Mihovil Joja
@mihojoja.bsky.social
MD, PhD student in Mahesh Desai lab in Luxembourg. Studying mucin-degrading bacteria in IBD.
Reposted by Mihovil Joja
Akkermansia muciniphila has potential as a next-generation #probiotic, but can it claim a niche and persist in a pre-existing, complex microbial community (in vitro)? 🦠🔍
#microsky
#microbiomesky
#glycotime
link.springer.com/article/10.1...
#microsky
#microbiomesky
#glycotime
link.springer.com/article/10.1...
Probiotic Engraftment of Akkermansia muciniphila in an In Vitro Synthetic Microbial Community - Microbial Ecology
Akkermansia muciniphila is a specialist mucin glycan-degrader that is common in the human gut. A. muciniphila is associated with host health and therefore proposed as a next-generation probiotic. Howe...
link.springer.com
November 20, 2025 at 11:27 AM
Akkermansia muciniphila has potential as a next-generation #probiotic, but can it claim a niche and persist in a pre-existing, complex microbial community (in vitro)? 🦠🔍
#microsky
#microbiomesky
#glycotime
link.springer.com/article/10.1...
#microsky
#microbiomesky
#glycotime
link.springer.com/article/10.1...
Reposted by Mihovil Joja
⏰ Timing is everything 🦠 as you will appreciate listening in!
🤓Keep abreast of the literature as @kknoop.bsky.social gives a round up summary of the review that inspired the latest @mucosalimmunol.bsky.social cover and guess the disease/pathogen with @ashu-mangalam.bsky.social ‘s Med Mystery 🎧
🤓Keep abreast of the literature as @kknoop.bsky.social gives a round up summary of the review that inspired the latest @mucosalimmunol.bsky.social cover and guess the disease/pathogen with @ashu-mangalam.bsky.social ‘s Med Mystery 🎧
Time for the August episode of the #MucosalMonday MI Podcast featuring a discussion with @michael-silverman.bsky.social, @marionbrunck.bsky.social, and Agnes Garcias Lopez; Medical mystery from @ashu-mangalam.bsky.social; and MI research with @kknoop.bsky.social open.spotify.com/show/0Q4Ve1x...
Timing Exposure to Microbes
open.spotify.com
August 26, 2025 at 11:32 AM
⏰ Timing is everything 🦠 as you will appreciate listening in!
🤓Keep abreast of the literature as @kknoop.bsky.social gives a round up summary of the review that inspired the latest @mucosalimmunol.bsky.social cover and guess the disease/pathogen with @ashu-mangalam.bsky.social ‘s Med Mystery 🎧
🤓Keep abreast of the literature as @kknoop.bsky.social gives a round up summary of the review that inspired the latest @mucosalimmunol.bsky.social cover and guess the disease/pathogen with @ashu-mangalam.bsky.social ‘s Med Mystery 🎧
Reposted by Mihovil Joja
Our August issue is online now www.mucosalimmunology.org/current, featuring microbes that are “living on the edge” from Mahesh Desai www.mucosalimmunology.org/article/S193...
August 8, 2025 at 2:06 PM
Our August issue is online now www.mucosalimmunology.org/current, featuring microbes that are “living on the edge” from Mahesh Desai www.mucosalimmunology.org/article/S193...
Reposted by Mihovil Joja
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
rdcu.be
July 16, 2025 at 9:20 PM
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Reposted by Mihovil Joja
Ever wondered why proton pump inhibitors raise the risk of C. diff infections? Is it due to pH shifts or direct antibacterial effects on the gut microbiome? We think it’s the pH. 🧪💡 Dive into Julia & Patrick’s new paper for the full story! 📖👇 #Microbiome #PPI
doi.org/10.1080/1949...
doi.org/10.1080/1949...
Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model
Clostridioides difficile infections often occur after antibiotic use, but they have also been linked to proton-pump inhibitor (PPI) therapy. The underlying mechanism – whether infection risk is due...
doi.org
June 17, 2025 at 12:32 PM
Ever wondered why proton pump inhibitors raise the risk of C. diff infections? Is it due to pH shifts or direct antibacterial effects on the gut microbiome? We think it’s the pH. 🧪💡 Dive into Julia & Patrick’s new paper for the full story! 📖👇 #Microbiome #PPI
doi.org/10.1080/1949...
doi.org/10.1080/1949...
Reposted by Mihovil Joja
Reposted by Mihovil Joja
To celebrate this (urp 🤢) exciting new journal series, we made a mini game!
Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder."
Share your high score with the hashtag #ResearchIntegrity
pagoba.shinyapps.io/publi_guess/
FUN!! 🤮 6/n
Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder."
Share your high score with the hashtag #ResearchIntegrity
pagoba.shinyapps.io/publi_guess/
FUN!! 🤮 6/n
June 10, 2025 at 5:49 AM
To celebrate this (urp 🤢) exciting new journal series, we made a mini game!
Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder."
Share your high score with the hashtag #ResearchIntegrity
pagoba.shinyapps.io/publi_guess/
FUN!! 🤮 6/n
Can YOU guess which journals are Discover, MDPI, or both? No cheating! There's even the challenge mode "APC Ladder."
Share your high score with the hashtag #ResearchIntegrity
pagoba.shinyapps.io/publi_guess/
FUN!! 🤮 6/n
Reposted by Mihovil Joja
Have you discovered the Night Science Podcast yet?
@nightsciencepod.bsky.social
@nightsciencepod.bsky.social
May 15, 2025 at 1:53 PM
Have you discovered the Night Science Podcast yet?
@nightsciencepod.bsky.social
@nightsciencepod.bsky.social
Reposted by Mihovil Joja
Very happy that HiBC is out: rdcu.be/ekSCO 🔥 @natcomms.nature.com Excellent team spirit, and, as always, great driving factor by @tcahitch.bsky.social ⭐⭐⭐⭐ We hope that these bacterial isolates from the human gut will facilitate many studies by others... 😀
HiBC: a publicly available collection of bacterial strains isolated from the human gut
Nature Communications - Here, the authors present and characterise a collection of human gut bacteria including novel taxa associated with health conditions and a large diversity of plasmids. All...
rdcu.be
May 6, 2025 at 1:14 PM
Very happy that HiBC is out: rdcu.be/ekSCO 🔥 @natcomms.nature.com Excellent team spirit, and, as always, great driving factor by @tcahitch.bsky.social ⭐⭐⭐⭐ We hope that these bacterial isolates from the human gut will facilitate many studies by others... 😀
Reposted by Mihovil Joja
Here are our ideas on developing tools and technologies for anaerobic bacteria! We hope you enjoy the read as much as we enjoyed brainstorming on the topic...
Here we share thoughts on next-gen cultivation: rdcu.be/ejPSb. Hope it helps 😄 Was fun to write with great colleagues @lisamaierlab.bsky.social @jselkrig.bsky.social @baerboletta.bsky.social @typaslab.bsky.social @mmmicrobiomelab.bsky.social @leibniz-dsmz.bsky.social @westermannlab.bsky.social
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research
Nature Biotechnology - Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
rdcu.be
April 30, 2025 at 6:53 AM
Here are our ideas on developing tools and technologies for anaerobic bacteria! We hope you enjoy the read as much as we enjoyed brainstorming on the topic...
Reposted by Mihovil Joja
Our "Guide to communicating microbiomes in the media", created in collaboration @lindsaybroadbent.bsky.social aims to help navigate the complexities of communicating microbiome research. Click the link in our bio to read and download the guide.
April 11, 2025 at 10:05 AM
Our "Guide to communicating microbiomes in the media", created in collaboration @lindsaybroadbent.bsky.social aims to help navigate the complexities of communicating microbiome research. Click the link in our bio to read and download the guide.
Reposted by Mihovil Joja
Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology
Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.
www.nature.com
April 4, 2025 at 2:09 AM
Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Reposted by Mihovil Joja
My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the #ETEC SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific #mucus degradation 🤯. Check it out: www.biorxiv.org/content/10.1...
Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin
Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence fact...
www.biorxiv.org
March 22, 2025 at 12:48 AM
My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the #ETEC SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific #mucus degradation 🤯. Check it out: www.biorxiv.org/content/10.1...
Reposted by Mihovil Joja
A very helpful read on tackling procrastination @naturebiotech.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology
Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write
www.nature.com
March 19, 2025 at 1:41 PM
A very helpful read on tackling procrastination @naturebiotech.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mihovil Joja
A must-read for any microbiome researcher 🦠📐and a new addition to our #bestpractices series
Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social
www.nature.com/articles/s41...
Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social
www.nature.com/articles/s41...
Planning and describing a microbiome data analysis - Nature Microbiology
We provide guidance on the planning, execution and description of statistical analyses in microbiome studies.
www.nature.com
February 21, 2025 at 2:48 PM
A must-read for any microbiome researcher 🦠📐and a new addition to our #bestpractices series
Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social
www.nature.com/articles/s41...
Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social
www.nature.com/articles/s41...
Reposted by Mihovil Joja
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
February 7, 2025 at 2:57 PM
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
Reposted by Mihovil Joja
OUT NOW: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
@harriswang.bsky.social & co
www.nature.com/articles/s41...
@harriswang.bsky.social & co
www.nature.com/articles/s41...
SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology
Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.
www.nature.com
February 3, 2025 at 6:23 PM
OUT NOW: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
@harriswang.bsky.social & co
www.nature.com/articles/s41...
@harriswang.bsky.social & co
www.nature.com/articles/s41...
Reposted by Mihovil Joja
OUT NOW: Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion
@lucyicm.bsky.social @cassiebakshani.bsky.social
#microsky 🧪
www.nature.com/articles/s41...
@lucyicm.bsky.social @cassiebakshani.bsky.social
#microsky 🧪
www.nature.com/articles/s41...
Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology
Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, wh...
www.nature.com
January 31, 2025 at 3:58 PM
OUT NOW: Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion
@lucyicm.bsky.social @cassiebakshani.bsky.social
#microsky 🧪
www.nature.com/articles/s41...
@lucyicm.bsky.social @cassiebakshani.bsky.social
#microsky 🧪
www.nature.com/articles/s41...
Reposted by Mihovil Joja
Dear mucosal immunologists!
Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.
Register and see you this July in Aachen! 👇🏼
emig2025.de
@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.
Register and see you this July in Aachen! 👇🏼
emig2025.de
@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
January 25, 2025 at 2:25 PM
Dear mucosal immunologists!
Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.
Register and see you this July in Aachen! 👇🏼
emig2025.de
@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open.
Register and see you this July in Aachen! 👇🏼
emig2025.de
@petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
Reposted by Mihovil Joja
Ten species comprise half of the bacteriology literature, leaving most species unstudied https://www.biorxiv.org/content/10.1101/2025.01.04.631297v1
January 5, 2025 at 8:17 AM
Ten species comprise half of the bacteriology literature, leaving most species unstudied https://www.biorxiv.org/content/10.1101/2025.01.04.631297v1
Reposted by Mihovil Joja
OUT NOW: Metagenomic immunoglobulin sequencing (MIg-seq) reveals IgA coating of microbial strains in the healthy human gut
by Justin Sonnenburg, Matt Olm, Sean Spencer & co
#microsky
www.nature.com/articles/s41...
by Justin Sonnenburg, Matt Olm, Sean Spencer & co
#microsky
www.nature.com/articles/s41...
Metagenomic immunoglobulin sequencing reveals IgA coating of microbial strains in the healthy human gut - Nature Microbiology
Metagenomic immunoglobulin sequencing (MIg-seq) uncovered patterns of IgA antibody binding of bacterial strains in the healthy human gut microbiome.
www.nature.com
January 2, 2025 at 5:38 PM
OUT NOW: Metagenomic immunoglobulin sequencing (MIg-seq) reveals IgA coating of microbial strains in the healthy human gut
by Justin Sonnenburg, Matt Olm, Sean Spencer & co
#microsky
www.nature.com/articles/s41...
by Justin Sonnenburg, Matt Olm, Sean Spencer & co
#microsky
www.nature.com/articles/s41...
Reposted by Mihovil Joja
Surgeons showed significantly greater manual dexterity compared with physicians, nurses, and non-clinical staff when assessed using a buzz wire game.
But had the highest rates of swearing
www.bmj.com/content/387/...
But had the highest rates of swearing
www.bmj.com/content/387/...
December 31, 2024 at 12:45 PM
Surgeons showed significantly greater manual dexterity compared with physicians, nurses, and non-clinical staff when assessed using a buzz wire game.
But had the highest rates of swearing
www.bmj.com/content/387/...
But had the highest rates of swearing
www.bmj.com/content/387/...
Reposted by Mihovil Joja
We are happy to announce that the MaAslin3 manuscript is now available on @biorxivpreprint! Check it out and feel free to post feedback on our forums!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
MaAsLin 3: Refining and extending generalized multivariable linear models for meta-omic association discovery
A key question in microbial community analysis is determining which microbial features are associated with community properties such as environmental or health phenotypes. This statistical task is imp...
www.biorxiv.org
December 17, 2024 at 6:10 PM
We are happy to announce that the MaAslin3 manuscript is now available on @biorxivpreprint! Check it out and feel free to post feedback on our forums!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mihovil Joja
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Mihovil Joja
Everyone talks about "strains", but what are they? Within the lab, we often come back to the review "Diversity within species: interpreting strains in microbiomes" by Thea Van Rossum (2020) when discussing at which phylogenetic resolution we do see different signals
www.nature.com/artic...
www.nature.com/artic...
Diversity within species: interpreting strains in microbiomes
Nature Reviews Microbiology - Large-scale metagenomic analyses are vastly increasing the rate of discovery of variation within species but they are also leading to scientific and semantic...
www.nature.com
December 7, 2024 at 2:00 PM
Everyone talks about "strains", but what are they? Within the lab, we often come back to the review "Diversity within species: interpreting strains in microbiomes" by Thea Van Rossum (2020) when discussing at which phylogenetic resolution we do see different signals
www.nature.com/artic...
www.nature.com/artic...