Michael Ward
@michael-e-ward.bsky.social
Physician scientist studying the biology of neurodegenerative disorders.
ORCID ID: 0000-0002-5296-8051
ORCID ID: 0000-0002-5296-8051
Reposted by Michael Ward
👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
August 21, 2025 at 6:03 PM
👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes
Reposted by Michael Ward
Hasegawa-Ogawa, Okano et al. identify a dominant-negative TDP-43 isoform regulated by #ALS-linked #RNA-binding proteins. hnRNP K promotes its expression, while hnRNP A1 and FUS suppress it. rupress.org/jcb/article/...
#Disease #Neuroscience #ProteinHomeostasis #RNAbiology
#Disease #Neuroscience #ProteinHomeostasis #RNAbiology
August 8, 2025 at 4:00 PM
Hasegawa-Ogawa, Okano et al. identify a dominant-negative TDP-43 isoform regulated by #ALS-linked #RNA-binding proteins. hnRNP K promotes its expression, while hnRNP A1 and FUS suppress it. rupress.org/jcb/article/...
#Disease #Neuroscience #ProteinHomeostasis #RNAbiology
#Disease #Neuroscience #ProteinHomeostasis #RNAbiology
Reposted by Michael Ward
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
July 11, 2025 at 8:59 PM
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
Reposted by Michael Ward
Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes
https://go.nature.com/3Z6mJ1X
https://go.nature.com/3Z6mJ1X
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
go.nature.com
June 4, 2025 at 7:59 AM
Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes
https://go.nature.com/3Z6mJ1X
https://go.nature.com/3Z6mJ1X
Thanks for hosting me - so much fun to meet with everybody at Berkeley!
Fantastic MTx-Neuro seminar by Michael Ward @michael-e-ward.bsky.social, incredible science and full house! @mti-ucb.bsky.social
May 21, 2025 at 4:24 AM
Thanks for hosting me - so much fun to meet with everybody at Berkeley!
Reposted by Michael Ward
Despite some ups and downs at NIH, we do have an open position for a postbac and are considering candidates.
Our work is at the intersection of neuroscience and AI, and we aim to understand how the brain's densely connected recurrent networks operate. 🧪
Our work is at the intersection of neuroscience and AI, and we aim to understand how the brain's densely connected recurrent networks operate. 🧪
May 15, 2025 at 9:02 PM
Despite some ups and downs at NIH, we do have an open position for a postbac and are considering candidates.
Our work is at the intersection of neuroscience and AI, and we aim to understand how the brain's densely connected recurrent networks operate. 🧪
Our work is at the intersection of neuroscience and AI, and we aim to understand how the brain's densely connected recurrent networks operate. 🧪
Reposted by Michael Ward
Why do lower-resolution images sometimes yield better results in deep learning for bioimaging analyses? 🤔📉
Mariana Ferreira's new preprint on #ReScale4DL explores this paradox and introduces optimal resolution design! @gomez-mariscal.bsky.social brainchild🧑🔬✨
Check: www.biorxiv.org/content/10.1...
Mariana Ferreira's new preprint on #ReScale4DL explores this paradox and introduces optimal resolution design! @gomez-mariscal.bsky.social brainchild🧑🔬✨
Check: www.biorxiv.org/content/10.1...
April 10, 2025 at 4:46 PM
Why do lower-resolution images sometimes yield better results in deep learning for bioimaging analyses? 🤔📉
Mariana Ferreira's new preprint on #ReScale4DL explores this paradox and introduces optimal resolution design! @gomez-mariscal.bsky.social brainchild🧑🔬✨
Check: www.biorxiv.org/content/10.1...
Mariana Ferreira's new preprint on #ReScale4DL explores this paradox and introduces optimal resolution design! @gomez-mariscal.bsky.social brainchild🧑🔬✨
Check: www.biorxiv.org/content/10.1...
talkingpointsmemo.com/edblog/the-w...
Not nearly enough coverage of this possibility by traditional media.
Not nearly enough coverage of this possibility by traditional media.
The White House’s Next Orchestrated Budget Crisis
This is something I’m still trying to get my head around –...
talkingpointsmemo.com
May 5, 2025 at 11:11 AM
talkingpointsmemo.com/edblog/the-w...
Not nearly enough coverage of this possibility by traditional media.
Not nearly enough coverage of this possibility by traditional media.
Reposted by Michael Ward
Explore #Neurodegeneration and Neural-Immune Interactions, June 8-11! Gain insights from experts like @dulaclab.bsky.social and @weissmanlab.bsky.social. Register now to save $200. Postdocs, enjoy an extra $275 off: hubs.la/Q035NHGV0
#KSNeuroImmune25 #KSNeuroDegen25 @michael-e-ward.bsky.social
#KSNeuroImmune25 #KSNeuroDegen25 @michael-e-ward.bsky.social
April 30, 2025 at 10:00 PM
Explore #Neurodegeneration and Neural-Immune Interactions, June 8-11! Gain insights from experts like @dulaclab.bsky.social and @weissmanlab.bsky.social. Register now to save $200. Postdocs, enjoy an extra $275 off: hubs.la/Q035NHGV0
#KSNeuroImmune25 #KSNeuroDegen25 @michael-e-ward.bsky.social
#KSNeuroImmune25 #KSNeuroDegen25 @michael-e-ward.bsky.social
Reposted by Michael Ward
LRP10 promotes trafficking of progranulin and prosaposin to lysosomes https://www.biorxiv.org/content/10.1101/2025.05.02.651888v1
May 3, 2025 at 2:30 PM
LRP10 promotes trafficking of progranulin and prosaposin to lysosomes https://www.biorxiv.org/content/10.1101/2025.05.02.651888v1
Reposted by Michael Ward
Important!! 🚨
“Using the rescission process, which requires only a simple majority in the Senate, the Republican majorities can vote to return the unspent funds. That will lop billions off the NIH budget.” 1/2
“Using the rescission process, which requires only a simple majority in the Senate, the Republican majorities can vote to return the unspent funds. That will lop billions off the NIH budget.” 1/2
New at Can We Still Govern: An anonymous NIH employee maps out the GOP budget gameplan to permanently gut our most important science agency.
Impoundment, delay and red tape will create artificial "savings" that become the new benchmark for NIH budgets.
donmoynihan.substack.com/p/the-nih-bu...
Impoundment, delay and red tape will create artificial "savings" that become the new benchmark for NIH budgets.
donmoynihan.substack.com/p/the-nih-bu...
The NIH budget is on a fast track to disaster
An NIH insider explains what Republicans are likely to do next, and what we can do
donmoynihan.substack.com
April 28, 2025 at 1:30 PM
Important!! 🚨
“Using the rescission process, which requires only a simple majority in the Senate, the Republican majorities can vote to return the unspent funds. That will lop billions off the NIH budget.” 1/2
“Using the rescission process, which requires only a simple majority in the Senate, the Republican majorities can vote to return the unspent funds. That will lop billions off the NIH budget.” 1/2
Reposted by Michael Ward
New at Can We Still Govern: An anonymous NIH employee maps out the GOP budget gameplan to permanently gut our most important science agency.
Impoundment, delay and red tape will create artificial "savings" that become the new benchmark for NIH budgets.
donmoynihan.substack.com/p/the-nih-bu...
Impoundment, delay and red tape will create artificial "savings" that become the new benchmark for NIH budgets.
donmoynihan.substack.com/p/the-nih-bu...
The NIH budget is on a fast track to disaster
An NIH insider explains what Republicans are likely to do next, and what we can do
donmoynihan.substack.com
April 28, 2025 at 12:50 PM
New at Can We Still Govern: An anonymous NIH employee maps out the GOP budget gameplan to permanently gut our most important science agency.
Impoundment, delay and red tape will create artificial "savings" that become the new benchmark for NIH budgets.
donmoynihan.substack.com/p/the-nih-bu...
Impoundment, delay and red tape will create artificial "savings" that become the new benchmark for NIH budgets.
donmoynihan.substack.com/p/the-nih-bu...
Reposted by Michael Ward
April 23, 2025 at 1:03 AM
Amazing team science effort, led by Marius Wernig’s group, to develop a silencing-resistant transgene cassette that maintains expression following iPSC differentiation. This was major barrier for iPSC-based experiments. Thanks to CZI for funding the research!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation
While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...
www.biorxiv.org
April 16, 2025 at 6:13 PM
Amazing team science effort, led by Marius Wernig’s group, to develop a silencing-resistant transgene cassette that maintains expression following iPSC differentiation. This was major barrier for iPSC-based experiments. Thanks to CZI for funding the research!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Michael Ward
Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation
While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...
www.biorxiv.org
April 15, 2025 at 3:37 PM
Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Reposted by Michael Ward
Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to [email protected]. Please share and repost!
April 13, 2025 at 4:37 PM
Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to [email protected]. Please share and repost!
Reposted by Michael Ward
I’ve always liked Tom Pollard’s framing of biological research: genetics gives you the parts list, biochemistry the functions/reactions and rates, cell biology the localisations and dynamics, and structural biology the fine detail. Put it all together and you get a mechanistic picture. 🤩
April 3, 2025 at 4:51 PM
I’ve always liked Tom Pollard’s framing of biological research: genetics gives you the parts list, biochemistry the functions/reactions and rates, cell biology the localisations and dynamics, and structural biology the fine detail. Put it all together and you get a mechanistic picture. 🤩
Reposted by Michael Ward
Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...
Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures
TDP-43 pathology characterizes neurodegenerative diseases. Scialò et al. use in vitro-generated
and patient-derived TDP-43 aggregates as seeds to show that seed-induced TDP-43 cytoplasmic
aggregation ...
www.cell.com
March 28, 2025 at 3:15 PM
Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...
Reposted by Michael Ward
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes!
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications
Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...
www.nature.com
March 23, 2025 at 9:25 AM
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes!
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.
@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.
www.nature.com/articles/s41...
One day left to submit an abstract for short talk consideration at the upcoming Keystone Neurodegeneration meeting (Whistler, BC, June 8-11). We have an amazing set of speakers lined up already - please join us! For more info, see: vimeo.com/1068280559/9...
25Z4-Event Promo-V1
This is "25Z4-Event Promo-V1" by Keystone Symposia on Vimeo, the home for high quality videos and the people who love them.
vimeo.com
March 24, 2025 at 4:31 PM
One day left to submit an abstract for short talk consideration at the upcoming Keystone Neurodegeneration meeting (Whistler, BC, June 8-11). We have an amazing set of speakers lined up already - please join us! For more info, see: vimeo.com/1068280559/9...