Paprapach Wongdontree
@paprapach.bsky.social
Postdoc at INSERM – IAME (France)
Studying E. coli persistence and tolerance in urinary tract infections.
Research interests: #antibiotic #resistance, #tolerance, and #persistence, and #membrane and #cellenvelope.
Previous work: S. aureus & B. subtilis
Studying E. coli persistence and tolerance in urinary tract infections.
Research interests: #antibiotic #resistance, #tolerance, and #persistence, and #membrane and #cellenvelope.
Previous work: S. aureus & B. subtilis
Reposted by Paprapach Wongdontree
MPKaDB: A pKa Database for Exploring pH Dependence in Membrane Proteins https://www.biorxiv.org/content/10.1101/2025.11.14.688495v1
November 17, 2025 at 4:21 PM
MPKaDB: A pKa Database for Exploring pH Dependence in Membrane Proteins https://www.biorxiv.org/content/10.1101/2025.11.14.688495v1
Reposted by Paprapach Wongdontree
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
November 17, 2025 at 6:17 PM
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
Reposted by Paprapach Wongdontree
BioPrediction-PPI: Simplifying the Prediction of Protein-Protein Interactions through Artificial Intelligence https://www.biorxiv.org/content/10.1101/2025.11.16.688401v1
November 17, 2025 at 6:46 PM
BioPrediction-PPI: Simplifying the Prediction of Protein-Protein Interactions through Artificial Intelligence https://www.biorxiv.org/content/10.1101/2025.11.16.688401v1
Reposted by Paprapach Wongdontree
🔊 New story!
This GlmR (of hope) article has it all. Cell shape, cytokinesis, c-di-AMP, and catalysis - the famous 4 Cs 💎?
There is also antibiotic resistance, phosphorylation, acetylation, and a (cool) model to explain what shapes Bacillus cells.
Excellent group effort. Congrats team!
#Microsky
This GlmR (of hope) article has it all. Cell shape, cytokinesis, c-di-AMP, and catalysis - the famous 4 Cs 💎?
There is also antibiotic resistance, phosphorylation, acetylation, and a (cool) model to explain what shapes Bacillus cells.
Excellent group effort. Congrats team!
#Microsky
Staying in the loop to make ends meet: roles and regulation of GlmR in Bacillus subtilis https://www.biorxiv.org/content/10.1101/2025.11.05.686802v1
November 6, 2025 at 5:06 AM
🔊 New story!
This GlmR (of hope) article has it all. Cell shape, cytokinesis, c-di-AMP, and catalysis - the famous 4 Cs 💎?
There is also antibiotic resistance, phosphorylation, acetylation, and a (cool) model to explain what shapes Bacillus cells.
Excellent group effort. Congrats team!
#Microsky
This GlmR (of hope) article has it all. Cell shape, cytokinesis, c-di-AMP, and catalysis - the famous 4 Cs 💎?
There is also antibiotic resistance, phosphorylation, acetylation, and a (cool) model to explain what shapes Bacillus cells.
Excellent group effort. Congrats team!
#Microsky
Reposted by Paprapach Wongdontree
Recruitment of the outer-membrane lipoprotein DolP to thedivision site via cardiolipin-mediated diffusion-stateswitching https://www.biorxiv.org/content/10.1101/2025.10.29.685289v1
October 30, 2025 at 2:17 AM
Recruitment of the outer-membrane lipoprotein DolP to thedivision site via cardiolipin-mediated diffusion-stateswitching https://www.biorxiv.org/content/10.1101/2025.10.29.685289v1
Reposted by Paprapach Wongdontree
Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...
Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex
Author summary Bacterial cell division is an ancient and essential process, but our molecular understanding of this process is primarily based on studies in a select few model systems. Recent work fou...
journals.plos.org
October 28, 2025 at 1:25 AM
Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...
Reposted by Paprapach Wongdontree
📢 We have an open position for a postdoc to join my lab. It's a great position @animecol-uu.bsky.social, fully salaried for 2.5 years with all benefits.
www.uu.se/en/about-uu/...
The project is about transmission patterns of bacteria and antimicrobial resistance (AMR) in aquatic insects. 🧬🦠 (1/3)
www.uu.se/en/about-uu/...
The project is about transmission patterns of bacteria and antimicrobial resistance (AMR) in aquatic insects. 🧬🦠 (1/3)
Postdoctoral researcher in molecular ecology - Uppsala University
Postdoctoral researcher in molecular ecology, Department of Ecology and Genetics, Uppsala University
www.uu.se
October 27, 2025 at 7:43 AM
📢 We have an open position for a postdoc to join my lab. It's a great position @animecol-uu.bsky.social, fully salaried for 2.5 years with all benefits.
www.uu.se/en/about-uu/...
The project is about transmission patterns of bacteria and antimicrobial resistance (AMR) in aquatic insects. 🧬🦠 (1/3)
www.uu.se/en/about-uu/...
The project is about transmission patterns of bacteria and antimicrobial resistance (AMR) in aquatic insects. 🧬🦠 (1/3)
Reposted by Paprapach Wongdontree
#MicrobiologyMonday: Staphylococcus aureus divides by building a septum and then splitting into 2 daughter cells. But how is septum formation coordinated with cell scission? Research in #mBio suggests cell wall mechanical stress could play a role: asm.social/2Eq
October 20, 2025 at 4:00 PM
#MicrobiologyMonday: Staphylococcus aureus divides by building a septum and then splitting into 2 daughter cells. But how is septum formation coordinated with cell scission? Research in #mBio suggests cell wall mechanical stress could play a role: asm.social/2Eq
Reposted by Paprapach Wongdontree
Identification of radical SAM enzymes responsible for the methylation and desaturation of archaeal lipids and an AttH hydratase mediating hydroxy-GDGT biosynthesis https://www.biorxiv.org/content/10.1101/2025.10.20.683597v1
October 22, 2025 at 2:18 AM
Identification of radical SAM enzymes responsible for the methylation and desaturation of archaeal lipids and an AttH hydratase mediating hydroxy-GDGT biosynthesis https://www.biorxiv.org/content/10.1101/2025.10.20.683597v1
Reposted by Paprapach Wongdontree
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Chromosome segregation dynamics during the cell cycle of Staphylococcus aureus - Nature Communications
Our understanding of chromosome organization and dynamics in spherical bacteria, such as Staphylococcus aureus, remains limited. Here, the authors show that chromosome replication and cell division cycles are not synchronized in S. aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle.
bit.ly
October 21, 2025 at 2:51 PM
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Reposted by Paprapach Wongdontree
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
October 22, 2025 at 11:10 AM
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
Reposted by Paprapach Wongdontree
PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging
www.findaphd.com/phds/project...
#microsky #bioimaging
Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick on FindAPhD.com
PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com
www.findaphd.com
October 22, 2025 at 8:29 AM
PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging
www.findaphd.com/phds/project...
#microsky #bioimaging
Reposted by Paprapach Wongdontree
We’re excited to announce the incredible speaker line-up for the Prokaryotic Cell Biology Conference! Join the leading researchers as they explore the latest advances in Nanoimaging, Cell Growth and Cellular Structures.
Join our speakers & register today! ➡️https://bit.ly/47rtkbw
#ProkaryoticCellBio
Join our speakers & register today! ➡️https://bit.ly/47rtkbw
#ProkaryoticCellBio
October 16, 2025 at 2:27 PM
We’re excited to announce the incredible speaker line-up for the Prokaryotic Cell Biology Conference! Join the leading researchers as they explore the latest advances in Nanoimaging, Cell Growth and Cellular Structures.
Join our speakers & register today! ➡️https://bit.ly/47rtkbw
#ProkaryoticCellBio
Join our speakers & register today! ➡️https://bit.ly/47rtkbw
#ProkaryoticCellBio
Reposted by Paprapach Wongdontree
Peptidoglycan recycling is critical for cell division, cell wall integrity and β-lactam resistance in Caulobacter crescentus https://www.biorxiv.org/content/10.1101/2025.10.15.682734v1
October 16, 2025 at 5:18 PM
Peptidoglycan recycling is critical for cell division, cell wall integrity and β-lactam resistance in Caulobacter crescentus https://www.biorxiv.org/content/10.1101/2025.10.15.682734v1
Reposted by Paprapach Wongdontree
Structural basis for MurJ inhibition by phage lysis protein SglPP7 suggesting convergence https://www.biorxiv.org/content/10.1101/2025.10.15.682725v1
October 16, 2025 at 5:19 PM
Structural basis for MurJ inhibition by phage lysis protein SglPP7 suggesting convergence https://www.biorxiv.org/content/10.1101/2025.10.15.682725v1
Reposted by Paprapach Wongdontree
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
September 20, 2025 at 9:29 AM
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
Reposted by Paprapach Wongdontree
Also see the accompanying paper from Carol Gross' lab that used a similar approach for Bacillus subtilis: www.cell.com/cell-systems...
Comprehensive genetic interaction analysis of the Bacillus subtilis envelope using double-CRISPRi
Koo et al. apply genome-scale double-CRISPRi to map cell envelope gene interactions
in Bacillus subtilis, revealing >1,000 genetic interactions and uncovering gene networks
in envelope biogenesis and ...
www.cell.com
October 4, 2025 at 8:48 AM
Also see the accompanying paper from Carol Gross' lab that used a similar approach for Bacillus subtilis: www.cell.com/cell-systems...
Reposted by Paprapach Wongdontree
#Perspective
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
How nutrient starvation impacts the gut microbiome - Nature Microbiology
In this Perspective, Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
www.nature.com
October 1, 2025 at 5:56 PM
#Perspective
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Reposted by Paprapach Wongdontree
Peptidoglycan remodelling improves salt resilience of Zymomonas mobilis https://www.biorxiv.org/content/10.1101/2025.10.04.680478v1
October 6, 2025 at 3:16 AM
Peptidoglycan remodelling improves salt resilience of Zymomonas mobilis https://www.biorxiv.org/content/10.1101/2025.10.04.680478v1
Reposted by Paprapach Wongdontree
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 6, 2025 at 9:34 AM
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
Reposted by Paprapach Wongdontree
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS
Tuberculosis remains the deadliest infectious disease caused by a single pathogen,
highlighting the urgent need for novel therapies. A deeper under...
www.pnas.org
September 23, 2025 at 3:32 AM
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Reposted by Paprapach Wongdontree
Architecture of a peptidoglycan peptidase complex involved in morphological transition in Helicobacter pylori. https://www.biorxiv.org/content/10.1101/2025.08.29.672660v1
August 30, 2025 at 5:17 AM
Architecture of a peptidoglycan peptidase complex involved in morphological transition in Helicobacter pylori. https://www.biorxiv.org/content/10.1101/2025.08.29.672660v1
Reposted by Paprapach Wongdontree
Uropathogenic #Ecoli #UPEC proliferate as round coccoid cells during intracellular infection; @alaskapokhrel.bsky.social @bill-lab.bsky.social &co show that accelerated division via FtsZ constriction drives this, the coccobacillus form persisting for generations @plosbiology.org 🧪 plos.io/4gdx97i
September 4, 2025 at 8:53 AM
Uropathogenic #Ecoli #UPEC proliferate as round coccoid cells during intracellular infection; @alaskapokhrel.bsky.social @bill-lab.bsky.social &co show that accelerated division via FtsZ constriction drives this, the coccobacillus form persisting for generations @plosbiology.org 🧪 plos.io/4gdx97i
Reposted by Paprapach Wongdontree
Here we show that >90% of Paenibacillus encode a unique Spo0B with a transmembrane domain! TM domain helps it interact with its phosphorelay partners. Congrats to @isabellalin.bsky.social who left for grad school this week and her mentor @cassidyprints.bsky.social! www.biorxiv.org/content/10.1...
Conservation of sporulation genes and a transmembrane-containing Spo0B variant in Paenibacillus
Sporulation is a strategy employed by many bacteria to survive harsh environmental conditions. The genus Paenibacillus includes spore-forming species notorious for spoiling pasteurized dairy products ...
www.biorxiv.org
August 28, 2025 at 11:27 PM
Here we show that >90% of Paenibacillus encode a unique Spo0B with a transmembrane domain! TM domain helps it interact with its phosphorelay partners. Congrats to @isabellalin.bsky.social who left for grad school this week and her mentor @cassidyprints.bsky.social! www.biorxiv.org/content/10.1...
Reposted by Paprapach Wongdontree
My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB)
MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...
lsa.umich.edu
August 26, 2025 at 1:29 PM
My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...