Marah C Runtsch
@marahclarice.bsky.social
Myeloid cells, immunometabolism, and cancer | PhD @uutah | postdoc @TCDDublin | current: senior scientist @medunigraz
Minnesota native
music and pop culture lover
Minnesota native
music and pop culture lover
Congrats to Sayan, Michael, Philipp, Ulrike, and everyone else who contributed to this new story! It was an effort of many years; so happy to be included as a part of this study. We hope it will contribute to the development of novel AML and other cancer therapies!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice
Lymphotoxin alpha represses acute myeloid leukemia by depleting TRAF2 and triggering cell death and myeloid differentiation.
www.science.org
November 27, 2025 at 8:54 AM
Congrats to Sayan, Michael, Philipp, Ulrike, and everyone else who contributed to this new story! It was an effort of many years; so happy to be included as a part of this study. We hope it will contribute to the development of novel AML and other cancer therapies!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Marah C Runtsch
We are all Dr. Brunkow 😴
“Dr. Brunkow said she did not expect to win a Nobel Prize. ‘My phone rang, and I saw a number from Sweden and thought, well that’s just spam of some sort, so I disabled the phone and went back to sleep,’“ www.nytimes.com/2025/10/06/h...
“Dr. Brunkow said she did not expect to win a Nobel Prize. ‘My phone rang, and I saw a number from Sweden and thought, well that’s just spam of some sort, so I disabled the phone and went back to sleep,’“ www.nytimes.com/2025/10/06/h...
Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems
www.nytimes.com
October 7, 2025 at 12:14 PM
We are all Dr. Brunkow 😴
“Dr. Brunkow said she did not expect to win a Nobel Prize. ‘My phone rang, and I saw a number from Sweden and thought, well that’s just spam of some sort, so I disabled the phone and went back to sleep,’“ www.nytimes.com/2025/10/06/h...
“Dr. Brunkow said she did not expect to win a Nobel Prize. ‘My phone rang, and I saw a number from Sweden and thought, well that’s just spam of some sort, so I disabled the phone and went back to sleep,’“ www.nytimes.com/2025/10/06/h...
Reposted by Marah C Runtsch
Congratulations to Gina and her team on the hard work and great effort; happy to be included in such a cool story! #immunosky #immunometabolism
One thing that comforts me in the current era is that, despite everything, really cool science continues to be published:
www.science.org/doi/10.1126/...
This could be a breakthrough for managing so many autoimmune diseases (still, in mice—don't get too excited).
www.science.org/doi/10.1126/...
This could be a breakthrough for managing so many autoimmune diseases (still, in mice—don't get too excited).
Adenosine 2A receptor–dependent activation of AMPK represses TH17 cell pathogenicity through epigenetic and metabolic reprogramming
Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity.
www.science.org
September 25, 2025 at 9:56 AM
Congratulations to Gina and her team on the hard work and great effort; happy to be included in such a cool story! #immunosky #immunometabolism
Reposted by Marah C Runtsch
Only single cell sequencing of the all these post docs will reveal why
September 19, 2025 at 8:54 AM
Only single cell sequencing of the all these post docs will reveal why
Still riding this high of seeing one of the greatest gigs of all time with some of the greatest people 💕 #oasis #murrayfield #feelingsupersonic #morningglory
August 14, 2025 at 9:55 PM
Still riding this high of seeing one of the greatest gigs of all time with some of the greatest people 💕 #oasis #murrayfield #feelingsupersonic #morningglory
Dear Europeans who like to suffer through the 30+ degree weather, unable to sleep:
July 21, 2025 at 9:14 AM
Dear Europeans who like to suffer through the 30+ degree weather, unable to sleep:
Reposted by Marah C Runtsch
Just out in Infection and Immunity!
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen
Live fast, die young: neutrophils streamline their metabolism to maximize inflammation | Infection and Immunity
Cell metabolism plays a key role in shaping immune cell differentiation and function,
with each immune cell subset depending on distinct metabolic pathways. While there
have been extensive studies and...
journals.asm.org
July 7, 2025 at 7:25 PM
Just out in Infection and Immunity!
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen
Reposted by Marah C Runtsch
A comparison of mouse vs human tumor microenvironments shows a major difference.
Mouse TMEs have more macrophages, while human TMEs have more T cells.
Chemokine expression patterns are also different.
Learn more: www.biorxiv.org/content/10.1...
Mouse TMEs have more macrophages, while human TMEs have more T cells.
Chemokine expression patterns are also different.
Learn more: www.biorxiv.org/content/10.1...
July 7, 2025 at 5:16 AM
A comparison of mouse vs human tumor microenvironments shows a major difference.
Mouse TMEs have more macrophages, while human TMEs have more T cells.
Chemokine expression patterns are also different.
Learn more: www.biorxiv.org/content/10.1...
Mouse TMEs have more macrophages, while human TMEs have more T cells.
Chemokine expression patterns are also different.
Learn more: www.biorxiv.org/content/10.1...
Can we use what we’ve learned so far about #immunometabolism in macrophages and neutrophils as cancer immunotherapy? Not yet, but someday. I’m happy to share our latest review, summarizing the state of the field in the context of #myeloidcells and #lungcancer
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Targeting myeloid cell immunometabolism to improve current non-small cell lung cancer therapies
Although recent advancements in immunotherapy have improved clinical outcomes, non-small cell lung cancer (NSCLC) is still the deadliest cancer type, …
www.sciencedirect.com
June 12, 2025 at 5:54 PM
Can we use what we’ve learned so far about #immunometabolism in macrophages and neutrophils as cancer immunotherapy? Not yet, but someday. I’m happy to share our latest review, summarizing the state of the field in the context of #myeloidcells and #lungcancer
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Mark your calendars for the next T Cell Europe Lecture, featuring Stefano Angiari sharing his latest #immunometabolism research, from @medunigraz.at June 3rd at 5pm CET 11am EST
www.t-cells.eu
www.t-cells.eu
T-Cell Connect Europe
EFIS-IL study group T CELL CONNECT EUROPE (TCC_EUROPE)
www.t-cells.eu
May 28, 2025 at 7:58 PM
Mark your calendars for the next T Cell Europe Lecture, featuring Stefano Angiari sharing his latest #immunometabolism research, from @medunigraz.at June 3rd at 5pm CET 11am EST
www.t-cells.eu
www.t-cells.eu
archive.ph/qvH9r
A great interview with one of my favorite “famous” people, Sufjan Stevens, in celebration of the 10th anniversary of one of the greatest and most developed albums of all time #carrieandlowell
A great interview with one of my favorite “famous” people, Sufjan Stevens, in celebration of the 10th anniversary of one of the greatest and most developed albums of all time #carrieandlowell
May 15, 2025 at 9:57 AM
archive.ph/qvH9r
A great interview with one of my favorite “famous” people, Sufjan Stevens, in celebration of the 10th anniversary of one of the greatest and most developed albums of all time #carrieandlowell
A great interview with one of my favorite “famous” people, Sufjan Stevens, in celebration of the 10th anniversary of one of the greatest and most developed albums of all time #carrieandlowell
Reposted by Marah C Runtsch
P-hacking
Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science.
www.nature.com/articles/d41...
Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science.
www.nature.com/articles/d41...
P hacking — Five ways it could happen to you
Some data practices can lead to statistically dubious findings. Here’s how to avoid them.
www.nature.com
May 15, 2025 at 8:05 AM
P-hacking
Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science.
www.nature.com/articles/d41...
Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science.
www.nature.com/articles/d41...
Reposted by Marah C Runtsch
🚀 Förderung für engagierte Forscher*innen! 💡🔬 Bei der Pioneering Minds Award Ceremony wurden die Forschungsförderungspreise "GESUNDHEIT3000" verliehen. Der Verein #MEFOgraz prämiert innovative Projekte zur Verbesserung von Vorsorge, Früherkennung, Diagnose oder Behandlung ➡ https://bit.ly/4i7H66d.
March 24, 2025 at 8:30 AM
🚀 Förderung für engagierte Forscher*innen! 💡🔬 Bei der Pioneering Minds Award Ceremony wurden die Forschungsförderungspreise "GESUNDHEIT3000" verliehen. Der Verein #MEFOgraz prämiert innovative Projekte zur Verbesserung von Vorsorge, Früherkennung, Diagnose oder Behandlung ➡ https://bit.ly/4i7H66d.
Reposted by Marah C Runtsch
#FactCheckingDay promotes media literacy and the importance of reliable information in the fight against disinformation.
ERC Scientific Council member @lukeanthonyoneill.bsky.social shares why acting to counter disinformation matters to him as a scientist. 👇
#FactsMatter
ERC Scientific Council member @lukeanthonyoneill.bsky.social shares why acting to counter disinformation matters to him as a scientist. 👇
#FactsMatter
April 2, 2025 at 7:01 AM
#FactCheckingDay promotes media literacy and the importance of reliable information in the fight against disinformation.
ERC Scientific Council member @lukeanthonyoneill.bsky.social shares why acting to counter disinformation matters to him as a scientist. 👇
#FactsMatter
ERC Scientific Council member @lukeanthonyoneill.bsky.social shares why acting to counter disinformation matters to him as a scientist. 👇
#FactsMatter
Reposted by Marah C Runtsch
Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...
Matrix-producing neutrophils populate and shield the skin
Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...
rdcu.be
March 19, 2025 at 9:28 PM
Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...
Reviewers! Your job is to improve the scientific quality and integrity of a paper and make suggestions to solidify conclusions, not to gatekeep and make authors jump through unnecessary hoops to reach some invisible bar you’ve set in order to stroke your ego! we’ve all got it tough, don’t make worse
March 18, 2025 at 8:22 AM
Reviewers! Your job is to improve the scientific quality and integrity of a paper and make suggestions to solidify conclusions, not to gatekeep and make authors jump through unnecessary hoops to reach some invisible bar you’ve set in order to stroke your ego! we’ve all got it tough, don’t make worse
My favorite part about living in Austria is that at random times I’ll get a letter saying “oops we owe you money!” from the electric company, employer, landlord, etc. My landlord randomly lowered my rent by €50/month and then sent me back the difference. Jarring as an American (in a good way)
March 13, 2025 at 8:33 AM
My favorite part about living in Austria is that at random times I’ll get a letter saying “oops we owe you money!” from the electric company, employer, landlord, etc. My landlord randomly lowered my rent by €50/month and then sent me back the difference. Jarring as an American (in a good way)
Reposted by Marah C Runtsch
Fascinating work from MALDI master Ramon Sun and collaborators on glycogen metabolism in NSCLC. A real tour de force and such beautiful images 😍 www.nature.com/articles/s42...
Glycogen drives tumour initiation and progression in lung adenocarcinoma - Nature Metabolism
Clarke, Hawkinson and colleagues study the contribution of glycogen accumulation in the onset and progression of lung cancer.
www.nature.com
March 11, 2025 at 4:10 PM
Fascinating work from MALDI master Ramon Sun and collaborators on glycogen metabolism in NSCLC. A real tour de force and such beautiful images 😍 www.nature.com/articles/s42...
Reposted by Marah C Runtsch
Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…
www.sciencedirect.com
March 10, 2025 at 6:38 PM
Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...
I love you, @theonion.com
Charli XCX Does Line Of Coke With 11-Year-Old Make-A-Wish Fan
Charli XCX Does Line Of Coke With 11-Year-Old Make-A-Wish Fan
MINNEAPOLIS—In a touching moment that left the terminally ill child excitedly rambling and beaming from ear to ear, witnesses confirmed Friday that Charli XCX had done a line of coke with 11-year-old ...
theonion.com
March 7, 2025 at 12:56 AM
I love you, @theonion.com
Reposted by Marah C Runtsch
Now online in Cancer Discovery: High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients - by Ling Cai, Nia Hammond, Brandon Faubert, @rjdlab.bsky.social, and colleagues doi.org/10.1158/2159...
February 17, 2025 at 5:32 PM
Now online in Cancer Discovery: High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients - by Ling Cai, Nia Hammond, Brandon Faubert, @rjdlab.bsky.social, and colleagues doi.org/10.1158/2159...
Reposted by Marah C Runtsch
Your cells are dying. All the time geneticliteracyproject.org/2025/01/27/y...
February 9, 2025 at 10:18 AM
Your cells are dying. All the time geneticliteracyproject.org/2025/01/27/y...