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Unfortunately due to grant funding, full scholarships aren't available for her intake. She's been an absolute star and was so determined to get into this, but is now left without a scholarship. Every contribution helps her get closer to a programme that changed my life 🌎

www.gofundme.com/f/support-be...

Unfortunately due to grant funding, full scholarships aren't available for her intake. She's been an absolute star and was so determined to get into this, but is now left without a scholarship. Every contribution helps her get closer to a programme that changed my life 🌎

🔗 TL;DR: New paper, new antibiotic combinations, new doctor 🎓 For all the juicy details, check out the full study here: doi.org/10.1093/jaca... #OpenAccess #ScienceTwitter #MedicalResearch #InfectiousDiseases #OneHealth #Microbiology @bsacandjac.bsky.social

👏 This work doesn’t happen in a vacuum: thanks to my principal supervisor Julia Dorin, and all my friends and colleagues at the LUMC, both in the Infectious Diseases department and the Leiden PulmoScience Lab

🤝 Together, this work adds to the growing evidence base for advancing SAAP-148, other HDPs, and halicin for antibacterial therapy against AMR strains, both in combination and sequential therapy #AntibioticAlternatives

💡 When assessing the combination of preventative SAAP-148 and post-infection halicin treatment in these cultures, I also found that SAAP-148 and halicin only acted synergistically in skin but not in lung tissue (still beneficial though!) #CombinationTherapy #SequentialTreatment

🔬 I expanded on this: instead using SAAP-148 as a preventative against AMR bacteria, applied in both HSEs and lung tissue cultures (PBECs). SAAP-148's activity was limited in PBECs against AMR bacteria, while active in HSEs due to the peptide being retained in cells

☝ However, our team showed that SAAP-148 was effective against AMR bacteria in the dish, and also when infecting skin cultures (HSEs). Also, combining SAAP-148 with halicin (a repurposed antibacterial) was synergistic against AMR bacteria. Read it: www.mdpi.com/2079-6382/11... #SynergisticTherapy

🔍 Few studies specifically investigate synergy between host defence peptides (HDPs), like SAAP-148, and conventional antibiotics. Even then, many don’t clarify this effects between agents, or assess them in more dimensional models. Reviewed here: www.mdpi.com/2079-6382/12...

🔗 TL;DR: New paper, new antibiotic combinations, new doctor 🎓 For all the juicy details, check out the full study here: doi.org/10.1093/jaca... #OpenAccess #ScienceTwitter #MedicalResearch #InfectiousDiseases #OneHealth #Microbiology @bsacandjac.bsky.social

👏 This work doesn’t happen in a vacuum: thanks to my principal supervisor Julia Dorin, and all my friends and colleagues at the LUMC, both in the Infectious Diseases department and the Leiden PulmoScience Lab

🤝 Together, this work adds to the growing evidence base for advancing SAAP-148, other HDPs, and halicin for antibacterial therapy against AMR strains, both in combination and sequential therapy #AntibioticAlternatives

💡 When assessing the combination of preventative SAAP-148 and post-infection halicin treatment in these cultures, I also found that SAAP-148 and halicin only acted synergistically in skin but not in lung tissue (still beneficial though!) #CombinationTherapy #SequentialTreatment