Lennart Hilbert
@lennarthilbert.bsky.social
Studying the cell nucleus in search of inspiration for future DNA computers. Systems Biology professor at Karlsruhe Institute of Technology, post opinions mine alone.
hilbertlab.org
hilbertlab.org
Pinned
Excited to share our new Perspective Article in Advanced Functional Materials:
Integrative Approaches for DNA Sequence-Controlled Functional Materials
We jointly cover scale-bridging simulation, machine learning & experiments from several groups.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Integrative Approaches for DNA Sequence-Controlled Functional Materials
We jointly cover scale-bridging simulation, machine learning & experiments from several groups.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Really cool to hear about it at the Center SynGen event, and now see it published. Of course I very much like this angle of building a synthetic model of cellular phase separation phenomena-like here of the RNA-mediated feedback as outlined by @jhenninger.bsky.social and colleagues
We’re excited to share our new work in Soft Matter: doi.org/10.1039/D5SM...
We demonstrate how in vitro transcription can drive biomolecular phase separation — and how that phase separation in turn regulates transcription.
We demonstrate how in vitro transcription can drive biomolecular phase separation — and how that phase separation in turn regulates transcription.
Condensation and activator/repressor control of a transcription-regulated biomolecular liquid
Cells operate in part by compartmentalizing chemical reactions. For example, recent work has shown that chromatin, the material that contains the cell's genome, can auto-regulate its structure by util...
doi.org
November 22, 2025 at 12:53 PM
Really cool to hear about it at the Center SynGen event, and now see it published. Of course I very much like this angle of building a synthetic model of cellular phase separation phenomena-like here of the RNA-mediated feedback as outlined by @jhenninger.bsky.social and colleagues
Excited to share our new Perspective Article in Advanced Functional Materials:
Integrative Approaches for DNA Sequence-Controlled Functional Materials
We jointly cover scale-bridging simulation, machine learning & experiments from several groups.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Integrative Approaches for DNA Sequence-Controlled Functional Materials
We jointly cover scale-bridging simulation, machine learning & experiments from several groups.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
November 22, 2025 at 12:27 PM
Excited to share our new Perspective Article in Advanced Functional Materials:
Integrative Approaches for DNA Sequence-Controlled Functional Materials
We jointly cover scale-bridging simulation, machine learning & experiments from several groups.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Integrative Approaches for DNA Sequence-Controlled Functional Materials
We jointly cover scale-bridging simulation, machine learning & experiments from several groups.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Almost all hands on deck today in Hilbert lab meeting. Postdoc Ewa very small on Zoom, PhD student Nils substituted for a colleague for a talk; associated fellow Simon and Master student Georg not in the photo. I just felt super happy I can work with this group, so I am sharing selfie greetings 👋 😃
November 17, 2025 at 9:35 PM
Almost all hands on deck today in Hilbert lab meeting. Postdoc Ewa very small on Zoom, PhD student Nils substituted for a colleague for a talk; associated fellow Simon and Master student Georg not in the photo. I just felt super happy I can work with this group, so I am sharing selfie greetings 👋 😃
Reposted by Lennart Hilbert
Registration is now open to attend Journal of Cell Science's meeting on Imaging Cell Dynamics, organised by Francesca Bottanelli, Guillaume Jacquemet, Michael Way and Giulia Zanetti.
Find out more: biologists.com/meetings/jcs...
#JCSimaging #Microscopy #Microscope #Imaging #Cells #CellScience
Find out more: biologists.com/meetings/jcs...
#JCSimaging #Microscopy #Microscope #Imaging #Cells #CellScience
October 9, 2025 at 11:15 AM
Registration is now open to attend Journal of Cell Science's meeting on Imaging Cell Dynamics, organised by Francesca Bottanelli, Guillaume Jacquemet, Michael Way and Giulia Zanetti.
Find out more: biologists.com/meetings/jcs...
#JCSimaging #Microscopy #Microscope #Imaging #Cells #CellScience
Find out more: biologists.com/meetings/jcs...
#JCSimaging #Microscopy #Microscope #Imaging #Cells #CellScience
Reposted by Lennart Hilbert
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Next Tuesday Oct 28, great talks of invited and local speakers of our Synthetic Genomics Center, in Heidelberg and on Zoom!
October 24, 2025 at 1:57 PM
Next Tuesday Oct 28, great talks of invited and local speakers of our Synthetic Genomics Center, in Heidelberg and on Zoom!
Last night Science Slam with a full house at Tollhaus, as part of @kit.edu Science Week. As one of four slammers, our PhD student Mona Wellhäusser @mofrawe.bsky.social entertained a huge audience, putting fish in jello for microscopy, (optically) slicing a pumpkin. Great show, fantastic atmosphere!
October 18, 2025 at 6:58 AM
Last night Science Slam with a full house at Tollhaus, as part of @kit.edu Science Week. As one of four slammers, our PhD student Mona Wellhäusser @mofrawe.bsky.social entertained a huge audience, putting fish in jello for microscopy, (optically) slicing a pumpkin. Great show, fantastic atmosphere!
Reposted by Lennart Hilbert
We are hiring ! If you want to become professor of Bioinformatics in the best city of North America, check the announcement below ! Also you do need to speak French (as long as you commit to learning it :) ) www.umontreal.ca/public/www/d...
www.umontreal.ca
October 10, 2025 at 11:48 AM
We are hiring ! If you want to become professor of Bioinformatics in the best city of North America, check the announcement below ! Also you do need to speak French (as long as you commit to learning it :) ) www.umontreal.ca/public/www/d...
Reposted by Lennart Hilbert
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
October 8, 2025 at 1:26 PM
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
Sharing a recent, deep insight:
The concept of a membrane-less organelle is an interesting one, like calling something a house without walls
The concept of a membrane-less organelle is an interesting one, like calling something a house without walls
October 7, 2025 at 11:03 AM
Sharing a recent, deep insight:
The concept of a membrane-less organelle is an interesting one, like calling something a house without walls
The concept of a membrane-less organelle is an interesting one, like calling something a house without walls
Happy 200th bday KIT 🥳
Das #KITKarlsruhe hat heute, am 7. Oktober 2025, Geburtstag: Auf den Tag genau vor 200 Jahren unterschrieb Großherzog Ludwig I. von Baden das Gründungsdekret für die erste Vorgängerinstitution der heutigen Exzellenzuniversität, die Polytechnische Schule in #Karlsruhe. www.kit.edu/kit/pi_2025_...
October 7, 2025 at 7:44 AM
Happy 200th bday KIT 🥳
Sadly, yes, and applies also past junior level! Sorry to everyone affected by my unreal email and task overload in the form of non-responsiveness 😣
If you’re applying to your dream lab for an internship/PhD/postdoc, always send a second email 1-2 weeks after the first one if you don’t hear back.
I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support
I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support
October 4, 2025 at 7:42 AM
Sadly, yes, and applies also past junior level! Sorry to everyone affected by my unreal email and task overload in the form of non-responsiveness 😣
Warming up for October start of KIT teaching by guest lecturing for @unistra.fr Cell Physics Master “Active Droplets”. First of three lectures today. 3:00 h sharp, start to finish 💪
Some travel impressions, including fancy and very white “Le Studium” on Strasbourg Central Campus 🤍
And, Gyoza 🥟
Some travel impressions, including fancy and very white “Le Studium” on Strasbourg Central Campus 🤍
And, Gyoza 🥟
September 26, 2025 at 3:38 PM
Warming up for October start of KIT teaching by guest lecturing for @unistra.fr Cell Physics Master “Active Droplets”. First of three lectures today. 3:00 h sharp, start to finish 💪
Some travel impressions, including fancy and very white “Le Studium” on Strasbourg Central Campus 🤍
And, Gyoza 🥟
Some travel impressions, including fancy and very white “Le Studium” on Strasbourg Central Campus 🤍
And, Gyoza 🥟
Reposted by Lennart Hilbert
The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.
August 13, 2025 at 5:28 PM
The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.
What a great doctoral defense by Tim Klingberg @fau.de
Based in the group of our collaborator @vasilyzaburdaev.bsky.social Tim decisively contributed to at least 3 of our own lab’s foundational projects, which he showed today at “Max Planck Zentrum Physik und Medizin”
Some impressions
Based in the group of our collaborator @vasilyzaburdaev.bsky.social Tim decisively contributed to at least 3 of our own lab’s foundational projects, which he showed today at “Max Planck Zentrum Physik und Medizin”
Some impressions
September 23, 2025 at 9:18 PM
What a great doctoral defense by Tim Klingberg @fau.de
Based in the group of our collaborator @vasilyzaburdaev.bsky.social Tim decisively contributed to at least 3 of our own lab’s foundational projects, which he showed today at “Max Planck Zentrum Physik und Medizin”
Some impressions
Based in the group of our collaborator @vasilyzaburdaev.bsky.social Tim decisively contributed to at least 3 of our own lab’s foundational projects, which he showed today at “Max Planck Zentrum Physik und Medizin”
Some impressions
Reposted by Lennart Hilbert
Congratulations to the Fritz Lipmann Lecturer Michael Rosen (Dallas) by the GBM president Harald Kolmar.
September 18, 2025 at 11:35 AM
Congratulations to the Fritz Lipmann Lecturer Michael Rosen (Dallas) by the GBM president Harald Kolmar.
Reposted by Lennart Hilbert
GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!
September 18, 2025 at 11:09 AM
GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!
If you are at GBM compact "Focus on Condensate Biology", we will be happy to talk to you at our lab's posters:
Mona Wellhäuser, MC15 @mofrawe.bsky.social
Yuzhi Bao, CA03 @yuzhibao.bsky.social
Lennart Hilbert, MC06
Conference abstracts:
gbm-compact.org/abstracts.html
*sketch added as click bait
Mona Wellhäuser, MC15 @mofrawe.bsky.social
Yuzhi Bao, CA03 @yuzhibao.bsky.social
Lennart Hilbert, MC06
Conference abstracts:
gbm-compact.org/abstracts.html
*sketch added as click bait
September 18, 2025 at 11:52 AM
If you are at GBM compact "Focus on Condensate Biology", we will be happy to talk to you at our lab's posters:
Mona Wellhäuser, MC15 @mofrawe.bsky.social
Yuzhi Bao, CA03 @yuzhibao.bsky.social
Lennart Hilbert, MC06
Conference abstracts:
gbm-compact.org/abstracts.html
*sketch added as click bait
Mona Wellhäuser, MC15 @mofrawe.bsky.social
Yuzhi Bao, CA03 @yuzhibao.bsky.social
Lennart Hilbert, MC06
Conference abstracts:
gbm-compact.org/abstracts.html
*sketch added as click bait
Reposted by Lennart Hilbert
Molekulare #Bionik: Der Zellkern als Vorbild für DNS-basierte #Computerchips. Forschende des #KITKarlsruhe (u. a. @lennarthilbert.bsky.social) nutzen zelluläre Informationsverarbeitung als Inspiration für die #Biotechnologie. www.kit.edu/kit/pi_2025_...
September 9, 2025 at 11:02 AM
Molekulare #Bionik: Der Zellkern als Vorbild für DNS-basierte #Computerchips. Forschende des #KITKarlsruhe (u. a. @lennarthilbert.bsky.social) nutzen zelluläre Informationsverarbeitung als Inspiration für die #Biotechnologie. www.kit.edu/kit/pi_2025_...
Simulation of the formation of a chromatin-attached condensate, which is visited by a gene undergoing transcriptional activation.
Read more about it here:
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Read more about it here:
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
September 9, 2025 at 6:40 AM
Simulation of the formation of a chromatin-attached condensate, which is visited by a gene undergoing transcriptional activation.
Read more about it here:
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Read more about it here:
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
"Chromatin-associated condensates as an inspiration for the system architecture of future DNA computers"
Highly conceptual Perspective article, supported by fresh data & simulations from our group. Containing my now 40 years of accumulated "wisdom".
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Highly conceptual Perspective article, supported by fresh data & simulations from our group. Containing my now 40 years of accumulated "wisdom".
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
September 8, 2025 at 1:50 PM
"Chromatin-associated condensates as an inspiration for the system architecture of future DNA computers"
Highly conceptual Perspective article, supported by fresh data & simulations from our group. Containing my now 40 years of accumulated "wisdom".
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Highly conceptual Perspective article, supported by fresh data & simulations from our group. Containing my now 40 years of accumulated "wisdom".
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
“We ask you to return your proof corrections within 48 hours.”
#sciencememe #academicmeme
#academemia
youtube.com/shorts/8N2eZ...
#sciencememe #academicmeme
#academemia
youtube.com/shorts/8N2eZ...
Marc Rebillet’s Late To Work Song 🔥😆
YouTube video by IndependentMindX
youtube.com
September 5, 2025 at 7:38 PM
“We ask you to return your proof corrections within 48 hours.”
#sciencememe #academicmeme
#academemia
youtube.com/shorts/8N2eZ...
#sciencememe #academicmeme
#academemia
youtube.com/shorts/8N2eZ...
Fine structural organization of the interphase nucleus in some mammalian cells, Monneron & Bernard, 1969
Gotta love these classic papers about nuclear architecture. In hindsight, all that we understand and discover today was already contained in their images.
www.sciencedirect.com/science/arti...
Gotta love these classic papers about nuclear architecture. In hindsight, all that we understand and discover today was already contained in their images.
www.sciencedirect.com/science/arti...
August 31, 2025 at 3:41 PM
Fine structural organization of the interphase nucleus in some mammalian cells, Monneron & Bernard, 1969
Gotta love these classic papers about nuclear architecture. In hindsight, all that we understand and discover today was already contained in their images.
www.sciencedirect.com/science/arti...
Gotta love these classic papers about nuclear architecture. In hindsight, all that we understand and discover today was already contained in their images.
www.sciencedirect.com/science/arti...
Nice paper showing how gene / TSS CpG-hypomethylation can allow long-range regulatory interactions, hypermetyhlation repress these interactions.
"Increased enhancer–promoter interactions during developmental enhancer activation in mammals"
www.nature.com/articles/s41...
@evgenykvon.bsky.social
"Increased enhancer–promoter interactions during developmental enhancer activation in mammals"
www.nature.com/articles/s41...
@evgenykvon.bsky.social
August 31, 2025 at 1:13 PM
Nice paper showing how gene / TSS CpG-hypomethylation can allow long-range regulatory interactions, hypermetyhlation repress these interactions.
"Increased enhancer–promoter interactions during developmental enhancer activation in mammals"
www.nature.com/articles/s41...
@evgenykvon.bsky.social
"Increased enhancer–promoter interactions during developmental enhancer activation in mammals"
www.nature.com/articles/s41...
@evgenykvon.bsky.social