Michelle Percharde
@mpercharde.bsky.social
Transposons, chromatin, development. Group leader @ the MRC LMS in London and UKRI FLF. Mum of 2, she/her. Www.perchardelab.com
Pinned
Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)
Reposted by Michelle Percharde
📣 We’re hiring 6 new Team Science postdocs!
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
MRC Postdoctoral Research Scientists x 6 - MRC Laboratory of Medical Sciences
Team Science Project
lms.mrc.ac.uk
November 20, 2025 at 1:43 PM
📣 We’re hiring 6 new Team Science postdocs!
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
☕ @katerinakraft.bsky.social @sedonamurphy.bsky.social @mattjones.bsky.social et al. identify extrachromosomal DNA(ecDNA)-interacting elements (EIEs) enriched for #TransposableElements in #ColorectalCancer. EIE 14 integrated within ecDNA acts as an enhancer to promote cancer fitness.
bit.ly/49iFC7C
bit.ly/49iFC7C
Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology
Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...
bit.ly
November 16, 2025 at 6:44 PM
Reposted by Michelle Percharde
Register now for our one-day symposium at the MRC Laboratory of Medical Sciences on environmental and metabolic control of early development on 4 December 2025!
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
November 14, 2025 at 4:56 PM
Register now for our one-day symposium at the MRC Laboratory of Medical Sciences on environmental and metabolic control of early development on 4 December 2025!
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
Spaces filling up for our @bsdb.bsky.social GRT symposium @mrc-lms.bsky.social on environment, metabolism and stem cell development 4th Dec 2025! Updated poster with talk titles below. Register here: www.symposia.org.uk/courses/stem...
Looking forward to seeing you there!
Looking forward to seeing you there!
November 10, 2025 at 1:54 PM
Spaces filling up for our @bsdb.bsky.social GRT symposium @mrc-lms.bsky.social on environment, metabolism and stem cell development 4th Dec 2025! Updated poster with talk titles below. Register here: www.symposia.org.uk/courses/stem...
Looking forward to seeing you there!
Looking forward to seeing you there!
Reposted by Michelle Percharde
We are launching 11 new #PhD opportunities today!
If you would like to contribute to the research at the LMS apply today!
#medicalscience #lifescience
If you would like to contribute to the research at the LMS apply today!
#medicalscience #lifescience
Studentships and PhD training
We have two core PhD programmes - traditional and transdisciplinary. Our PhD students are registered with Imperial and are embedded in our dedicated research facility.
lms.mrc.ac.uk
October 9, 2025 at 2:01 PM
We are launching 11 new #PhD opportunities today!
If you would like to contribute to the research at the LMS apply today!
#medicalscience #lifescience
If you would like to contribute to the research at the LMS apply today!
#medicalscience #lifescience
Reposted by Michelle Percharde
We have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...
October 2, 2025 at 6:51 PM
We have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...
Reposted by Michelle Percharde
World’s first AI-designed viruses a step towards AI-generated life. #Nature
Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.
www.nature.com/articles/d41...
Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.
www.nature.com/articles/d41...
World’s first AI-designed viruses a step towards AI-generated life
Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.
www.nature.com
September 20, 2025 at 5:46 PM
World’s first AI-designed viruses a step towards AI-generated life. #Nature
Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.
www.nature.com/articles/d41...
Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.
www.nature.com/articles/d41...
Come be our head of bioinformatics at @mrc-lms.bsky.social !
Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...
Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...
Head of Bioinformatics - MRC Laboratory of Medical Sciences
We are recruiting for a Head of Bioinformatics to lead our Bioinformatics facility
lms.mrc.ac.uk
September 19, 2025 at 8:25 AM
Come be our head of bioinformatics at @mrc-lms.bsky.social !
Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...
Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...
Reposted by Michelle Percharde
it appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond
July 31, 2025 at 2:50 PM
it appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond
Reposted by Michelle Percharde
Join the #LMS! Our institute is advertising for junior #GroupLeader positions in #Physiology and #Metabolism. Closing date for applications: August 31st!
📢 We have PLT openings!
If you carry out ambitious research in an area relevant to Human Metabolic Disease then get in touch! We are especially interested in research focused in Metabolic Physiology using murine and/or human in vivo models and Immunometabolism.
Apply now!
If you carry out ambitious research in an area relevant to Human Metabolic Disease then get in touch! We are especially interested in research focused in Metabolic Physiology using murine and/or human in vivo models and Immunometabolism.
Apply now!
Programme Leader Track - MRC Laboratory of Medical Sciences
We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.
lms.mrc.ac.uk
July 27, 2025 at 9:37 AM
Join the #LMS! Our institute is advertising for junior #GroupLeader positions in #Physiology and #Metabolism. Closing date for applications: August 31st!
Reposted by Michelle Percharde
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
Study reveals the hidden benefits of weight loss on fat tissue
Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...
lms.mrc.ac.uk
July 9, 2025 at 3:19 PM
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open.
www.symposia.org.uk/courses/stem...
www.symposia.org.uk/courses/stem...
July 8, 2025 at 11:01 AM
🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open.
www.symposia.org.uk/courses/stem...
www.symposia.org.uk/courses/stem...
Reposted by Michelle Percharde
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
June 27, 2025 at 3:07 PM
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
The Chromatin And Development lab are hiring a postdoc!
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...
lms.mrc.ac.uk
June 26, 2025 at 3:19 PM
The Chromatin And Development lab are hiring a postdoc!
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
Reposted by Michelle Percharde
This should almost have an international reach: about what the rainbow flag means for queer people, by Oslo Pride.
For noen kan et lite regnbueflagg bety at vi føler oss tryggere. Man ser flagget og tenker; « her kan jeg passe inn»
En enkel måte å vite at jeg også blir satt pris på.
Veldig fin video
Oslo Pride🌈
En enkel måte å vite at jeg også blir satt pris på.
Veldig fin video
Oslo Pride🌈
May 28, 2025 at 6:55 PM
This should almost have an international reach: about what the rainbow flag means for queer people, by Oslo Pride.
LTRs as dogs…can be friendly, quite helpful at times. LINEs as cats? Also pretty nice in some cases, but also will get angry and scratch out your eyes. Hmm #TEsky 🤔
I love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬
May 26, 2025 at 6:20 PM
LTRs as dogs…can be friendly, quite helpful at times. LINEs as cats? Also pretty nice in some cases, but also will get angry and scratch out your eyes. Hmm #TEsky 🤔
Reposted by Michelle Percharde
I love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬
May 26, 2025 at 5:41 PM
I love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬
Reposted by Michelle Percharde
In this Review, @bryonyleeke.bsky.social, Imke Staffhorst and @mpercharde.bsky.social @mrc-lms.bsky.social explore roles of the nucleolus in mammalian development, focusing on genome organisation and chromatin regulation:
doi.org/10.1242/dev....
doi.org/10.1242/dev....
May 16, 2025 at 8:51 AM
In this Review, @bryonyleeke.bsky.social, Imke Staffhorst and @mpercharde.bsky.social @mrc-lms.bsky.social explore roles of the nucleolus in mammalian development, focusing on genome organisation and chromatin regulation:
doi.org/10.1242/dev....
doi.org/10.1242/dev....
The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
May 14, 2025 at 3:29 PM
The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Calling undergrads! Our summer internship programme @mrc-lms.bsky.social is still open if you want to try out a summer research project. Great way to get a taste of research, inc a generous stipend. Lots of interesting labs are hosting, including us ;) Closing 15/5/25.
lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk/work-and-stu...
LMS Undergraduate Summer Programme - MRC Laboratory of Medical Sciences
Our LMS Undergraduate Summer Programme is a fantastic, fully-funded opportunity for undergraduate students to gain hands on laboratory experience to support their scientific journeys.
lms.mrc.ac.uk
May 7, 2025 at 4:17 PM
Calling undergrads! Our summer internship programme @mrc-lms.bsky.social is still open if you want to try out a summer research project. Great way to get a taste of research, inc a generous stipend. Lots of interesting labs are hosting, including us ;) Closing 15/5/25.
lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk/work-and-stu...
Reposted by Michelle Percharde
I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
Transposable elements as genome regulators in normal and malignant haematopoiesis - Blood Cancer Journal
Blood Cancer Journal - Transposable elements as genome regulators in normal and malignant haematopoiesis
www.nature.com
May 6, 2025 at 4:31 PM
I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
Reposted by Michelle Percharde
🚨🚨#Hiring!
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
April 23, 2025 at 12:45 PM
🚨🚨#Hiring!
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
Reposted by Michelle Percharde
Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.
April 28, 2025 at 2:26 AM
Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.
Reposted by Michelle Percharde
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration
Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...
www.biorxiv.org
April 7, 2025 at 1:26 PM
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Michelle Percharde
Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
April 6, 2025 at 4:24 PM
Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social