Massimiliano Stagi
@mstagi.bsky.social
Scientist 🧬 | Microscopy Enthusiast 🔬
pcwww.liv.ac.uk/~maxstagi/
pcwww.liv.ac.uk/~maxstagi/
Pinned
Massimiliano Stagi
@mstagi.bsky.social
· Nov 17
Hello, world! Looking forward to connecting with new and old friends.
Reposted by Massimiliano Stagi
An #NIH-funded research team has developed an mRNA vaccine to treat pancreatic cancer. Results from the clinical trial were published this week in Nature.
#pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky
#pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky
In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group
Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.
www.mskcc.org
February 23, 2025 at 8:00 AM
Reposted by Massimiliano Stagi
Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar.
This thursday, usual time and place.
This thursday, usual time and place.
February 3, 2025 at 6:55 PM
Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar.
This thursday, usual time and place.
This thursday, usual time and place.
Our new study: www.science.org/doi/10.1126/.... It provides useful tools for studying LLOME lysosomal damage.
RpH-ILV: Probe for lysosomal pH and acute LLOMe-induced membrane permeabilization in cell lines and Drosophila
The ratiometric lysosomal probe RpH-ILV enables improved pH tracking and reveals lysosomal dynamics and susceptibility to damage.
www.science.org
January 4, 2025 at 7:16 PM
Our new study: www.science.org/doi/10.1126/.... It provides useful tools for studying LLOME lysosomal damage.
Reposted by Massimiliano Stagi
An important and beautiful structure of the native dystrophin glycoprotein complex!.
December 11, 2024 at 8:42 PM
An important and beautiful structure of the native dystrophin glycoprotein complex!.
Reposted by Massimiliano Stagi
‘Dark proteome’ survey reveals thousands of new human genes | Science www.science.org/content/arti...
‘Dark proteome’ survey reveals thousands of new human genes
Database confirms that overlooked segments of the genome code for a multitude of tiny proteins
www.science.org
November 30, 2024 at 12:32 PM
‘Dark proteome’ survey reveals thousands of new human genes | Science www.science.org/content/arti...
Reposted by Massimiliano Stagi
MITOtalks have not made it here (yet) but we are excited to host two fantastic trainee talks this week on MITOchats - Alia Edington from Friedman lab at UTSW and David Eberhardt from Chaudhuri at UUtah - visit www.mitotalks.org for more info and zoom link to join! #mitochondria please share!
November 11, 2024 at 5:43 PM
MITOtalks have not made it here (yet) but we are excited to host two fantastic trainee talks this week on MITOchats - Alia Edington from Friedman lab at UTSW and David Eberhardt from Chaudhuri at UUtah - visit www.mitotalks.org for more info and zoom link to join! #mitochondria please share!
Reposted by Massimiliano Stagi
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
www.science.org
November 26, 2024 at 5:31 PM
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Massimiliano Stagi
Beautiful imaging on the cover but also check out the beautiful imaging inside and our story on #endosomes and #GTPase cascades
👋🏻Our November issue's out!
Cover: Imaging #Ovulation
👉🏼Comments on #embryo models & #MembraneContactSites
🔬on: #PlasmaMembrane #endosomes #CellDeath #metabolism #mTOR #BiomolecularCondensation #gastruloids #organoids #ProteinQualityControl & more!
www.nature.com/ncb/volumes/...
Cover: Imaging #Ovulation
👉🏼Comments on #embryo models & #MembraneContactSites
🔬on: #PlasmaMembrane #endosomes #CellDeath #metabolism #mTOR #BiomolecularCondensation #gastruloids #organoids #ProteinQualityControl & more!
www.nature.com/ncb/volumes/...
November 20, 2024 at 6:36 PM
Beautiful imaging on the cover but also check out the beautiful imaging inside and our story on #endosomes and #GTPase cascades
Reposted by Massimiliano Stagi
We’re hiring tenure-track faculty focused on Systems & #ComputationalNeuroscience at the Friedman Brain Institute at Mount Sinai!
We're starting to review applications so submit yours ASAP! 👇
We're starting to review applications so submit yours ASAP! 👇
📢 Calling all Systems & Computational Neuroscience researchers! The #FriedmanBrainInstitute invites applications for full-time, tenure-track faculty position. While application review process begins next week, applications are still being accepted! Apply Now👉 neuroscience.mssm.edu/docs/Faculty...
November 20, 2024 at 8:15 PM
We’re hiring tenure-track faculty focused on Systems & #ComputationalNeuroscience at the Friedman Brain Institute at Mount Sinai!
We're starting to review applications so submit yours ASAP! 👇
We're starting to review applications so submit yours ASAP! 👇
Reposted by Massimiliano Stagi
In a move that surprised the scientific community, DeepMind released the source code and model weights for AlphaFold 3, its groundbreaking AI system for predicting molecular interactions.
medcloudinsider.com/Articles/202...
#ai #healthcaretech #medicaltech
medcloudinsider.com/Articles/202...
#ai #healthcaretech #medicaltech
DeepMind Releases AlphaFold 3 Code and Weights -- MedCloudInsider
In a move that surprised the scientific community, DeepMind, a division of Google parent company Alphabet focused on developing general-purpose artificial intelligence technology, has released the sou...
medcloudinsider.com
November 20, 2024 at 5:42 PM
In a move that surprised the scientific community, DeepMind released the source code and model weights for AlphaFold 3, its groundbreaking AI system for predicting molecular interactions.
medcloudinsider.com/Articles/202...
#ai #healthcaretech #medicaltech
medcloudinsider.com/Articles/202...
#ai #healthcaretech #medicaltech
Reposted by Massimiliano Stagi
Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳
November 19, 2024 at 8:22 PM
Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳
Reposted by Massimiliano Stagi
Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1
Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1
The efficient recognition and removal of apoptotic cells by phagocytes is critical to prevent second
www.biorxiv.org
November 19, 2024 at 10:30 AM
Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1
Reposted by Massimiliano Stagi
Impact of #Ageing and Disuse on #Neuromuscular Junction and #Mitochondrial Function and Morphology: Current Evidence and Controversies
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 18, 2024 at 8:33 AM
Impact of #Ageing and Disuse on #Neuromuscular Junction and #Mitochondrial Function and Morphology: Current Evidence and Controversies
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Massimiliano Stagi
Fueling neurodegeneration: metabolic insights into microglia functions
jneuroinflammation.biomedcentral.com/articles/10....
jneuroinflammation.biomedcentral.com/articles/10....
November 18, 2024 at 9:06 AM
Fueling neurodegeneration: metabolic insights into microglia functions
jneuroinflammation.biomedcentral.com/articles/10....
jneuroinflammation.biomedcentral.com/articles/10....
Reposted by Massimiliano Stagi
Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib
November 17, 2024 at 4:04 PM
Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib
Reposted by Massimiliano Stagi
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
November 17, 2024 at 4:20 PM
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
Reposted by Massimiliano Stagi
Evidence for heterogeneity in endosomal-origin organelles and their positions from @melikel.bsky.social
No significant differences in the distance of the subpopulations from the nucleus. NPC1-positive late endosomes/lysosomes can be closely positioned to mitochondria
doi.org/10.1083/jcb....
No significant differences in the distance of the subpopulations from the nucleus. NPC1-positive late endosomes/lysosomes can be closely positioned to mitochondria
doi.org/10.1083/jcb....
November 16, 2024 at 5:24 AM
Evidence for heterogeneity in endosomal-origin organelles and their positions from @melikel.bsky.social
No significant differences in the distance of the subpopulations from the nucleus. NPC1-positive late endosomes/lysosomes can be closely positioned to mitochondria
doi.org/10.1083/jcb....
No significant differences in the distance of the subpopulations from the nucleus. NPC1-positive late endosomes/lysosomes can be closely positioned to mitochondria
doi.org/10.1083/jcb....
Hello, world! Looking forward to connecting with new and old friends.
November 17, 2024 at 8:34 AM
Hello, world! Looking forward to connecting with new and old friends.
Reposted by Massimiliano Stagi
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.
G. Napolitano,A. Esposito, and A. Ballabio.
November 16, 2024 at 4:31 PM
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.
G. Napolitano,A. Esposito, and A. Ballabio.
Reposted by Massimiliano Stagi
This #fluorescencefriday I am gonna introduce some work from the lab :) We identified a new GTPase cascades that we believe drives cargo flow along post-Golgi pathways! Compartments positive for ARF1 shed ARF1 (green) to acquire Rab11 (magenta) to become recycling endosomes. Can you spot an event?
November 15, 2024 at 1:55 PM
This #fluorescencefriday I am gonna introduce some work from the lab :) We identified a new GTPase cascades that we believe drives cargo flow along post-Golgi pathways! Compartments positive for ARF1 shed ARF1 (green) to acquire Rab11 (magenta) to become recycling endosomes. Can you spot an event?