Microglia are important immune cells in the brain. Mutations in microglia cause microgliopathies. Microglia replacement has emerged as a groundbreaking therapeutic paradigm that enables correction of ...

Sill and colleagues present an expanded DNA methylation classifier for CNS tumors. Building upon the 2021 WHO classification, this resource introduces a hierarchical taxonomy of 184 subclasses. It enhances classification accuracy for rare entities and provides integrated genomic data from a single, streamlined assay for modern neuro-oncology.

Brain metastasis (BrM) represents the most common intracranial malignancy, arising in up to 30% of all adult cancer patients and contributing significantly to cancer-related morbidity and mortality. B...

Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...

Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for transformative micro...

Cellular & Molecular Immunology - Microglia across evolution: from conserved origins to functional divergence

Using a mouse model that selectively lacks TET2 in myeloid cells, Sharma et al. show that myeloid cells and sympathetic neurons form a signaling nexus that controls serotonin production by enterochromaffin cells, which modulates colonic inflammation. Further, physiological stress uses sympathetic cues to drive serotonin production and worsen colitis.

Gliomas respond poorly to therapy and are considered immunologically “cold” tumors. Cakmak et al. identify tertiary lymphoid structures (TLSs) in a subset of gliomas that show signs of functional adaptive immune activation and are associated with longer overall patient survival and an immune-permissive tumor microenvironment. Such TLSs may represent a key determinant of glioma immune landscape, with clinical relevance.

AbstractBACKGROUND. The use of CAR T-cell therapy has been delayed in primary central nervous system lymphomas (PCNSL) due to the fear of unacceptable neur

Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.