Luc Reym⌬nd
@lreymond.bsky.social
Organic chemistry passionate 🧪, mountain addict 🧗 & freediver 🤿. EPFL scientist and @spirochrome.com co-founder. 🇨🇭
Reposted by Luc Reym⌬nd
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
November 27, 2025 at 2:14 PM
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
Reposted by Luc Reym⌬nd
Did you know that @jcellsci.bsky.social has a new editor for neuronal cell biology? It's that guy @roylab-ucsd.bsky.social, I've heard good things about him
Interview with Journal of Cell Science Editor Subhojit Roy
ABSTRACT. Subhojit Roy is Professor of Pathology at the University of California San Diego (UCSD) in the USA. Subhojit completed his MD in Kolkata, India and then moved to Temple University in Philade...
journals.biologists.com
November 24, 2025 at 4:14 PM
Did you know that @jcellsci.bsky.social has a new editor for neuronal cell biology? It's that guy @roylab-ucsd.bsky.social, I've heard good things about him
Reposted by Luc Reym⌬nd
What's up Bluesky....here's some live-cell imaging taken in my lab
November 24, 2025 at 12:11 PM
What's up Bluesky....here's some live-cell imaging taken in my lab
Reposted by Luc Reym⌬nd
The images in the main text are also definitely worth a look!
November 24, 2025 at 1:34 PM
The images in the main text are also definitely worth a look!
Reposted by Luc Reym⌬nd
A new article from Nicolas Plachta's lab with incredible imaging of live human embryos using our probes SPY555-DNA and SPY650-FastAct
www.science.org/doi/full/10....
The study shows that frequent errors during cell division directly cause many early developmental failures and morphological defects
www.science.org/doi/full/10....
The study shows that frequent errors during cell division directly cause many early developmental failures and morphological defects
November 24, 2025 at 1:34 PM
A new article from Nicolas Plachta's lab with incredible imaging of live human embryos using our probes SPY555-DNA and SPY650-FastAct
www.science.org/doi/full/10....
The study shows that frequent errors during cell division directly cause many early developmental failures and morphological defects
www.science.org/doi/full/10....
The study shows that frequent errors during cell division directly cause many early developmental failures and morphological defects
Reposted by Luc Reym⌬nd
In our new #Preprint, we pilot a revolutionary new idea: no supplemental data (it has 21 figures, though):
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
www.biorxiv.org/content/10.1...
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
www.biorxiv.org/content/10.1...
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
We have previously shown that the calcium sensing receptor (CaSR) activates different G proteins and second messengers in single cells, and that GPCR and G protein-mediated ERK activity can be highly ...
www.biorxiv.org
November 24, 2025 at 8:29 AM
In our new #Preprint, we pilot a revolutionary new idea: no supplemental data (it has 21 figures, though):
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
www.biorxiv.org/content/10.1...
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
www.biorxiv.org/content/10.1...
Got a connected bird feeder, guests quickly became regular customers! Here a couple of blue tit
November 22, 2025 at 9:04 AM
Got a connected bird feeder, guests quickly became regular customers! Here a couple of blue tit
With snow in the garden, that means skiing season is definitely getting closer!
November 20, 2025 at 4:20 PM
With snow in the garden, that means skiing season is definitely getting closer!
Reposted by Luc Reym⌬nd
Thank you @prelights.bsky.social for highlighting HAK-actin!
HAK-actin is a great tool for ExM actin staining.
spirochrome.com/product/hak-...
HAK-actin is a great tool for ExM actin staining.
spirochrome.com/product/hak-...
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 20, 2025 at 9:54 AM
Thank you @prelights.bsky.social for highlighting HAK-actin!
HAK-actin is a great tool for ExM actin staining.
spirochrome.com/product/hak-...
HAK-actin is a great tool for ExM actin staining.
spirochrome.com/product/hak-...
Reposted by Luc Reym⌬nd
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 19, 2025 at 11:58 AM
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Reposted by Luc Reym⌬nd
Quite a busy day on #Bluesky !
Been a while since we have been #preLight -ed !
Discover HAK-Actin if you haven't already ;)
Been a while since we have been #preLight -ed !
Discover HAK-Actin if you haven't already ;)
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 19, 2025 at 12:36 PM
Cool, the HAK-actin preprint was showcased by @prelights.bsky.social
A good reason to read it if you haven't yet 😜
A good reason to read it if you haven't yet 😜
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 19, 2025 at 12:28 PM
Cool, the HAK-actin preprint was showcased by @prelights.bsky.social
A good reason to read it if you haven't yet 😜
A good reason to read it if you haven't yet 😜
Hike'n fondue in Valais with friends! 😋
The fall colors are splendid.
The fall colors are splendid.
November 15, 2025 at 2:34 PM
Hike'n fondue in Valais with friends! 😋
The fall colors are splendid.
The fall colors are splendid.
Reposted by Luc Reym⌬nd
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 13, 2025 at 4:20 PM
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Luc Reym⌬nd
Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain - Nature Communications
Synapses are diverse within a single neuron. Here, the authors present a method for single-cell synaptome imaging of endogenous protein subpopulations in the mouse brain, enabling spatial mapping of s...
www.nature.com
November 11, 2025 at 6:19 PM
Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...
Went looking for quartz over the weekend. I was lucky to find a nice untouched pocket with well-formed crystals (after 3h of search!). The first picture shows the cluster in situ within the crack and the other one shows the same crystals as a detached piece.
November 10, 2025 at 8:23 PM
Went looking for quartz over the weekend. I was lucky to find a nice untouched pocket with well-formed crystals (after 3h of search!). The first picture shows the cluster in situ within the crack and the other one shows the same crystals as a detached piece.
Firing water rockets with the kids never gets old, especially for me! 🚀
November 8, 2025 at 3:41 PM
Firing water rockets with the kids never gets old, especially for me! 🚀
🥝 The kiwi harvest is the last one of the year in the garden.
Happily surprised by the quantity given the very moderate bloom in spring.
Happily surprised by the quantity given the very moderate bloom in spring.
November 8, 2025 at 3:30 PM
🥝 The kiwi harvest is the last one of the year in the garden.
Happily surprised by the quantity given the very moderate bloom in spring.
Happily surprised by the quantity given the very moderate bloom in spring.
Reposted by Luc Reym⌬nd
🚨Curious how synthetic fluorophores simplify microscopy? Our review covers applications such as super-resolution microscopy and biosensing. 🎉👩🔬Congrats to my first PhD student, Agnese Nicoli, for the fearless deep dive! 🔬 ⚗️
D-CHAB @ethz.ch
www.nature.com/articles/s41...
D-CHAB @ethz.ch
www.nature.com/articles/s41...
Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology
Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...
www.nature.com
November 5, 2025 at 9:29 PM
🚨Curious how synthetic fluorophores simplify microscopy? Our review covers applications such as super-resolution microscopy and biosensing. 🎉👩🔬Congrats to my first PhD student, Agnese Nicoli, for the fearless deep dive! 🔬 ⚗️
D-CHAB @ethz.ch
www.nature.com/articles/s41...
D-CHAB @ethz.ch
www.nature.com/articles/s41...
Reposted by Luc Reym⌬nd
More information about Flipper-TR on our website spirochrome.com/product/flip...
Flipper-TR® - Live cell membrane tension probe - spirochrome
Flipper-TR® is a live cell membrane tension probe
spirochrome.com
November 4, 2025 at 9:19 AM
More information about Flipper-TR on our website spirochrome.com/product/flip...
Reposted by Luc Reym⌬nd
👉🦠Interested in bacterial membrane tension?
Our membrane tension probe Flipper-TR is a top tool for the job!
A new article in @pnas.org demonstrates how Flipper-TR efficiently stains bacterial membranes and responds to various stimuli altering membrane tension.
🔗 doi.org/10.1073/pnas...
🧪
Our membrane tension probe Flipper-TR is a top tool for the job!
A new article in @pnas.org demonstrates how Flipper-TR efficiently stains bacterial membranes and responds to various stimuli altering membrane tension.
🔗 doi.org/10.1073/pnas...
🧪
Exploring bacteria–surface interactions with a fluorescent membrane tension probe | PNAS
Understanding how bacteria interact with surfaces is critical for advancing applications
in biofilm and biofouling prevention, biomaterial developm...
doi.org
November 4, 2025 at 9:19 AM
👉🦠Interested in bacterial membrane tension?
Our membrane tension probe Flipper-TR is a top tool for the job!
A new article in @pnas.org demonstrates how Flipper-TR efficiently stains bacterial membranes and responds to various stimuli altering membrane tension.
🔗 doi.org/10.1073/pnas...
🧪
Our membrane tension probe Flipper-TR is a top tool for the job!
A new article in @pnas.org demonstrates how Flipper-TR efficiently stains bacterial membranes and responds to various stimuli altering membrane tension.
🔗 doi.org/10.1073/pnas...
🧪
Reposted by Luc Reym⌬nd
October 29, 2025 at 9:30 AM
Reposted by Luc Reym⌬nd
Live cell ACTIN imaging has never been easier with SPY650-FastAct_X!
1. Add the probe to the cells
2. Image 1h later
SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.
image credits: @stephanlab.bsky.social
1. Add the probe to the cells
2. Image 1h later
SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.
image credits: @stephanlab.bsky.social
October 29, 2025 at 9:30 AM
Live cell ACTIN imaging has never been easier with SPY650-FastAct_X!
1. Add the probe to the cells
2. Image 1h later
SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.
image credits: @stephanlab.bsky.social
1. Add the probe to the cells
2. Image 1h later
SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.
image credits: @stephanlab.bsky.social
Reposted by Luc Reym⌬nd
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
May 23, 2025 at 7:57 PM
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)