Yue Kris Wu
@kriswu.bsky.social
Postdoc at the Center for Theoretical Neuroscience at Columbia University
Reposted by Yue Kris Wu
Inviting apps for a workshop to develop a project focused on a mechanistic understanding of canonical cortical computations at the circuit level. Deadline is 1/5/2026: https://www.simonsfoundation.org/simons-foundation-now-accepting-applications-for-workshop-on-canonical-cortical-computations
Simons Foundation Now Accepting Applications for Workshop on Canonical Cortical Computations
Simons Foundation Now Accepting Applications for Workshop on Canonical Cortical Computations on Simons Foundation
www.simonsfoundation.org
November 24, 2025 at 6:47 PM
Inviting apps for a workshop to develop a project focused on a mechanistic understanding of canonical cortical computations at the circuit level. Deadline is 1/5/2026: https://www.simonsfoundation.org/simons-foundation-now-accepting-applications-for-workshop-on-canonical-cortical-computations
Reposted by Yue Kris Wu
Episode #34 in #TheoreticalNeurosciencePodcast: On balanced neural networks – with Nicolas Brunel
theoreticalneuroscience.no/thn34
Cortical neurons seem to receive about the same amount of excitation and inhibition. One of the founders of this key idea in 1990s explains.
theoreticalneuroscience.no/thn34
Cortical neurons seem to receive about the same amount of excitation and inhibition. One of the founders of this key idea in 1990s explains.
November 8, 2025 at 9:05 AM
Episode #34 in #TheoreticalNeurosciencePodcast: On balanced neural networks – with Nicolas Brunel
theoreticalneuroscience.no/thn34
Cortical neurons seem to receive about the same amount of excitation and inhibition. One of the founders of this key idea in 1990s explains.
theoreticalneuroscience.no/thn34
Cortical neurons seem to receive about the same amount of excitation and inhibition. One of the founders of this key idea in 1990s explains.
Reposted by Yue Kris Wu
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
October 31, 2025 at 4:08 AM
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
Reposted by Yue Kris Wu
How does our brain excel at complex object recognition, yet get fooled by simple illusory contours? What unifying principle governs all Gestalt laws of perceptual organization?
We may have an answer: integration of learned priors through feedback. New paper with @kenmiller.bsky.social! 🧵
We may have an answer: integration of learned priors through feedback. New paper with @kenmiller.bsky.social! 🧵
October 24, 2025 at 2:00 PM
How does our brain excel at complex object recognition, yet get fooled by simple illusory contours? What unifying principle governs all Gestalt laws of perceptual organization?
We may have an answer: integration of learned priors through feedback. New paper with @kenmiller.bsky.social! 🧵
We may have an answer: integration of learned priors through feedback. New paper with @kenmiller.bsky.social! 🧵
Reposted by Yue Kris Wu
📣 WTI is hiring faculty positions! Are you interested in advancing our understanding of the brain + how it gives rise to cognition?
Two calls are open:
Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review
🔗 wti.yale.edu/opportunities
#KnowTogether
Two calls are open:
Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review
🔗 wti.yale.edu/opportunities
#KnowTogether
October 3, 2025 at 4:43 PM
📣 WTI is hiring faculty positions! Are you interested in advancing our understanding of the brain + how it gives rise to cognition?
Two calls are open:
Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review
🔗 wti.yale.edu/opportunities
#KnowTogether
Two calls are open:
Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review
🔗 wti.yale.edu/opportunities
#KnowTogether
Reposted by Yue Kris Wu
Happy to share that I just started a W2 professorship at the University of Bremen! Yay tenure! While I already start teaching now, the lab will stay in Freiburg until May while we get things ready. Super excited about this new chapter! We’re also hiring! Please get in touch if you’re interested!
October 3, 2025 at 11:31 PM
Happy to share that I just started a W2 professorship at the University of Bremen! Yay tenure! While I already start teaching now, the lab will stay in Freiburg until May while we get things ready. Super excited about this new chapter! We’re also hiring! Please get in touch if you’re interested!
Reposted by Yue Kris Wu
How does the brain decide? 🧠
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Transitions in dynamical regime and neural mode during perceptual decisions - Nature
Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...
www.nature.com
September 17, 2025 at 8:12 PM
How does the brain decide? 🧠
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Reposted by Yue Kris Wu
Do you see a white square?
A new study, supported by our #OpenScope team, identified the key neural circuit and cell type involved with inferring details that don't exist in illusions like the one below.
🔗 alleninstitute.org/news/scienti...
#OpenScienceWeek
A new study, supported by our #OpenScope team, identified the key neural circuit and cell type involved with inferring details that don't exist in illusions like the one below.
🔗 alleninstitute.org/news/scienti...
#OpenScienceWeek
September 15, 2025 at 9:33 PM
Do you see a white square?
A new study, supported by our #OpenScope team, identified the key neural circuit and cell type involved with inferring details that don't exist in illusions like the one below.
🔗 alleninstitute.org/news/scienti...
#OpenScienceWeek
A new study, supported by our #OpenScope team, identified the key neural circuit and cell type involved with inferring details that don't exist in illusions like the one below.
🔗 alleninstitute.org/news/scienti...
#OpenScienceWeek
Reposted by Yue Kris Wu
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Motor cortex flexibly deploys a high-dimensional repertoire of subskills
Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...
www.biorxiv.org
September 8, 2025 at 4:34 PM
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Yue Kris Wu
The University of Notre Dame is hiring 5 tenure or tenure-track professors in Neuroscience, including Computational Neuroscience, across 4 departments.
Come join me at ND! Feel free to reach out with any questions.
And please share!
apply.interfolio.com/173031
Come join me at ND! Feel free to reach out with any questions.
And please share!
apply.interfolio.com/173031
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 3, 2025 at 5:26 PM
The University of Notre Dame is hiring 5 tenure or tenure-track professors in Neuroscience, including Computational Neuroscience, across 4 departments.
Come join me at ND! Feel free to reach out with any questions.
And please share!
apply.interfolio.com/173031
Come join me at ND! Feel free to reach out with any questions.
And please share!
apply.interfolio.com/173031
Reposted by Yue Kris Wu
📢We're #hiring Group Leaders!
Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.
🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines
Apply by Nov. 4👉 https://janelia.link/groupleader
Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.
🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines
Apply by Nov. 4👉 https://janelia.link/groupleader
August 26, 2025 at 7:00 PM
📢We're #hiring Group Leaders!
Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.
🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines
Apply by Nov. 4👉 https://janelia.link/groupleader
Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.
🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines
Apply by Nov. 4👉 https://janelia.link/groupleader
Reposted by Yue Kris Wu
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
August 1, 2025 at 9:06 AM
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
Reposted by Yue Kris Wu
Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
Assembly-based computations through contextual dendritic gating of plasticity
Neuronal assemblies — groups of strongly connected neurons — are considered the basic building blocks of perception and memory in the brain by encoding representations of specific concepts. Despite re...
www.biorxiv.org
July 25, 2025 at 10:53 AM
Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information.
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
www.biorxiv.org/content/10.1...
Detailed 🧵 below 👇 1/12
Reposted by Yue Kris Wu
I’m excited to share my final co-first author paper from my postdoc in Dan Dombeck's lab!
We explored how behavior, senses, and neurons influence how much information in the brain changes over time.
www.nature.com/articles/s41...
#science #research #neuroscience #hippocampus #placecells
We explored how behavior, senses, and neurons influence how much information in the brain changes over time.
www.nature.com/articles/s41...
#science #research #neuroscience #hippocampus #placecells
Hippocampal representations drift in stable multisensory environments - Nature
Tracking of individual place cells in mouse CA1 shows that representational drift is not influenced by changes in environment or behaviour, and is lower for more excitable place cells.
www.nature.com
July 23, 2025 at 4:12 PM
I’m excited to share my final co-first author paper from my postdoc in Dan Dombeck's lab!
We explored how behavior, senses, and neurons influence how much information in the brain changes over time.
www.nature.com/articles/s41...
#science #research #neuroscience #hippocampus #placecells
We explored how behavior, senses, and neurons influence how much information in the brain changes over time.
www.nature.com/articles/s41...
#science #research #neuroscience #hippocampus #placecells
Reposted by Yue Kris Wu
👨💻 Open PI position in our institute 👨💻 !! If you are an expert in Computational Neuroscience and want to start your lab in Bordeaux, contact us !
www.fens.org/careers/job-...
@neuromagendie.bsky.social
@neurobordeaux.bsky.social
www.fens.org/careers/job-...
@neuromagendie.bsky.social
@neurobordeaux.bsky.social
July 10, 2025 at 3:13 PM
👨💻 Open PI position in our institute 👨💻 !! If you are an expert in Computational Neuroscience and want to start your lab in Bordeaux, contact us !
www.fens.org/careers/job-...
@neuromagendie.bsky.social
@neurobordeaux.bsky.social
www.fens.org/careers/job-...
@neuromagendie.bsky.social
@neurobordeaux.bsky.social
Reposted by Yue Kris Wu
We are seeking two independent Max Planck Research Groups working in scientific disciplines relevant to our institute. Applications should be sent in PDF format no later than 15th August 2025. Visit our call for applications on our institute website for detailed information!
July 8, 2025 at 7:49 AM
We are seeking two independent Max Planck Research Groups working in scientific disciplines relevant to our institute. Applications should be sent in PDF format no later than 15th August 2025. Visit our call for applications on our institute website for detailed information!
Reposted by Yue Kris Wu
⌛ One week left to submit your poster abstracts and travel grant applications for the #BernsteinConference 2025!
🗓️ Deadline: July 15
All info and submission 👉 bernstein-network.de/bernstein-co...
🗓️ Deadline: July 15
All info and submission 👉 bernstein-network.de/bernstein-co...
July 8, 2025 at 7:02 AM
⌛ One week left to submit your poster abstracts and travel grant applications for the #BernsteinConference 2025!
🗓️ Deadline: July 15
All info and submission 👉 bernstein-network.de/bernstein-co...
🗓️ Deadline: July 15
All info and submission 👉 bernstein-network.de/bernstein-co...
Reposted by Yue Kris Wu
New group leader position in computational neuroscience @ Neurocentre Magendie, INSERM, Bordeaux! More info here: www.bordeaux-neurocampus.fr/group-leader...
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
Group leader tenured-track position in Computational Neuroscience - Bordeaux Neurocampus
Neurocentre Magendie
www.bordeaux-neurocampus.fr
July 4, 2025 at 12:26 PM
New group leader position in computational neuroscience @ Neurocentre Magendie, INSERM, Bordeaux! More info here: www.bordeaux-neurocampus.fr/group-leader...
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
⚠️ Application deadline: end of September 2025
@neurobordeaux.bsky.social @neuromagendie.bsky.social
Reposted by Yue Kris Wu
Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...
Discovering cognitive strategies with tiny recurrent neural networks - Nature
Modelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...
doi.org
July 2, 2025 at 7:03 PM
Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...
Reposted by Yue Kris Wu
Out today in @nature.com: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 25, 2025 at 10:38 PM
Out today in @nature.com: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yue Kris Wu
Very happy that this work is finally out in @pnas.org! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits | PNAS
Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to
stabilize key features of network activity, but whether these di...
www.pnas.org
May 31, 2025 at 3:19 PM
Very happy that this work is finally out in @pnas.org! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Happy to share our new preprint! We show how cell-type-specific synaptic scaling mechanisms shape memory representations during associative learning and highlight a critical role of top-down inputs in modulating this process. www.biorxiv.org/content/10.1...
Cell-type-specific synaptic scaling mechanisms differentially contribute to associative learning
Excitatory synaptic scaling regulates network dynamics by proportionally adjusting excitatory synaptic strengths after sensory perturbations. During associative learning, blocking excitatory scaling i...
www.biorxiv.org
May 15, 2025 at 11:24 AM
Happy to share our new preprint! We show how cell-type-specific synaptic scaling mechanisms shape memory representations during associative learning and highlight a critical role of top-down inputs in modulating this process. www.biorxiv.org/content/10.1...
Reposted by Yue Kris Wu
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested.
1/n
rdcu.be/el18q
A short thread follows for those interested.
1/n
Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
rdcu.be
May 14, 2025 at 4:32 PM
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested.
1/n
rdcu.be/el18q
A short thread follows for those interested.
1/n
Reposted by Yue Kris Wu
Theory of interaction between untuned modulatory inputs and tuned sensory inputs https://www.biorxiv.org/content/10.1101/2025.04.28.651100v1
May 3, 2025 at 4:15 AM
Theory of interaction between untuned modulatory inputs and tuned sensory inputs https://www.biorxiv.org/content/10.1101/2025.04.28.651100v1
Reposted by Yue Kris Wu
Neuroscientists: I remember an essay (probably in @elife.bsky.social) by Eve Marder about being a finisher, not someone who endlessly starts new projects - and this playing a big role in a scientific career.
I can't find it in the Living Science collection, does anyone know which one I mean?
I can't find it in the Living Science collection, does anyone know which one I mean?
December 6, 2024 at 10:17 AM
Neuroscientists: I remember an essay (probably in @elife.bsky.social) by Eve Marder about being a finisher, not someone who endlessly starts new projects - and this playing a big role in a scientific career.
I can't find it in the Living Science collection, does anyone know which one I mean?
I can't find it in the Living Science collection, does anyone know which one I mean?