Simon A. Sharples, PhD 🇨🇦
@neurosharps.bsky.social
Research Fellow studying motor systems neuroscience in Cincinnati
I'm particularly proud to have one of my images selected and featured on the cover of the latest issue of @jphysiol.bsky.social
In this issue, you can also read about my latest work on gamma motoneurons! Check it out!!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
In this issue, you can also read about my latest work on gamma motoneurons! Check it out!!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Our latest issue is now live🎉
Featuring cover art from Sharples et al. (2025) depicting a motoneuron from the lumbar spinal cord of a newborn mouse📷🔬
🔗 Read the full issue here: physoc.onlinelibrary.wiley.com/toc/14697793...
Featuring cover art from Sharples et al. (2025) depicting a motoneuron from the lumbar spinal cord of a newborn mouse📷🔬
🔗 Read the full issue here: physoc.onlinelibrary.wiley.com/toc/14697793...
November 25, 2025 at 3:55 PM
I'm particularly proud to have one of my images selected and featured on the cover of the latest issue of @jphysiol.bsky.social
In this issue, you can also read about my latest work on gamma motoneurons! Check it out!!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
In this issue, you can also read about my latest work on gamma motoneurons! Check it out!!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Check out our recent publication from my postdoc in @uniofstandrews.bsky.social in the Miles Lab published in @cp-cellreports.bsky.social that describes a cholinergic spinal circuit that is vital for fine-tuning motor output during breathing.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A cholinergic spinal pathway for the adaptive control of breathing
The ability to amplify motor neuron (MN) output is essential for generating high-intensity motor actions. This is critical for breathing that must be …
www.sciencedirect.com
August 15, 2025 at 8:37 PM
Check out our recent publication from my postdoc in @uniofstandrews.bsky.social in the Miles Lab published in @cp-cellreports.bsky.social that describes a cholinergic spinal circuit that is vital for fine-tuning motor output during breathing.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Want to learn more about gamma motoneurons?
Check out our recent preprint from my postdoctoral work in the Miles Lab @uniofstandrews.bsky.social providing insight into how these cells are tuned to support motor function.
www.biorxiv.org/content/10.1...
Check out our recent preprint from my postdoctoral work in the Miles Lab @uniofstandrews.bsky.social providing insight into how these cells are tuned to support motor function.
www.biorxiv.org/content/10.1...
Intrinsic mechanisms contributing to the biophysical signature of mouse gamma motoneurons
Precise motor control relies on continuous sensory feedback from muscles, a process in which gamma motoneurons play a key role. These specialized spinal neurons innervate intrafusal muscle fibres, mod...
www.biorxiv.org
July 1, 2025 at 1:43 PM
Want to learn more about gamma motoneurons?
Check out our recent preprint from my postdoctoral work in the Miles Lab @uniofstandrews.bsky.social providing insight into how these cells are tuned to support motor function.
www.biorxiv.org/content/10.1...
Check out our recent preprint from my postdoctoral work in the Miles Lab @uniofstandrews.bsky.social providing insight into how these cells are tuned to support motor function.
www.biorxiv.org/content/10.1...
Reposted by Simon A. Sharples, PhD 🇨🇦
Congratulations & welcome to Dr Simon Sharples from cincychildrens.bsky.social who joins us as one of our 2025 Editorial Board Fellows! 🎓 🎉
June 5, 2025 at 12:03 PM
Congratulations & welcome to Dr Simon Sharples from cincychildrens.bsky.social who joins us as one of our 2025 Editorial Board Fellows! 🎓 🎉
Reposted by Simon A. Sharples, PhD 🇨🇦
Just learned that the Sensorimotor Neuroscience (SMN) study section is postponed indefinitely. Over 100 proposals to understand and treat sensorimotor diseases that will not be evaluated or funded. Thousands of hours wasted by writers and reviewers. All due to the Republican block on NIH operation.
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
2025 Study section tracking
docs.google.com
February 26, 2025 at 3:09 PM
Just learned that the Sensorimotor Neuroscience (SMN) study section is postponed indefinitely. Over 100 proposals to understand and treat sensorimotor diseases that will not be evaluated or funded. Thousands of hours wasted by writers and reviewers. All due to the Republican block on NIH operation.
🚨 New Research Alert! 🚨
Thrilled to share my final PhD paper—also my first as corresponding author, recently published in @iScience! We investigated spinal circuits that contribute to episodic locomotor activity.
www.sciencedirect.com/science/arti...
Thrilled to share my final PhD paper—also my first as corresponding author, recently published in @iScience! We investigated spinal circuits that contribute to episodic locomotor activity.
www.sciencedirect.com/science/arti...
Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord
Spinal circuits generate locomotor rhythms, but the mechanisms behind episodic locomotor behaviors remain unclear. This study investigated dopamine-in…
www.sciencedirect.com
February 21, 2025 at 2:59 PM
🚨 New Research Alert! 🚨
Thrilled to share my final PhD paper—also my first as corresponding author, recently published in @iScience! We investigated spinal circuits that contribute to episodic locomotor activity.
www.sciencedirect.com/science/arti...
Thrilled to share my final PhD paper—also my first as corresponding author, recently published in @iScience! We investigated spinal circuits that contribute to episodic locomotor activity.
www.sciencedirect.com/science/arti...
We've always wondered what V0g's were up to. Now we're a big step closer to knowing! Nice to see this great work out!
🥁 Elisa Toscano idenitified a new subtype of propriospinal neurons and found a role in the execution of skilled movements🤸♂️. Great job from Elisa and everybody involved 💪. @alesantuz.bsky.social, @lowensteined.bsky.social. Check it out and let us know what you think:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Identification of V0g propriospinal neurons and their role in locomotor control
Propriospinal neurons relay sensory and motor information across the spinal cord and are critical components of the circuits coordinating body movements. Their diversity and roles in motor control are...
www.biorxiv.org
February 14, 2025 at 1:55 PM
We've always wondered what V0g's were up to. Now we're a big step closer to knowing! Nice to see this great work out!
Reposted by Simon A. Sharples, PhD 🇨🇦
If you're interested in spasticity, we've just published a reliable way to optogenetically induce hindlimb spasticity after spinal cord injury. All the credit goes to PhD graduate Sara Goltash and postdoc @alaliberte.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
February 6, 2025 at 4:22 PM
If you're interested in spasticity, we've just published a reliable way to optogenetically induce hindlimb spasticity after spinal cord injury. All the credit goes to PhD graduate Sara Goltash and postdoc @alaliberte.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
It's shaping up to be a fantastic summer for motor control meetings.
Registration for the second Motor Circuits Meeting hosted in St Andrews June 17-20 has just opened. Looking forward to catching up with friends and colleagues at the meeting!!
motor-circuits.wp.st-andrews.ac.uk/registration/
Registration for the second Motor Circuits Meeting hosted in St Andrews June 17-20 has just opened. Looking forward to catching up with friends and colleagues at the meeting!!
motor-circuits.wp.st-andrews.ac.uk/registration/
Registration and Call for Abstracts – Motor Control: Spinal Circuits and Beyond
motor-circuits.wp.st-andrews.ac.uk
February 3, 2025 at 6:22 PM
It's shaping up to be a fantastic summer for motor control meetings.
Registration for the second Motor Circuits Meeting hosted in St Andrews June 17-20 has just opened. Looking forward to catching up with friends and colleagues at the meeting!!
motor-circuits.wp.st-andrews.ac.uk/registration/
Registration for the second Motor Circuits Meeting hosted in St Andrews June 17-20 has just opened. Looking forward to catching up with friends and colleagues at the meeting!!
motor-circuits.wp.st-andrews.ac.uk/registration/
Really looking forward to this!
Abstract submission is live for the 2025 Motoneuron meeting in St. John’s, Newfoundland. Deadline for submissions is 0830 NST on March 11, 2025. If you’re interested in Motoneurons - please join us!
Visit Motoneuron.org to submit!
Visit Motoneuron.org to submit!
February 3, 2025 at 1:55 PM
Really looking forward to this!
🚨 New Research! 🚨
Our new preprint is live on BioRxiv. Check out the link below if you're interested in learning more about how spinal circuits modulate breathing!
www.biorxiv.org/content/10.1...
Our new preprint is live on BioRxiv. Check out the link below if you're interested in learning more about how spinal circuits modulate breathing!
www.biorxiv.org/content/10.1...
www.biorxiv.org
January 22, 2025 at 9:29 PM
🚨 New Research! 🚨
Our new preprint is live on BioRxiv. Check out the link below if you're interested in learning more about how spinal circuits modulate breathing!
www.biorxiv.org/content/10.1...
Our new preprint is live on BioRxiv. Check out the link below if you're interested in learning more about how spinal circuits modulate breathing!
www.biorxiv.org/content/10.1...