Huge thanks to the co-authors from the Whelan and Miles Labs that made this all possible!

We hope this work sparks future research into the cell types driving episodic activity leading to their integration in computational models of the locomotor CPG.

These circuits also influence dorsal horn networks and can be entrained by sensory afferents.

By studying dopamine-elicited episodic rhythmic activity in isolated spinal cords of newborn mice, we found that episode-generating circuits arise from ventral horn interneurons across thoracic, lumbar, and sacral segments.

Locomotor CPGs are known for generating rhythm and pattern, but locomotor behaviors are often episodic. The circuits behind this remain poorly understood.