Morten Kjos
@mkjos.bsky.social
Molecular microbiology. Bacterial cell biology. Infection biology. Bacteriocins. Antibiotics. AMR. Associate professor at Norwegian University of Life Sciences.
Reposted by Morten Kjos
Really cool paper from @vincentdebakker.bsky.social @jonbakerlab.bsky.social now published @natcomms.nature.com #MicroSky www.nature.com/articles/s41...
Multi-omics profiling reveals atypical sugar utilization and a key membrane composition regulator in Streptococcus pneumoniae - Nature Communications
The pathogen Streptococcus pneumoniae can adapt to diverse microenvironments in the human body. Here, De Bakker et al. study these adaptation responses, showing unusual sugar utilization and identifyi...
www.nature.com
November 25, 2025 at 1:44 PM
Really cool paper from @vincentdebakker.bsky.social @jonbakerlab.bsky.social now published @natcomms.nature.com #MicroSky www.nature.com/articles/s41...
Reposted by Morten Kjos
Happy to finally show our story of the connection between nucleoid conformation, transcription & predation in our favorite predator Bdellovibrio bacteriovorus. 🧵 1/n
📝New preprint! #MicroSky
🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.
🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.
www.biorxiv.org/content/10.1...
🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.
🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.
www.biorxiv.org/content/10.1...
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle
The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...
www.biorxiv.org
September 26, 2025 at 9:09 AM
Happy to finally show our story of the connection between nucleoid conformation, transcription & predation in our favorite predator Bdellovibrio bacteriovorus. 🧵 1/n
Reposted by Morten Kjos
📝New preprint! #MicroSky
🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.
🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.
www.biorxiv.org/content/10.1...
🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.
🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.
www.biorxiv.org/content/10.1...
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle
The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...
www.biorxiv.org
September 25, 2025 at 7:12 AM
📝New preprint! #MicroSky
🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.
🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.
www.biorxiv.org/content/10.1...
🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.
🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.
www.biorxiv.org/content/10.1...
Reposted by Morten Kjos
Cool work by @mkjos.bsky.social Daniel Straume showing that the competence-induced peptidoglycan hydrolase LytF promotes pilus extrusion, thereby enhancing the efficiency of DNA uptake in S, sanguinis. Is this also a major function of the pneumococcal CbpD fratricide?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
LytF contributes to pilus extrusion during natural competence in Streptococcus sanguinis SK36.
Streptococci may enter a physiological state called competence, during which they express a specific set of genes required for exogenous DNA uptake and its subsequent integration into the genome throu...
www.biorxiv.org
September 8, 2025 at 7:24 AM
Cool work by @mkjos.bsky.social Daniel Straume showing that the competence-induced peptidoglycan hydrolase LytF promotes pilus extrusion, thereby enhancing the efficiency of DNA uptake in S, sanguinis. Is this also a major function of the pneumococcal CbpD fratricide?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Morten Kjos
OUT NOW: Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice
#microsky 🧪
www.nature.com/articles/s41...
#microsky 🧪
www.nature.com/articles/s41...
Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice - Nature Microbiology
InducTn-seq, a method for inducible mutagenesis followed by transposon insertion site sequencing, enables temporal control of transposition to bypass population bottlenecks and enable the quantificati...
www.nature.com
March 27, 2025 at 4:35 PM
OUT NOW: Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice
#microsky 🧪
www.nature.com/articles/s41...
#microsky 🧪
www.nature.com/articles/s41...
Reposted by Morten Kjos
Check out the new paper by my fantastic Lab neighbour @tunglejic.bsky.social and superstar postdoc @tommclean.bsky.social about long-range gene silencing by the CTPase KorB. Congrats to the whole Team!
OUT NOW: KorB is a DNA clamp which slides along DNA to mediate long-range gene silencing upon interaction with the clamp-locking KorA protein
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology
Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...
www.nature.com
January 23, 2025 at 7:15 PM
Check out the new paper by my fantastic Lab neighbour @tunglejic.bsky.social and superstar postdoc @tommclean.bsky.social about long-range gene silencing by the CTPase KorB. Congrats to the whole Team!
Reposted by Morten Kjos
Confirmed speakers for the next Great Wall Symposium is coming along! thegreatwall-symposium.org/program/
Abstracts will open next week 15th so start thinking!
September 15-17th, Catania, Sicily
Its a Microbiological opportunity you cant refuse!
Abstracts will open next week 15th so start thinking!
September 15-17th, Catania, Sicily
Its a Microbiological opportunity you cant refuse!
January 10, 2025 at 9:44 AM
Confirmed speakers for the next Great Wall Symposium is coming along! thegreatwall-symposium.org/program/
Abstracts will open next week 15th so start thinking!
September 15-17th, Catania, Sicily
Its a Microbiological opportunity you cant refuse!
Abstracts will open next week 15th so start thinking!
September 15-17th, Catania, Sicily
Its a Microbiological opportunity you cant refuse!
Reposted by Morten Kjos
Very interesting study showing that the large bacterial bottlenecks observed during pneumococcal pneumonia are caused by the Blp bacteriocins and that this interspecies killing liberates pneumolysin triggering inflammation for optimal bacterial replication in the lung. www.nature.com/articles/s42...
Pneumococcal pneumonia is driven by increased bacterial turnover due to bacteriocin-mediated intra-strain competition - Communications Biology
Profiling of pneumococcal population structure during infection reveals an unappreciated role of bacteriocins in driving the development of pneumonia by facilitating the release of inflammatory mediat...
www.nature.com
December 6, 2024 at 12:19 PM
Very interesting study showing that the large bacterial bottlenecks observed during pneumococcal pneumonia are caused by the Blp bacteriocins and that this interspecies killing liberates pneumolysin triggering inflammation for optimal bacterial replication in the lung. www.nature.com/articles/s42...
Reposted by Morten Kjos
Really proud of our new paper, my first as last author. We explored the importance of homologous recombination genes in transformation and genotoxic stress tolerance during competence. Give it a read/like! 🙂
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Competence induction of homologous recombination genes protects pneumococcal cells from genotoxic stress | mBio
Homologous recombination (HR) is a mechanism of DNA strand exchange important for
both the maintenance and plasticity of bacterial genomes. Bacterial HR is driven by
the recombinase RecA along with ma...
journals.asm.org
November 29, 2024 at 3:32 PM
Really proud of our new paper, my first as last author. We explored the importance of homologous recombination genes in transformation and genotoxic stress tolerance during competence. Give it a read/like! 🙂
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Morten Kjos
Great review by @pinholab.bsky.social and Simon Foster on the current knowledge regarding growth, elongation and division of Staphylococcus aureus www.annualreviews.org/content/jour...
November 21, 2024 at 5:42 PM
Great review by @pinholab.bsky.social and Simon Foster on the current knowledge regarding growth, elongation and division of Staphylococcus aureus www.annualreviews.org/content/jour...
Reposted by Morten Kjos
Straight from the cellars of NIPH, we have a paper out on pneumococcal lineage (GPSC) dynamics in response to childhood vaccination. Resuscitating freeze-dried cultures was a substantial effort, but worked surprisingly well. Have a look if interested! genomemedicine.biomedcentral.com/articles/10....
A genome-based survey of invasive pneumococci in Norway over four decades reveals lineage-specific responses to vaccination - Genome Medicine
Background Streptococcus pneumoniae is a major cause of mortality globally. The introduction of pneumococcal conjugate vaccines (PCVs) has reduced the incidence of the targeted serotypes significantly...
genomemedicine.biomedcentral.com
October 26, 2024 at 3:14 PM
Straight from the cellars of NIPH, we have a paper out on pneumococcal lineage (GPSC) dynamics in response to childhood vaccination. Resuscitating freeze-dried cultures was a substantial effort, but worked surprisingly well. Have a look if interested! genomemedicine.biomedcentral.com/articles/10....
Reposted by Morten Kjos
o hello new followers!
I'm Renske, and our very fresh lab in Groningen works on the bacterial predator Bdellovibrio bacteriovorus. We're interested in what tools Bdello uses to eat their prey, the knife & fork, tongue and saliva, so to say.
I occasionally post pictures of my knitting work too
I'm Renske, and our very fresh lab in Groningen works on the bacterial predator Bdellovibrio bacteriovorus. We're interested in what tools Bdello uses to eat their prey, the knife & fork, tongue and saliva, so to say.
I occasionally post pictures of my knitting work too
November 7, 2024 at 12:40 PM
o hello new followers!
I'm Renske, and our very fresh lab in Groningen works on the bacterial predator Bdellovibrio bacteriovorus. We're interested in what tools Bdello uses to eat their prey, the knife & fork, tongue and saliva, so to say.
I occasionally post pictures of my knitting work too
I'm Renske, and our very fresh lab in Groningen works on the bacterial predator Bdellovibrio bacteriovorus. We're interested in what tools Bdello uses to eat their prey, the knife & fork, tongue and saliva, so to say.
I occasionally post pictures of my knitting work too
Reposted by Morten Kjos
Great collaboration with @mortenkj.bsky.social to figure out which genes are required for Staphylococcus aureus to live in milk. Important to know due to Staphs ability to cause bovine mastitis and food poisoning. #MicroSky www.biorxiv.org/content/10.1...
Genome-wide analysis of fitness determinants of Staphylococcus aureus during growth in milk
Staphylococcus aureus is a major concern in the dairy industry due to its significance as a pathogen causing bovine mastitis as well as a source of food poisoning. The nutrient-rich milk environment s...
www.biorxiv.org
November 2, 2024 at 9:56 AM
Great collaboration with @mortenkj.bsky.social to figure out which genes are required for Staphylococcus aureus to live in milk. Important to know due to Staphs ability to cause bovine mastitis and food poisoning. #MicroSky www.biorxiv.org/content/10.1...
Reposted by Morten Kjos
Genome-wide CRISPRi screens for high-throughput fitness quantification and identification of determinants for dalbavancin susceptibility in Staphylococcus aureus
#mSystemsJ from @mortenkj.bsky.social and @jwveening.bsky.social eening
journals.asm.org/doi/10.1128/...
#mSystemsJ from @mortenkj.bsky.social and @jwveening.bsky.social eening
journals.asm.org/doi/10.1128/...
June 6, 2024 at 11:42 AM
Genome-wide CRISPRi screens for high-throughput fitness quantification and identification of determinants for dalbavancin susceptibility in Staphylococcus aureus
#mSystemsJ from @mortenkj.bsky.social and @jwveening.bsky.social eening
journals.asm.org/doi/10.1128/...
#mSystemsJ from @mortenkj.bsky.social and @jwveening.bsky.social eening
journals.asm.org/doi/10.1128/...