Maithy (he/him)
@mkuppusamy.bsky.social
Proteomics | Mass Spectrometry | Reposts are my bookmarks!
Reposted by Maithy (he/him)
By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
June 10, 2025 at 1:11 PM
By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
Non-reduced native glycan analysis is key.
We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.
Reposted by Maithy (he/him)
🚀 Over 1k public datasets in @pride-ebi.bsky.social now have direct links to GEO, unlocking matched transcriptomics data! Final stats are dropping this week, but this is a big step toward a unified way to annotate #multiomics and build cross-database references in #PRIDE. 🧬🔗 #FAIRdata
May 7, 2025 at 7:51 AM
🚀 Over 1k public datasets in @pride-ebi.bsky.social now have direct links to GEO, unlocking matched transcriptomics data! Final stats are dropping this week, but this is a big step toward a unified way to annotate #multiomics and build cross-database references in #PRIDE. 🧬🔗 #FAIRdata
@deutsche-bahn.bsky.social you are the worst!!
April 30, 2025 at 5:08 PM
@deutsche-bahn.bsky.social you are the worst!!
Reposted by Maithy (he/him)
Gute Neuigkeiten zum #Weltmalariatag 2025: Der neue #Impfstoff gegen #Malaria wirkt - so gibt es deutlich weniger schwere Verläufe & Todesfälle bei geimpften Kindern. Es ist ein Schritt voran im Kampf gegen eine der tödlichsten #Infektionskrankheiten. via @gavi.org www.gavi.org/vaccineswork...
Malaria vaccination sees child deaths drop in Kenya’s lake region
In Kenya’s lake region, malaria vaccination has contributed to a drop in both mortality and disease severity among kids, experts confirm.
www.gavi.org
April 25, 2025 at 8:34 AM
Gute Neuigkeiten zum #Weltmalariatag 2025: Der neue #Impfstoff gegen #Malaria wirkt - so gibt es deutlich weniger schwere Verläufe & Todesfälle bei geimpften Kindern. Es ist ein Schritt voran im Kampf gegen eine der tödlichsten #Infektionskrankheiten. via @gavi.org www.gavi.org/vaccineswork...
Reposted by Maithy (he/him)
ibaqpy: A scalable #Python package for baseline quantification in proteomics leveraging #SDRF metadata www.sciencedirect.com/science/arti.... We continue our effort to provide tools and algorithms that leverage SDRF metadata to perform quantitative proteomics analysis.
Ibaqpy: A scalable Python package for baseline quantification in proteomics leveraging SDRF metadata
Intensity-based absolute quantification (iBAQ) is essential in proteomics as it allows for the assessment of a protein's absolute abundance in various…
www.sciencedirect.com
April 25, 2025 at 12:22 PM
ibaqpy: A scalable #Python package for baseline quantification in proteomics leveraging #SDRF metadata www.sciencedirect.com/science/arti.... We continue our effort to provide tools and algorithms that leverage SDRF metadata to perform quantitative proteomics analysis.
Reposted by Maithy (he/him)
#Skyline #proteomics #MassSpec
@maccoss.bsky.social Hope everyone that uses Skyline shows their support skyline.ms/project/home...
@maccoss.bsky.social Hope everyone that uses Skyline shows their support skyline.ms/project/home...
April 21, 2025 at 10:10 PM
#Skyline #proteomics #MassSpec
@maccoss.bsky.social Hope everyone that uses Skyline shows their support skyline.ms/project/home...
@maccoss.bsky.social Hope everyone that uses Skyline shows their support skyline.ms/project/home...
Reposted by Maithy (he/him)
Fascinating article about a cluster of ALS cases. If you think about it, this is a situation in which the researchers skimmed a large number of variables and identified a correlate which is then considered the potential cause.>
H/t @scientificdiscovery.dev
www.theatlantic.com/health/archi...
H/t @scientificdiscovery.dev
www.theatlantic.com/health/archi...
An ‘Impossible’ Disease Outbreak in the Alps
In one tiny town, more than a dozen people were diagnosed with the rare neurodegenerative disease ALS. Why?
www.theatlantic.com
March 30, 2025 at 6:37 AM
Fascinating article about a cluster of ALS cases. If you think about it, this is a situation in which the researchers skimmed a large number of variables and identified a correlate which is then considered the potential cause.>
H/t @scientificdiscovery.dev
www.theatlantic.com/health/archi...
H/t @scientificdiscovery.dev
www.theatlantic.com/health/archi...
Reposted by Maithy (he/him)
I am re-sharing since I don't get the feeling anyone noticed this pearl of wisdom (not by me). People I know who frequently "win" at pitches/proposals are following the Heilmeier formula: from simple communicating up to presenting concisely on project webpages to full on proposals.
I have an abbreviated version of the Heilmeier Catechism written on a post it note on my computer (What, Who, What do w/it, Impact) and didn't know it was part of a formal thing. If you want to know the best way frame any pitch, this is how. 100% an IYKYK situation.
www.darpa.mil/about/heilme...
www.darpa.mil/about/heilme...
www.darpa.mil
March 26, 2025 at 1:56 PM
I am re-sharing since I don't get the feeling anyone noticed this pearl of wisdom (not by me). People I know who frequently "win" at pitches/proposals are following the Heilmeier formula: from simple communicating up to presenting concisely on project webpages to full on proposals.
@DGMS Annual MS conference #TeamMassSpec #Göttingen
March 4, 2025 at 4:03 PM
@DGMS Annual MS conference #TeamMassSpec #Göttingen
Reposted by Maithy (he/him)
Reminder that Europepmc.org exists. In case anyone should need it for any reason.
Europe PMCHome - Europe PMC
Europe PMC is an archive of life sciences journal literature.
Europepmc.org
March 2, 2025 at 4:08 AM
Reminder that Europepmc.org exists. In case anyone should need it for any reason.
#TeamMassspec Astral peeps, would love to know your experience with the data size, processing softwares and the time it takes. Thanks for the help!
February 13, 2025 at 6:07 AM
#TeamMassspec Astral peeps, would love to know your experience with the data size, processing softwares and the time it takes. Thanks for the help!
Reposted by Maithy (he/him)
🦷 Enamel proteins identify a female Byzantine ascetic - challenging assumptions that extreme religious self-punishment was just for men.
In harsh, arid environments where DNA doesn't survive, proteins in tooth enamel can still reveal biological sex.
www.sciencedirect.com/science/arti...
In harsh, arid environments where DNA doesn't survive, proteins in tooth enamel can still reveal biological sex.
www.sciencedirect.com/science/arti...
February 9, 2025 at 6:46 AM
🦷 Enamel proteins identify a female Byzantine ascetic - challenging assumptions that extreme religious self-punishment was just for men.
In harsh, arid environments where DNA doesn't survive, proteins in tooth enamel can still reveal biological sex.
www.sciencedirect.com/science/arti...
In harsh, arid environments where DNA doesn't survive, proteins in tooth enamel can still reveal biological sex.
www.sciencedirect.com/science/arti...
Reposted by Maithy (he/him)
Identifying receptor kinase substrates using an 8,000 peptide kinase client library enriched for conserved phosphorylation sites #MCP #MassSpec www.mcponline.org/article/S153...
Identifying receptor kinase substrates using an 8,000 peptide kinase client library enriched for conserved phosphorylation sites
In eukaryotic organisms, protein kinases regulate diverse protein activities and signaling
pathways through phosphorylation of specific protein substrates. Isolating and characterizing
kinase substrat...
www.mcponline.org
February 8, 2025 at 8:25 AM
Identifying receptor kinase substrates using an 8,000 peptide kinase client library enriched for conserved phosphorylation sites #MCP #MassSpec www.mcponline.org/article/S153...
Reposted by Maithy (he/him)
Titrating biotinylated probe and streptavidin conc to find the sweat spot is the key step in high throughput chemoproteomics workflow.. Especially balancing the target(s) specificity and yield.. Liked the heatmap depicting intensity of specific and nonspecific proteins from the pulldown..
January 28, 2025 at 8:50 PM
Titrating biotinylated probe and streptavidin conc to find the sweat spot is the key step in high throughput chemoproteomics workflow.. Especially balancing the target(s) specificity and yield.. Liked the heatmap depicting intensity of specific and nonspecific proteins from the pulldown..
Reposted by Maithy (he/him)
PathwayPilot: A User-Friendly Tool for Visualizing and Navigating Metabolic Pathways #MCP www.mcponline.org/article/S153...
PathwayPilot: A User-Friendly Tool for Visualizing and Navigating Metabolic Pathways
Metaproteomics, the study of collective proteomes in environmental communities, plays
a crucial role in understanding microbial functionalities affecting ecosystems and
human health. Pathway analysis ...
www.mcponline.org
January 28, 2025 at 9:34 AM
PathwayPilot: A User-Friendly Tool for Visualizing and Navigating Metabolic Pathways #MCP www.mcponline.org/article/S153...
Reposted by Maithy (he/him)
Development, optimization and validation of a highly sensitive and selective method for the determination of PFAS in animal-based food #Chemosphere #MassSpec www.sciencedirect.com/science/arti...
Development, optimization and validation of a highly sensitive and selective method for the determination of PFAS in animal-based food
Perfluorocarboxylic acids and perfluorosulfonic acids accumulate in food webs, thus posing a serious threat to food safety. The European Food Safety A…
www.sciencedirect.com
January 26, 2025 at 10:41 AM
Development, optimization and validation of a highly sensitive and selective method for the determination of PFAS in animal-based food #Chemosphere #MassSpec www.sciencedirect.com/science/arti...
Reposted by Maithy (he/him)
A universal spectrum annotator for complex peptidoforms in mass spectrometry-based proteomics www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
January 26, 2025 at 10:40 AM
A universal spectrum annotator for complex peptidoforms in mass spectrometry-based proteomics www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
I am trying to curate available CO-IP MS data for a protein and am appalled and saddened by the number of publications without MS raw/search data. I did not think this would be the case! #TeamMassSpec
January 22, 2025 at 8:22 AM
I am trying to curate available CO-IP MS data for a protein and am appalled and saddened by the number of publications without MS raw/search data. I did not think this would be the case! #TeamMassSpec
Reposted by Maithy (he/him)
I took biochem in 2001, and for nearly 20 years read amino acid sequences daily… and I never knew Dayhoff named them or even the logic behind things like Q until last Friday (h/t Mike Janech). Also, this is another big Dayhoff moment for me. She was incredible!
#proteomics #bioinformatics
#proteomics #bioinformatics
Dr. Margaret Oakley Dayhoff
biology.arizona.edu
November 24, 2024 at 12:39 PM
I took biochem in 2001, and for nearly 20 years read amino acid sequences daily… and I never knew Dayhoff named them or even the logic behind things like Q until last Friday (h/t Mike Janech). Also, this is another big Dayhoff moment for me. She was incredible!
#proteomics #bioinformatics
#proteomics #bioinformatics
#TeamMassSpec how do you organize your MS raw file storage? Would love to hear your suggestions!
How do you store your Mass Spec raw files?
1️⃣ <a href="https://poll.blue/p/noHzLq/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">According to the instrument and month/year
2️⃣ <a href="https://poll.blue/p/noHzLq/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on project/date/sample
3️⃣ <a href="https://poll.blue/p/noHzLq/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on the user and let them organize
4️⃣ <a href="https://poll.blue/p/noHzLq/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Other
📊 Show results
1️⃣ <a href="https://poll.blue/p/noHzLq/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">According to the instrument and month/year
2️⃣ <a href="https://poll.blue/p/noHzLq/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on project/date/sample
3️⃣ <a href="https://poll.blue/p/noHzLq/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on the user and let them organize
4️⃣ <a href="https://poll.blue/p/noHzLq/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Other
📊 Show results
November 17, 2024 at 3:20 PM
#TeamMassSpec how do you organize your MS raw file storage? Would love to hear your suggestions!
How do you store your Mass Spec raw files?
1️⃣ <a href="https://poll.blue/p/noHzLq/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">According to the instrument and month/year
2️⃣ <a href="https://poll.blue/p/noHzLq/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on project/date/sample
3️⃣ <a href="https://poll.blue/p/noHzLq/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on the user and let them organize
4️⃣ <a href="https://poll.blue/p/noHzLq/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Other
📊 Show results
1️⃣ <a href="https://poll.blue/p/noHzLq/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">According to the instrument and month/year
2️⃣ <a href="https://poll.blue/p/noHzLq/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on project/date/sample
3️⃣ <a href="https://poll.blue/p/noHzLq/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on the user and let them organize
4️⃣ <a href="https://poll.blue/p/noHzLq/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Other
📊 Show results
November 17, 2024 at 3:18 PM
How do you store your Mass Spec raw files?
1️⃣ <a href="https://poll.blue/p/noHzLq/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">According to the instrument and month/year
2️⃣ <a href="https://poll.blue/p/noHzLq/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on project/date/sample
3️⃣ <a href="https://poll.blue/p/noHzLq/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on the user and let them organize
4️⃣ <a href="https://poll.blue/p/noHzLq/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Other
📊 Show results
1️⃣ <a href="https://poll.blue/p/noHzLq/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">According to the instrument and month/year
2️⃣ <a href="https://poll.blue/p/noHzLq/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on project/date/sample
3️⃣ <a href="https://poll.blue/p/noHzLq/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Based on the user and let them organize
4️⃣ <a href="https://poll.blue/p/noHzLq/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Other
📊 Show results