Navneet Vasistha
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nvasistha.bsky.social
Navneet Vasistha
@nvasistha.bsky.social
Asst. Prof at UCPH, Denmark. I research how things go wrong in neurodev disorders. Still trying to figure out how the world works. Indian at heart (whatever that means)
Pinned
As a student in India, I remember re-reading Annual Review articles for days or months to understand a topic in considerable detail.

Fast forward a few decades and I have co-authored a review in Annual Review of Neuroscience with Prof. Akira Sawa! 🥳

Here's a 🧵 describing its contents:
Reposted by Navneet Vasistha
Boosting SYNGAP1 levels via viral delivery can normalize brain waves in mice.

By @cqchoi.com

www.thetransmitter.org/spectrum/gen...

#neuroskyence
Gene replacement therapy normalizes some traits in SYNGAP1 model mice
The first published virus-based gene therapy for SYNGAP1 deletion yields benefits despite the gene’s long length and complexity.
www.thetransmitter.org
November 20, 2025 at 2:06 PM
Most sources will tell you that the shinkansen is modelled after birds (kingfisher by most accounts), but tell me you don't see a giraffe from this angle (the headlight mischievously placed as a nostril)
September 13, 2025 at 3:16 PM
Reposted by Navneet Vasistha
Inspired by this post, here is: How I learned that the Charité-Berlin has its own exterminator (1/n)
My lab has faced numerous challenges over the years, but this latest is tough. A Philadelphia sewer rat just sauntered out of a hole in the wall. Not a timid field mouse, not a lab rat — a Camus plague RAT.
August 2, 2025 at 7:26 PM
It boggles me how journals continue to milk controversial issues and publish articles that don't even justify their own title, let alone undertake an honest scientific response to the marker previously laid down by other researchers.

www.science.org/doi/10.1126/...
Identification of proliferating neural progenitors in the adult human hippocampus
Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into que...
www.science.org
July 4, 2025 at 10:06 PM
Reposted by Navneet Vasistha
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
The evolving neurobiology of early-life stress
This review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...
www.cell.com
May 23, 2025 at 9:35 AM
Such an incredible resource! Kudos to everyone at Allen + collaborating labs for making this available to all 👏🏽👏🏽
In the battle against brain disease, researchers can now rely on a new arsenal of genetic tools – The Armamentarium.

Together with scientists from across the NIH BRAIN Initiative, we’ve created and published over 1000 new enhancer AAV vectors.

🧠📈
May 24, 2025 at 9:45 AM
Reposted by Navneet Vasistha
My memories of Prof Narlikar are the physics TV show for kids on doordarshan and him explaining eclipses telescoper.blog/2025/05/20/r...
R.I.P. Jayant Narlikar (1938-2025)
Professor Jayant Vishnu Narlikar (1938-2025) I heard this morning of the death at the age of 86 of renowned Indian cosmologist Jayant Vishnu Narlikar. I understand he died peacefully in his sleep i…
telescoper.blog
May 20, 2025 at 10:21 PM
Reposted by Navneet Vasistha
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
What started as a master's project has finally culminated in new insights on how/when large genetic deletions and duplications impact brain development.
🔬Ever wondered how studying Copy Number Variations in the genome can reveal key insights into the etiology of Neurodevelopmental Disorders--- and even highlight vulnerable cell sub-types at crucial developmental stages?

Check it out here to see the power of scRNA-seq analysis: shorturl.at/jJN51
🧠📚🧬
Rare Copy Number Variants Reveal Critical Cell Types and Periods of Brain Development in Neurodevelopmental Disorders
Multiple copy number variations (CNVs) in the human genome are associated with neurodevelopmental disorders (NDDs). Their markedly larger effect sizes…
shorturl.at
May 9, 2025 at 5:10 PM
Cracker of an episode putting India's Freedom of speech (or lack of it) in the context of her political history

Kudos to @kunalkamra.bsky.social and Srijan Mandal!

youtu.be/13DdsXBaTSA?...
Absolute Freedom of Speech. Almost. | Nope w/ Kunal Kamra | Episode 004
YouTube video by Kunal Kamra
youtu.be
April 22, 2025 at 8:18 AM
Reposted by Navneet Vasistha
Data quality in #scRNAseq and #snRNAseq is really important. We spent 3 years testing different nuclei isolation protocols. The dataset I'm working on atm has a median value of 0.016% reads derived from mitochondria per cell.

Find out how in our new preprint. (;

1/2
March 26, 2025 at 8:53 PM
This is so cool and checks so many boxes in terms of ease and prophylaxis!
Loving this research - chewing gum could keep some viruses at bay according to some new research testing anti-viral containing chewing gum using robot jaws- yup robot jaws that chewed for 15mins! 🧪
New Virus-Trapping Gum Could Help Neutralize Herpes Infections
A special type of chewing gum can 'trap' and neutralize some influenza and herpes viruses, according to new experiments from scientists in the US and Finland.
www.sciencealert.com
April 17, 2025 at 7:35 PM
Reposted by Navneet Vasistha
Our Collaborative work on TRMT1, a tRNA-modifying enzyme, is out in @ajhgnews.bsky.social. A team of human geneticists led by Drs. Houlden' @qs-neurogenetics.bsky.social and Dragony Fu' labs identified 43 individuals from 31 families with biallelic TRMT1 variants.
www.cell.com/ajhg/fulltex...
Biallelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder
We identify bi-allelic variants in TRMT1, encoding a tRNA-modification enzyme, that cause intellectual disability and developmental delay. Functional studies in human cells and zebrafish provide insig...
www.cell.com
April 17, 2025 at 3:13 AM
As a student in India, I remember re-reading Annual Review articles for days or months to understand a topic in considerable detail.

Fast forward a few decades and I have co-authored a review in Annual Review of Neuroscience with Prof. Akira Sawa! 🥳

Here's a 🧵 describing its contents:
April 11, 2025 at 9:02 PM
Gdańsk you beauty! Will definitely come see you again.
April 9, 2025 at 5:56 AM
Have heard about back to back lectures talk about early specification of upper layer cortical neurons with wildly different outcomes. I don't think this was repeated and the cause died down after a few publications from each group.
My question is first whether you have been involved in such a rap beef in your science? Or have you observed one go down? Was it (is it 😬) progress accelerating? does this help us with the misnamed replication crisis which is really about generalization and methods fidelity?
March 29, 2025 at 6:20 PM
Reposted by Navneet Vasistha
Really pleased to see this initiative from @cbmnimhans.bsky.social
As scientists, we often speak about which aspects of #psychiatric disorders we model in the lab but we don't have insights from lived experiences.
So if you/ a near one is willing, please consider being a part of this initiative.
March 24, 2025 at 9:22 AM
Reposted by Navneet Vasistha
In leu of NIH cuts at Columbia, many folks are asking why aren't universities using endowment funds to support the research mission of their faculty scientists?

Inspired by @jeremymberg.bsky.social bluetorials here are a few of the reasons that is not a sustainable option

1/n
March 12, 2025 at 4:38 PM
Copenhagen Airport released their advert celebrating a 100 years recently. Notice anything?

youtu.be/kvruKsQFfCM?...

#cphairport #copenhagen #københavn
CPH 100 år
YouTube video by Copenhagen Airport
youtu.be
January 12, 2025 at 8:44 PM
Alright, just started watching #TheBear and I am all for an anxiety advisory what before that one take sequence in S1E7!

What a fantastic piece of writing, directing and acting. Just too good 👏🏾👏🏾

youtu.be/1K3z62yoiOA?...
Kitchen Nightmare | The Bear | FX
YouTube video by FX Networks
youtu.be
December 21, 2024 at 9:23 PM
Is anyone else frustrated by the anachronism in the miniseries Lessons in Chemistry?
I mean it's great to hear some solid biochemistry that was the talk around the 50s but virology and genetics had almost solved the heredity principle problem before it.
November 23, 2024 at 11:00 AM
Are there any mouse researchers here who use a UV light based ocular system to genotype fluorescent strains?

I am looking to buy one and could do with a referral.

Please repost or pass on to some one who might know.

🧠🐀
November 15, 2024 at 1:19 PM
Reposted by Navneet Vasistha
Hi to all new followers! We are an indie Indian (hehe) boardgame publisher based in Chennai, India. We primarily work on games based on facets of Indian culture - travel, architecture, food and whatnot. We have 2 published games and a few other fun projects!
November 13, 2024 at 4:29 AM