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The Journal of Physiology @jphysiol.bsky.social · 14h

Xiaolong Gao offers this #Perspective on the work of Závoti & Csanády (2025) into #molecular and pharmacological evaluation of rare, cystic fibrosis-causing missense mutations of the #CFTR channel 💭

🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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The Journal of Physiology @jphysiol.bsky.social · 16h

In this recent study, Morten Hostrup et al. found that #clenbuterol induces lean mass and muscle protein accretion, but attenuates #cardiorespiratory fitness and desensitizes muscle β2-adrenergic signalling 💉🚴

📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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The Journal of Physiology @jphysiol.bsky.social · 18h

Gabriel Calheiros Antunes et al. performed this sex-dependent study and observed that time-restricted feeding combined with exercise improves hepatic and glycaemic #metabolism in obese mice⏰ 🍽️

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Journal of Physiology @jphysiol.bsky.social · 21h

In this study, Hong Li et al. investigated modulation of #neurometabolites in sensory processing brain areas during motor learning ⚙️ 🧠

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Journal of Physiology @jphysiol.bsky.social · 3d

This study by Emmanuel V. Araujo et al. observed that #oxytocinergic signalling in the #respiratory parafacial region increases the activity of chemosensitive neurons and respiratory output 🫁 ⚙️

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Journal of Physiology @jphysiol.bsky.social · 3d

#Research by Katie Greenin-Whitehead et al. finds that ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells 🔬 🧠

🔗 📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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The Journal of Physiology @jphysiol.bsky.social · 3d

Mohammadreza Kariman of medunigraz.at et al. undertook computational modelling of the impact of anatomical changes on ECGs in left ventricular #hypertrophy 🫀 💻

📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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The Journal of Physiology @jphysiol.bsky.social · 4d

In this study, Olivér Závoti & László Csanády performed #molecular and pharmacological evaluation of rare, cystic fibrosis-causing missense mutations of the #CFTR channel 🔬🧬

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Journal of Physiology @jphysiol.bsky.social · 4d

Brian Lam of yorkuniversity.bsky.social et al. observed that #endurance training increases a ubiquitylated form of #histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2-dependent manner 🏃 🧬

📜 🔗 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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The Journal of Physiology @jphysiol.bsky.social · 4d

Megan L. Lance et al. investigated the #hyperaemic and #metaboreflex response of the #diaphragm during fatiguing diaphragmatic work in humans 🫁 📝

📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Journal of Physiology @jphysiol.bsky.social · 5d

Recent #Research by Jadwiga N. Bilchak of pennmedicine.bsky.social et al. finds that #KCC2 enhancers normalize reflex responses and improve #locomotor function after chronic spinal cord injury 🧠 ⚙️

📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Journal of Physiology @jphysiol.bsky.social · 5d

🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

The endogenous circadian system impairs nighttime blood pressure responses to active standing in older adults

Abstract figure legend Compared to midlife adults, older adults have an impaired blood pressure response to active standing. These differences are exacerbated during the night, which may increase the...

physoc.onlinelibrary.wiley.com

The Journal of Physiology @jphysiol.bsky.social · 5d

In this study, Filip Ježek of charlesuni.cuni.cz et al. performed theoretical analysis of power-law stress relaxation and calcium-dependent passive #mechanics in #cardiac muscle 🫀 ⚙️

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Journal of Physiology @jphysiol.bsky.social · 5d

🎓 EDITOR'S CHOICE🎓

#Research by Saurabh Suhas Thosar & Steven A. Shea of @occhealthsci.bsky.social observes that elderly humans show an impaired blood pressure adaptation to arising from bed during the nighttime.

📜 🔗https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP289266

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The Journal of Physiology @jphysiol.bsky.social · 6d

Paolo Spaiardi et al. found that transient capacitance changes recorded from vestibular type I hair cells are produced by GK,L gating and do not involve #neurotransmitter exocytosis 🧠 💉

📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Journal of Physiology @jphysiol.bsky.social · 6d

#Research by Bettina K. M. Firmke of uniregensburg.bsky.social et al. found that #hypoxia-inducible factor-2 stabilization is not sufficient to induce erythropoietin production in deeper medullary #fibroblasts 🔬 📜

🔗 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Reposted by The Journal of Physiology

The Journal of Precision Medicine: Health and Disease @jprecmed.bsky.social · 7d

📣 CALL FOR PAPERS📣

Examining New Approach Methodologies #NAMs in #precisionmedicine 💉🔎

Submit by 28 February 2026 ⏰

🔗 For topics and more information:

www.sciencedirect.com/special-issu...

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The Journal of Physiology @jphysiol.bsky.social · 7d

In a recent study, Alexey V. Dvornikov & Samantha P. Harris of uarizona.bsky.social observed that #myosin-binding protein C slows #cardiac myofibril relaxation kinetics 🫀 💉

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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The Journal of Physiology @jphysiol.bsky.social · 7d

📣 Call for Papers📣

For the special issue "Placental and fetal brain interfaces: how effective are they in protecting against drugs and toxins?" 🧠 💊

⏰ Deadline: 15 October 2025

🔗 For more information & how to submit: physoc.onlinelibrary.wiley.com/hub/journal/...

The Journal of Physiology @jphysiol.bsky.social · 7d

Leah S. Halls of ugaresearch.bsky.social et al. observed that #dihydrosterculic acid induces #hepatic PPARα target gene expression in mice 🧬 🔎

📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Journal of Physiology @jphysiol.bsky.social · 10d

This #Perspective by Sandra K. Hunter examines #testosterone and androgen receptors in females, based on research by Alexander et al. (2025) ✍️

🔗 Available here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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The Journal of Physiology @jphysiol.bsky.social · 10d

Recent #Research by Guillaume P. Ducrocq et al. finds that GsMTx-4 inhibits the #exercise pressor reflex and the muscle #mechanoreflex primarily through TRPC inhibition 🔎 🔬

📜 🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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The Journal of Physiology @jphysiol.bsky.social · 10d

Dayna A. Zimmerman et al. observed that #metformin and #insulin exacerbate one-carbon metabolism deficits in #pregnant growth restricted rats and impacts the placenta, fetal liver and pancreas 💉 🔎

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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The Journal of Physiology @jphysiol.bsky.social · 11d

Andrew W. D'Souza & Michael K. Stickland discuss the work of Sayegh et al. (2025) examining peripheral chemoreflex constraint of skeletal muscle blood flow ✍️

Read the #Perspective here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Reposted by The Journal of Physiology

The Journal of Precision Medicine: Health and Disease @jprecmed.bsky.social · 11d

This #Review article by Khaoula El Mekkaoui (of ucdavis.bsky.social, vtt.fi & csaalto.bsky.social) et al. examines the impact of the social exposome in #cardiovascular health and disease 🫀📖

🔗 Read the #OpenAccess article here: www.jprecisionmedicine.org/article/S305...

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