NealeLab
@labneale.bsky.social
Recombination, Meiosis, Chromosomes, DNA Break Repair
https://twitter.com/LabNeale
https://twitter.com/LabNeale
Pinned
NealeLab
@labneale.bsky.social
· Dec 5
Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress - Nature Communications
Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...
www.nature.com
Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...
Reposted by NealeLab
Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair
www.yeastgenome.org/reference/39...
www.yeastgenome.org/reference/39...
November 13, 2025 at 8:57 PM
Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair
www.yeastgenome.org/reference/39...
www.yeastgenome.org/reference/39...
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae
Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor
academic.oup.com
November 13, 2025 at 8:40 PM
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Matching T-shirt and slide @gdsc-sussex.bsky.social from Sir Paul Nurse
November 7, 2025 at 4:13 PM
Matching T-shirt and slide @gdsc-sussex.bsky.social from Sir Paul Nurse
Fantastic celebration of Tony Carr’s scientific career at the @gdsc-sussex.bsky.social retreat 2025
November 7, 2025 at 3:08 PM
Fantastic celebration of Tony Carr’s scientific career at the @gdsc-sussex.bsky.social retreat 2025
Reposted by NealeLab
Vital piece of investigative reporting from Sky. They've uncovered the X algorithm which feeds users extremist right wing material from the moment they join the site. It is a far-right radicalisation engine, by design.
news.sky.com/story/the-x-...
news.sky.com/story/the-x-...
Elon Musk is boosting the British right - and this shows how
Elon Musk is boosting the British right - and this shows how
news.sky.com
November 6, 2025 at 7:23 AM
Vital piece of investigative reporting from Sky. They've uncovered the X algorithm which feeds users extremist right wing material from the moment they join the site. It is a far-right radicalisation engine, by design.
news.sky.com/story/the-x-...
news.sky.com/story/the-x-...
Reposted by NealeLab
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 30, 2025 at 8:41 PM
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Good old @nathanwpyle.bsky.social 😀
October 27, 2025 at 12:46 PM
Good old @nathanwpyle.bsky.social 😀
Reposted by NealeLab
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by NealeLab
I'm always reminded of Tim Hunt's description of going to the library: "flipping through tables of contents of all the latest issues, hoping there isn't something relevant to your work..." 3/n
September 30, 2025 at 11:29 AM
I'm always reminded of Tim Hunt's description of going to the library: "flipping through tables of contents of all the latest issues, hoping there isn't something relevant to your work..." 3/n
Reposted by NealeLab
Excited to announce that our PearlAI DependANT tool for identifying targeted treatments for patients with Cancer of Unknown Primary is one of the 48 projects funded by the UKRI Proof of Concept programme !!
www.ukri.org/news/48-proj...
www.ukri.org/news/48-proj...
48 projects backed to turn cutting-edge research into businesses
UKRI backs cutting-edge projects, from home tests for endometriosis to AI for accessible travel, to grow into market-leading products and services.
www.ukri.org
September 25, 2025 at 8:48 AM
Excited to announce that our PearlAI DependANT tool for identifying targeted treatments for patients with Cancer of Unknown Primary is one of the 48 projects funded by the UKRI Proof of Concept programme !!
www.ukri.org/news/48-proj...
www.ukri.org/news/48-proj...
Slowly recovering after just briefly visiting that "other" place we used to hang out in and Tweet. So much hate and misinformation...😔
September 15, 2025 at 12:02 PM
Slowly recovering after just briefly visiting that "other" place we used to hang out in and Tweet. So much hate and misinformation...😔
Reposted by NealeLab
👩🔬 We’re hiring! Join a dynamic team driving innovation in blood cancer research at the University of Sussex. Collaborate with experts, grow your skills in protein biochemistry, and contribute to vital discoveries.
👉 Apply here: www.jobs.ac.uk/job/DOP599/r...
👉 Apply here: www.jobs.ac.uk/job/DOP599/r...
Research Technician – Protein Biochemistry at University of Sussex
Discover Research Technician – Protein Biochemistry jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.
www.jobs.ac.uk
September 12, 2025 at 10:00 AM
👩🔬 We’re hiring! Join a dynamic team driving innovation in blood cancer research at the University of Sussex. Collaborate with experts, grow your skills in protein biochemistry, and contribute to vital discoveries.
👉 Apply here: www.jobs.ac.uk/job/DOP599/r...
👉 Apply here: www.jobs.ac.uk/job/DOP599/r...
Reposted by NealeLab
Looking forward to contributing to Social DNAing @columbiauniversity.bsky.social @columbiacancer.bsky.social later today!
September 11, 2025 at 8:52 AM
Looking forward to contributing to Social DNAing @columbiauniversity.bsky.social @columbiacancer.bsky.social later today!
Reposted by NealeLab
Yesterday’s #EasternArc session on HE in Palestine felt like a direct call to action - so much can be achieved if we put effort into working with/round clunky university processes - pooling open resources, giving Gaza students honorary fellowships to enable library access… 1/2
September 11, 2025 at 10:07 AM
Yesterday’s #EasternArc session on HE in Palestine felt like a direct call to action - so much can be achieved if we put effort into working with/round clunky university processes - pooling open resources, giving Gaza students honorary fellowships to enable library access… 1/2
The irony
Reporting a new Banksy mural which attacks the legal system for criminalizing protests against genocide, the BBC adds "the graffiti has been covered up and guarded". Thanks Dad.
September 8, 2025 at 8:46 PM
The irony
Reposted by NealeLab
#NEW_PAPER
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...
rdcu.be
August 27, 2025 at 11:16 AM
#NEW_PAPER
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
Reposted by NealeLab
#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify...
rdcu.be
August 29, 2025 at 2:20 PM
#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
Reposted by NealeLab
#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
doi.org
September 3, 2025 at 3:13 PM
#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Interested in the nuclease–helicase DNA2?
Fantastic new recombination-replication-checkpoint mechanics uncovered by Jessica Hudson et al: @u-rass.bsky.social @gdsc-sussex.bsky.social
www.nature.com/articles/s41...
Fantastic new recombination-replication-checkpoint mechanics uncovered by Jessica Hudson et al: @u-rass.bsky.social @gdsc-sussex.bsky.social
www.nature.com/articles/s41...
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
www.nature.com
September 3, 2025 at 8:52 PM
Interested in the nuclease–helicase DNA2?
Fantastic new recombination-replication-checkpoint mechanics uncovered by Jessica Hudson et al: @u-rass.bsky.social @gdsc-sussex.bsky.social
www.nature.com/articles/s41...
Fantastic new recombination-replication-checkpoint mechanics uncovered by Jessica Hudson et al: @u-rass.bsky.social @gdsc-sussex.bsky.social
www.nature.com/articles/s41...
Reposted by NealeLab
New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...
Insight into Meiotic DNA End Resection: Mechanisms and Regulation
Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic ch…
www.sciencedirect.com
August 16, 2025 at 7:32 PM
New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...
Reposted by NealeLab
The floating museum Galeón Andalucía looking spectacular and formidable in harbour at Shoreham-by-Sea today.
August 31, 2025 at 5:09 AM
The floating museum Galeón Andalucía looking spectacular and formidable in harbour at Shoreham-by-Sea today.
Reposted by NealeLab
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature Communications
The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers…
www.nature.com
August 28, 2025 at 11:07 AM
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by NealeLab
I'm looking to recruit a PhD student to study patterns of local adaptation and introgression across the spruce hybrid zone in the Rockies near Calgary. Projects can include field work, bioinformatics, pop gen theory, or comparison to plant/ conifer species
yeamanlab.weebly.com/uploads/5/7/...
yeamanlab.weebly.com/uploads/5/7/...
August 20, 2025 at 8:19 PM
I'm looking to recruit a PhD student to study patterns of local adaptation and introgression across the spruce hybrid zone in the Rockies near Calgary. Projects can include field work, bioinformatics, pop gen theory, or comparison to plant/ conifer species
yeamanlab.weebly.com/uploads/5/7/...
yeamanlab.weebly.com/uploads/5/7/...