Olivier Saulnier
@olivier-saulnier.bsky.social
Junior Group Leader at institutcurie.bsky.social
Crosstalk between embryonic development and childhood cancers 🎗️
https://institut-curie.org/team/saulnier
Crosstalk between embryonic development and childhood cancers 🎗️
https://institut-curie.org/team/saulnier
Pinned
Let's build a starter pack for childhood cancer research.
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
RNA-binding proteins mediate the maturation of chromatin topology during differentiation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RNA-binding proteins mediate the maturation of chromatin topology during differentiation - Nature Cell Biology
Dehingia, Milewska-Puchała and colleagues find a pervasive lncRNA-mediated increase in interactions between CTCF and RNA-binding proteins during embryonic stem cell differentiation. These interactions...
www.nature.com
September 10, 2025 at 2:45 PM
RNA-binding proteins mediate the maturation of chromatin topology during differentiation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do
In this comprehensive review, Karreman & Winkler explore how neural influences on
the brain’s metastatic process govern brain tropism, colonization, and growth. Conversely,
metastatic cancer has disti...
www.cell.com
September 4, 2025 at 3:32 PM
Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Cell-type-specific enrichment of somatic aneuploidy in the mammalian brain
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Cell-type-specific enrichment of somatic aneuploidy in the mammalian brain
Mutations during brain development can alter the DNA of neurons, impacting their genetic
identity. Using single-nucleus DNA methylation sequencing data from the adult mouse
brain, Mukamel et al. ident...
www.cell.com
September 4, 2025 at 7:09 AM
Cell-type-specific enrichment of somatic aneuploidy in the mammalian brain
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
www.biorxiv.org/content/10.1...
SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms
SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms
SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms
The alternative splicing of the adapter protein NUMB is dysregulated in multiple cancer types, regulating its functional divergence towards either tumor suppression or oncogenesis in an isoform depend...
www.biorxiv.org
August 28, 2025 at 1:07 PM
www.biorxiv.org/content/10.1...
SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms
SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
www.nature.com
July 10, 2025 at 7:15 AM
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants - Nature Biotechnology
The effects of oncofusions and other protein variants on chromatin remodeling are identified by PROD-ATAC.
www.nature.com
July 3, 2025 at 2:47 PM
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gene context drift identifies drug targets to mitigate cancer treatment resistance
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Gene context drift identifies drug targets to mitigate cancer treatment resistance
Jassim et al. introduce a graph-embedding computational pipeline (RECODR) that measures
changes in gene co-expression context during cancer treatment. RECODR enables the
design of highly effective com...
www.cell.com
July 1, 2025 at 12:28 PM
Gene context drift identifies drug targets to mitigate cancer treatment resistance
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
The transition from benign to malignant growth is a pivotal yet poorly understood step in cancer progression that marks the shift from a pathologically inert condition to a clinically lethal disease. ...
www.biorxiv.org
June 13, 2025 at 11:08 AM
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Olivier Saulnier
🧪 New paper alert!
In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠
www.nature.com/articles/s41...
In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠
www.nature.com/articles/s41...
Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X - Nature Communications
Genetic mutations in the DDX3X gene are associated with a neurodevelopmental disorder primarily affecting females. Here authors show that Ddx3x mediates sexual dimorphisms during brain development at ...
www.nature.com
May 18, 2025 at 3:39 PM
🧪 New paper alert!
In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠
www.nature.com/articles/s41...
In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠
www.nature.com/articles/s41...
Radiation-induced amphiregulin drives tumour metastasis
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Radiation-induced amphiregulin drives tumour metastasis - Nature
Radiotherapy induces expression of the EGFR ligand amphiregulin, which promotes metastasis growth at remote sites in mouse models and human patients by shifting myeloid cells towards an immunosup...
doi.org
May 19, 2025 at 7:35 AM
Radiation-induced amphiregulin drives tumour metastasis
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Olivier Saulnier
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Reposted by Olivier Saulnier
I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
Transposable elements as genome regulators in normal and malignant haematopoiesis - Blood Cancer Journal
Blood Cancer Journal - Transposable elements as genome regulators in normal and malignant haematopoiesis
www.nature.com
May 6, 2025 at 4:31 PM
I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
Reposted by Olivier Saulnier
📆 5-6 juin 2025 : Paris Kids Cancer, co-dirigé par l’ @ap-hp.bsky.social , @gustaveroussy.fr, l’Institut National du Cancer et l’Institut Curie, organise son 1er symposium sur le système immunitaire chez l'enfant et sa dysrégulation
ℹ️ plus d'information : curie.fr/symposium-paris-kids-cancer-2025
ℹ️ plus d'information : curie.fr/symposium-paris-kids-cancer-2025
May 6, 2025 at 3:22 PM
📆 5-6 juin 2025 : Paris Kids Cancer, co-dirigé par l’ @ap-hp.bsky.social , @gustaveroussy.fr, l’Institut National du Cancer et l’Institut Curie, organise son 1er symposium sur le système immunitaire chez l'enfant et sa dysrégulation
ℹ️ plus d'information : curie.fr/symposium-paris-kids-cancer-2025
ℹ️ plus d'information : curie.fr/symposium-paris-kids-cancer-2025
Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure
LaBelle et al. show immune microenvironment changes following chemo-/radiotherapy
and immune checkpoint blockade therapy via single-cell RNA-seq of matched tumor, T cells,
and myeloid cells in pediatr...
www.cell.com
May 6, 2025 at 10:02 AM
Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Olivier Saulnier
Spatial mapping of transcriptomic plasticity in metastatic #PancreaticCancer 🧪 www.nature.com/articles/s41...
Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer - Nature
Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation i...
www.nature.com
April 25, 2025 at 6:51 AM
Spatial mapping of transcriptomic plasticity in metastatic #PancreaticCancer 🧪 www.nature.com/articles/s41...
Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth - Nature Cell Biology
Abeysundara, Rasnitsyn, Fong et al. report that the presence of leptomeningeal metastatic tumour cells leads to the recruitment and remodelling of fibroblasts, which, in turn, facilitate the colonizat...
www.nature.com
April 24, 2025 at 1:04 PM
Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congratulations @haldipur.bsky.social, It's great to see it out! 🧠
Mapping the developmental profile of ventricular zone-derived neurons in the human cerebellum
doi.org/10.1073/pnas...
Mapping the developmental profile of ventricular zone-derived neurons in the human cerebellum
doi.org/10.1073/pnas...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
April 22, 2025 at 3:05 PM
Congratulations @haldipur.bsky.social, It's great to see it out! 🧠
Mapping the developmental profile of ventricular zone-derived neurons in the human cerebellum
doi.org/10.1073/pnas...
Mapping the developmental profile of ventricular zone-derived neurons in the human cerebellum
doi.org/10.1073/pnas...
Reposted by Olivier Saulnier
A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DNA-guided transcription factor interactions extend human gene regulatory code - Nature
A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...
www.nature.com
April 9, 2025 at 4:51 PM
A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Olivier Saulnier
🔴 Dans un entretien à @lexpress.bsky.social, Yasmine Belkaid DG @pasteur.fr, Bana Jabri DG @institutimagine.bsky.social et Alain Puisieux, Pdt du Directoire de l’Institut Curie, lancent un appel pour défendre la #science face aux menaces qui pèsent sur elle.
➡️ www.lexpress.fr/sciences-san...
➡️ www.lexpress.fr/sciences-san...
April 8, 2025 at 5:29 PM
🔴 Dans un entretien à @lexpress.bsky.social, Yasmine Belkaid DG @pasteur.fr, Bana Jabri DG @institutimagine.bsky.social et Alain Puisieux, Pdt du Directoire de l’Institut Curie, lancent un appel pour défendre la #science face aux menaces qui pèsent sur elle.
➡️ www.lexpress.fr/sciences-san...
➡️ www.lexpress.fr/sciences-san...
The path to leptomeningeal metastasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The path to leptomeningeal metastasis - Nature Reviews Cancer
Metastasis to the leptomeninges causes substantial neurological morbidity and mortality. Owing to the lack of mechanistic studies in this area, patients still face a bleak clinical prognosis. In this ...
www.nature.com
April 8, 2025 at 2:52 PM
The path to leptomeningeal metastasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Olivier Saulnier
✨So happy to see part of my PhD work with @lippilab.bsky.social out today in @cp-neuron.bsky.social! ✨
We developed new tools to study microRNA-target networks with greater spatial and temporal resolution and found neuronal subtype- and developmental stage-specific roles:
We developed new tools to study microRNA-target networks with greater spatial and temporal resolution and found neuronal subtype- and developmental stage-specific roles:
MicroRNA mechanisms instructing Purkinje cell specification
Zolboot et al. introduce DD-T6B and SAP-seq, methods for investigating microRNA function
with enhanced spatiotemporal resolution, and identify Purkinje cell-specific microRNAs
and targets instructing ...
www.cell.com
April 2, 2025 at 7:27 PM
✨So happy to see part of my PhD work with @lippilab.bsky.social out today in @cp-neuron.bsky.social! ✨
We developed new tools to study microRNA-target networks with greater spatial and temporal resolution and found neuronal subtype- and developmental stage-specific roles:
We developed new tools to study microRNA-target networks with greater spatial and temporal resolution and found neuronal subtype- and developmental stage-specific roles:
Reposted by Olivier Saulnier
our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
March 26, 2025 at 5:11 PM
our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors
doi.org/10.1016/j.im...
doi.org/10.1016/j.im...
Redirecting
doi.org
March 20, 2025 at 3:04 PM
Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors
doi.org/10.1016/j.im...
doi.org/10.1016/j.im...
Please repost to get the word out! @nkgarg.bsky.social and I are excited to present a personalized feed for academics! It shows posts about papers from accounts you’re following bsky.app/profile/pape...
March 14, 2025 at 12:53 PM
Reposted by Olivier Saulnier
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
March 11, 2025 at 1:20 PM
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n