Olivier Duss
@olivierduss.bsky.social
Group leader @embl.org European Molecular Biology Laboratory
#RNA biology | #single-molecule #biophysics | #structural biology | #biochemistry | #quantitative biology | #chemical biology | #synthetic biology - https://www.embl.org/groups/duss/
#RNA biology | #single-molecule #biophysics | #structural biology | #biochemistry | #quantitative biology | #chemical biology | #synthetic biology - https://www.embl.org/groups/duss/
The story of how multiple RBPs cooperate to repress translation is now out in @cp-cellreports.bsky.social by @marcopayr.bsky.social and in a great collaboration with @hennig-lab.bsky.social!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
November 7, 2025 at 3:34 PM
The story of how multiple RBPs cooperate to repress translation is now out in @cp-cellreports.bsky.social by @marcopayr.bsky.social and in a great collaboration with @hennig-lab.bsky.social!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Thinking Like a Scientist, Part Two: The Omics Illusion network.febs.org/posts/thinki... #FEBSnet
Thinking like a Scientist: The Limits of Genome Editing and Omics
Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...
network.febs.org
November 7, 2025 at 1:10 PM
Thinking Like a Scientist, Part Two: The Omics Illusion network.febs.org/posts/thinki... #FEBSnet
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
November 1, 2025 at 5:56 AM
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Reposted by Olivier Duss
Travel’s got me wiped, but catching up with @colindascheele.bsky.social, @pierresantucci.bsky.social & @olivierduss.bsky.social at #FEBS2025 made it totally worth it. Huge thanks to Pelin Telkoparan and Dilek Cevik for the wonderful hospitality—what a time in Istanbul!
July 8, 2025 at 10:11 PM
Travel’s got me wiped, but catching up with @colindascheele.bsky.social, @pierresantucci.bsky.social & @olivierduss.bsky.social at #FEBS2025 made it totally worth it. Huge thanks to Pelin Telkoparan and Dilek Cevik for the wonderful hospitality—what a time in Istanbul!
Reposted by Olivier Duss
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
www.science.org
May 15, 2025 at 7:51 PM
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-molecule multimodal timing of in vivo mRNA synthesis
mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...
www.biorxiv.org
April 29, 2025 at 8:31 PM
The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Olivier Duss
Five people have seen a color never before visible to the naked human eye, thanks to a new retinal stimulation technique called Oz.
Learn more in #ScienceAdvances: scim.ag/442Hjn6
Learn more in #ScienceAdvances: scim.ag/442Hjn6
Novel color via stimulation of individual photoreceptors at population scale
Image display by cell-by-cell retina stimulation, enabling colors impossible to see under natural viewing.
scim.ag
April 21, 2025 at 5:56 PM
Five people have seen a color never before visible to the naked human eye, thanks to a new retinal stimulation technique called Oz.
Learn more in #ScienceAdvances: scim.ag/442Hjn6
Learn more in #ScienceAdvances: scim.ag/442Hjn6
Reposted by Olivier Duss
Check out our preprint at BioRxiv revealing mechanisms of mRNP assembly during translation repression: (www.biorxiv.org/content/10.1...). Great collaboration with Olivier Duss (@olivierduss.bsky.social). Great Work Marco Payr (@marcopayr.bsky.social) and thanks for the video, explaining our paper.
April 11, 2025 at 4:35 AM
Check out our preprint at BioRxiv revealing mechanisms of mRNP assembly during translation repression: (www.biorxiv.org/content/10.1...). Great collaboration with Olivier Duss (@olivierduss.bsky.social). Great Work Marco Payr (@marcopayr.bsky.social) and thanks for the video, explaining our paper.
Ever wondered how several individual RBPs cooperate to repress translation?
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
April 12, 2025 at 11:29 AM
Ever wondered how several individual RBPs cooperate to repress translation?
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
Reposted by Olivier Duss
Great work led by our PhD student Iuliia Kotova in collaboration with Fan Liu @fan-liu.bsky.social, Boris Bogdanow, Lars Mühlberg, and Olivier Duss @olivierduss.bsky.social and Guelsah Gabriel labs. Structural analysis by our PhD student Konstantin Gilep.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Snapshot of in-cell protein contact sites reveals new host factors and hijacking of paraspeckles during influenza A virus infection
Influenza A virus (IAV) exploits the host cellular machinery to facilitate its replication, yet many host-IAV interactions remain unexplored in the cellular context. Detailed information about interac...
www.biorxiv.org
March 29, 2025 at 1:55 PM
Great work led by our PhD student Iuliia Kotova in collaboration with Fan Liu @fan-liu.bsky.social, Boris Bogdanow, Lars Mühlberg, and Olivier Duss @olivierduss.bsky.social and Guelsah Gabriel labs. Structural analysis by our PhD student Konstantin Gilep.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Olivier Duss
Reposted by Olivier Duss
The RNA helicase HrpA rescues collided ribosomes in E. coli
The RNA helicase HrpA rescues collided ribosomes in E. coli
Antibiotics that inhibit ribosomes lead to collisions on mRNAs when upstream ribosomes catch up with stalled ones. Campbell et al. show that the HrpA protein in E. coli senses ribosome collisions and removes the stalled ribosome, helping cells survive in…
dlvr.it
March 11, 2025 at 11:32 AM
The RNA helicase HrpA rescues collided ribosomes in E. coli
Reposted by Olivier Duss
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 1, 2025 at 1:40 PM
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Olivier Duss
Just published: My (Janosch Hennig) view on the current capabilities of AF3 and similar for RNA and protein-RNA complex structure prediction plus a bit of forward looking: doi.org/10.1002/cbic...
Structural biology of RNA and protein‐RNA complexes after AlphaFold3
Recent breakthroughs in AI-mediated protein structure prediction have significantly accelerated research and generated valuable hypotheses within the field of structural biology and beyond. Notably, ...
doi.org
February 13, 2025 at 10:23 AM
Just published: My (Janosch Hennig) view on the current capabilities of AF3 and similar for RNA and protein-RNA complex structure prediction plus a bit of forward looking: doi.org/10.1002/cbic...
Reposted by Olivier Duss
Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 6, 2025 at 7:38 PM
Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Olivier Duss
#cryoET of Mycoplasma pneumoniae Chloramphenicol-bound ribosomes at a global 3.0 Å resolution
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 12, 2024 at 11:16 AM
#cryoET of Mycoplasma pneumoniae Chloramphenicol-bound ribosomes at a global 3.0 Å resolution
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC !
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Structural and kinetic insights into tRNA promoter engagement by yeast general transcription factor TFIIIC
Abstract. Transcription of transfer RNA (tRNA) genes by RNA polymerase (Pol) III requires the general transcription factor IIIC (TFIIIC), which recognizes
academic.oup.com
December 11, 2024 at 7:39 AM
Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC !
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Cool collaboration with the Müller and Eustermann Labs @embl.org !
academic.oup.com/nar/advance-...
Reposted by Olivier Duss
EMBL Group Leader @olivierduss.bsky.social and his research team discovered how two molecular machines in bacteria work together and watched their interactions as a real-time movie.
Discover how they put snapshots in motion 👉 www.embl.org/news/science...
#MolBiol 🧪 @natureportfolio.bsky.social
Discover how they put snapshots in motion 👉 www.embl.org/news/science...
#MolBiol 🧪 @natureportfolio.bsky.social
December 4, 2024 at 4:05 PM
EMBL Group Leader @olivierduss.bsky.social and his research team discovered how two molecular machines in bacteria work together and watched their interactions as a real-time movie.
Discover how they put snapshots in motion 👉 www.embl.org/news/science...
#MolBiol 🧪 @natureportfolio.bsky.social
Discover how they put snapshots in motion 👉 www.embl.org/news/science...
#MolBiol 🧪 @natureportfolio.bsky.social
First paper of our lab today @natureportfolio.bsky.social by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
December 4, 2024 at 8:53 PM
First paper of our lab today @natureportfolio.bsky.social by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
Reposted by Olivier Duss
Congratulations, Olivier Duss, Simone Köhler, and Eva Kowalinski! 👏
The three EMBL Group Leaders have received ERC Consolidator Grants #ERCCoG for their innovative research projects aimed at understanding fundamental cellular mechanisms.
#MolBiol 🧪👇
Read more here: www.embl.org/news/awards-...
The three EMBL Group Leaders have received ERC Consolidator Grants #ERCCoG for their innovative research projects aimed at understanding fundamental cellular mechanisms.
#MolBiol 🧪👇
Read more here: www.embl.org/news/awards-...
December 3, 2024 at 11:05 AM
Congratulations, Olivier Duss, Simone Köhler, and Eva Kowalinski! 👏
The three EMBL Group Leaders have received ERC Consolidator Grants #ERCCoG for their innovative research projects aimed at understanding fundamental cellular mechanisms.
#MolBiol 🧪👇
Read more here: www.embl.org/news/awards-...
The three EMBL Group Leaders have received ERC Consolidator Grants #ERCCoG for their innovative research projects aimed at understanding fundamental cellular mechanisms.
#MolBiol 🧪👇
Read more here: www.embl.org/news/awards-...
Very grateful to get support from the #ERC Consolidator grant!
-to study how #transcription, #translation and #DNA repair cooperate
-combining #single-molecule #microscopy in vitro & live cells and #cryoET
-obtaining a real-time movie 🎥 🎞️
-hiring soon @embl.org!
www.embl.org/news/awards-...
-to study how #transcription, #translation and #DNA repair cooperate
-combining #single-molecule #microscopy in vitro & live cells and #cryoET
-obtaining a real-time movie 🎥 🎞️
-hiring soon @embl.org!
www.embl.org/news/awards-...
December 4, 2024 at 8:41 AM
Very grateful to get support from the #ERC Consolidator grant!
-to study how #transcription, #translation and #DNA repair cooperate
-combining #single-molecule #microscopy in vitro & live cells and #cryoET
-obtaining a real-time movie 🎥 🎞️
-hiring soon @embl.org!
www.embl.org/news/awards-...
-to study how #transcription, #translation and #DNA repair cooperate
-combining #single-molecule #microscopy in vitro & live cells and #cryoET
-obtaining a real-time movie 🎥 🎞️
-hiring soon @embl.org!
www.embl.org/news/awards-...
Reposted by Olivier Duss
Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...
Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics - Nature Microbiology
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and ...
www.nature.com
December 2, 2024 at 10:33 AM
Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...
Reposted by Olivier Duss
Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics
November 27, 2024 at 11:25 AM
Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics
Reposted by Olivier Duss
I'm excited to share the preprint for the first chunk of my PhD work! We combined DMS structure probing with nascent RNA enrichment to report high-resolution, dynamic structures of transcripts just after synthesis - inside cells. @karlaneugebauer.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...
www.biorxiv.org
November 27, 2024 at 1:48 PM
I'm excited to share the preprint for the first chunk of my PhD work! We combined DMS structure probing with nascent RNA enrichment to report high-resolution, dynamic structures of transcripts just after synthesis - inside cells. @karlaneugebauer.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...