Maxx Chatsko
@maxx.living.tech
Teaching scientists how to invest. Founder of Solt DB @living.tech , a biotech equities research firm and public benefit company. Long-suffering Pittsburgh Pirates fan.
All that harmful research like studying 2x yearly RNAi medicines that reduce cholesterol and lipids to prevent heart disease, or gene editing tools that mitigate painful attacks in hereditary angioedema, or bispecific antibodies that crush granny's cancer into remission.
🚨 BREAKING: It’s being reported that the CDC in the US is ending its experiments on monkeys! Approximately 200 macaques currently used in harmful research will be affected; future research on primates will also be discontinued. 🐵 🙌🏼
November 25, 2025 at 5:32 AM
All that harmful research like studying 2x yearly RNAi medicines that reduce cholesterol and lipids to prevent heart disease, or gene editing tools that mitigate painful attacks in hereditary angioedema, or bispecific antibodies that crush granny's cancer into remission.
Reposted by Maxx Chatsko
Journalist challenge: Use “Machine Learning” when you mean machine learning and “LLM” when you mean LLM. Ditch “AI” as a catch-all term, it’s not useful for readers and it helps companies trying to confuse the public by obscuring the roles played by different technologies. 🧪
November 22, 2025 at 4:50 PM
Journalist challenge: Use “Machine Learning” when you mean machine learning and “LLM” when you mean LLM. Ditch “AI” as a catch-all term, it’s not useful for readers and it helps companies trying to confuse the public by obscuring the roles played by different technologies. 🧪
Reposted by Maxx Chatsko
It’s widely known (and, I think, pretty uncontroversial) that learning requires effort — specifically, if you don’t have to work at getting the knowledge, it won’t stick.
Even if an LLM could be trusted to give you correct information 100% of the time, it would be an inferior method of learning it.
Even if an LLM could be trusted to give you correct information 100% of the time, it would be an inferior method of learning it.
Relying on ChatGPT to teach you about a topic leaves you with shallower knowledge than Googling and reading about it, according to new research that compared what more than 10,000 people knew after using one method or the other.
Shared by @gizmodo.com: buff.ly/yAAHtHq
Shared by @gizmodo.com: buff.ly/yAAHtHq
November 21, 2025 at 12:49 PM
It’s widely known (and, I think, pretty uncontroversial) that learning requires effort — specifically, if you don’t have to work at getting the knowledge, it won’t stick.
Even if an LLM could be trusted to give you correct information 100% of the time, it would be an inferior method of learning it.
Even if an LLM could be trusted to give you correct information 100% of the time, it would be an inferior method of learning it.
Reposted by Maxx Chatsko
In a world in which people with too much power and influence desperately need to be told and to understand when they are wrong, we are suddenly all inescapably drowning in sycophancy machines.
November 21, 2025 at 3:53 AM
In a world in which people with too much power and influence desperately need to be told and to understand when they are wrong, we are suddenly all inescapably drowning in sycophancy machines.
The Cowboys win one stinking primetime game and it ripples across the fabric of reality
BREAKING: Bitcoin drops below $90,000 for the first time in seven months, erasing the cryptocurrency’s gains for 2025. Read more: bloom.bg/47LOHVn
📷️: Andrey Rudakov/Bloomberg
📷️: Andrey Rudakov/Bloomberg
November 18, 2025 at 5:02 AM
The Cowboys win one stinking primetime game and it ripples across the fabric of reality
One day investors are going to buy the wrong dip. I still have the memes from 2022 to prove it!
November 14, 2025 at 3:00 PM
One day investors are going to buy the wrong dip. I still have the memes from 2022 to prove it!
Reposted by Maxx Chatsko
Young adults are growing increasingly economically dislocated on.ft.com/48bAuRE | opinion
Young adults are growing increasingly economically dislocated
A disconnected class is taking shape, but is absent from the headline statistics
on.ft.com
November 14, 2025 at 5:07 AM
Young adults are growing increasingly economically dislocated on.ft.com/48bAuRE | opinion
Reposted by Maxx Chatsko
America’s nuclear comeback is fueled by $80 billion — but not a single new reactor is close to turning on
Billions Flow to US Nuclear Sector With Payoff Still Years Away
Washington’s $80 billion investment in nuclear reactors won’t yield carbon-free power anytime soon.
bloom.bg
November 12, 2025 at 1:00 PM
America’s nuclear comeback is fueled by $80 billion — but not a single new reactor is close to turning on
I like how CRISPR Therapeutics $CRSP reveals data for a gene editing candidate in 12 ppl and the media can't get enough, when an RNAi drug candidate (zodasiran) for the same target is objectively better on every measure & it's not mentioned in a single article.
This is how technological hype works.
This is how technological hype works.
November 9, 2025 at 1:28 AM
I like how CRISPR Therapeutics $CRSP reveals data for a gene editing candidate in 12 ppl and the media can't get enough, when an RNAi drug candidate (zodasiran) for the same target is objectively better on every measure & it's not mentioned in a single article.
This is how technological hype works.
This is how technological hype works.
"83% of companies in the S&P 500 beat earnings estimates"
Do earnings beat estimates, or do estimates miss earnings?
Do earnings beat estimates, or do estimates miss earnings?
November 7, 2025 at 2:21 AM
"83% of companies in the S&P 500 beat earnings estimates"
Do earnings beat estimates, or do estimates miss earnings?
Do earnings beat estimates, or do estimates miss earnings?
Reposted by Maxx Chatsko
Did not expect one of the best paragraphs I’d read about baseball would come from an Irish newspaper
www.irishexaminer.com/sport-column...
www.irishexaminer.com/sport-column...
November 2, 2025 at 2:22 PM
Did not expect one of the best paragraphs I’d read about baseball would come from an Irish newspaper
www.irishexaminer.com/sport-column...
www.irishexaminer.com/sport-column...
What are we doing as a nation right now?
"FDA official who resigned on Sunday was sued by a Canadian pharmaceutical company, which accused him of soliciting a bribe and tanking its stock with false statements as part of a revenge campaign against a former colleague."
🎁🔗
www.wsj.com/health/pharm...
"FDA official who resigned on Sunday was sued by a Canadian pharmaceutical company, which accused him of soliciting a bribe and tanking its stock with false statements as part of a revenge campaign against a former colleague."
🎁🔗
www.wsj.com/health/pharm...
FDA Official Steps Down, Sued By Drugmaker
George Tidmarsh, who resigned Sunday, is accused in a lawsuit of seeking a bribe and defaming a drug.
www.wsj.com
November 3, 2025 at 1:12 AM
What are we doing as a nation right now?
"FDA official who resigned on Sunday was sued by a Canadian pharmaceutical company, which accused him of soliciting a bribe and tanking its stock with false statements as part of a revenge campaign against a former colleague."
🎁🔗
www.wsj.com/health/pharm...
"FDA official who resigned on Sunday was sued by a Canadian pharmaceutical company, which accused him of soliciting a bribe and tanking its stock with false statements as part of a revenge campaign against a former colleague."
🎁🔗
www.wsj.com/health/pharm...
Mark Zuckerberg: “I think it’s the right strategy to aggressively front load building capacity. That way, we’re prepared for the most optimistic case. In the worst case, we would just slow building new infrastructure for some period while we grow into what we build.”
My sweet summer child.
My sweet summer child.
October 31, 2025 at 6:31 AM
Mark Zuckerberg: “I think it’s the right strategy to aggressively front load building capacity. That way, we’re prepared for the most optimistic case. In the worst case, we would just slow building new infrastructure for some period while we grow into what we build.”
My sweet summer child.
My sweet summer child.
Reposted by Maxx Chatsko
AI agents tried to do graphic design, video editing, game development, and administrative chores like scraping data. "Even the best could perform less than 3 percent of the work, earning $1,810 out of a possible $143,991," writes @willknight.bsky.social www.wired.com/story/ai-age...
AI Agents Are Terrible Freelance Workers
A new benchmark measures how well AI agents can automate economically valuable chores. Human-level AI is still some ways off.
www.wired.com
October 29, 2025 at 11:32 PM
AI agents tried to do graphic design, video editing, game development, and administrative chores like scraping data. "Even the best could perform less than 3 percent of the work, earning $1,810 out of a possible $143,991," writes @willknight.bsky.social www.wired.com/story/ai-age...
Annual revenue / cash flow? / net income? / Market cap
Guardant Health $GH = 🅰️
Natera $NTRA = 🅱️
Exact Sciences $EXAS = 💩
🅰️ <$1 billion / No / Not close / $12 billion
🅱️ $2 billion / Yes / Not close / $26 billion
💩 $3.1 billion / Yes / Yes / $12 billion
Guardant Health $GH = 🅰️
Natera $NTRA = 🅱️
Exact Sciences $EXAS = 💩
🅰️ <$1 billion / No / Not close / $12 billion
🅱️ $2 billion / Yes / Not close / $26 billion
💩 $3.1 billion / Yes / Yes / $12 billion
October 30, 2025 at 3:02 AM
Annual revenue / cash flow? / net income? / Market cap
Guardant Health $GH = 🅰️
Natera $NTRA = 🅱️
Exact Sciences $EXAS = 💩
🅰️ <$1 billion / No / Not close / $12 billion
🅱️ $2 billion / Yes / Not close / $26 billion
💩 $3.1 billion / Yes / Yes / $12 billion
Guardant Health $GH = 🅰️
Natera $NTRA = 🅱️
Exact Sciences $EXAS = 💩
🅰️ <$1 billion / No / Not close / $12 billion
🅱️ $2 billion / Yes / Not close / $26 billion
💩 $3.1 billion / Yes / Yes / $12 billion
Nvidia $NVDA is 👉not👈 the world's first $5 trillion company.
➡️ Dutch East India Co = $10.2 trillion (1640s)
➡️ The Mississippi Co = $8.4 trillion (1710s)
➡️ South China Sea Co = $5.5 trillion (1720s)
➡️ Nvidia = $5.0 trillion (2025)
➡️ Dutch East India Co = $10.2 trillion (1640s)
➡️ The Mississippi Co = $8.4 trillion (1710s)
➡️ South China Sea Co = $5.5 trillion (1720s)
➡️ Nvidia = $5.0 trillion (2025)
October 29, 2025 at 5:51 PM
Nvidia $NVDA is 👉not👈 the world's first $5 trillion company.
➡️ Dutch East India Co = $10.2 trillion (1640s)
➡️ The Mississippi Co = $8.4 trillion (1710s)
➡️ South China Sea Co = $5.5 trillion (1720s)
➡️ Nvidia = $5.0 trillion (2025)
➡️ Dutch East India Co = $10.2 trillion (1640s)
➡️ The Mississippi Co = $8.4 trillion (1710s)
➡️ South China Sea Co = $5.5 trillion (1720s)
➡️ Nvidia = $5.0 trillion (2025)
Reposted by Maxx Chatsko
I spend way more time thinking through scenarios like this than having AI FOMO: www.wsj.com/economy/jobs...
October 29, 2025 at 1:53 AM
I spend way more time thinking through scenarios like this than having AI FOMO: www.wsj.com/economy/jobs...
Bill Gates literally "wrote" a book about the climate disaster.
October 29, 2025 at 1:44 AM
Bill Gates literally "wrote" a book about the climate disaster.
Reposted by Maxx Chatsko
There's been endless talk about an AI bubble, but less about exactly how, why, and how much it's a bubble. So I turned to the framework put forward by scholars Brent Goldfarb and David A. Kirsch, authors of "Bubbles and Crashes," for assessing tech bubbles.
Spoiler: On a scale of 1 to 8, AI is an 8
Spoiler: On a scale of 1 to 8, AI is an 8
AI Is the Bubble to Burst Them All
I talked to the scholars who literally wrote the book on tech bubbles—and applied their test.
www.wired.com
October 27, 2025 at 8:58 PM
There's been endless talk about an AI bubble, but less about exactly how, why, and how much it's a bubble. So I turned to the framework put forward by scholars Brent Goldfarb and David A. Kirsch, authors of "Bubbles and Crashes," for assessing tech bubbles.
Spoiler: On a scale of 1 to 8, AI is an 8
Spoiler: On a scale of 1 to 8, AI is an 8
If the trade negotiations with Canada were called off over an ad, then let's hope he's not watching the World Series.
October 25, 2025 at 2:38 AM
If the trade negotiations with Canada were called off over an ad, then let's hope he's not watching the World Series.
Reposted by Maxx Chatsko
US PhD admissions shrink as fears over Trump’s cuts take hold. [In some cases, to zero.] Story by @alexwitze.bsky.social www.nature.com/articles/d41...
US PhD admissions shrink as fears over Trump’s cuts take hold
Some doctoral programmes are admitting no students at all amid uncertainty about federal science funding.
www.nature.com
October 22, 2025 at 4:49 PM
US PhD admissions shrink as fears over Trump’s cuts take hold. [In some cases, to zero.] Story by @alexwitze.bsky.social www.nature.com/articles/d41...
What stage of the bubble are we in? Reddit ad from FINRA
October 22, 2025 at 12:41 AM
What stage of the bubble are we in? Reddit ad from FINRA
Reposted by Maxx Chatsko
Confirmation bias researchers keep looking for evidence of confirmation bias.
And they keep finding it!
And they keep finding it!
October 17, 2025 at 9:26 PM
Confirmation bias researchers keep looking for evidence of confirmation bias.
And they keep finding it!
And they keep finding it!
Fortune magazine from October 11, 1999.
October 12, 2025 at 7:51 AM
Fortune magazine from October 11, 1999.