Kyle MacQuarrie MD PhD
@kylemacquarrie.bsky.social
Pediatric oncologist and physician-scientist in Chicago, Asst Prof, big ol’ science nerd, 🏳️🌈, views my own, etc etc
May you live long enough to see your favorite angsty music as a teenager turn into a performance by the Lyric Opera.
November 22, 2025 at 1:16 AM
May you live long enough to see your favorite angsty music as a teenager turn into a performance by the Lyric Opera.
Reposted by Kyle MacQuarrie MD PhD
We are witnessing a poisonous effort to destroy what the vast majority of Americans know is a key pillar of public health.
Vaccines are responsible for 40% of the reduction in child mortality achieved in the last half century.
Vaccines are responsible for 40% of the reduction in child mortality achieved in the last half century.
November 20, 2025 at 6:23 PM
We are witnessing a poisonous effort to destroy what the vast majority of Americans know is a key pillar of public health.
Vaccines are responsible for 40% of the reduction in child mortality achieved in the last half century.
Vaccines are responsible for 40% of the reduction in child mortality achieved in the last half century.
Reposted by Kyle MacQuarrie MD PhD
Wow
About that exclusive, "closed-to-press" MAHA summit last week with RFK and JD Vance: I got in.
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
November 21, 2025 at 5:31 PM
Wow
Reposted by Kyle MacQuarrie MD PhD
You read what you can, with an honest attempt at being comprehensive. If you missed something, hopefully the editors/reviewers will point it out. If they don't, well, it happens; a reader or the authors might mention it, and now you know.
We haven't been able to "read everything" for many years.
We haven't been able to "read everything" for many years.
How do we make sense of scientific literature that is growing explosively to the point where no-one could read all the relevant papers, and is contaminated with fraudulent and LLM-generated papers? I think that science isn't currently equipped to deal with this, and we need to. #science #metascience
November 21, 2025 at 1:59 PM
You read what you can, with an honest attempt at being comprehensive. If you missed something, hopefully the editors/reviewers will point it out. If they don't, well, it happens; a reader or the authors might mention it, and now you know.
We haven't been able to "read everything" for many years.
We haven't been able to "read everything" for many years.
Reposted by Kyle MacQuarrie MD PhD
Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
November 11, 2025 at 6:55 PM
Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs"
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
Registration is free. Join us!
tinyurl.com/f9njvnyu
#chromatin #genomics #northwestern #biology #dna
Reposted by Kyle MacQuarrie MD PhD
Also, and not for nothing, I have zero idea how much my services cost.
Is there going to be an app we can use when we have a gunshot wound and need to determine which emergency room is cheaper tonight?
Cassidy: "If she goes and gets 2 types of shampoo & one is a dollar cheaper, she'll get the cheaper one & the other lowers their price. Once you give her the power of making the decision, she's gonna shop -- that begins to save her money and squeezes waste out of the healthcare system."
November 19, 2025 at 11:35 PM
Also, and not for nothing, I have zero idea how much my services cost.
Work email came out swinging this morning.
November 19, 2025 at 1:37 PM
Work email came out swinging this morning.
Reposted by Kyle MacQuarrie MD PhD
The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
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November 18, 2025 at 11:02 AM
The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
Reposted by Kyle MacQuarrie MD PhD
Just as saving for retirement starts early, so should protecting your heart. A new study led by Sadiya Khan introduces a first-of-its-kind online calculator that to help younger adults forecast and understand their risk of a heart event over the next 30 years — bit.ly/4i8g13F
November 17, 2025 at 4:02 PM
Just as saving for retirement starts early, so should protecting your heart. A new study led by Sadiya Khan introduces a first-of-its-kind online calculator that to help younger adults forecast and understand their risk of a heart event over the next 30 years — bit.ly/4i8g13F
Mishearing of my first name has reached never before seen heights today.
November 17, 2025 at 2:58 PM
Mishearing of my first name has reached never before seen heights today.
Reposted by Kyle MacQuarrie MD PhD
as a physician, patient, and human, I can say that relieving pain is not “useless”
November 13, 2025 at 4:50 PM
as a physician, patient, and human, I can say that relieving pain is not “useless”
Would like to know who I register a complaint with about this much snow before Thanksgiving.
November 10, 2025 at 3:40 PM
Would like to know who I register a complaint with about this much snow before Thanksgiving.
So grateful that technology tells me the sort of thing that really matters at 11 PM for me and my airport uber driver - like where the nearest Sunglass Hut is.
November 7, 2025 at 1:45 PM
So grateful that technology tells me the sort of thing that really matters at 11 PM for me and my airport uber driver - like where the nearest Sunglass Hut is.
All right, Philly, I’ll concede you make some compelling points on a beautiful fall day.
November 4, 2025 at 8:41 PM
All right, Philly, I’ll concede you make some compelling points on a beautiful fall day.
Co-pilot kept pushing to have me let it ‘analyze’ some data I put in a spreadsheet and generate a pathway diagram for me.
I am very excited to report that I will now be focusing on ‘Signuling pathways’ and the role of the ‘cell cyrvcel’. Groundbreaking science to come!
I am very excited to report that I will now be focusing on ‘Signuling pathways’ and the role of the ‘cell cyrvcel’. Groundbreaking science to come!
November 4, 2025 at 4:15 PM
Co-pilot kept pushing to have me let it ‘analyze’ some data I put in a spreadsheet and generate a pathway diagram for me.
I am very excited to report that I will now be focusing on ‘Signuling pathways’ and the role of the ‘cell cyrvcel’. Groundbreaking science to come!
I am very excited to report that I will now be focusing on ‘Signuling pathways’ and the role of the ‘cell cyrvcel’. Groundbreaking science to come!
Reposted by Kyle MacQuarrie MD PhD
Think we've got DNA all figured out? Nope. Researchers at Northwestern University say our genome has a geometric code, and we may be "living, breathing computational systems." 😲
H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social
kimbellard.medium.com/life-is-geom...
H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social
kimbellard.medium.com/life-is-geom...
Life Is Geometry
In 2025, we’ve got DNA all figured out, right? It’s been over fifty years since Crick and Watson (and Franklin) discovered the double helix…
kimbellard.medium.com
November 3, 2025 at 10:09 PM
Think we've got DNA all figured out? Nope. Researchers at Northwestern University say our genome has a geometric code, and we may be "living, breathing computational systems." 😲
H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social
kimbellard.medium.com/life-is-geom...
H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social
kimbellard.medium.com/life-is-geom...
Reposted by Kyle MacQuarrie MD PhD
Scaling back DEI isn’t just a moral setback—it’s a loss of innovation.
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
November 3, 2025 at 2:05 PM
Scaling back DEI isn’t just a moral setback—it’s a loss of innovation.
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
Putting on my trick or treating game face (/horns).
October 31, 2025 at 9:37 PM
Putting on my trick or treating game face (/horns).
Signs that Halloween is intense in your neighborhood: when you organize the 500+ pieces of candy you’ll hand out tonight before you even leave for work this morning.
October 31, 2025 at 12:41 PM
Signs that Halloween is intense in your neighborhood: when you organize the 500+ pieces of candy you’ll hand out tonight before you even leave for work this morning.
Reposted by Kyle MacQuarrie MD PhD
New CPGE research in Advanced Science describes a language hidden in the genome, beyond the DNA sequence. The geometric code may help cells “remember” how to create and preserve memories, functioning like a network of living computers.
#chromatin #dna
www.mccormick.northwestern.edu/news/article...
#chromatin #dna
www.mccormick.northwestern.edu/news/article...
From Sequence to Shape: Scientists Discover the Possible Geometric Blueprint of Complex Life
New research from Professors Vadim Backman and Igal Szleifer reveals the language that stores cell memory -- written in the shape of the genome itself.
www.mccormick.northwestern.edu
October 29, 2025 at 6:15 PM
New CPGE research in Advanced Science describes a language hidden in the genome, beyond the DNA sequence. The geometric code may help cells “remember” how to create and preserve memories, functioning like a network of living computers.
#chromatin #dna
www.mccormick.northwestern.edu/news/article...
#chromatin #dna
www.mccormick.northwestern.edu/news/article...
Early access for our paper is now live!
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome - Almassalha - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
This study introduces a new hypothesis: exons, introns, and intergenic segments are non-random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented...
advanced.onlinelibrary.wiley.com
October 27, 2025 at 10:00 PM
Early access for our paper is now live!
Now I have to be on the lookout for iPSC tags.
October 26, 2025 at 6:29 PM
Now I have to be on the lookout for iPSC tags.
Reposted by Kyle MacQuarrie MD PhD
An editorial in @thelancetrheum.bsky.social about prioritizing diversity in rheumatology - whether it's in clinical trials, in other research, in clinical practice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 23, 2025 at 12:56 PM
An editorial in @thelancetrheum.bsky.social about prioritizing diversity in rheumatology - whether it's in clinical trials, in other research, in clinical practice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kyle MacQuarrie MD PhD
NEWS: ICE arrests Chicago man whose teenage daughter is fighting cancer: “He belongs with her.” I spent yesterday afternoon with Ofelia Torres and her mother, Sandibell, talking about Ruben Torres. Here’s the story www.chicagotribune.com/2025/10/21/i...
ICE arrests Chicago man whose teenage daughter is fighting cancer: ‘He belongs with her’
Ofelia Torres has spent almost every day of the past month at Lurie Children’s Hospital, where the 16-year-old Lake View High School student is fighting cancer.
www.chicagotribune.com
October 21, 2025 at 7:02 PM
NEWS: ICE arrests Chicago man whose teenage daughter is fighting cancer: “He belongs with her.” I spent yesterday afternoon with Ofelia Torres and her mother, Sandibell, talking about Ruben Torres. Here’s the story www.chicagotribune.com/2025/10/21/i...