Dr Manvendra Singh
@manusingh.bsky.social
Investigating Human Endogenous Retroelements at the Interface of Epigenetics & Diseases-INHERITED
Alum: Feschotte lab, Cornell University New York, Clinical Neuroscience, MPI Gottingen, Izsvak lab, MDC Berlin, Uni of Bath UK, CCMB Hyderabad, JNU New Delhi
Alum: Feschotte lab, Cornell University New York, Clinical Neuroscience, MPI Gottingen, Izsvak lab, MDC Berlin, Uni of Bath UK, CCMB Hyderabad, JNU New Delhi
Pinned
Dr Manvendra Singh
@manusingh.bsky.social
· Sep 23
I'd be leaving soon for the new challenges
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
Reposted by Dr Manvendra Singh
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
October 2, 2025 at 1:47 PM
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
Reposted by Dr Manvendra Singh
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 24, 2025 at 3:12 PM
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dr Manvendra Singh
Paper accepted!!!!
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
September 23, 2025 at 10:04 PM
Paper accepted!!!!
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
Reposted by Dr Manvendra Singh
One of my all-time faves
Evolution is more like a tinkerer than an engineer. New things happen not by perfect engineering but by working with what's already available and repurposing existing objects through recombinations and modifications. This is a classic lesson for any kind of innovation, including that of new ideas..
August 13, 2025 at 2:37 AM
One of my all-time faves
Reposted by Dr Manvendra Singh
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
academicjobsonline.org/ajo/jobs/30607
Cornell University, Molecular Biology & Genetics
Job #AJO30607, WDR-00055221 Assistant Professor, Molecular Biology & Genetics, Cornell University, Ithaca, New York, US
academicjobsonline.org
September 23, 2025 at 12:50 PM
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
academicjobsonline.org/ajo/jobs/30607
I'd be leaving soon for the new challenges
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
September 23, 2025 at 10:14 AM
I'd be leaving soon for the new challenges
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
Before I go, here are a few brain’s stories on the table:
1 out in Nat Comm,
1 in press at Mol Psy,
and 🤞 for the third.
Preprints here:
www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...; www.biorxiv.org/content/10.1...;
Onwards. 🖤
Reposted by Dr Manvendra Singh
www.cell.com/cell/abstrac...
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that
facilitate photosynthesis and eventual digestion to mediate starvation resistance.
www.cell.com
September 17, 2025 at 5:04 PM
www.cell.com/cell/abstrac...
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
Reposted by Dr Manvendra Singh
A study published in Genome Biology explores the role of transposable elements in antiviral resistance to HIV. The findings open new avenues for understanding the molecular mechanisms of viral control and developing targeted interventions for HIV-1 treatment.
#Epigenetics
#Epigenetics
Transposable elements may enhance antiviral resistance in HIV-1 elite controllers
Genome Biology
bit.ly
September 15, 2025 at 5:30 PM
A study published in Genome Biology explores the role of transposable elements in antiviral resistance to HIV. The findings open new avenues for understanding the molecular mechanisms of viral control and developing targeted interventions for HIV-1 treatment.
#Epigenetics
#Epigenetics
Reposted by Dr Manvendra Singh
New ERC Starting Grant for Juliane Glaser to study role of epigenetic mechanisms, specifically the control of transposable elements, in mammalian embryonic development.
Read all details here: www.ie-freiburg.mpg.de/6057908/2025...
Congratulations @julianeg.bsky.social
@erc.europa.eu #ERCStG
Read all details here: www.ie-freiburg.mpg.de/6057908/2025...
Congratulations @julianeg.bsky.social
@erc.europa.eu #ERCStG
September 4, 2025 at 10:43 AM
New ERC Starting Grant for Juliane Glaser to study role of epigenetic mechanisms, specifically the control of transposable elements, in mammalian embryonic development.
Read all details here: www.ie-freiburg.mpg.de/6057908/2025...
Congratulations @julianeg.bsky.social
@erc.europa.eu #ERCStG
Read all details here: www.ie-freiburg.mpg.de/6057908/2025...
Congratulations @julianeg.bsky.social
@erc.europa.eu #ERCStG
Reposted by Dr Manvendra Singh
17 ERC Starting Grants for Max Planck scientists! This puts the Max Planck Society at the top of the European ranking. mpg.de/25324951/erc... Congratulations to all grantees 🎉👏 #ERCStG @erc.europa.eu
17 ERC Starting Grants for Max Planck
In 2025, the Max Planck Society received 17 Starting Grants from the ERC. This puts the MPG at the top of the European ranking.
mpg.de
September 5, 2025 at 2:11 PM
17 ERC Starting Grants for Max Planck scientists! This puts the Max Planck Society at the top of the European ranking. mpg.de/25324951/erc... Congratulations to all grantees 🎉👏 #ERCStG @erc.europa.eu
Not sure if they tested cooperative bindings of TFs, which might have been the key player for determining their activator/repressive roles. Also, it might not be feasible to test in Yeast system for all TFs. Great study, anyways.
The "Low overlap of transcription factor DNA binding and regulatory targets" paper shows our dual futility conjecture identified in humans applies in yeast too—for many transcription factors, most of their locations do not match the transcription factor motif. 🖥️🧬 www.nature.com/articles/s41...
September 3, 2025 at 9:36 PM
Not sure if they tested cooperative bindings of TFs, which might have been the key player for determining their activator/repressive roles. Also, it might not be feasible to test in Yeast system for all TFs. Great study, anyways.
Reposted by Dr Manvendra Singh
August 14, 2025 at 6:05 PM
Reposted by Dr Manvendra Singh
lh3/longdust: Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome github.com/lh3/longdust 🧬🖥️🧪
GitHub - lh3/longdust: Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome
Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome - lh3/longdust
github.com
August 1, 2025 at 3:30 PM
lh3/longdust: Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome github.com/lh3/longdust 🧬🖥️🧪
Reposted by Dr Manvendra Singh
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
www.nature.com
July 28, 2025 at 3:34 PM
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
Reposted by Dr Manvendra Singh
🧵1/ Introducing Stellarscope: an EM-based tool for quantifying locus-specific transposable element expression in single cells.
A single-cell transposable element atlas of human cell identity: Cell Reports Methods www.cell.com/cell-reports...
@hamarillo.bsky.social #TEHub #singlecell #genomics
A single-cell transposable element atlas of human cell identity: Cell Reports Methods www.cell.com/cell-reports...
@hamarillo.bsky.social #TEHub #singlecell #genomics
A single-cell transposable element atlas of human cell identity
Reyes-Gopar et al. introduce Stellarscope, a computational approach for quantifying
locus-specific transposable element expression in single-cell RNA sequencing data.
The authors profile human PBMCs a...
www.cell.com
July 22, 2025 at 2:47 PM
🧵1/ Introducing Stellarscope: an EM-based tool for quantifying locus-specific transposable element expression in single cells.
A single-cell transposable element atlas of human cell identity: Cell Reports Methods www.cell.com/cell-reports...
@hamarillo.bsky.social #TEHub #singlecell #genomics
A single-cell transposable element atlas of human cell identity: Cell Reports Methods www.cell.com/cell-reports...
@hamarillo.bsky.social #TEHub #singlecell #genomics
Reposted by Dr Manvendra Singh
Exactly two weeks left to submit your abstract to the EMBO Mobile Genome Workshop.
☝️this year we will select from abstracts 2 “long” talks to highlight last minute breakthrough from early career scientists. Apply! July 29th
☝️this year we will select from abstracts 2 “long” talks to highlight last minute breakthrough from early career scientists. Apply! July 29th
⏰ Abstract deadline for 'The mobile genome' is 29 July!
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
July 15, 2025 at 12:35 PM
Exactly two weeks left to submit your abstract to the EMBO Mobile Genome Workshop.
☝️this year we will select from abstracts 2 “long” talks to highlight last minute breakthrough from early career scientists. Apply! July 29th
☝️this year we will select from abstracts 2 “long” talks to highlight last minute breakthrough from early career scientists. Apply! July 29th
Just dropped our Mobile DNA review on HERVH, an ancient retrovirus now repurposed to build and defend the early human embryo. Call it genomic up-cycling!
I felt HERVH went unnoticed this year, so we published this as a refresher; two fresh data papers - coming soon.
🔗 doi.org/10.1186/s131...
🧵1/3
I felt HERVH went unnoticed this year, so we published this as a refresher; two fresh data papers - coming soon.
🔗 doi.org/10.1186/s131...
🧵1/3
July 15, 2025 at 9:15 AM
Just dropped our Mobile DNA review on HERVH, an ancient retrovirus now repurposed to build and defend the early human embryo. Call it genomic up-cycling!
I felt HERVH went unnoticed this year, so we published this as a refresher; two fresh data papers - coming soon.
🔗 doi.org/10.1186/s131...
🧵1/3
I felt HERVH went unnoticed this year, so we published this as a refresher; two fresh data papers - coming soon.
🔗 doi.org/10.1186/s131...
🧵1/3
Reposted by Dr Manvendra Singh
Woohoo! From superstars ionut and Marta in the Frisén lab! www.science.org/doi/10.1126/... can’t wait to see what the anti-neurogenesis folks say about it 😃
Identification of proliferating neural progenitors in the adult human hippocampus
Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into que...
www.science.org
July 3, 2025 at 6:54 PM
Woohoo! From superstars ionut and Marta in the Frisén lab! www.science.org/doi/10.1126/... can’t wait to see what the anti-neurogenesis folks say about it 😃
Reposted by Dr Manvendra Singh
Reposted by Dr Manvendra Singh
Complete ape genomes! 🦍🦧 Our closest relatives get the deluxe sequencing treatment, resolving the most complex & often most interesting parts of the genome.
Happy to make a tiny contribution alongside @panpan100.bsky.social to awesome teamwork & fantastic resource.
www.nature.com/articles/s41...
Happy to make a tiny contribution alongside @panpan100.bsky.social to awesome teamwork & fantastic resource.
www.nature.com/articles/s41...
May 8, 2025 at 7:47 AM
Complete ape genomes! 🦍🦧 Our closest relatives get the deluxe sequencing treatment, resolving the most complex & often most interesting parts of the genome.
Happy to make a tiny contribution alongside @panpan100.bsky.social to awesome teamwork & fantastic resource.
www.nature.com/articles/s41...
Happy to make a tiny contribution alongside @panpan100.bsky.social to awesome teamwork & fantastic resource.
www.nature.com/articles/s41...
Reposted by Dr Manvendra Singh
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
April 30, 2025 at 10:45 AM
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Lovely! The addiction model 😍
So glad to see it out.
Big Congrats to Sylvia and @jonowells.bsky.social
So glad to see it out.
Big Congrats to Sylvia and @jonowells.bsky.social
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
April 30, 2025 at 12:48 PM
Lovely! The addiction model 😍
So glad to see it out.
Big Congrats to Sylvia and @jonowells.bsky.social
So glad to see it out.
Big Congrats to Sylvia and @jonowells.bsky.social
Reposted by Dr Manvendra Singh
Two rejuvenating days of exciting science, fun times, and beautiful sights in Tuebingen 🇩🇪
THANKS to Vikas Bansal & Daniel Sauter @unituebingen.bsky.social
and Susana Coelho @maxplanckcampus.bsky.social for hosting & @manusingh.bsky.social for joining 🙏😊
THANKS to Vikas Bansal & Daniel Sauter @unituebingen.bsky.social
and Susana Coelho @maxplanckcampus.bsky.social for hosting & @manusingh.bsky.social for joining 🙏😊
March 29, 2025 at 8:22 AM
Two rejuvenating days of exciting science, fun times, and beautiful sights in Tuebingen 🇩🇪
THANKS to Vikas Bansal & Daniel Sauter @unituebingen.bsky.social
and Susana Coelho @maxplanckcampus.bsky.social for hosting & @manusingh.bsky.social for joining 🙏😊
THANKS to Vikas Bansal & Daniel Sauter @unituebingen.bsky.social
and Susana Coelho @maxplanckcampus.bsky.social for hosting & @manusingh.bsky.social for joining 🙏😊
Reposted by Dr Manvendra Singh
I am Absolutely delighted to share the preprint of our last collaborative efforts where we investigated the impact of sonostimulation of Mesenchymal Stem Cells. Thread -1-
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sonoepigenetics: Spatiotemporal Calcium Dynamics and cAMP Signaling Driven by High Frequency Nanomechanostimulation Regulates Transient Epigenetic Modifications and Early Osteogenic Commitment in Mese...
Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which thi...
www.biorxiv.org
March 19, 2025 at 10:31 AM
I am Absolutely delighted to share the preprint of our last collaborative efforts where we investigated the impact of sonostimulation of Mesenchymal Stem Cells. Thread -1-
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dr Manvendra Singh
🤯 cryo-ET of copia viral-like particles lurking at the nuclear pore of intact Drosophila eggs!
Amazing work by @svenklumpe.bsky.social & more cool findings in this collaborative paper illuminating the replication cycle of an iconic retrotransposon!
www.cell.com/cell/fulltex...
Amazing work by @svenklumpe.bsky.social & more cool findings in this collaborative paper illuminating the replication cycle of an iconic retrotransposon!
www.cell.com/cell/fulltex...
March 17, 2025 at 2:25 PM
🤯 cryo-ET of copia viral-like particles lurking at the nuclear pore of intact Drosophila eggs!
Amazing work by @svenklumpe.bsky.social & more cool findings in this collaborative paper illuminating the replication cycle of an iconic retrotransposon!
www.cell.com/cell/fulltex...
Amazing work by @svenklumpe.bsky.social & more cool findings in this collaborative paper illuminating the replication cycle of an iconic retrotransposon!
www.cell.com/cell/fulltex...