schief
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A good news article in Nature today following up on these papers
www.nature.com/articles/d41...
www.nature.com/articles/d41...
August 1, 2025 at 7:06 PM
A good news article in Nature today following up on these papers
www.nature.com/articles/d41...
www.nature.com/articles/d41...
After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models
An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.
www.science.org
July 30, 2025 at 7:15 PM
After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Prof. Shane Crotty
Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 19, 2025 at 9:00 PM
Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans
Seasonal influenza vaccines are most frequently delivered as intramuscular inactivated vaccines which elicit systemic responses against the immunodominant hemagglutinin (HA) head domain. An intranasal...
www.biorxiv.org
July 21, 2025 at 2:48 PM
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Our wonderful LJI colleague Alex Sette was knighted this week! In recognition of his extraordinary contributions to immunology.
As one measure of Alex's impact on immunology, he has over 140,000 scientific citations, and has 964 papers that have been cited at least 10 times.
As one measure of Alex's impact on immunology, he has over 140,000 scientific citations, and has 964 papers that have been cited at least 10 times.
News: LJI Professor Alessandro Sette (@settelab.bsky.social) receives Order of Merit from the Italian Republic
Dr. Sette knighted for outstanding research and leadership in the field of immunology bit.ly/4d17zRd
#medicine #health #ImmuneSystem #science #SanDiego
Dr. Sette knighted for outstanding research and leadership in the field of immunology bit.ly/4d17zRd
#medicine #health #ImmuneSystem #science #SanDiego
LJI Professor Alessandro Sette receives Order of Merit from the Italian Republic
Sette knighted for outstanding research and leadership in the field of immunology
bit.ly
May 2, 2025 at 4:00 PM
Our wonderful LJI colleague Alex Sette was knighted this week! In recognition of his extraordinary contributions to immunology.
As one measure of Alex's impact on immunology, he has over 140,000 scientific citations, and has 964 papers that have been cited at least 10 times.
As one measure of Alex's impact on immunology, he has over 140,000 scientific citations, and has 964 papers that have been cited at least 10 times.
Reposted by Prof. Shane Crotty
News: LJI Professor Alessandro Sette (@settelab.bsky.social) receives Order of Merit from the Italian Republic
Dr. Sette knighted for outstanding research and leadership in the field of immunology bit.ly/4d17zRd
#medicine #health #ImmuneSystem #science #SanDiego
Dr. Sette knighted for outstanding research and leadership in the field of immunology bit.ly/4d17zRd
#medicine #health #ImmuneSystem #science #SanDiego
LJI Professor Alessandro Sette receives Order of Merit from the Italian Republic
Sette knighted for outstanding research and leadership in the field of immunology
bit.ly
May 1, 2025 at 3:07 PM
News: LJI Professor Alessandro Sette (@settelab.bsky.social) receives Order of Merit from the Italian Republic
Dr. Sette knighted for outstanding research and leadership in the field of immunology bit.ly/4d17zRd
#medicine #health #ImmuneSystem #science #SanDiego
Dr. Sette knighted for outstanding research and leadership in the field of immunology bit.ly/4d17zRd
#medicine #health #ImmuneSystem #science #SanDiego
One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper…
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Diverse priming outcomes under conditions of very rare precursor B cells
B cells that give rise to neutralizing antibody responses can be extremely rare in
the naive B cell repertoire. Madden et al. show that delivery strategy and adjuvant
selection affect the recruitment ...
www.cell.com
April 7, 2025 at 1:50 PM
One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper…
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social
www.cell.com/immunity/ful...