Tatiana Engel
banner
engeltatiana.bsky.social
Tatiana Engel
@engeltatiana.bsky.social
Computational neuroscientist @princetonneuro.bsky.social deciphering natural and advancing artificial intelligence.
Pinned
Out today in @nature.com: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables.
www.nature.com/articles/s41...
Thank you for having me on BrainInspired, Paul @braininspired.bsky.social! It was such an honor to be on my favorite show—a rare place where we can leisurely talk about manifolds, latent circuits, power laws, and other esoteric ideas, and still be taken seriously in knowing they are all real.
Are manifolds real?
Are latent circuits real?
Tatiana @engeltatiana.bsky.social uses one, infers the other, and says yes to both.

Also, how timescales are different and the same across the entire brain...

braininspired.co/podcast/226/
December 5, 2025 at 4:42 AM
Our work with @pawa-pawa.bsky.social is out in Nature Machine Intelligence! The choice of activation function affects the representations, dynamics, and circuit solutions that emerge in RNNs trained on cognitive tasks. Activation matters!
www.nature.com/articles/s42...
October 24, 2025 at 7:18 PM
A study led by Cina Aghamohammadi is now out in ‪@natcomms.nature.com‬! We developed a mathematical framework for partitioning spiking variability, which revealed that spiking irregularity is nearly invariant for each neuron and decreases along the cortical hierarchy.
www.nature.com/articles/s41...
October 12, 2025 at 12:42 AM
Reposted by Tatiana Engel
Two flagship papers from the International Brain Laboratory, now out in ‪@Nature.com‬:
🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0
🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +
September 3, 2025 at 4:22 PM
Reposted by Tatiana Engel
Princeton’s @ilanawitten.bsky.social, @engeltatiana.bsky.social, and @jpillowtime.bsky.social have created the first-ever brain-wide activity map during decision making in mice as part of an international group effort known as the @intlbrainlab.bsky.social.

🔗 pni.princeton.edu/news/2025/fi...
September 3, 2025 at 3:17 PM
New work with @shiyanliang.bsky.social‬, @roxana-zeraati.bsky.social, @intlbrainlab.bsky.social, Anna Levina. We uncover the principles that organize single-neuron timescales across the entire brain, unifying regional specialization with universal brain-wide dynamics: www.biorxiv.org/content/10.1...
Excited to share our new preprint on the brain-wide organization of intrinsic timescales at single neuron resolution. Work w/ @roxana-zeraati.bsky.social, @intlbrainlab.bsky.social, Anna Levina, @engeltatiana.bsky.social : www.biorxiv.org/content/10.1...
September 2, 2025 at 4:08 PM
Out today in @nature.com: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables.
www.nature.com/articles/s41...
June 25, 2025 at 10:38 PM
Reposted by Tatiana Engel
“Like a group of skiers descending a mountain, each [neuron] prefers a slightly different path, but all are shaped by the same slope,” says PNI's @engeltatiana.bsky.social‬ on her lab’s new ‪@nature.com‬ study revealing how the brain makes decisions.

📰: pni.princeton.edu/news/2025/al...
June 25, 2025 at 3:06 PM
Reposted by Tatiana Engel
Into population dynamics? Coming to #CNS2025 but not quite ready to head home?

Come join us! at the Symposium on "Neural Population Dynamics and Latent Representations"! 🧠
📆 July 10th
📍 Scuola Superiore Sant’Anna, Pisa (and online)
👉 Free registration: neurobridge-tne.github.io
#compneuro
June 21, 2025 at 10:24 AM
Our new paper with @chrismlangdon is just out in @natureneuro.bsky.social! We show that high-dimensional RNNs use low-dimensional circuit mechanisms for cognitive tasks and identify a latent inhibitory mechanism for context-dependent decisions in PFC data.
www.nature.com/articles/s41...
February 12, 2025 at 6:19 PM
Reposted by Tatiana Engel
The latent circuit model identifies low-dimensional mechanisms of task execution from heterogeneous neural responses. This approach revealed a latent inhibitory mechanism for context-dependent decisions in neural network models and prefrontal cortex 🧪🧠

www.nature.com/articles/s41...
Latent circuit inference from heterogeneous neural responses during cognitive tasks - Nature Neuroscience
The latent circuit model identifies low-dimensional mechanisms of task execution from heterogenous neural responses. This approach reveals a latent inhibitory mechanism for context-dependent decisions...
www.nature.com
February 11, 2025 at 11:53 AM