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lesliedaymicro.bsky.social
Leslie Day, PhD
@lesliedaymicro.bsky.social
46 followers 59 following 9 posts
Anaerobic Microbiologist
Damon Runyon Fellow
Postdoc @ O’Toole Lab, Dartmouth
Posts Replies Media Videos
Reposted by Leslie Day, PhD
smartalyk.bsky.social
DAY 168
SPECIES 168 - Prevotella intermedia
STAGE: Bacteria
MEDIUM: Arches Paper. Chromatek & HWC Watercolor. Sakura pen

Thanks to @lesliedaymicro.bsky.social for suggesting it!

#sciart #watercolor #bacteria #painting #art #paint
November 20, 2025 at 7:34 AM
Reposted by Leslie Day, PhD
environmicrobio.bsky.social
Clone-FISH paper out: Manuscript/resource alert #microsky 🦠 We present a collection of 30 E. coli (CloneFISH) cultures, each carrying a plasmid for the heterologous expression of a (near) full-length 16S rRNA gene from one of 30 lineages of archaea, including 17 yet uncultured ones.
List of available cultures Ecoli cells (Dapi, on left) expressing bacterial (center) and archaeal 16S rRNA.
November 17, 2025 at 2:36 PM
Reposted by Leslie Day, PhD
phylogenomics.bsky.social
Science is awesome ... www.cell.com/trends/biote... #violacein #pigments
One-pot production of colored bacterial cellulose
Zhou et al. report the one-pot production of colored bacterial cellulose (BC) as a sustainable alternative to petroleum-based fabrics. Metabolic engineering enhanced colorant yields, while co-culture ...
www.cell.com
November 16, 2025 at 5:04 AM
Reposted by Leslie Day, PhD
evgenii-protasov.bsky.social
Assembly, architecture and functional roles of microbial surface layers
#microbiology #archaea #bacteria
@natrevmicro.nature.com
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 15, 2025 at 10:04 AM
Reposted by Leslie Day, PhD
jcamthrash.bsky.social
Increased mutation rates and diversity are dominant features of Geobacter multiheme cytochromes
www.biorxiv.org/content/10.1... #jcampubs
November 7, 2025 at 3:13 PM
Reposted by Leslie Day, PhD
fabricejpierre.bsky.social
"Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus"

pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus - PubMed
P. melaninogenica enhanced neutrophil and epithelial defense against S. aureus, but the benefits of epithelial cell regulation by P. melaninogenica were lost with CFTR dysfunction. CFTR modulators rescued P. melaninogenica responsiveness in epithelial cells, highlighting the potential for synergisti …
pubmed.ncbi.nlm.nih.gov
November 7, 2025 at 12:38 PM
lesliedaymicro.bsky.social
Prevotella is the clear favorite of the 4-member cookie community (not like I’m surprised) @bassamhafi.bsky.social @fabricejpierre.bsky.social
November 6, 2025 at 9:14 PM
Reposted by Leslie Day, PhD
geiselbiofilm.bsky.social
Congratulations to Bassam el Hafi, who successfully defended his PhD thesis yesterday! He did a terrific job! Bassam connected microbial interactions to the complexity of human communication. Thanks also to Sarah Clark of the Anschutz School of Medicine who served at Bassam's outside examiner.
November 6, 2025 at 1:44 PM
Reposted by Leslie Day, PhD
geiselbiofilm.bsky.social
New in JB: A minireview from my team, led by a recently graduated PhD student Kaitlyn Barrack, compares the microbiota and physiology of the CF gut with features of the gut in inflammatory bowel disease - there are many similarities!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 30, 2025 at 12:42 PM
Reposted by Leslie Day, PhD
microyunha.bsky.social
We're thrilled to announce SeqHub, an AI-enabled platform for biological sequence analysis. SeqHub brings together sequence search, genome annotation, and data sharing in one place.
October 28, 2025 at 1:47 PM
Reposted by Leslie Day, PhD
geiselbiofilm.bsky.social
Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing.
journals.asm.org/doi/10.1128/...
@asm.org
October 7, 2025 at 8:32 PM
Reposted by Leslie Day, PhD
damonrunyon.org
Earlier this month, we proudly welcomed the newest cohort of Damon Runyon Fellows! These 16 brilliant postdocs will receive four years of independent funding to advance their investigation of causes, treatments, and prevention strategies for all types of cancer. Read more: https://bit.ly/4nc25Hq
September 19, 2025 at 4:54 PM
Reposted by Leslie Day, PhD
asm.org
In #mBio, dive into story behind the 1989 discovery of Helicobacter pylori CagA, the first tumorigenic bacterial protein. This article recounts the early steps in the investigative process and relates some of the unexpected discoveries that ensued. asm.social/2C1
Gel of the initial cloned cagA product in λgt11 on 20 July 1989.
September 24, 2025 at 6:13 PM
Reposted by Leslie Day, PhD
fabricejpierre.bsky.social
Happy to finally see this out! Bassam El Halfi (@bassamhafi.bsky.social - my first rotation student when I started my post-doc in @geiselbiofilm.bsky.social) did an amazing job investigating mechanisms of interspecies metabolic interactions. Check it out! #microsky

journals.asm.org/doi/10.1128/...
Pseudomonas aeruginosa supports the survival of Prevotella melaninogenica in a cystic fibrosis lung polymicrobial community through metabolic cross-feeding | mBio
Polymicrobial interactions impact disease outcomes in pwCF who suffer from chronic respiratory infections. Previous work established a CF-relevant polymicrobial community model that allows experimenta...
journals.asm.org
September 12, 2025 at 6:46 PM
Reposted by Leslie Day, PhD
geiselbiofilm.bsky.social
Excited to share our latest work, driven by my recently graduated PhD student Kaitlyn Barrack, exploring the mechanisms of bacterial dysbiosis in the CF gut - including a role for a colorectal cancer-associated genotoxin in this competition.
www.biorxiv.org/content/10.1...
@kbarrack.bsky.social
September 5, 2025 at 12:57 PM
Reposted by Leslie Day, PhD
geiselbiofilm.bsky.social
Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team.
www.nature.com/articles/s41...
September 5, 2025 at 12:21 PM
Reposted by Leslie Day, PhD
spearmicrobe.bsky.social
The latest and greatest from an amazing team of authors. See what you think:

A Comprehensive Framework for Assessing Terrestrial Analogue Field Sites for Ocean Worlds - Stern - 2025 - Journal of Geophysical Research: Planets - Wiley Online Library agupubs.onlinelibrary.wiley.com/doi/10.1029/...
A Comprehensive Framework for Assessing Terrestrial Analogue Field Sites for Ocean Worlds
The choice of analogue field site for ocean worlds research requires traceability to a well-developed science question We present a two-step process to evaluate field sites with respect to their ...
agupubs.onlinelibrary.wiley.com
September 5, 2025 at 10:31 PM
lesliedaymicro.bsky.social
Incredibly honored to be a Damon Runyon Fellow! @damonrunyon.org
geiselbiofilm.bsky.social George O'Toole (he/him/his) @geiselbiofilm.bsky.social · Sep 5
I'm very excited to report that Leslie Day, a post doc in the lab, was awarded a Damon Runyon Cancer Research Fund post-doctoral fellowship to support her work over the next 4 years! Congrats to Leslie!
tinyurl.com/3p26njb6
September 6, 2025 at 3:44 AM
Reposted by Leslie Day, PhD
geiselbiofilm.bsky.social
Our newest manuscript on the gut-lung axis in CF, lead by Rebecca Valls, explores sex and intestinal regional differences in response to Bacteroides. Check it out!
www.biorxiv.org/content/10.1...
August 28, 2025 at 12:10 PM
Reposted by Leslie Day, PhD
geiselbiofilm.bsky.social
We had the O'Toole Lab Reunion on Sat here at Dartmouth, celebrating 26 amazing years - science is all about the people, and I have been fortunate to have a great bunch of folks in the lab over the years! And THANKS to all the lab members who did all the organizing!
August 25, 2025 at 7:13 PM
Reposted by Leslie Day, PhD
asm.org
Microbes rarely exist alone; instead, they live in dynamic communities. In #IAIJournal, researchers discuss the interplay between the host environment & microbiome metabolism & the impacts on disease progression in host-associated polymicrobial communities. asm.social/2yf
Drivers of microbial community dynamics in host-associated environments. Environmental factors, such as nutrient availability, oxygen, pH, and tissue topography, collectively shape the composition and microbiome metabolism of microbial communities within the host. The central panel represents a snapshot of a microbial community at a given time. The right panel illustrates community dynamics, including temporal shifts in microbial populations and interactions between community members that drive community composition and the microbiome metabolism. Microbial interactions are categorized as cooperative (blue) or competitive (red), reflecting the ecological forces that influence microbial stability, succession, and pathogenicity. This conceptual map emphasizes the context-dependent nature of microbial behavior and the importance of studying communities within physiologically relevant environments. Created in BioRender. Arriaga, S. (2025)
August 20, 2025 at 5:56 PM
Reposted by Leslie Day, PhD
geiselbiofilm.bsky.social
Excited about our most recent paper lead by Kaitlyn Barrack, a minireview in JB comparing the CF and IBD guts - from microbiomes to physiologies. There are many similarities...
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology @kbarrack.bsky.social
August 18, 2025 at 4:11 PM
Reposted by Leslie Day, PhD
ukbiofilms.bsky.social
✨Our annual #BiofilmCreate Competition is open for 2025!

🎨 📷 Showcase your talent in #photography / #art whilst highlighting the impact of #biofilms

🏆Gift cards will be awarded in both categories

🗳️biofilms.ac.uk/create

#science #scicomm #AMR #MicroSky
August 11, 2025 at 12:03 PM
lesliedaymicro.bsky.social
Microbial Diversity 💜
August 3, 2025 at 4:19 PM
Reposted by Leslie Day, PhD
geiselbiofilm.bsky.social
JB Editor's Choice: Our latest in the Microbial Model Systems series (journals.asm.org/topic/sss-ta...) is "Milestones in the development of Myxococcus xanthus as a model multicellular bacterium" - from many contributors!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
August 1, 2025 at 2:48 PM